Many breakthroughs in the laboratories often do not bridge the gap between research and commercialization. However, silicon photonics bucked the trend, with industry observers estimating the ...commercial market to close in on a billion dollars in 2020 <xref ref-type="bibr" rid="ref45">45 . Silicon photonics leverages the billions of dollars and decades of research poured into silicon semiconductor device processing to enable high yield, robust processing, and most of all, low cost. Silicon is also a good optical material, with transparency in the commercially important infrared wavelength bands, and is a suitable platform for large-scale photonic integrated circuits. Silicon photonics is therefore slated to address the world's ever-increasing needs for bandwidth. It is part of an emerging ecosystem which includes designers, foundries, and integrators. In this paper, we review most of the foundries that presently enable silicon photonics integrated circuits fabrication. Some of these are pilot lines of major research institutes, and others are fully commercial pure-play foundries. Since silicon photonics has been commercially active for some years, foundries have released process design kits (PDK) that contain a standard device library. These libraries represent optimized and well-tested photonic elements, whose performance reflects the stability and maturity of the integration platforms. We will document the early works in silicon photonics, as well as its commercial status. We will provide a comprehensive review of the development of silicon photonics and the foundry services which enable the productization, including various efforts to develop and release PDK devices. In this context, we will report the long-standing efforts and contributions that previously IME/A * STAR and now AMF has dedicated to accelerating this journey.
Topological insulators are insulating materials that display massless, Dirac-like surface states in which the electrons have only one spin degree of freedom on each surface. These states have been ...imaged by photoemission, but little information on their transport parameters, for example, mobility, is available. We report the observation of Shubnikov-de Haas oscillations arising from the surface states in nonmetallic crystals of Bi(2)Te(3). In addition, we uncovered a Hall anomaly in weak fields, which enables the surface current to be seen directly. Both experiments yield a surface mobility (9000 to 10,000 centimeter(2) per volt-second) that is substantially higher than in the bulk. The Fermi velocity of 4 x 10(5) meters per second obtained from these transport experiments agrees with angle-resolved photoemission experiments.
Occult peritoneal metastasis (PM) in advanced gastric cancer (AGC) patients is highly possible to be missed on computed tomography (CT) images. Patients with occult PMs are subject to late detection ...or even improper surgical treatment. We therefore aimed to develop a radiomic nomogram to preoperatively identify occult PMs in AGC patients.
A total of 554 AGC patients from 4 centers were divided into 1 training, 1 internal validation, and 2 external validation cohorts. All patients’ PM status was firstly diagnosed as negative by CT, but later confirmed by laparoscopy (PM-positive n = 122, PM-negative n = 432). Radiomic signatures reflecting phenotypes of the primary tumor (RS1) and peritoneum region (RS2) were built as predictors of PM from 266 quantitative image features. Individualized nomograms of PM status incorporating RS1, RS2, or clinical factors were developed and evaluated regarding prediction ability.
RS1, RS2, and Lauren type were significant predictors of occult PM (all P < 0.05). A nomogram of these three factors demonstrated better diagnostic accuracy than the model with RS1, RS2, or clinical factors alone (all net reclassification improvement P < 0.05). The area under curve yielded was 0.958 95% confidence interval (CI) 0.923–0.993, 0.941 (95% CI 0.904–0.977), 0.928 (95% CI 0.886–0.971), and 0.920 (95% CI 0.862–0.978) for the training, internal, and two external validation cohorts, respectively. Stratification analysis showed that this nomogram had potential generalization ability.
CT phenotypes of both primary tumor and nearby peritoneum are significantly associated with occult PM status. A nomogram of these CT phenotypes and Lauren type has an excellent prediction ability of occult PM, and may have significant clinical implications on early detection of occult PM for AGC.
Genetic manipulations of insect populations for pest control have been advocated for some time, but there are few cases where manipulated individuals have been released in the field and no cases ...where they have successfully invaded target populations. Population transformation using the intracellular bacterium Wolbachia is particularly attractive because this maternally-inherited agent provides a powerful mechanism to invade natural populations through cytoplasmic incompatibility. When Wolbachia are introduced into mosquitoes, they interfere with pathogen transmission and influence key life history traits such as lifespan. Here we describe how the wMel Wolbachia infection, introduced into the dengue vector Aedes aegypti from Drosophila melanogaster, successfully invaded two natural A. aegypti populations in Australia, reaching near-fixation in a few months following releases of wMel-infected A. aegypti adults. Models with plausible parameter values indicate that Wolbachia-infected mosquitoes suffered relatively small fitness costs, leading to an unstable equilibrium frequency <30% that must be exceeded for invasion. These findings demonstrate that Wolbachia-based strategies can be deployed as a practical approach to dengue suppression with potential for area-wide implementation.
Tungsten copper (W-Cu) composites, as a traditional refractory material, are promising materials for manufacture of electrical contacts and electrodes, heavy duty electronic contacts, welding and ...electro-forging dies, heat sinks, packaging material, arcing resistance electrodes and thermal management devices owing to their excellent properties. This critical review presents and discusses the current progress of W-Cu composites. Starting with an introduction of the synthesis methods for W-Cu composites, including the conventional and modern preparation approaches. After that we focus on the description of the improvement of mechanical properties and arc-erosion properties by modification techniques. Finally, the advantages of W-Cu composites in applications such as electrical contacts, electronic packaging materials, and heat sinks, as well as military materials, are described, respectively.
•W-Cu composites have been developed and widely used over a wide range.•This critical review presents and discusses the current progress of W-Cu composites.•Graphene is a promising reinforcement phase for W-Cu composites in the further.
This study aimed to investigate the clinical characteristics and long-term prognosis of mycoplasma pneumoniae pneumonia (MPP)-associated thrombosis and to gain a better understanding of the diagnosis ...and treatment of the disease.
The medical records of 14 children with MPP-associated thrombosis between January 2016 and April 2020 were retrospectively reviewed at the Tianjin Children's Hospital.
The ages of the patients ranged from 3 to 12 years old. Among the 14 cases, there were five cases of pulmonary embolism, two cases of cerebral infarction, one case of splenic infarction, one case of cardiac embolism, two cases of cardiac embolism with comorbid pulmonary embolism, one case of internal carotid artery and pulmonary embolism, one case of combined internal carotid artery and the cerebral infarction, and one case combined cardiac embolism and lower limb artery embolism. All cases had elevated D-dimer levels. After thrombolysis and anticoagulation therapy, three cases with cerebral embolism still suffered from neurological sequelae. In contrast, the remaining cases did not develop complications.
MPP-associated thrombosis can occur in any vessel of the body. Thrombosis-associated symptoms may be complex and non-specific. Elevated D-dimer levels in a child with refractory mycoplasma pneumoniae pneumonia should raise suspicion of thrombosis. The long-term prognosis of thrombosis was favorable after the timely administration of anticoagulant therapy.
Ring Current Morphology From MMS Observations Tan, X.; Dunlop, M. W.; Dong, X.‐C. ...
Journal of geophysical research. Space physics,
April 2023, 2023-04-00, 20230401, Letnik:
128, Številka:
4
Journal Article
Recenzirano
Odprti dostop
We directly estimate the in situ current density of the Earth’s ring current (RC) using the curlometer method and investigate its morphology using the small spatial separations and high accuracy of ...the Magnetospheric Multiscale mission. Through statistical analysis of data from September 2015 to the end of 2016, covering the region of 2–8 RE (Earth radius, 6,371 km), we reveal an almost complete near‐equatorial (within ±20° $\pm 20{}^{\circ}$) RC morphology in terms of radial distance and magnetic local time (MLT) which complements and extends that found from previous studies. We found no evidence of RC enhancement on the dusk side during geomagnetic active periods, but details of MLT asymmetries in, and the boundary between, the inner (eastward) and outer (westward) currents are revealed. We propose that part of the asymmetry demonstrated here suggests that in addition to the overall persistence of the westward RC, two large banana‐like currents are directly observed, one which could arise from a peak of plasma pressure near ∼4.8 RE on the noon side and the other from a valley of plasma pressure which could arise near ∼4.8 RE on the night side.
Plain Language Summary
Large‐scale current systems existing in space affect the magnetic field on the surface of Earth and the ring current has a dominant influence. Space weather drives large variations in these currents which disturb the surface magnetic fields. When the disturbance is violent, it is called a magnetic storm and may have a disastrous impact on satellite and ground systems. Using the high‐precision magnetic field data of the four spacecraft in NASA’s Magnetospheric Multiscale mission, by employing a multispacecraft analysis method, we calculate the distribution of local current density in space. Through statistical analysis of the current in the region, we study its morphology. We confirm the asymmetry of the ring current found in previous studies and suggest a new explanation for part of the asymmetry, that is, that the generally westward ring current is superimposed on closed, banana‐like currents.
Key Points
General trends of ring current morphology are revealed by statistical analysis of current density, directly calculated from multispacecraft analysis of Magnetospheric Multiscale mission data
Banana‐like currents (at both inner and outer L‐shells) are directly observed, resulting in both day–night and dawn–dusk asymmetry
Although an inner asymmetric eastward current is confirmed, no westward dusk‐side, storm time, ring current enhancement is observed
For conventional titanium matrix composites (TiMCs), there is always a trade-off issue between enhanced strength and ductility of these materials. In this study, we explore a new design methodology ...by reinforcing titanium alloy matrix with carbonaceous nanomaterials and investigate the mechanisms for achieving a good balance of their strength and ductility. The TiMCs were synthesized through a low-cost powder metallurgy route using pre-mixed Ti-6Al-4V (TC4) powders and various carbon based nanofillers, including graphite powders (GPs), graphene oxide nanosheets (GONs) and graphene nanoplates (GNPs), and were further rolled at a temperature of 1173 K with a deformation of 66.7%. Among these three types of carbon reinforcing sources, the GNPs are more easily reacted with TC4 matrix and form more contents of TiC phases after sintering owing to their larger amounts of defects than those of the GPs and GONs. TiC products are identified to play a bridging role for not only connecting the TC4 matrix but also forming coherent interfaces with the TC4 matrix, thus facilitating a strong interfacial bonding of the composites. The as-rolled GNPs/TC4 composites exhibit a 0.2% yield strength of 1146.36 MPa (with an elongation of ∼8.1%), which is 24.6%, 9.22% and 5.62% higher than those of pure TC4, GPs/TC4 and GONs/TC4 composites. The GNPs/TC4 nanocomposites show a better balance of strength and ductility than those of the other two types of nanocomposites. The synergetic strengthening mechanisms are identified to be Orowan strengthening effect, effective load transfer capability of GNPs, and in-situ formation of interfacial TiC structures, which provide optimum interfacial microstructures to achieve good mechanical properties of the TiMCs.
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Dengue fever is the most important mosquito-borne viral disease of humans with more than 50 million cases estimated annually in more than 100 countries. Disturbingly, the geographic range of dengue ...is currently expanding and the severity of outbreaks is increasing. Control options for dengue are very limited and currently focus on reducing population abundance of the major mosquito vector, Aedes aegypti. These strategies are failing to reduce dengue incidence in tropical communities and there is an urgent need for effective alternatives. It has been proposed that endosymbiotic bacterial Wolbachia infections of insects might be used in novel strategies for dengue control. For example, the wMelPop-CLA Wolbachia strain reduces the lifespan of adult A. aegypti mosquitoes in stably transinfected lines. This life-shortening phenotype was predicted to reduce the potential for dengue transmission. The recent discovery that several Wolbachia infections, including wMelPop-CLA, can also directly influence the susceptibility of insects to infection with a range of insect and human pathogens has markedly changed the potential for Wolbachia infections to control human diseases. Here we describe the successful transinfection of A. aegypti with the avirulent wMel strain of Wolbachia, which induces the reproductive phenotype cytoplasmic incompatibility with minimal apparent fitness costs and high maternal transmission, providing optimal phenotypic effects for invasion. Under semi-field conditions, the wMel strain increased from an initial starting frequency of 0.65 to near fixation within a few generations, invading A. aegypti populations at an accelerated rate relative to trials with the wMelPop-CLA strain. We also show that wMel and wMelPop-CLA strains block transmission of dengue serotype 2 (DENV-2) in A. aegypti, forming the basis of a practical approach to dengue suppression.
For metal matrix composites (MMCs), introduction of low-dimensional nano-carbon materials (NCMs) into three dimensional metallic matrix is commonly applied to enhance mechanical and physical ...properties of metals and thus significantly extend their wide range applications. However, the interfaces between the NCMs and metal matrix are always a major issue for achieving the best enhancement effects. In this paper, we investigated interfacial structures of graphene nanoplates (GNPs) reinforced Cu matrix composites fabricated using a simple and industrially scalable strategy, through integration of interface engineering design methodology and a spark plasma sintering (SPS) process. We then systematically evaluated their physico-mechanical properties, interfacial characteristics and strengthening mechanisms. The in-situ formed WxCy nano-layers and carbide nanoparticles on the surfaces of GNPs and near the interfaces of Cu grains promote strong interfacial bonding and improves the cohesive strength of Cu based nanocomposites. The GNPs-W/Cu composites show a good balance between strength and electrical conductivity. Their 0.2% yield strength and ultimate tensile strength have been improved up to 239.13% (112.73%) and 197.76% (72.51%), respectively, when compared with those of pure copper (or GNPs/Cu composites). Electrical conductivity of GNPs-W/Cu composites shows no apparent changes after the addition of the GNPs. The dislocation strengthening, refinement strengthening and load transfer strengthening were achieved simultaneously through the engineered interfaces in GNPs-W/Cu matrix composites. This work has provided a new strategy to fabricate high-performance NCMs enhanced MMCs by using the interface engineering methodology.
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