ABSTRACT
We present a first-look analysis of the JWST ERO data in the SMACS J0723.3-7327 cluster field. We begin by reporting 10 new spectroscopic redshifts from λobs = 1.8–5.2 μm NIRSpec ...medium-resolution (R = λ/Δλ = 1000) data. These are determined via multiple high-SNR emission line detections with five objects at 1 < z < 3 displaying multiple rest-frame near-infrared Hydrogen Paschen lines, and five objects at 5 < z < 9 displaying rest-frame optical Oxygen and Hydrogen Balmer lines. For the five higher-redshift galaxies we extract fluxes in six NIRCam bands spanning λobs = 0.8–5 μm and perform spectral energy distribution fitting in combination with existing HST photometry. The 7 < z < 9 objects exhibit a U-shaped pattern across the F277W, F356W, and F444W bands, indicating a Balmer break seen in emission (Balmer jump) and high-equivalent-width O iii emission. This indicates an extremely young stellar population with the bulk of the current mass having formed within the past 10 Myr. We report robust stellar masses and mean stellar ages from our spectral fitting with the four z > 6 galaxies exhibiting low-stellar masses from log10 (M*/M⊙) = 7.1–8.2, and correspondingly young mean stellar ages of only a few Myr. This work highlights the critical importance of combining large upcoming NIRCam surveys with NIRSpec follow-up to measure the spectroscopic redshifts necessary to robustly constrain physical parameters.
ABSTRACT
We report a robust sample of 10 massive quiescent galaxies at redshift, z > 3, selected using the first data from the JWST Cosmic Evolution Early Release Science programme. Three of these ...galaxies are at 4 < z < 5, constituting the best evidence to date for quiescent galaxies significantly before z = 4. These extreme galaxies have stellar masses in the range log10(M*/M⊙) = 10.1–11.1, and formed the bulk of their mass around z ≃ 10, with two objects having star formation histories that suggest they had already reached log10(M*/M⊙) > 10 by z ≳ 8. We report number densities for our sample, demonstrating that, based on the small area of JWST imaging so far available, previous work appears to have underestimated the number of quiescent galaxies at 3 < z < 4 by a factor of 3–5, due to a lack of ultra-deep imaging data at $\lambda \gt 2\, \mu$m. This result deepens the existing tension between observations and theoretical models, which already struggle to reproduce previous estimates of z > 3 quiescent galaxy number densities. Upcoming wider-area JWST imaging surveys will provide larger samples of such galaxies and more robust number densities, as well as providing opportunities to search for quiescent galaxies at z > 5. The galaxies we report are excellent potential targets for JWST NIRSpec spectroscopy, which will be required to understand in detail their physical properties, providing deeper insights into the processes responsible for forming massive galaxies and quenching star formation during the first billion years.
ABSTRACT
We utilize JWST NIRCam medium-band imaging to search for extreme redshift (z ≥ 9.5) galaxy candidates in the Hubble ultra deep field (HUDF) and the additional pointing within the GOODS-South ...field provided by the second NIRCam module. Our search reveals six robust candidates, three of which have recently been spectroscopically confirmed. One of these three is the previously controversial z ≃ 12 galaxy candidate UDF-22980 which is now detected in five JWST NIRCam medium-band filters (F182M, F210M, F430M, F460M, and F480M), efficiently excluding alternative low-redshift solutions and allowing us to now report a secure photometric redshift of zphot = 11.6 ± 0.2. We also detect two galaxies at z ≥ 12.5 including a newly-detected candidate in the imaging provided by the second NIRCam module (south-west of the HUDF) at zphot = 12.6 ± 0.6. We determine the physical properties of the six galaxies by fitting the 14-band photometry with Bagpipes. We find stellar masses of log (M⋆/M⊙) ≃ 7.5−8.7 and star-formation rates of $\log (\rm {SFR}/M_{\odot }^{-1} \rm {yr}^{-1}) \simeq 0.3 - 5.0$. Despite the relatively small cosmological volume covered by the HUDF itself and the second NIRCam module imaging, we find that the existence of these galaxies is fully consistent with the latest measurements of both the ultraviolet luminosity function and cosmic star-formation rate density at z ≃ 11, supporting a gradual steady decline in the cosmic star-formation rate density out to at least z ≃ 15.
ABSTRACT
We study the rest-frame ultraviolet (UV) continuum slopes (β) of galaxies at redshifts 8 < z < 16 (〈z〉 = 10), using a combination of JWST ERO and ERS NIRCam imaging and ground-based ...near-infrared imaging of the COSMOS field. The combination of JWST and ground-based imaging provides a wide baseline in both redshift and absolute UV magnitude (−22.6 < MUV < −17.9), sufficient to allow a meaningful comparison to previous results at lower redshift. Using a power-law fitting technique, we find that our full sample (median MUV = −19.3 ± 1.3) returns an inverse-variance weighted mean value of 〈β〉 = −2.10 ± 0.05, with a corresponding median value of β = −2.29 ± 0.09. These values imply that the UV colours of galaxies at z > 8 are, on average, no bluer than the bluest galaxies in the local universe (e.g. NGC 1705; β = −2.46). We find evidence for a β − MUV relation, such that brighter UV galaxies display redder UV slopes ($\rm {d}\beta / \rm {d} M_{\rm UV} = -0.17 \pm 0.05$). Comparing to results at lower redshift, we find that the slope of our β − MUV relation is consistent with the slope observed at z ≃ 5 and that, at a given MUV, our 8 < z < 16 galaxies are bluer than their z ≃ 5 counterparts, with an inverse-variance weighted mean offset of 〈Δβ〉 = −0.38 ± 0.09. We do not find strong evidence that any objects in our sample display ultra-blue UV continuum slopes (i.e. β ≲ −3) that would require their UV emission to be dominated by ultra-young, dust-free stellar populations with high Lyman-continuum escape fractions. Comparing our results to the predictions of theoretical galaxy formation models, we find that the galaxies in our sample are consistent with the young, metal-poor, and moderately dust-reddened galaxies expected at z > 8.
ABSTRACT
We reduce and analyse the available JWST ERO and ERS NIRCam imaging (SMACS0723, GLASS, CEERS) in combination with the latest deep ground-based near-infrared imaging in the COSMOS field ...(provided by UltraVISTA DR5) to produce a new measurement of the evolving galaxy UV luminosity function (LF) over the redshift range z = 8 − 15. This yields a new estimate of the evolution of UV luminosity density (ρUV), and hence cosmic star formation rate density (ρSFR) out to within <300 Myr of the Big Bang. Our results confirm that the high-redshift LF is best described by a double power law (rather than a Schechter) function up to z ∼ 10, and that the LF and the resulting derived ρUV (and thus ρSFR), continues to decline gradually and steadily up to z ∼ 15 (as anticipated from previous studies which analysed the pre-existing data in a consistent manner to this study). We provide details of the 61 high-redshift galaxy candidates, 47 of which are new, that have enabled this new analysis. Our sample contains 6 galaxies at z ≥ 12, one of which appears to set a new redshift record as an apparently robust galaxy candidate at z ≃ 16.4, the properties of which we therefore consider in detail. The advances presented here emphasize the importance of achieving high dynamic range in studies of early galaxy evolution, and re-affirm the enormous potential of forthcoming larger JWST programmes to transform our understanding of the young Universe.
ABSTRACT
We present a new determination of the evolving galaxy ultraviolet (UV) luminosity function (LF) over the redshift range 9.5 < z < 12.5 based on a wide-area (>250 arcmin2) data set of JWST ...NIRCam near-infrared imaging assembled from 13 public JWST surveys. Our relatively large-area search allows us to uncover a sample of 61 robust z > 9.5 candidates detected at ≥8σ, and hence place new constraints on the intermediate-to-bright end of the UV LF. When combined with our previous JWST + UltraVISTA results, this allows us to measure the form of the LF over a luminosity range corresponding to four magnitudes (M1500). At these early times we find that the galaxy UV LF is best described by a double power-law function, consistent with results obtained from recent ground-based and early JWST studies at similar redshifts. Our measurements provide further evidence for a relative lack of evolution at the bright-end of the UV LF at z = 9–11, but do favour a steep faint-end slope (α ≤ −2). The luminosity-weighted integral of our evolving UV LF provides further evidence for a gradual smooth (exponential) decline in co-moving star-formation rate density (ρSFR) at least out to z ≃ 12, with our determination of ρSFR(z = 11) lying significantly above the predictions of many theoretical models of galaxy evolution.
ABSTRACT
We present a study of the connection between the escape fraction of Lyman-alpha ($\mathrm{Ly\, \alpha }$) and Lyman-continuum (LyC) photons within a sample of N = 152 star-forming galaxies ...selected from the VANDELS survey at 3.85 ≤ zspec ≤ 4.95 (〈zspec〉 = 4.36). By combining measurements of H$\, \alpha$ equivalent width $(W_{\rm {\lambda }}(\rm {H\, \alpha }))$ derived from broad-band photometry with measurements of Ly$\, \alpha$ equivalent width $(W_{\rm {\lambda }}(\rm {Ly\, \alpha }))$ from the VANDELS spectra, we individually estimate $f_{\rm {esc}}^{\rm {Ly\alpha }}$ for our full sample. In agreement with previous studies, we find a positive correlation between $W_{\rm {\lambda }}(\rm {Ly\, \alpha })$ and $f_{\rm {esc}}^{\rm {Ly\alpha }}$, with $f_{\rm {esc}}^{\rm {Ly\alpha }}$ increasing from $f_{\rm {esc}}^{\rm {Ly\alpha }}\simeq 0.04$ at $W_{\rm {\lambda }}(\rm {Ly\, \alpha })=10$ Å to $f_{\rm {esc}}^{\rm {Ly\alpha }}\simeq 0.1$ at $W_{\rm {\lambda }}(\rm {Ly\, \alpha })=25$ Å. For the first time at z ≃ 4–5, we investigate the relationship between $f_{\rm {esc}}^{\rm {Ly\alpha }}$ and $f_{\rm {esc}}^{\rm {LyC}}$ using $f_{\rm {esc}}^{\rm {LyC}}$ estimates derived using the equivalent widths of low-ionization, far-ultraviolet absorption lines in composite VANDELS spectra. Our results indicate that $f_{\rm {esc}}^{\rm {LyC}}$ rises monotonically with $f_{\rm {esc}}^{\rm {Ly\alpha }}$, following a relation of the form $f_{\rm {esc}}^{\rm {LyC}}$$\simeq 0.15^{+0.06}_{-0.04}$$f_{\rm {esc}}^{\rm {Ly\alpha }}$. Based on composite spectra of sub-samples with approximately constant Wλ(Lyα), but widely different $f_{\rm {esc}}^{\rm {Ly\alpha }}$, we demonstrate that the $f_{\rm {esc}}^{\rm {LyC}}$−$f_{\rm {esc}}^{\rm {Ly\alpha }}$correlation is not driven by a secondary correlation between $f_{\rm {esc}}^{\rm {Ly\alpha }}$ and Wλ(Lyα). The observed $f_{\rm {esc}}^{\rm {LyC}}$−$f_{\rm {esc}}^{\rm {Ly\alpha }}$ correlation is in good qualitative agreement with theoretical predictions and provides further evidence that estimates of $f_{\rm {esc}}^{\rm {LyC}}$ within the Epoch of Reionization should be based on proxies sensitive to neutral gas density/geometry and dust attenuation.
ABSTRACT
We present a spectrophotometric study of a mass-complete sample of quiescent galaxies at 1.0 < z < 1.3 with $\mathrm{log_{10}}(M_{\star }/\mathrm{{\rm M}_{\odot }}) \ge 10.3$ drawn from the ...VANDELS survey, exploring the relationship between stellar mass, age, and star-formation history. Within our sample of 114 galaxies, we derive a stellar–mass versus stellar–age relation with a slope of $1.20^{+0.28}_{-0.27}$ Gyr per decade in stellar mass. When combined with recent literature results, we find evidence that the slope of this relation remains consistent over the redshift interval 0 < z < 4. The galaxies within the VANDELS quiescent sample display a wide range of star-formation histories, with a mean quenching time-scale of 1.4 ± 0.1 Gyr. We also find a large scatter in the quenching time-scales of the VANDELS quiescent galaxies, in agreement with previous evidence that galaxies at z ∼ 1 cease star formation via multiple mechanisms. We then focus on the oldest galaxies in our sample, finding that the number density of galaxies that quenched before z = 3 with stellar masses $\mathrm{log_{10}}(M_{\star }/\mathrm{{\rm M}_{\odot }}) \ge 10.6$ is $1.12_{-0.72}^{+1.47} \times 10^{-5} \ \mathrm{Mpc}^{-3}$. Although uncertain, this estimate is in good agreement with the latest observational results at 3 < z < 4, tentatively suggesting that neither rejuvenation nor merger events are playing a major role in the evolution of the oldest massive quiescent galaxies within the redshift interval 1 < z < 3.
ABSTRACT We present an analysis of the ultraviolet (UV) continuum slopes (β) for a sample of 172 galaxy candidates at 8 < zphot < 16 selected from a combination of JWST NIRCam imaging and ...COSMOS/UltraVISTA ground-based near-infrared imaging. Focusing primarily on a new sample of 121 galaxies at 〈z〉 ≃ 11 selected from ≃ 320 arcmin2 of public JWST imaging data across 15 independent data sets, we investigate the evolution of β in the galaxy population at z ≥ 9. We find a significant trend between β and redshift, with the inverse-variance weighted mean UV slope evolving from 〈β〉 = −2.17 ± 0.06 at z = 9.5 to 〈β〉 = −2.59 ± 0.06 at z = 11.5. Based on a comparison with stellar population models including nebular continuum emission, we find that at z > 10.5 the average UV continuum slope is consistent with the intrinsic blue limit of dust-free stellar populations (βint ≃ −2.6). These results suggest that the moderately dust-reddened galaxy population at z < 10 was essentially unattenuated at z ≃ 11. The extremely blue galaxies being uncovered at z > 10 place important constraints on dust attenuation in galaxies in the early Universe, and imply that the already observed galaxy population is likely supplying an ionizing photon budget capable of maintaining ionized intergalactic medium fractions of ≳ 5 per cent at z ≃ 11.
Abstract
Background
Myotonic dystrophy type 1 (DM1) is an incurable multisystem disease caused by a CTG-repeat expansion in the DM1 protein kinase (
DMPK
) gene. The OPTIMISTIC clinical trial ...demonstrated positive and heterogenous effects of cognitive behavioral therapy (CBT) on the capacity for activity and social participations in DM1 patients. Through a process of reverse engineering, this study aims to identify druggable molecular biomarkers associated with the clinical improvement in the OPTIMISTIC cohort.
Methods
Based on full blood samples collected during OPTIMISTIC, we performed paired mRNA sequencing for 27 patients before and after the CBT intervention. Linear mixed effect models were used to identify biomarkers associated with the disease-causing CTG expansion and the mean clinical improvement across all clinical outcome measures.
Results
We identified 608 genes for which their expression was significantly associated with the CTG-repeat expansion, as well as 1176 genes significantly associated with the average clinical response towards the intervention. Remarkably, all 97 genes associated with both returned to more normal levels in patients who benefited the most from CBT. This main finding has been replicated based on an external dataset of mRNA data of DM1 patients and controls, singling these genes out as candidate biomarkers for therapy response. Among these candidate genes were
DNAJB12
,
HDAC5
, and
TRIM8
, each belonging to a protein family that is being studied in the context of neurological disorders or muscular dystrophies. Across the different gene sets, gene pathway enrichment analysis revealed disease-relevant impaired signaling in, among others, insulin-, metabolism-, and immune-related pathways. Furthermore, evidence for shared dysregulations with another neuromuscular disease, Duchenne muscular dystrophy, was found, suggesting a partial overlap in blood-based gene dysregulation.
Conclusions
DM1-relevant disease signatures can be identified on a molecular level in peripheral blood, opening new avenues for drug discovery and therapy efficacy assessments.
