•Deep learning (DL) is used to predict the radiotherapy dose in esophageal cancer.•This study elaborates an automated tool combining DL models and NTCP models.•The automated model-based approach ...redirects esophageal cancer patients to PT.•The automated tool succeeds in predicting which patients should be referred to PT.
This study aims to investigate how accurate our deep learning (DL) dose prediction models for intensity modulated radiotherapy (IMRT) and pencil beam scanning (PBS) treatments, when chained with normal tissue complication probability (NTCP) models, are at identifying esophageal cancer patients who are at high risk of toxicity and should be switched to proton therapy (PT).
Two U-Net were created, for photon (XT) and proton (PT) plans, respectively. To estimate the dose distribution for each patient, they were trained on a database of 40 uniformly planned patients using cross validation and a circulating test set. These models were combined with a NTCP model for postoperative pulmonary complications. The NTCP model used the mean lung dose, age, histology type, and body mass index as predicting variables. The treatment choice is then done by using a ΔNTCP threshold between XT and PT plans. Patients with ΔNTCP ≥ 10% were referred to PT.
Our DL models succeed in predicting dose distributions with a mean error on the mean dose to the lungs (MLD) of 1.14 ± 0.93% for XT and 0.66 ± 0.48% for PT. The complete automated workflow (DL chained with NTCP) achieved 100% accuracy in patient referral. The average residual (ΔNTCP ground truth - ΔNTCP predicted) is 1.43 ± 1.49%.
This study evaluates our DL dose prediction models in a broader patient referral context and demonstrates their ability to support clinical decisions.
We report the case of a 28-year-old man who presented at the emergency department with recent left painful scrotal swelling, without history of genitourinary infection or trauma. On physical ...examination, left scrotal swelling with nodular palpation was noted. Contrast enhanced sonography demonstrated nodular vascularized thickening of the tunica vaginalis. Surgical exploration revealed multiples solid nodules of the vaginal wall, with, at frozen section analysis, fibroblastic tissue, vessels and chronic inflammation without malignity, suggestive of fibrous pseudotumor of the tunica vaginalis. We discuss the sonographic aspect of this rare entity and the difficulty to establish a diagno- sis of benignity without surgical exploration.
A comparison of X-ray powder diffraction patterns, IR spectra, and crystal structures of structurally related compounds belonging to the butyrophenone family has been undertaken to obtain information ...about the elements of chemical structure which predispose a substance to exhibit polymorphism. Five butyrophenones, differing by the nature of only one substituent, were selected. After crystallization from 15 solvents, it appears that two compounds of the group exhibit more than one crystalline form. An explanation of the absence of polymorphism in the other compounds of the group is proposed and discussed.
A second polymorph of spiperone, 8-3-(p-fluorobenzoyl)-propyl-1-phenyl-1,3,8-triazaspiro4,5 decan-4-one, has been isolated and characterized by thermal analysis and IR spectrometry. Its structure was ...solved by X-ray diffraction analysis. The results are compared with those previously obtained on spiperone, the main difference being in the conformation of the side chain and in the nature of the hydrogen bonding.
Ketonic oxidation products of cyclobarbital Bouche, R; Draguet-Brughmans, M; Flandre, J P ...
Journal of pharmaceutical sciences,
July 1978, Letnik:
67, Številka:
7
Journal Article
Recenzirano
Chemical or biochemical oxidation of cyclobarbital yielded 5-(3-oxo-1-cyclohexen-1-yl)-5-ethyl -2,4,6,- (1H,3H,5H)-pyrimidinetrione, and photochemical oxidation gave ...5-(6-oxo-1-cyclohexen-1-yl)-5-ethyl-2,4,6-(1H,3H,3H)-pyrimidinetrione. These compounds were isolated and purified by TLC, and their structures were determined by UV, IR, NMR, and mass spectral data; the crystalline structure was determined by X-ray diffraction.
Paper presented at the VII International Colloquium of the SGAV, Brussels, 3-6 Sept 1986. A method of individualizing speech instruction for profoundly deaf individuals is described. The phonological ...production of four Ss were recorded & analyzed, & some general tendencies determined. All Ss tended to devoice voiced conss to some extent. Ss had difficulty in producing constrictive conss. Ss were also found to have in common some specific difficulties in attaining a particular point of articulation. Use of such phonological sampling can provide a good measure of the areas in which patients are progressing & areas in which intensive therapy may be required. 3 Tables, 2 References. B. Annesser Murray
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