The process e^{+}e^{-}→D_{s}^{*+}D_{s}^{*-} is studied with a semi-inclusive method using data samples at center-of-mass energies from threshold to 4.95 GeV collected with the BESIII detector ...operating at the Beijing Electron Positron Collider. The Born cross sections of the process are measured for the first time with high precision in this energy region. Two resonance structures are observed in the energy-dependent cross sections around 4.2 and 4.4 GeV. By fitting the cross sections with a coherent sum of three Breit-Wigner amplitudes and one phase-space amplitude, the two significant structures are assigned masses of (4186.8±8.7±30) and (4414.6±3.4±6.1) MeV/c^{2}, widths of (55±15±53) and (122.5±7.5±8.1) MeV, where the first errors are statistical and the second ones are systematic. The inclusion of a third Breit-Wigner amplitude is necessary to describe a structure around 4.79 GeV.
Refractory chronic GVHD (cGVHD) is an important complication after allogeneic hematopoietic SCT and is prognostic of poor outcome. MSCs are involved in tissue repair and modulating immune responses ...in vitro and in vivo. From April 2005 to October 2008, 19 patients with refractory cGVHD were treated with MSCs derived from the BM of volunteers. The median dose of MSCs was 0.6 × 10(6) cells per kg body weight. Fourteen of 19 patients (73.7%) responded well to MSCs, achieving a CR (n=4) or a PR (n=10). The immunosuppressive agent could be tapered to less than 50% of the starting dose in 5 of 14 surviving patients, and five patients could discontinue immunosuppressive agents. The median duration between MSC administration and immunosuppressive therapy discontinuation was 324 days (range, 200-550 days). No patients experienced adverse events during or immediately after MSC infusion. The 2-year survival rate was 77.7% in this study. Clinical improvement was accompanied by the increasing ratio of CD5+CD19+/CD5-CD19+ B cells and CD8+CD28-/CD8+CD28+ T cells. In conclusion, transfusion of MSCs expanded in vitro, irrespective of the donor, might be a safe and effective salvage therapy for patients with steroid-resistant, cGVHD.
► The grain size of the as-extruded Mg–Zn–Ca alloy was refined by trace Mn addition. ► The basal texture was enhanced in the as-extruded Mg–Zn–Ca–Mn alloy due to the lower volume fraction of ...recrystallized grains. ► The tensile yield strength (TYS) of Mg–Zn–Ca alloy was improved through trace Mn addition, a good balance of strength and ductility was achieved.
The effect of trace Mn addition on the microstructure, texture and mechanical properties of the as-cast and as-extruded Mg–5.25
wt.% Zn–0.6
wt.% Ca (ZX51) alloys was investigated in this study. Mn addition had a negligible effect on the grain size of the as-cast ZX51 alloy. However, the addition of Mn led to the obvious decrease of grain size in the as-extruded Mg–5.25
wt.% Zn–0.6
wt.% Ca–0.3
wt.% Mn (ZXM510) alloy, because the Mn addition restricted the grain growth during the hot extrusion process. After the addition of Mn, the basal fiber texture with most of {0
0
0
2} planes parallel to the extrusion direction (ED) was significantly enhanced in the as-extruded ZXM510 alloy. Both tensile yield strength (TYS) and ultimate tensile strength (UTS) were increased in the as-extruded ZXM510 alloy, while the ductility was slightly decreased, which was ascribed to the grain refinement and texture strengthening.
Using 2.93 fb −1 of e+e− collision data taken at a center-of-mass energy of 3.773 GeV with the BESIII detector, we report the first measurements of the absolute branching fractions of 14 hadronic ...D0(+) decays to exclusive final states with an η , e.g., D0 → K−π+η , K0Sπ0η , K+K−η , K0SK0Sη, K−π+π0η , K0Sπ+π−η , K0Sπ0π0η , and π+π−π0η ; D+ → K0Sπ+η,K0SK+η, K−π+π+η, K0Sπ+π0η, π+π+π−η , and π+π0π0η. Among these decays, the D0 → K−π+η and D+→K0Sπ+η decays have the largest branching fractions, which are B (D0 → K−π+η) = ( 1.853 ± 0.02 5 stat ± 0.03 1 syst ) % and B ( D+ → K0Sπ+η ) = ( 1.309 ± 0.03 7 stat ± 0.03 1 syst ) % , respectively. The charge-parity asymmetries for the six decays with highest event yields are determined, and no statistically significant charge-parity violation is found.
Observation of e+e- → γX(3872) at BESIII Achasov, M N; Albayrak, O; Ambrose, D J ...
Physical review letters,
2014-Mar-07, Letnik:
112, Številka:
9
Journal Article
Recenzirano
Odprti dostop
With data samples collected with the BESIII detector operating at the BEPCII storage ring at center-of-mass energies from 4.009 to 4.420 GeV, the process e+e-→ γX(3872) is observed for the first time ...with a statistical significance of 6.3σ. The measured mass of the X(3872) is (3871.9 ± 0.7s tat ± 0.2 syst) MeV/c(2), in agreement with previous measurements. Measurements of the product of the cross section σe+e- → γX(3872) and the branching fraction BX(3872)→π+π-J/ψ at center-of-mass energies 4.009, 4.229, 4.260, and 4.360 GeV are reported. Our measurements are consistent with expectations for the radiative transition process Y(4260) → γX(3872).
The purpose of this meta‐analysis was to evaluate the efficacy of denosumab, compared with zoledronic acid (ZA), in delaying skeletal‐related events (SREs) and enhancing overall survival in patients ...with advanced solid tumours and bone metastases. A systematic literature search of several electronic databases, including PubMed, Medline, Embase, the Cochrane Library, CKNI and Web of Science with Conference Proceedings, was performed. Only randomised controlled trials assessing denosumab in comparison with ZA, in patients with advanced solid tumours and metastatic‐stage disease, were included. The primary outcome was the time to first SRE. The risk of developing subsequent on‐study SREs and overall survival were also evaluated. Three randomised controlled trials with a total of 5,544 patients with advanced solid tumours and bone metastases were included in the meta‐analysis. There were 2,776 patients treated with denosumab and 2,768 treated with ZA. The pooled analysis showed that denosumab was superior to ZA in delaying time to first on‐study SRE (odds ratio OR: 0.82; 95% CI: 0.75–0.89, p < 0.0001) and multiple SREs (risk ratio: 0.81; 95% CI: 0.74–0.88, p < 0.0001). However, no significant difference was found in overall survival improvement between denosumab and ZA (OR: 1.02; 95% CI: 0.91–1.15, p = 0.71). This meta‐analysis indicates that denosumab is superior to ZA in delaying SREs for patients with bone metastases. No significant difference was observed between denosumab and ZA, regarding overall survival. We support denosumab as a potential novel treatment option for the management of bone metastases in advanced solid tumours.
Accumulation evidence shows that β-amyloid (Aβ) is a neurotoxic and accumulation of Aβ is responsible for the pathology of Alzheimer's disease (AD). However, it is currently not fully understood what ...makes Aβ toxic and accumulated. Previous studies demonstrate that Aβ is a suitable substrate for glycation, producing one form of the advanced glycation endproducts (AGEs). We speculated that Aβ-AGE formation may exacerbate the neurotoxicity. To explore whether the Aβ-AGE is more toxic than the authentic Aβ and to understand the molecular mechanisms, we synthesized glycated Aβ by incubating Aβ with methylglyoxal (MG) in vitro and identified the formation of glycated Aβ by fluorescence spectrophotometer. Then, we treated the primary hippocampal neurons cultured 8 days in vitro with Aβ-AGE or Aβ for 24 h. We observed that glycation exacerbated neurotoxicity of Aβ with upregulation of receptor for AGE (RAGE) and activation of glycogen synthase kinase-3 (GSK-3), whereas simultaneous application of RAGE antibody or GSK-3 inhibitor reversed the neuronal damages aggravated by glycated Aβ. Thereafter, we found that Aβ is also glycated with an age-dependent elevation of AGEs in Tg2576 mice, whereas inhibition of Aβ-AGE formation by subcutaneously infusion of aminoguanidine for 3 months significantly rescued the early cognitive deficit in mice. Our data reveal for the first time that the glycated Aβ is more toxic. We propose that the glycated Aβ with the altered secondary structure may be a more suitable ligand than Aβ for RAGE and subsequent activation of GSK-3 that can lead to cascade pathologies of AD, therefore glycated Aβ may be a new therapeutic target for AD.
Molybdenum is a refractory metal that is stable in a body-centred cubic structure at all temperatures before melting. Plastic deformation via structural transitions has never been reported for pure ...molybdenum, while transformation coupled with plasticity is well known for many alloys and ceramics. Here we demonstrate a structural transformation accompanied by shear deformation from an original -oriented body-centred cubic structure to a -oriented face-centred cubic lattice, captured at crack tips during the straining of molybdenum inside a transmission electron microscope at room temperature. The face-centred cubic domains then revert into -oriented body-centred cubic domains, equivalent to a lattice rotation of 54.7°, and ~15.4% tensile strain is reached. The face-centred cubic structure appears to be a well-defined metastable state, as evidenced by scanning transmission electron microscopy and nanodiffraction, the Nishiyama-Wassermann and Kurdjumov-Sachs relationships between the face-centred cubic and body-centred cubic structures and molecular dynamics simulations. Our findings reveal a deformation mechanism for elemental metals under high-stress deformation conditions.
•High-solid system by inoculating multifunctional activated sludge was established.•High methane yield of 380.8 mL⋅gVS−1 was achieved at OLR of 3.5 g VS·L−1d−1.•The acclimation mechanism of the novel ...activated sludge was explored.
High solid anaerobic digestion (HSAD) was an emerging bioconversion technology which had the advantages of small digester, less digestate and low heating energy. A one-stage anaerobic system in CSTR by inoculating activated sludge of simultaneous propionate degradation and methanogenesis was proposed to improve the high-solid digestion performance and to stabilize the reaction process. Semi-continuous mode was successfully used to perform HSAD from cellulosic ethanol whole stillage at an initial substrate loading of 15.4% (w/w) dry matter content with different OLRs from 1.5 to 5.0 gVS·L−1 d−1 at an HRT of 30 days. The average methane yield during whole digestion reached 349.9 mL⋅gVS−1 with a total VS removal rate of 61.3%. The acclimation mechanism of multifunctional activated sludge was also explored by analyzing the functional property, physiological activity and microbial community structure. The results indicated the feasibility and efficiency of multifunctional activated sludge in a semi-continuous high-solid stirred tank reactor system.
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