Triple negative breast cancer is known for its visceral metastasis. We have found that CXCR4 is overexpressed in triple negative breast cancer and is associated with visceral metastasis. We further ...investigated whether CXCR4 is a prognostic factor affecting survival following visceral metastasis in breast cancer patients. Our results indicate that increased CXCR4 expression among breast cancer patients with visceral metastasis was positively correlated with poor overall survival (P<0.001). Silencing of CXCR4 was associated with a decrease in the tumorigenic properties of MDA-MB-231 breast cancer cells, caused reversion of EMT and suppression of MMP-9, increased apoptosis, and caused a reduced incidence of tumor lung metastasis in mice. These results are indicative of CXCR4 having a predictive role in patients with visceral metastasis and indicate that shRNA knock down of CXCR4 might be a novel therapeutic strategy to prevent breast cancer metastasis when CXCR4 is overexpressed.
Bone homeostasis is continually maintained by the process of bone remodeling throughout life. Recent studies have demonstrated that Wnt signaling pathways play a fundamental role in the process of ...bone homeostasis and remodeling. Intracellular Wnt signaling cascades are initially triggered by a Wnt ligand–receptor complex formation. In previous studies, the blocking of Wnt ligands from different osteoblastic differentiation stages could cause defective bone development at an early stage. Osteocytes, the most abundant and long-lived type of bone cell, are a crucial orchestrator of bone remodeling. However, the role of Wnt ligands on osteocyte and bone remodeling remains unclear. In our present study, we found that, besides osteoblasts, osteocytes also express multiple Wnt ligands in the bone environment. Then, we used a Dmp1-Cre mouse line, in which there is expression in a subset of osteoblasts but mainly osteocytes, to study the function of Wnt ligands on osteocyte and bone remodeling in vivo. Furthermore, we explored the role of Wnt ligands on osteocytic mineralization ability, as well as the regulatory function of osteocytes on the process of osteoblastic differentiation and osteoclastic migration and maturity in vitro. We concluded that Wnt proteins play an important regulatory role in 1) the process of perilacunar/canalicular remodeling, as mediated by osteocytes, and 2) the balance of osteogenesis and bone resorption at the bone surface, as mediated by osteoblasts and osteoclasts, at least partly through the canonical Wnt/β-catenin signaling pathway and the OPG/RANKL signaling pathway.
Using (10.087±0.044)×10^{9} J/ψ events collected with the BESIII detector at the BEPCII storage ring, the processes Λp→Λp and Λover ¯p→Λover ¯p are studied, where the Λ/Λover ¯ baryons are produced ...in the process J/ψ→ΛΛover ¯ and the protons are the hydrogen nuclei in the cooling oil of the beam pipe. Clear signals are observed for the two reactions. The cross sections in -0.9≤cosθ_{Λ/Λover ¯}≤0.9 are measured to be σ(Λp→Λp)=(12.2±1.6_{stat}±1.1_{syst}) and σ(Λover ¯p→Λover ¯p)=(17.5±2.1_{stat}±1.6_{syst}) mb at the Λ/Λover ¯ momentum of 1.074 GeV/c within a range of ±0.017 GeV/c, where the θ_{Λ/Λover ¯} are the scattering angles of the Λ/Λover ¯ in the Λp/Λover ¯p rest frames. Furthermore, the differential cross sections of the two reactions are also measured, where there is a slight tendency of forward scattering for Λp→Λp, and a strong forward peak for Λover ¯p→Λover ¯p. We present an approach to extract the total elastic cross sections by extrapolation. The study of Λover ¯p→Λover ¯p represents the first study of antihyperon-nucleon scattering, and these new measurements will serve as important inputs for the theoretical understanding of the (anti)hyperon-nucleon interaction.Using (10.087±0.044)×10^{9} J/ψ events collected with the BESIII detector at the BEPCII storage ring, the processes Λp→Λp and Λover ¯p→Λover ¯p are studied, where the Λ/Λover ¯ baryons are produced in the process J/ψ→ΛΛover ¯ and the protons are the hydrogen nuclei in the cooling oil of the beam pipe. Clear signals are observed for the two reactions. The cross sections in -0.9≤cosθ_{Λ/Λover ¯}≤0.9 are measured to be σ(Λp→Λp)=(12.2±1.6_{stat}±1.1_{syst}) and σ(Λover ¯p→Λover ¯p)=(17.5±2.1_{stat}±1.6_{syst}) mb at the Λ/Λover ¯ momentum of 1.074 GeV/c within a range of ±0.017 GeV/c, where the θ_{Λ/Λover ¯} are the scattering angles of the Λ/Λover ¯ in the Λp/Λover ¯p rest frames. Furthermore, the differential cross sections of the two reactions are also measured, where there is a slight tendency of forward scattering for Λp→Λp, and a strong forward peak for Λover ¯p→Λover ¯p. We present an approach to extract the total elastic cross sections by extrapolation. The study of Λover ¯p→Λover ¯p represents the first study of antihyperon-nucleon scattering, and these new measurements will serve as important inputs for the theoretical understanding of the (anti)hyperon-nucleon interaction.
Using a sample of about 10(10) J/Psi events collected at a center-of-mass energy root s = 3.097 GeV with the BESIII detector, the electromagnetic Dalitz decays J/Psi -> e(+)e(-) pi(+)pi(-) eta', ...with eta' -> gamma pi(+)pi(-) and eta' -> pi(+)pi(-) eta, have been studied. The decay J/Psi -> e(+)e(-) X(1835) is observed with a significance of 15 sigma, and also an e(+)e(-) invariant-mass dependent transition form factor of J/Psi -> e(+)e(-) X(1835) is presented for the first time. The intermediate states X(2120) and X(2370) are also observed in the pi(+)pi(-) eta' invariant-mass spectrum with significances of 5.3 sigma and 7.3 sigma. The corresponding product branching fractions for J/Psi -> e(+)e(-) X, X -> pi(+) pi(-) eta' X = X(1835), X(2120), and X(2370) are reported.
We report the measurement of the inclusive cross sections for e^{+}e^{-}→nOCH (where nOCH denotes non-open charm hadrons) with improved precision at center-of-mass (c.m.) energies from 3.645 to ...3.871 GeV. We observe three resonances: R(3760), R(3780), and R(3810) with significances of 8.1σ, 13.7σ, and 8.8σ, respectively. The R(3810) state is observed for the first time, while the R(3760) and R(3780) states are observed for the first time in the nOCH cross sections. Two sets of resonance parameters describe the energy-dependent line shape of the cross sections well. In set I set II, the R(3810) state has mass (3805.7±1.1±2.7) (3805.7±1.1±2.7) MeV/c^{2}, total width (11.6±2.9±1.9) (11.5±2.8±1.9) MeV, and an electronic width multiplied by the nOCH decay branching fraction of (10.9±3.8±2.5) (11.0±3.4±2.5) eV. In addition, we measure the branching fractions BR(3760)→nOCH=(25.2±16.1±30.4)%(6.4±4.8±7.7)% and BR(3780)→nOCH=(12.3±6.6±8.3)%(10.4±4.8±7.0)% for the first time. The R(3760) state can be interpreted as an open-charm (OC) molecular state, but containing a simple four-quark state component. The R(3810) state can be interpreted as a hadrocharmonium state.
Based on data samples collected with the BESIII detector at the BEPCII collider, the process e^{+}e^{-}→Σ^{+}Σover ¯^{-} is studied at center-of-mass energies sqrts=2.3960, 2.6454, and 2.9000 GeV. ...Using a fully differential angular description of the final state particles, both the relative magnitude and phase information of the Σ^{+} electromagnetic form factors in the timelike region are extracted. The relative phase between the electric and magnetic form factors is determined to be sinΔΦ=-0.67±0.29(stat)±0.18(syst) at sqrts=2.3960 GeV, ΔΦ=55°±19°(stat)±14°(syst) at sqrts=2.6454 GeV, and 78°±22°(stat)±9°(syst) at sqrts=2.9000 GeV. For the first time, the phase of the hyperon electromagnetic form factors is explored in a wide range of four-momentum transfer. The evolution of the phase along with four-momentum transfer is an important input for understanding its asymptotic behavior and the dynamics of baryons.
To investigate the clinicopathological characteristics of acidophil stem cell pituitary neuroendocrine tumors (PitNET)/adenoma.
Five cases of acidophil stem cell PitNET/adenoma were diagnosed between ...May 2022 and July 2023 at the Second Hospital of Hebei Medical University, Shijiazhuang, China. The clinicopathological features of the tumor were analyzed by using histology, immunohistochemistry, and electron microscopy. The relevant literature was reviewed.
There were 1 male and 4 females, aged from 23 to 69 years. Patient 3 was 55 years old at the time of diagnosis and first surgery, and relapsed 5 years later. The patients' median age was 32 years. Patients 1 and 5 showed elevated blood prolactin, with various degrees of hormonal symptoms except Patient 3, who showed only tumor compression symptoms. Imaging studies showed that all cases involved the sellar floor. The tumors of Patients 1, 2 and 5 were closely related to the cavernous sinus segment of the internal carotid artery. The tumors exhibited a diffus
► Environmental effects on SCC of A537 steel were studied by slow strain rate test. ► SCC susceptibility increased with increasing corrosion-induced stress. ► SCC initiated at the interface between ...MnS inclusion and matrix.
Slow strain rate testing showed that stress corrosion cracking (SCC) of A537 steels could occur in both simulated seawater and alternating wet–dry environments. The SCC mechanism was anodic dissolution (AD) under anode polarization and open circuit potential, and hydrogen induced cracking (HIC) under cathode polarization with high potential difference. The additive stress σp, induced by the corrosion process controlled susceptibility to SCC, regardless of the AD mechanism or HIC under either anodic or cathodic polarization conditions. SCC initiated at the interface between matrix and MnS inclusions, which was as anodic phases to promote the AD process.
The quantum entangled J/ψ→Σ^{+}Σover ¯^{-} pairs from (1.0087±0.0044)×10^{10} J/ψ events taken by the BESIII detector are used to study the nonleptonic two-body weak decays Σ^{+}→nπ^{+} and Σover ...¯^{-}→nover ¯π^{-}. The CP-odd weak decay parameters of the decays Σ^{+}→nπ^{+} (α_{+}) and Σover ¯^{-}→nover ¯π^{-} (αover ¯_{-}) are determined to be 0.0481±0.0031_{stat}±0.0019_{syst} and -0.0565±0.0047_{stat}±0.0022_{syst}, respectively. The decay parameter αover ¯_{-} is measured for the first time, and the accuracy of α_{+} is improved by a factor of 4 compared to the previous results. The simultaneously determined decay parameters allow the first precision CP symmetry test for any hyperon decay with a neutron in the final state with the measurement of A_{CP}=(α_{+}+αover ¯_{-})/(α_{+}-αover ¯_{-})=-0.080±0.052_{stat}±0.028_{syst}. Assuming CP conservation, the average decay parameter is determined as ⟨α_{+}⟩=(α_{+}-αover ¯_{-})/2=-0.0506±0.0026_{stat}±0.0019_{syst}, while the ratios α_{+}/α_{0} and αover ¯_{-}/αover ¯_{0} are -0.0490±0.0032_{stat}±0.0021_{syst} and -0.0571±0.0053_{stat}±0.0032_{syst}, where α_{0} and αover ¯_{0} are the decay parameters of the decays Σ^{+}→pπ^{0} and Σover ¯^{-}→pover ¯π^{0}, respectively.
PDF
