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zadetkov: 28
1.
  • The mycobacterial cell envelope - a moving target
    Dulberger, Charles L; Rubin, Eric J; Boutte, Cara C Nature reviews. Microbiology, 01/2020, Letnik: 18, Številka: 1
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    Mycobacterium tuberculosis, the leading cause of death due to infection, has a dynamic and immunomodulatory cell envelope. The cell envelope structurally and functionally varies across the length of ...
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  • Mutations in dnaA and a cry... Mutations in dnaA and a cryptic interaction site increase drug resistance in Mycobacterium tuberculosis
    Hicks, Nathan D; Giffen, Samantha R; Culviner, Peter H ... PLOS pathogens, 11/2020, Letnik: 16, Številka: 11
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    Genomic dissection of antibiotic resistance in bacterial pathogens has largely focused on genetic changes conferring growth above a single critical concentration of drug. However, reduced ...
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3.
  • MAIT recognition of a stimu... MAIT recognition of a stimulatory bacterial antigen bound to MR1
    López-Sagaseta, Jacinto; Dulberger, Charles L; McFedries, Amanda ... The Journal of immunology (1950), 11/2013, Letnik: 191, Številka: 10
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    MR1-restricted mucosal-associated invariant T (MAIT) cells represent a subpopulation of αβ T cells with innate-like properties and limited TCR diversity. MAIT cells are of interest because of their ...
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4.
  • Prophages encode phage-defe... Prophages encode phage-defense systems with cognate self-immunity
    Owen, Siân V.; Wenner, Nicolas; Dulberger, Charles L. ... Cell host & microbe, 11/2021, Letnik: 29, Številka: 11
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    Temperate phages are pervasive in bacterial genomes, existing as vertically inherited islands termed prophages. Prophages are vulnerable to predation of their host bacterium by exogenous phages. ...
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5.
  • Human Leukocyte Antigen F P... Human Leukocyte Antigen F Presents Peptides and Regulates Immunity through Interactions with NK Cell Receptors
    Dulberger, Charles L.; McMurtrey, Curtis P.; Hölzemer, Angelique ... Immunity, 06/2017, Letnik: 46, Številka: 6
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    Evidence is mounting that the major histocompatibility complex (MHC) molecule HLA-F (human leukocyte antigen F) regulates the immune system in pregnancy, infection, and autoimmunity by signaling ...
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6.
  • Transposon mutagenesis in M... Transposon mutagenesis in Mycobacterium abscessus identifies an essential penicillin-binding protein involved in septal peptidoglycan synthesis and antibiotic sensitivity
    Akusobi, Chidiebere; Benghomari, Bouchra S; Zhu, Junhao ... eLife, 06/2022, Letnik: 11
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    ( ) is a rapidly growing non-tuberculous mycobacterium (NTM) that causes a wide range of infections. Treatment of infections is difficult because the bacterium is intrinsically resistant to many ...
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7.
  • Mycobacteriophages as Genom... Mycobacteriophages as Genomic Engineers and Anti-infective Weapons
    Sullivan, Mark R; Rubin, Eric J; Dulberger, Charles L MBio, 05/2021, Letnik: 12, Številka: 3
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    (Mab) is an emerging pathogen that is highly tolerant to current antibiotic therapies, and the current standard of care has a high failure rate. Mycobacteriophages represent a promising alternative ...
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8.
  • molecular basis for Mucosal... molecular basis for Mucosal-Associated Invariant T cell recognition of MR1 proteins
    López-Sagaseta, Jacinto; Dulberger, Charles L; Crooks, James E ... Proceedings of the National Academy of Sciences - PNAS, 05/2013, Letnik: 110, Številka: 19
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    Mucosal-associated invariant T (MAIT) cells are an evolutionarily conserved αβ T-cell lineage that express a semi-invariant T-cell receptor (TCR) restricted to the MHC related-1 (MR1) protein. MAIT ...
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9.
  • Tuberculosis treatment fail... Tuberculosis treatment failure associated with evolution of antibiotic resilience
    Liu, Qingyun; Zhu, Junhao; Dulberger, Charles L ... Science, 12/2022, Letnik: 378, Številka: 6624
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    The widespread use of antibiotics has placed bacterial pathogens under intense pressure to evolve new survival mechanisms. Genomic analysis of 51,229 ( )clinical isolates has identified an essential ...
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  • Fluorogenic Probes of the M... Fluorogenic Probes of the Mycobacterial Membrane as Reporters of Antibiotic Action
    Wuo, Michael G.; Dulberger, Charles L.; Warner, Theodore C. ... Journal of the American Chemical Society, 07/2024, Letnik: 146, Številka: 26
    Journal Article
    Recenzirano

    The genus Mycobacterium includes species such as Mycobacterium tuberculosis, which can cause deadly human diseases. These bacteria have a protective cell envelope that can be remodeled to facilitate ...
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zadetkov: 28

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