We present results of a multi-site photometric campaign on the high-amplitude \(\delta\)\,Scuti star KIC\,6382916 in the {\it Kepler} field. The star was observed over a 85-d interval at five ...different sites in North America and Europe during 2011. {\it Kepler} photometry and ground-based multicolour light curves of KIC\,6382916 are used to investigate the pulsational content and to identify the principal modes. High-dispersion spectroscopy was also obtained in order to derive the stellar parameters and projected rotational velocity. From an analysis of the {\it Kepler} time series, three independent frequencies and a few hundred combination frequencies are found. The light curve is dominated by two modes with frequencies \(f_{1}\)= 4.9107 and \(f_{2}\)= 6.4314\,d\(^{-1}\). The third mode with \(f_{3}\)= 8.0350\,d\(^{-1}\) has a much lower amplitude. We attempt mode identification by examining the amplitude ratios and phase differences in different wavebands from multicolour photometry and comparing them to calculations for different spherical harmonic degree, \(l\). We find that the theoretical models for \(f_1\) and \(f_2\) are in a best agreement with the observations and lead to value of l = 1 modes, but the mode identification of \(f_3\) is uncertain due to its low amplitude. Non-adiabatic pulsation models show that frequencies below 6\,d\(^{-1}\) are stable, which means that the low frequency of \(f_1\) cannot be reproduced. This is further confirmation that current models predict a narrower pulsation frequency range than actually observed.
We report on a multi-site photometric campaign on the high-amplitude \(\delta\) Scuti star V2367 Cyg in order to determine the pulsation modes. We also used high-dispersion spectroscopy to estimate ...the stellar parameters and projected rotational velocity. Time series multicolour photometry was obtained during a 98-d interval from five different sites. These data were used together with model atmospheres and non-adiabatic pulsation models to identify the spherical harmonic degree of the three independent frequencies of highest amplitude as well as the first two harmonics of the dominant mode. This was accomplished by matching the observed relative light amplitudes and phases in different wavebands with those computed by the models. In general, our results support the assumed mode identifications in a previous analysis of Kepler data.
Thrombosis of the brachiocephalic veins or superior vena cava (SVC) is rare. This study was conducted to determine the prevalence and characteristics of thrombosis of brachiocephalic veins and SVC , ...and its association with symptomatic pulmonary embolism (PE). The prevalence of thrombosis involving the brachiocephalic veins and SVC was evaluated retrospectively at a university hospital during the 3-year period. Patients were identified by hospital records and review of computer-generated lists of of all venograms, contrast-enhanced chest computed tomography, and magnetic resonance angiograms of the upper extremity and SVC. Thrombosis of the brachiocephalic veins and SVC was diagnosed in 33 (0.03 %) of 100,942 patients of all ages (32 of 70,751 adult patients >or= 20 years; 0.04%). Twenty-three (70%) patients initially had secondary thrombosis with multiple risk factors: associated with malignancy in 14 (42%) patients, chronic disorders in 13 (39%) patients, central venous lines (CVL) and peripheral venous lines (PVL) in 9 (27%) patients, and thrombophilia in 10 (38%) of 26 patients. Swelling of the arm, head, and neck was present in 32 (97%) patients. Symptomatic PE developed before thrombosis being treated in 12 (36%) patients. All patients except eight (three, thrombolytic; five, thrombectomy) received anticoagulant therapy. Thrombosis of the SVC and brachiocephalic veins is an uncommon but serious complication in patients with malignancy, chronic disorders, CVL, PVL, and thrombophilia. Because it is important clinical problem with frequent PE, the patients with appropriate clinical findings should be diagnosed early with imaging tests and treated with anticoagulant drugs.
Our aim was to determine the efficacy of ifosfamide, mesna, and interferon alpha combination therapy in malignant mesothelioma (MM) patients. Fourty-two patients (39 evaluable) with histologically ...proven MM were enrolled into this study from January 1999 to October 2002. The drug schedule consisted of a combination of ifosfamide, 3000 mg/m2 1-3 d intravenous infusion (iv), the uroprotective agent mesna, 3000 mg/m2 1-3 d iv every 3 wk, and interferon alpha2a, 4.5 MU subcutaneously (sc) 3 d/wk for 6 mo as first-line chemotherapy. Overall, 140 cycles were administered to the 39 patients (median, 3.5 cycles; range, 1 to 6 cycles). Among the 39 patients, 8 partial remissions (PR) (21%) were observed. Thirteen patients (33%) had stable disease for at least 8 wk and 18 (46%) had progressive disease. Overall survival (OAS) and progression free survival (PFS) for all patients were 10.0 +/- 2.9 mo (95%CI 4.3-15.7) and 5.0 +/- 1.9 mo (95%CI 1.38-8.62), respectively. One and two year survival rates were calculated as 39% and 5%, respectively. All of the PR patients had the epithelial type of MM. Their survival time was 21.0 +/- 5.7 mo (95% CI 9.9-32.1) and significantly longer than that of nonresponders (p=0.0061). The toxicity of the drug combination was mild and well tolerated. There were no treatment-related deaths. Grade 3-4 neutropenia and febrile neutropenia were seen in 10 patients (26%) and 3 patients (8%), respectively. Chemotherapy was stopped in three patients because of renal function deficiency. One of these patients who had peritoneal MM required hemodialysis. In conclusion, this combination therapy showed encouraging antitumor activity with modest toxicity.
This is the first description of a patient with Marfan syndrome and an aneurysm of the ventricular septum. Apart from a borderline dilatation of the ascending aorta, there were no cardiovascular ...manifestations of Marfan syndrome. A transesophageal echocardiographic examination showed a large aneurysm of the ventricular septum. To prevent the imminent rupture and the acute occurrence of a significant left-to-right-shunt on the ventricular level, as well as increasing irritation of tricuspid valve, an elective operation was performed. Besides the routine cardiological diagnostics, the search for intracardial defects is also necessary in patients with Marfan syndrome.
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