This open access book reviews the trends of persistent organic pollutants (POPs) in human milk and discusses the main findings of five global surveys that were coordinated by the World Health ...Organization (WHO) and the United Nations Environment Programme (UNEP) from 2000 to 2019. Human milk was selected as core matrix for human exposure under the Global Monitoring Plan for effectiveness evaluation of the Stockholm Convention on Persistent Organic Pollutants. Milk from well-defined groups of mothers was collected and mixed to form a representative sample per country. Datasets collected represent the largest global human tissues survey with a harmonized protocol, carried out in a uniform format for more than two decades. Altogether 69 countries participated in these studies between 2000 and 2015, and more than 40 countries participated in the study from 2016 to 2019. Divided into 5 parts, the book offers an authoritative overview of human milk biomonitoring; collates the harmonized sampling requirements and analytical methods for the identification and quantification of contaminants in human milk; examines the results of the WHO/UNEP-coordinated exposure studies, including the identification of selected chlorinated pesticides, dioxin-like compounds, industrial chemicals like polychlorinated biphenyls (PCB) and chlorinated paraffins, polybrominated POPs and PFAS, among others; and traces geographic, temporal and cross-substance trends and correlations, and human health risks. The book finishes by providing the reader with the summary of the main findings and outlook from these studies, in which the comparison of concentrations found for the wide range of POPs listed in the Stockholm Convention allowed the identification of possible needs for actions and follow-ups in different countries/regions. This book contributes to the understanding of exposure to hazardous chemicals and pollution as addressed by the UN Sustainable Development Goals on Good Health and Well-being (SDG 3) and will appeal to environmental and analytical chemists, researchers, professionals, and policymakers interested in learning more about contaminants in human milk. Given its breadth, this book will also appeal to a broader audience interested in maternal and child health.
•A PBPK model was derived describing uptake of PFOS from contaminated fodder into consumption milk.•Almost all PFOS is eliminated through the milk.•PFOS elimination rate is low.•Single pollution ...events may lead to reaching the TDI in the vulnerable population.•Other exposure routes in the food chain should be quantified as well.
Dietary intake is the predominant route for human exposure to perfluorooctane sulfonic acid (PFOS). Single pollution events may thus affect human exposure if polluted ground and water is used to produce animal feed or food. In this study, a physiologically based pharmacokinetic (PBPK-) model is derived that describes the uptake of PFOS from contaminated feed by cows and its subsequent elimination through the cows’ milk. Parameter values of the model were estimated by fitting to experimental data of a cow feeding trial. Model calculations showed that almost all PFOS ingested is excreted through the cows’ milk. The elimination rate, however, was low as the estimated half-life in the cow was 56days and it may, thus, take a long time after an initial pollution event to produce PFOS-free milk. The derived model can be used to estimate the transfer of PFOS through the dairy food chain and can be used for comparison of various contamination routes.
Dementia and advanced cancer are complex, life-limiting conditions that benefit from specialized palliative care (SPC) interventions at the end of life. The objective was to study possible ...differences in care for patients with concomitant advanced cancer and dementia (CA-DEM) or cancer only (CA) regarding access to SPC, acute hospital care, and place of death.
A retrospective observational registry study on health care consumption data from the Stockholm Regional Council involving logistic regression analyses of age, sex, living arrangements, comorbidities, dementia diagnosis, and socio-economic status.
Of the 12,667 persons aged ≥65 years who died from advanced cancer between 2015 and 2019, 605 had concomitant dementia. Of these, 76% of patients with CA and 42% of patients with CA-DEM had access to SPC (p<.0001). There were more admissions to palliative care for persons not living in nursing homes (p<.0001), women (p<.0001), socioeconomically privileged patients (p<.05), those with fewer comorbidities (p<.0001), and younger patients (<85 years) (p<.0001). Access to SPC reduced ER visits, hospitalizations, and acute hospital deaths for CA, whereas access to SPC only reduced hospital deaths in the CA-DEM group.
The probability of being admitted to SPC was lower in cancer patients with known dementia. Access to SPC reduced emergency room visits and acute admissions to hospitals for the whole group, and hospital deaths both for CA and CA-DEM.
A supermassive black hole, obscured by cosmic dust, powers the nearby active galaxy NGC 1068. Neutrinos, which rarely interact with matter, could provide information on the galaxy’s active core. We ...searched for neutrino emission from astrophysical objects using data recorded with the IceCube neutrino detector between 2011 and 2020. The positions of 110 known gamma-ray sources were individually searched for neutrino detections above atmospheric and cosmic backgrounds. We found that NGC 1068 has an excess of
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neutrinos at tera–electron volt energies, with a global significance of 4.2σ, which we interpret as associated with the active galaxy. The flux of high-energy neutrinos that we measured from NGC 1068 is more than an order of magnitude higher than the upper limit on emissions of tera–electron volt gamma rays from this source.
Nearby active galaxy emits neutrinos
Observations have shown a diffuse background of high-energy neutrinos, which is known to be of extragalactic origin. However, it has been difficult to identify individual sources that contribute to this background. The IceCube Collaboration reanalyzed the arrival directions of astrophysical neutrinos and then searched for point sources (see the Perspective by Murase). They identified evidence for neutrino emission from NGC 1068 (also known as Messier 77), a nearby active galaxy. Its properties are quite different from TXS 0506+056, which was found to be a neutrino source in 2018, leading the investigators to suggest that there might be more than one population contributing to the neutrino background. —KTS
The arrival directions of astrophysical neutrinos indicate point source neutrino emission from NGC 1068.
Abstract
We present a measurement of the high-energy astrophysical muon–neutrino flux with the IceCube Neutrino Observatory. The measurement uses a high-purity selection of 650k neutrino-induced muon ...tracks from the northern celestial hemisphere, corresponding to 9.5 yr of experimental data. With respect to previous publications, the measurement is improved by the increased size of the event sample and the extended model testing beyond simple power-law hypotheses. An updated treatment of systematic uncertainties and atmospheric background fluxes has been implemented based on recent models. The best-fit single power-law parameterization for the astrophysical energy spectrum results in a normalization of
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and a spectral index
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, constrained in the energy range from 15 TeV to 5 PeV. The model tests include a single power law with a spectral cutoff at high energies, a log-parabola model, several source-class-specific flux predictions from the literature, and a model-independent spectral unfolding. The data are consistent with a single power-law hypothesis, however, spectra with softening above one PeV are statistically more favorable at a two-sigma level.
The origin of high-energy cosmic rays, atomic nuclei that continuously impact Earth's atmosphere, is unknown. Because of deflection by interstellar magnetic fields, cosmic rays produced within the ...Milky Way arrive at Earth from random directions. However, cosmic rays interact with matter near their sources and during propagation, which produces high-energy neutrinos. We searched for neutrino emission using machine learning techniques applied to 10 years of data from the IceCube Neutrino Observatory. By comparing diffuse emission models to a background-only hypothesis, we identified neutrino emission from the Galactic plane at the 4.5σ level of significance. The signal is consistent with diffuse emission of neutrinos from the Milky Way but could also arise from a population of unresolved point sources.
The IceCube Neutrino Observatory has established the existence of a high-energy all-sky neutrino flux of astrophysical origin. This discovery was made using events interacting within a fiducial ...region of the detector surrounded by an active veto and with reconstructed energy above 60 TeV, commonly known as the high-energy starting event sample (HESE). We revisit the analysis of the HESE sample with an additional 4.5 years of data, newer glacial ice models, and improved systematics treatment. This paper describes the sample in detail, reports on the latest astrophysical neutrino flux measurements, and presents a source search for astrophysical neutrinos. We give the compatibility of these observations with specific isotropic flux models proposed in the literature as well as generic power-law-like scenarios. Assuming νe: νμ: ντ= 1 : 1 : 1 , and an equal flux of neutrinos and antineutrinos, we find that the astrophysical neutrino spectrum is compatible with an unbroken power law, with a preferred spectral index of 2.87−0.19+0.20 for the 68% confidence interval.
Numerous studies demonstrate that free glutamine can be added to commercially available crystalline amino acid-based preparations before their administration. Instability during heat sterilization ...and prolonged storage and limited solubility (35 g/L at 20°C) hamper the use of free glutamine in the routine clinical setting. Indeed, there are many well-controlled and valuable trials with free glutamine, yet its use is restricted to clinical research. The obvious limitations of using free glutamine initiated an intensive search for alternative substrates. Synthetic glutamine dipeptides are stable under heat sterilization and highly soluble; these properties qualify the dipeptides as suitable constituents of nutritional preparations. Industrial production of these dipeptides at a reasonable price is an essential prerequisite for implications of dipeptide-containing solutions in clinical practice. Recent development of novel synthesis procedures allows increased capacity in industrial-scale production. Basic studies with synthetic glutamine-containing short-chain peptides provide convincing evidence that these new substrates are cleared rapidly from plasma after parenteral administration, without being accumulated in tissues and with negligible loss in urine. The presence of membrane-bound as well as tissue-free extracellular hydrolase activity facilitates a prompt and quantitative peptide hydrolysis, the liberated amino acids being available for protein synthesis and/or generation of energy. In the clinical setting, glutamine dipeptide nutrition beneficially influences outcome (nitrogen balance, immunity, gut integrity, hospital stay, morbidity and mortality). The provision of conditionally indispensable glutamine should be considered a necessary replacement of a deficiency rather than a supplementation. The beneficial effects observed with glutamine dipeptide nutrition should be seen simply as a correction of disadvantages produced by the inadequacy of conventional clinical nutrition. The availability of stable dipeptide preparations certainly facilitates, for the first time, adequate amino acid nutrition of critically ill, malnourished or stressed patients in the routine clinical setting and, thus, represents a new dimension in artificial nutrition.
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