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Zinc plant leach residues (ZPLRs) are hazardous solid wastes generated from zinc metal production owing to their substantial contents of lead (Pb), a toxic heavy metal. This study ...investigated the detoxification of historic ZPLRs from Kabwe, Zambia by removing Pb using a coupled extraction-cementation method in chloride media. For the coupled extraction-cementation method, micro-scale zero-valent iron (mZVI) was added during ZPLRs leaching in acidified chloride solution. Cemented Pb on the surface of mZVI was recovered easily from the leaching pulp by magnetic separation. Pb removal was evaluated in different solution compositions (NaCl:1–5.13 M, HCl: 0–0.1 M) with and without the addition of mZVI. The addition of mZVI during ZPLRs leaching (i.e., coupled extraction-cementation) increased Pb removal from 3% to 24%, 1.3% to 27.5%, 5.2% to 34.9%, and 6.5% to 55.8% when NaCl concentration was fixed at 0.86 M and HCl concentrations were 0 M, 0.01 M, 0.05 M and 0.1 M, respectively. When NaCl concentration was increased above 3.42 M and HCl maintained at 0.1 M HCl, Pb removal increased to 80%. Analysis of the Pb-loaded mZVI (magnetic fraction) by scanning electron microscopy with energy dispersive X-ray spectroscopy (SEM-EDX) and X-ray photoelectron spectroscopy (XPS) revealed that Pb was recovered during leaching via cementation as Pb°. The toxicity characteristic leaching procedure (TCLP) and in vitro solubility and bioavailability research consortium gastric phase (SBRC-G) tests for Pb of ZPLRs before and after treatment decreased drastically from 11.3 to 3.5 mg/L (below 5 mg/L threshold) and 12 300 to 2 840 mg/Kg, respectively.
Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) are used for non-small cell lung cancer patients with an EGFR gene mutation. However, skin disorders are known as adverse ...events. In the present study, we investigated whether EGFR-TK occupancy is useful as an index for assessing clinical efficacy and adverse events for the proper use and development of EGFR-TKIs. Average binding occupancies (
Φ
ss
) of EGFR-TKIs, gefitinib and erlotinib, for the EGFR-TK of cancer or skin cells were calculated. The relationships of
Φ
ss
with response rate (RR) or frequency of rash were analyzed using the ternary complex model. Then, the relationships between the dose of EGFR-TKIs and RR or frequency of rash were examined. Gefitinib showed a greater difference for
Φ
ss
value for both wild-type and mutant EGFR as compared to erlotinib at usual dose. The RR increased in a nonlinear manner rapidly rising when
Φ
ss
exceeded 95%. It was thought that a very high
Φ
ss
value might be needed to obtain the therapeutic effect of EGFR-TKIs. Meanwhile, the frequency of rash increased in a linear manner along with elevation of
Φ
ss
. It was shown that the
K
d
ratio (
K
d
for mutant/
K
d
for wild type) was less than 0.001, when the high RR and low frequency of rash were obtained simultaneously. The results showed that the therapeutic effects and skin disorder can be assessed by using
Φ
ss
. Furthermore, it is likely that a proper choice of drug and dose can be made by using
Φ
ss
in EGFR-TKI therapy.
Zinc plant leach residues (ZPLRs) contain significant amounts of metal compounds of lead (Pb), zinc (Zn), iron (Fe), etc., hence, they are considered as a secondary source of metals. On the other ...hand, ZPLRs are regarded as hazardous materials because they contain heavy metals that pollute the environment. Resources and environmental concerns of ZPLRs were addressed in this study by removing/recovering Pb and Zn using a concurrent dissolution and cementation technique. To cement the dissolved Pb and Zn in leaching pulp, zero-valent aluminum (ZVAl) was added during ZPLRs leaching in the hydrochloric (HCl)–sodium chloride (NaCl) solution. The resulting cemented metals were agglomerated and separated by sieving. Lead removal increased with increasing both NaCl and HCl concentrations. However, when ZVAl was added, significant Pb removal was achieved at a low concentration. Zinc was not cemented out of the pulp using ZVAl and its recovery from ZPLRs was dependent on the HCl concentration only. By applying a concurrent dissolution and cementation technique, both Pb and Zn were removed using a low concentration of NaCl, and most importantly Pb—the most toxic metal in ZPLRs—was captured and separated before the solid-liquid separation, hence, eliminating the need for extensive washing of the generated residues to remove the inherent residual solution.
When railway vehicles run on sharp curves, the coefficient of friction (COF) between the outer rail and the leading-outside wheel flange of a bogie is an important value related to problems such as ...wheel/rail severe wear, squeak noise arising from wheel/rail contact, and running safety against flange-climb derailment. In general, it is difficult to grasp the actual state of COF, which changes from moment to moment during commercial operations. From the viewpoint of running safety and maintenance, it is desirable to detect curved tracks with relatively high COF from the entire service line. The monitoring bogie, which can measure wheel/rail contact forces during commercial operations, has realized a long-term observation of wheel/rail contact forces. For further applications of the monitoring bogie, the simulation-based estimation method of COF at the wheel flange have been proposed in the author’s previous paper. Furthermore, an investigation based on roller-rig tests have been conducted. However, the probability of the flange wear progress cannot be determined only by COF at the wheel flange, and other factors should be involved. The wear number is used to assess rolling contact fatigue and wheel/rail wear progress. In the present paper, on the basis of a multi-body dynamics simulation model of the roller-rig equipment, the difference of the wear number among four lubrication conditions on the bogie is clarified. The estimation method of COF is extended to estimate the wear number simultaneously. The extended method is applied to the roller-rig test and the wear number is estimated. The estimated wear number shows qualitative agreement with the amount of wear debris, which is observed in the roller-rig test conducted in previous research.
Zinc plant leach residues (ZPLRs), particularly those produced using old technologies, have both economic importance as secondary raw materials and have environmental impacts because they contain ...hazardous heavy metals that pose risks to human health and the environment. Therefore, the extraction and recovery of these metals from ZPLRs has both economic and environmental benefits. In this study, we investigated the removal of lead (Pb) and zinc (Zn) from ZPLRs by alkaline (NaOH) leaching and the concurrent cementation of dissolved Pb and Zn using aluminum (Al) metal powder. The effects of the leaching time, NaOH concentration, solid-to-liquid ratio (S/L), and dosage of Al metal powder on the extraction of Pb and Zn were investigated. Pb and Zn removal efficiencies increased with increasing NaOH concentrations and decreasing S/Ls. The Pb and Zn removal efficiencies were 62.2% and 27.1%, respectively, when 2.5 g/50 mL (S/L) of ZPLRs were leached in a 3 M NaOH solution for 30 min. The extraction of Pb and Zn could be attributed to the partitioning of these metals in relatively more mobile phases—water-soluble, exchangeable, and carbonate phases—in ZPLRs. Around 100% of dissolved Pb and less than 2% of dissolved Zn were cemented in leaching pulp when Al metal powder was added. Minerals in the solid residues, particularly iron oxides minerals, were found to suppress the cementation of extracted Zn in leaching pulp, and when they were removed by filtration, Zn was recovered by Al metal powder via cementation.
The derailment coefficient, which is calculated based on the wheel-rail contact forces, indicates the running safety of a railway vehicle with respect to flange climb derailment. The value of the ...derailment coefficient changes constantly due to numerous factors associated with the vehicle and track conditions while the vehicle runs on a service line. Therefore, it is desirable to monitor the state of the wheel/rail contact in order to ensure the running safety. Recently, a new monitoring bogie, which can measure the derailment coefficient during commercial operations, has been developed and introduced into some service lines. Large-scale data have been collected by this monitoring bogie. In this paper, the temporal subtraction analysis is carried out for preparing appropriate plan for reducing the derailment coefficient based on these data. In the analysis, the vehicle running position is important for accurate calculation of the difference between two waveforms. However, the vehicle running position contains errors because of the accumulated error of integral calculation of the vehicle velocity. The present paper proposes a method which modifies the running position along track so that the two waveforms are well matched. The proposed method is based on DP matching, and the waveforms of the track irregularity of twist estimated by the monitoring bogie are used in the method. After DP matching, an example of temporal subtraction analysis of the derailment coefficient between two periods is performed. Finally, by using the long-term measurements acquired by the monitoring bogie, the monthly variation of the derailment coefficient for a certain spot on the track is shown as a practical example.
The coefficient of friction (COF) between the outer rail and the leading-outside wheel flange of a railway bogie running on sharp curved track is an important parameter for the progress of wheel/rail ...wear and running safety. Therefore, it is desired to grasp the actual state of COF of wheels especially at the leading-outside wheel flange. In the author’s previous studies, a roller-rig experiment was conducted with changing lubrication condition of each wheel of the bogie to figure out relationship between lubrication conditions and wheel/rail contact forces such as tangential, lateral and vertical directions. In this paper, a method to estimate the value of COF of leading-outside wheel with look-up tables built by repetitive numerical simulations is explained. In the construction of the look-up tables, friction coefficients for each wheel in the numerical simulation model are changed while collecting calculated wheel/rail contact forces. A railway bogie running on roller-rig test is considered for both numerical simulations and experiment with different lubrication condition, therefore look-up tables are built with a half-vehicle model running on the roller-rig. By inputting the wheel/rail contact forces measured in roller-rig test into the look-up tables built by simulations, and the COF of leading-outside wheel flange is estimated. The result shows that the lubrication condition of leading-outside wheel flange can be estimated by the proposed method especially when the value of COF is large and is useful for the detection of high COF condition.
Abstract
In multi-cellular organisms, cell-to-cell communication is crucial for adapting to changes in the surrounding environment. In plants, plasmodesmata (PD) provide a unique pathway for ...cell-to-cell communication. PD interconnect most cells and generate a cytoplasmic continuum, allowing the trafficking of various micro- and macromolecules between cells. This molecular trafficking through PD is dynamically regulated by altering PD permeability dependent on environmental changes, thereby leading to an appropriate response to various stresses; however, how PD permeability is dynamically regulated is still largely unknown. Moreover, studies on the regulation of PD permeability have been conducted primarily in a limited number of angiosperms. Here, we studied the regulation of PD permeability in the moss Physcomitrella patens and report that molecular trafficking through PD is rapidly and reversibly restricted by abscisic acid (ABA). Since ABA plays a key role in various stress responses in the moss, PD permeability can be controlled by ABA to adapt to surrounding environmental changes. This ABA-dependent restriction of PD trafficking correlates with a reduction in PD pore size. Furthermore, we also found that the rate of macromolecular trafficking is higher in an ABA-synthesis defective mutant, suggesting that the endogenous level of ABA is also important for PD-mediated macromolecular trafficking. Thus, our study provides compelling evidence that P. patens exploits ABA as one of the key regulators of PD function.
It is important to secure running safety of railway vehicles against wheel-climb derailment accidents. The safety is often discussed according to the value of derailment coefficients for the leading ...outside wheel of a railway bogie running on sharp curves. Therefore, the detailed force induced mechanism which influences the value of derailment coefficients should be clarified. One of the most dominant factors affecting the value of derailment coefficients is magnitudes of the coefficient of friction (COF) between wheel and rail. Since the gauge corner of the outer rail and the top of the inner rail are lubricated at some sharp curves, COF of wheels of a bogie are different from each other and show complicated variation. In this study, the effect of lubrication for the running safety of the railway bogie is investigated while considering the detailed force induced mechanism of the derailment coefficient increase utilizing both multibody dynamics simulations and experiments. Experiments and simulations are conducted with a roller-rig test equipment under various conditions of wheel/rail lubrication. In this research, a method to identify whether the bogie is in suitably lubricated condition in terms of running safety is discussed. The proposed method making use of the longitudinal force measurement with mono-link type axle supporting device is mentioned.
The derailment coefficient is calculated from wheel-rail contact forces and it indicates the running safety of the railway vehicle especially in sharp curves. The derailment coefficient is affected ...by many factors such as the track irregularities, the vehicle parameters and the friction characteristics between wheel and rail. Therefore, monitoring of the derailment coefficient is desired to evaluate the running safety of the vehicle. Recently, a new monitoring bogie which can collect time series data of the derailment coefficient during commercial operation has been developed, and a large scale data is collected. However, there was no way to use such a data efficiently because an efficient method and an analysis tool have not been developed. In this research, a new analysis tool which can easily handle a large scale data and assist analysis of the derailment coefficient has been designed using MATLAB. In addition to measuring the derailment coefficient, the wheel load reduction and the track irregularity of twist are also measured. The tool can extract points where the derailment coefficient increases from a large scale data, and quickly show detailed information. On the basis of the information displayed on the user-interface, the data analyst can identify factors that increase the derailment coefficient. Not only analysis focused on a particular curve, but also the tool has the function for comparison of some curves. Analysis of the time change of the derailment coefficient is also possible. This paper shows the basic design of the analysis tool and gives some examples of analysis using this tool.
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