En el mundo, se han expandido las políticas de estandarización y rendición de cuentas por resultados, y a su vez, en los últimos años, ha crecido la demanda por generar escuelas más inclusivas. Uno ...de los actores centrales para lograr tal inclusión son las educadoras diferenciales (maestra de educación especial), sin embargo, existe escasa investigación sobre ellas. Esta investigación pretende comprender los modos en que estas políticas influyen en su trabajo y en sus subjetividades. Para ello, se desarrolló un estudio de casos, en el que se entrevistaron a diez educadoras en Chile, luego se seleccionaron a dos de ellas, a las que se les realizó un seguimiento etnográfico durante cinco meses (240 horas de observación). Los hallazgos relevan una identidad docente tensionada que se debate entre la inclusión y la estandarización, como también se evidencian resistencias por parte de las docentes frente a los mandatos de la rendición de cuentas.
Abstract
The main computing and storage facility of INFN (Italian Institute for Nuclear Physics) running at CNAF hosts and manages tens of Petabytes of data produced by the LHC (Large Hadron ...Collider) experiments at CERN and other scientific collaborations in which INFN is involved. Most of these data are stored on tape resources of different technologies. All the tape drives can be used for administrative tasks (as repack, audit, space reclamation), as well to write and read data of all the experiments. Moreover, the usage of tape resources by scientific communities will become considerably more intense in the next years and the amount of data on tape will double by 2025. For these reasons, the issue of the concurrent access to tape drives is significant. We designed a software solution to optimize the efficiency of the shared usage of tape drives in our environment and put it in production in January 2020. In this paper we present the experience with such dynamic tape resources allocation in production. Comparing it with the previous static allocation method, we observed an improvement in reading throughput up to 85%. Moreover, we describe the new features added to our solution to optimize the efficiency of the shared usage of tape drives of different technologies.
Venous ulcers are the most common form of leg ulcers. Venous disease has a significant impact on quality of life and work productivity. In addition, the costs associated with the long-term care of ...these chronic wounds are substantial. Although the exact pathogenic steps leading from venous hypertension to venous ulceration remain unclear, several hypotheses have been developed to explain the development of venous ulceration. A better understanding of the current pathophysiology of venous ulceration has led to the development of new approaches in its management. New types of wound dressings, topical and systemic therapeutic agents, surgical modalities, bioengineered tissue, matrix materials, and growth factors are all novel therapeutic options that may be used in addition to the “gold standard,” compression therapy, for venous ulcers. This review discusses current aspects of the epidemiology, pathophysiology, clinical presentation, diagnostic assessment, and current therapeutic options for chronic venous insufficiency and venous ulceration. (J Am Acad Dermatol 2001;44:401-21.)
Learning objective: At the conclusion of this learning activity, participants should be familiar with the 3 main types of lower extremity ulcers and should improve their understanding of the epidemiology, pathogenesis, risk factors, clinical presentation, diagnostic assessment, and current therapies for chronic venous insufficiency and venous ulcers.
Background The aim of this study was to compare the anti-adhesion efficacy of a biodegradable, in situ , macromolecular cross-linking hydrogel made from oxidized dextran/N-carboxyethyl chitosan ...(Odex/CEC) with a commercially available carboxymethylcellulose/modified hyaluronan barrier film (Seprafilm; Genzyme Corporation, Cambridge, MA) in a rat cecum abrasion model. Methods The rat model utilized a cecal abrasion and abdominal wall insult surgical protocol. The 2% Odex/CEC hydrogel treatment was applied by syringe to coat both the cecal and the abdominal wall insults, while other animals were treated with Seprafilm applied to the cecal injury only. Control animals did not receive any treatment. Animals were sacrificed after post operative day 21 and adhesion severity was quantitatively graded using a whole number scale from 0 – 3. Histological analysis was also performed for animals receiving Odex/CEC hydrogel treatment and no treatment (control). Results Mean adhesion score was 2.09 ± 1.22 for control animals, 1.00 ± 1.00 for 2% Odex/CEC hydrogel animals, and 1.25 ± 1.22 for Seprafilm animals. Hydrogel treated animals showed significantly lower adhesion scores than control animals ( P < 0.05), while Seprafilm demonstrated a marginally lower adhesion score ( P < 0.1) compared with the controls. Histological analysis of an Odex/CEC treated rat showed tissue repair and small fragments of hydrogel inside both healed abdominal and cecal surfaces. Conclusions Both Seprafilm and the 2% Odex/CEC hydrogel showed a significantly decreased adhesion score compared with the control. However, the hydrogel, compared with Seprafilm, offers ease of application and ability to conform to complex tissue geometries that could provide surgeons with another prophylactic treatment to prevent abdominal adhesions.
The INFN CNAF Tier-1 has become the Italian national data center for the INFN computing activities since 2005. As one of the reference sites for data storage and computing provider in the High Energy ...Physics (HEP) community it offers resources to all the four LHC experiments and many other HEP and non-HEP collaborations. The CDF experiment has used the INFN Tier-1 resources for many years and, after the end of data taking in 2011, it faced the challenge to both preserve the large amount of scientific data produced and give the possibility to access and reuse the whole information in the future using the specific computing model. For this reason starting from the end of 2012 the CDF Italian collaboration, together with the INFN CNAF and Fermilab (FNAL), introduced a Long Term Data Preservation (LTDP) project with the purpose of preserving and sharing all the CDF data and the related analysis framework and knowledge. This is particularly challenging since part of the software releases is no longer supported and the amount of data to be preserved is rather large. The first objective of the collaboration was the copy of all the CDF RUN-2 raw data and user level ntuples (about 4 PB) from FNAL to the INFN CNAF tape library backend using a dedicated network link. This task was successfully accomplished during the last years and, in addition, a system to implement regular integrity check of data has been developed. This system ensures that all the data are completely accessible and it can automatically retrieve an identical copy of problematic or corrupted file from the original dataset at FNAL. The setup of a dedicated software framework, which allows users to access and analyse the data with the complete CDF analysis chain, was also carried out with the addition of users and system administrators detailed documentation for the long-term future. Furthermore a second and more ambitious objective emerged during 2016 with a feasibility study for reading the first CDF RUN-1 dataset now stored as an unique copy in a huge amount (about 4000) of old Exabyte tape cartridges. With the installation of compatible refurbished tape drive autoloaders an initial test bed was completed and the first phase of the Exabyte tapes reading activity started. In the present article, we will illustrate the state of the art of the LTDP project with a particular attention to the technical solutions adopted in order to store and maintain the CDF data and the analysis framework, and to overcome the issues that have arisen during the recent activities. The CDF model could also prove useful for designing new data preservation projects for other experiments or use cases.
The LHCb experiment will undergo a major upgrade during the second long shutdown (2019 - 2020). The upgrade will concern both the detector and the Data Acquisition system, which are to be rebuilt in ...order to optimally exploit the foreseen higher event rate. The Event Builder is the key component of the DAQ system, for it gathers data from the sub-detectors and builds up the whole event. The Event Builder network has to manage an incoming data rate of 32 Tb/s from a 40 MHz bunch-crossing frequency, with a cardinality of about 500 nodes. In this contribution we present an Event Builder implementation based on the InfiniBand network technology. This software relies on the InfiniBand verbs, which offers a user space interface to employ the Remote Direct Memory Access capabilities provided by the InfiniBand network devices. We will present the performance of the software on a cluster connected with 100 Gb/s InfiniBand network.
The Tier-1 at CNAF is the main INFN computing facility offering computing and storage resources to more than 30 different scientific collaborations including the 4 experiments at the LHC. It is also ...foreseen a huge increase in computing needs in the following years mainly driven by the experiments at the LHC (especially starting with the run 3 from 2021) but also by other upcoming experiments such as CTA1 While we are considering the upgrade of the infrastructure of our data center, we are also evaluating the possibility of using CPU resources available in other data centres or even leased from commercial cloud providers. Hence, at INFN Tier-1, besides participating to the EU project HNSciCloud, we have also pledged a small amount of computing resources (∼ 2000 cores) located at the Bari ReCaS2 for the WLCG experiments for 2016 and we are testing the use of resources provided by a commercial cloud provider. While the Bari ReCaS data center is directly connected to the GARR network3 with the obvious advantage of a low latency and high bandwidth connection, in the case of the commercial provider we rely only on the General Purpose Network. In this paper we describe the set-up phase and the first results of these installations started in the last quarter of 2015, focusing on the issues that we have had to cope with and discussing the measured results in terms of efficiency.
Background:
Elase is a widely used ointment consisting of a combination of 2 proteolytic enzymes, fibrinolysin and desoxyribonuclease (DNAse). It is said to promote debridement of necrotic and ...purulent debris from skin ulcers.
Objective:
Our purpose was to assess the efficacy and safety of this ointment and its components in the treatment of chronic ulcers of the lower extremity.
Methods:
This was a double-blind, randomized, prospective study of 84 patients with leg ulcers exhibiting necrotic and purulent debris, who were treated for 21 days with twice-daily applications of the ointment, fibrinolysin, DNAse, or who received the ointment vehicle (placebo). We assessed 6 efficacy features: ulcer size, purulent exudate, necrotic tissue, erythema, pain, and overall condition of the lesion at days 8, 15, and 21 after initiation of treatment. We also assessed the frequency of adverse effects.
Results:
All treatments produced some improvement in the efficacy parameters and overall condition of the ulcers by week 3, but no statistically significant difference was found when compared with placebo. No serious adverse effects were noted. A later retrospective reanalysis of the data found a statistically significant reduction of purulent exudate only at days 3 and 7 of treatment in the group treated with the complete ointment, but not in the other features.
Conclusion:
The proteolytic ointment provides no long-term clinical benefit in reducing purulent exudate, pain, erythema, necrotic tissue, or overall condition of chronic leg ulcers when compared with either of its two components or placebo. (J Am Acad Dermatol 1998;39:737-40.)
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