Professional guidance as a process of student empowerment must be accessible to all people following the principles of educational equity and inclusion. The improvement of its quality can come from ...the integration of technologies in the work of the counselors. Aware of the lack of studies and the current relevance of vocational training, this research aims to analyze the opinion of counselors about the importance, interest and difficulties they detect in the integration of technologies. An empirical study has been carried out with a sample made up of 47.11% of the Spanish population (57 guidance professionals). Data collection was carried out with a validated online questionnaire (.81 Cronbach's Alpha).
The results show a high interest in the inclusion of technologies in professional guidance, recognizing their importance in their daily work. They identify the lack of training and time as difficulties in achieving this challenge. It is concluded that guidance can be nourished by the potential of technologies and the proactive attitude that counselors demonstrate to train in this field and achieve higher quality.
La orientación profesional como proceso de empoderamiento del alumnado debe ser accesible a todas las personas siguiendo los principios de equidad e inclusión educativa. La mejora de su calidad puede venir dada por la integración de tecnologías en la labor de las personas orientadoras. Conscientes de la falta de estudios y de la relevancia actual de la formación profesional, esta investigación tiene como objetivo analizar la opinión de las personas orientadoras acerca de la importancia, el interés y las dificultades que detectan en la integración de tecnologías. Se ha llevado a cabo un estudio empírico con una muestra formada por el 47,11 % de la población española (57 profesionales de la orientación). La recogida de datos se ha realizado con un cuestionario validado online (.81 Alpha de Cronbach).
Los resultados evidencian un elevado interés en la inclusión de tecnologías en la orientación profesional, reconociendo la importancia de éstas en sus labores diarias. Identifican como dificultades para alcanzar este reto la falta de formación y tiempo. Se concluye que la orientación puede nutrirse de las potencialidades de las tecnologías y de la actitud proactiva que demuestran las personas orientadoras para formarse en este campo y alcanzar mayor calidad.
El mundo laboral en continuo cambio y el desarrollo de las tecnologías como apoyo al crecimiento y modernización de todos los ámbitos de la vida de las personas motiva la realización de esta ...investigación: una revisión sistemática que se centra en analizar e indagar la evolución e integración de las tecnologías en la orientación profesional. Se realizó una búsqueda en cinco bases de datos (Scopus, Web of Science, Scielo, Dialnet y ERIC) durante enero y febrero de 2021, utilizando como criterios de inclusión: artículos y comunicaciones de congresos que vinculan tecnología y orientación profesional, escritos en español, inglés, francés y portugués, publicados en los últimos 10 años, englobados en el área de conocimiento de las Ciencias Sociales y con acceso al texto completo. Tras un registro inicial de 1.198 trabajos se obtuvo una muestra de 28 artículos para su análisis en profundidad, con los que se aplicó la estadística textual como método para evaluar el riesgo de sesgo. Los resultados muestran que en la orientación profesional las tecnologías que actualmente más se utilizan son los sitios web y los programas informáticos. Al mismo tiempo, se constató un escaso uso de los juegos y mundos virtuales. Se concluye que, aunque la razón principal de introducir las tecnologías es buscar la interactividad y la motivación del alumnado, la mayoría de las investigaciones de la década 2010 a 2020, se centran en recursos tecnológicos de carácter informativo, obviando tecnologías más innovadoras y participativas como los mundos virtuales y los juegos.
Intensive Care to facilitate Organ Donation (ICOD) consists of the initiation or continuation of intensive care measures in patients with a devastating brain injury (DBI) in whom curative treatment ...is deemed futile and death by neurological criteria (DNC) is foreseen, to incorporate organ donation into their end-of-life plans. In this study we evaluate the outcomes of patients subject to ICOD and identify radiological and clinical factors associated with progression to DNC. In this first prospective multicenter study we tested by multivariate regression the association of clinical and radiological severity features with progression to DNC. Of the 194 patients, 144 (74.2%) patients fulfilled DNC after a median of 25 h (95% IQR: 17-44) from ICOD onset. Two patients (1%) shifted from ICOD to curative treatment, both were alive at discharge. Factors associated with progression to DNC included: age below 70 years, clinical score consistent with severe brain injury, instability, intracranial hemorrhage, midline shift ≥5 mm and certain types of brain herniation. Overall 151 (77.8%) patients progressed to organ donation. Based on these results, we conclude that ICOD is a beneficial and efficient practice that can contribute to the pool of deceased donors.
The Luna Valley complex geosite (northwestern Spain) is a region of geoheritage significance located in an area with high environmental value. Geological studies began in the mid-20th century and ...continue to provide scientific data of significant relevance to the knowledge regarding the Palaeozoic stratigraphy of northern Gondwana and the tectonics of the Variscan orogen. This region also has high value for geoeducation, being visited regularly by both students and the general public. Educational use of the area has promoted the creation of several publicly available materials and activities that include trails, guides, displays and brochures, as well as the development of a small museum. However, over time, weathering; the abandonment of rural life; and the intensive, uncontrolled, and careless use of this region as a geosite for scientific and educational purposes has led to significant degradation and the consequent loss of its geoheritage value. This paper describes the geology of five key geosites in the Luna Valley. This is followed by a review of the promotional initiatives carried out in the area. These data, along with our knowledge of the area, allow us to develop a heritage analysis that includes the main geological interests, conservation status and some key management issues for each of these five individual sites. Several recommendations aim to control the physical degradation of the geosites, encourage their regular monitoring and the updating of the outreach materials using virtual tools, and promote the involvement of the local population in the conservation of this unique site.
Las políticas de protección social son de carácter transitorio y sus objetivos son los de aminorar o regular los embates de las políticas económicas. El presente artículo científico tiene por ...objetivo, elaborar un análisis acerca de las dimensiones política de la protección social en salud mental familiar en Colombia, a partir de los compendios normativos, elementos de gobernanza, así como compromiso y liderazgo estatal, este es el resultado de un proceso de investigación científica dotado de rigor y vigor, haciendo uso de la investigación cualitativa documental hermenéutico interpretativa. Luego de aplicar dicha metodología apropiada, se obtiene como resultado la confrontación y desarrollo de conceptos en los cuales se incluye la mente, procesos mentales, familia, Estado, gobernabilidad, gobernanza, gestión y las instituciones sociales dentro del enfoque sistémico, también se valora la connotación y servicio en el ámbito de la política protección social, enmarcada en acciones sociales, asistencia sociales y la intervención sanitaria mental de forma colectiva y universal; con ello se muestra como conclusión lo transcendente de la familia como eje, base, institución en los procesos de toma de decisiones política de protección social para atender la salud mental y el centro que se consolida la familia para abordar la misma.
Alzheimer’s disease (AD) is the most common form of dementia and cases are rising worldwide. The effort to fight this disease is hampered by a lack of disease-modifying treatments and the absence of ...an early, accurate diagnostic tool. Neuropathology begins years or decades before symptoms occur and, upon onset of symptoms, diagnosis can take a year or more. Such delays postpone treatment and make research into the early stages of the disease difficult. Ideally, clinicians require a minimally invasive test that can detect AD in its early stages, before cognitive symptoms occur. Advances in proteomic technologies have facilitated the study of promising biomarkers of AD. Over the last two years (2019–2021) studies have identified and validated many species which can be measured in cerebrospinal fluid (CSF), plasma, or in both fluids, and which have a high predictive value for AD. We herein discuss proteins which have been highlighted as promising biomarkers of AD in the last two years, and consider implications for future research within the research framework of the amyloid (A), tau (T), neurodegeneration (N) scoring system. We review recently identified species of amyloid and tau which may improve diagnosis when used in combination with current measures such as amyloid-beta-42 (Aβ42), total tau (t-tau) and phosphorylated tau (p-tau). In addition, several proteins have been identified as likely proxies for neurodegeneration, including neurofilament light (NfL), synaptosomal-associated protein 25 (SNAP-25) and neurogranin (NRGN). Finally, proteins originating from diverse processes such as neuroinflammation, lipid transport and mitochondrial dysfunction could aid in both AD diagnosis and patient stratification.
•Early diagnosis of Alzheimer’s disease would improve treatment and inform research.•Numerous proteomics studies on the subject have been published over the last two years.•Within, we discuss some of the most exciting work from 2019–2021.•Proteins are placed within the Amyloid, Tau, Neurodegeneration (AT(N)) framework described by Jack and colleagues in 2016.•We highlight a number of promising putative proteins biomarkers.
The fragile X mental retardation protein (FMRP) is an RNA-binding protein that regulates mRNA metabolism. FMRP has been largely studied in the brain, where the absence of this protein leads to ...fragile X syndrome, the most frequent form of inherited intellectual disability. Since the identification of the FMRP gene in 1991, many studies have primarily focused on understanding the function/s of this protein. Hundreds of potential FMRP mRNA targets and several interacting proteins have been identified. Here, we report the identification of FMRP mRNA targets in the mammalian brain that support the key role of this protein during brain development and in regulating synaptic plasticity. We compared the genes from databases and genome-wide association studies with the brain FMRP transcriptome, and identified several FMRP mRNA targets associated with autism spectrum disorders, mood disorders and schizophrenia, showing a potential common pathway/s for these apparently different disorders.
The CYFIP1/SRA1 gene is located in a chromosomal region linked to various neurological disorders, including intellectual disability, autism, and schizophrenia. CYFIP1 plays a dual role in two ...apparently unrelated processes, inhibiting local protein synthesis and favoring actin remodeling. Here, we show that brain-derived neurotrophic factor (BDNF)-driven synaptic signaling releases CYFIP1 from the translational inhibitory complex, triggering translation of target mRNAs and shifting CYFIP1 into the WAVE regulatory complex. Active Rac1 alters the CYFIP1 conformation, as demonstrated by intramolecular FRET, and is key in changing the equilibrium of the two complexes. CYFIP1 thus orchestrates the two molecular cascades, protein translation and actin polymerization, each of which is necessary for correct spine morphology in neurons. The CYFIP1 interactome reveals many interactors associated with brain disorders, opening new perspectives to define regulatory pathways shared by neurological disabilities characterized by spine dysmorphogenesis.
•BDNF-Rac1 signaling redistributes CYFIP1 between eIF4E and WRC•FRET demonstrates that BDNF-Rac1 signaling alters CYFIP1 conformation•CYFIP1-eIF4E-WRC regulates ARC synthesis, actin polymerization, and spine morphology•The CYFIP1 interactome is enriched in genes implicated in neurological disorders
CYFIP1 plays a dual role in inhibiting local protein synthesis and favoring actin remodeling. De Rubeis et al. show that BDNF-driven synaptic signaling releases CYFIP1 from the translational inhibitory complex, triggering translation of target mRNAs and shifting CYFIP1 into the WAVE regulatory complex.
Normothermic regional perfusion (NRP) allows the in situ perfusion of organs with oxygenated blood in donation after the circulatory determination of death (DCDD). We aimed at evaluating the impact ...of NRP on the short‐term outcomes of kidney transplants in controlled DCDD (cDCDD). This is a multicenter, nationwide, retrospective study comparing cDCDD kidneys obtained with NRP versus the standard rapid recovery (RR) technique. During 2012–2018, 2302 cDCDD adult kidney transplants were performed in Spain using NRP (n = 865) or RR (n = 1437). The study groups differed in donor and recipient age, warm, and cold ischemic time and use of ex situ machine perfusion. Transplants in the NRP group were more frequently performed in high‐volume centers (≥90 transplants/year). Through matching by propensity score, two cohorts with a total of 770 patients were obtained. After the matching, no statistically significant differences were observed between the groups in terms of primary nonfunction (p = .261) and mortality at 1 year (p = .111). However, the RR of kidneys was associated with a significantly increased odds of delayed graft function (OR 1.97 95% CI 1.43–2.72; p < .001) and 1‐year graft loss (OR 1.77 95% CI 1.01–3.17; p = .034). In conclusion, compared with RR, NRP appears to improve the short‐term outcomes of cDCDD kidney transplants.
This multicenter, nationwide, retrospective study that uses propensity score matching shows lower delayed graft function and higher 1‐year graft survival rates for transplants using kidneys from controlled donation after circulatory determination of death donors procured with normothermic regional perfusion versus through rapid recovery.
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