Highlights • In a randomized controlled experiment, people who performed kind acts for others showed favorable changes in immune cell gene expression profiles. • Gene expression changes represented ...reductions in the conserved transcriptional response to adversity (CTRA). • No significant changes in CTRA gene expression were observed in a control condition or for people who performed kind acts for the world in general or for themselves. • These results may help explain previously observed health advantages associated with prosocial behavior.
Positive emotions are highly valued and frequently sought. Beyond just being pleasant, however, positive emotions may also lead to long-term benefits in important domains, including work, physical ...health, and interpersonal relationships. Research thus far has focused on the broader functions of positive emotions. According to the broaden-and-build theory, positive emotions expand people’s thought–action repertoires and allow them to build psychological, intellectual, and social resources. New evidence suggests that positive emotions—particularly gratitude—may also play a role in motivating individuals to engage in positive behaviors leading to self-improvement. We propose and offer supportive evidence that expressing gratitude leads people to muster effort to improve themselves via increases in connectedness, elevation, humility, and specific negative states including indebtedness.
Viral respiratory tract infections are the main causative agents of the onset of infection-induced asthma and asthma exacerbations that remain mechanistically unexplained. Here we found that ...deficiency in signaling via type I interferon receptor led to deregulated activation of group 2 innate lymphoid cells (ILC2 cells) and infection-associated type 2 immunopathology. Type I interferons directly and negatively regulated mouse and human ILC2 cells in a manner dependent on the transcriptional activator ISGF3 that led to altered cytokine production, cell proliferation and increased cell death. In addition, interferon-γ (IFN-γ) and interleukin 27 (IL-27) altered ILC2 function dependent on the transcription factor STAT1. These results demonstrate that type I and type II interferons, together with IL-27, regulate ILC2 cells to restrict type 2 immunopathology.
Could 10 min of gratitude per week have the potential to change the trajectories of young students' lives? With over 1,000 ninth- and tenth-grade students, we tested whether a simple 4-week ...classroom-based gratitude intervention would prompt increases in well-being and motivate students to become better people and attain better grades. Over the course of 1 month, students were assigned to spend 10 min each week writing gratitude letters to their parents, teachers, coaches, or friends and completing additional gratitude-related reflection activities or to try to become more organized each week by listing their daily activities and reflecting on the obstacles and benefits (control). Importantly, relative to controls, students in the gratitude conditions reported greater LS and motivation to improve themselves and maintained these levels throughout the semester. This sustained self-improvement motivation and LS were partially mediated by increases in feelings of connectedness, elevation, and indebtedness. Interestingly, negative affect partially mediated the effect of gratitude on LS, but not on improvement motivation. No group differences emerged in academic performance over time. This study provides evidence that expressing gratitude and reflecting on their benefactors' actions may help keep high school students motivated and satisfied with their lives over the course of a semester.
•Prosocial engagement reduces CTRA gene expression.•Protocol adherence moderates the effects of kind acts on gene expression.•The genomic impact of kind acts depends on their intended recipient.
...Prosocial behavior has been linked to improved physical health, but the biological mechanisms involved remain unclear. This study tested whether a 4-week kindness intervention could reduce expression of a stress-related immune response gene signature known as the Conserved Transcriptional Response to Adversity (CTRA).
In a diverse sample of community adults (N = 182), study participants were randomly assigned to perform 3 kind acts for other people, to perform 3 kind acts for themselves, or to list daily activities (control), on one day per week over 4 weeks. CTRA gene expression was measured by RNA sequencing of dried blood spots (DBS) collected at baseline and 5 weeks later (1 week after completing study assignments). Participants’ descriptions of their kind acts were coded for protocol adherence and act content.
Participants who were randomized to perform kind acts for others showed significant reductions in CTRA gene expression relative to controls. Participants who were randomized to perform kind acts for themselves also showed significant reductions in CTRA gene expression relative to controls, but this pattern emerged only for those who failed to perform the requested self-kind acts (protocol non-adherent). Those who fully adhered to the self-kindness protocol showed no change in CTRA gene expression and did not differ from controls. Act content analyses implicated self-stress-reducing behavior in the paradoxical effects of self-kindness and the physical presence of others in the effects of prosocial behavior.
Prosocial engagement—doing something kind for others rather than oneself—reduces CTRA gene expression. The nature of kind acts and their intended recipient plays a key role in shaping the genomic impact of kindness
Abstract
On 7 February 2020, precipitation within the comma-head region of an extratropical cyclone was sampled remotely and in situ by two research aircraft, providing a vertical cross section of ...microphysical observations and fine-scale radar measurements. The sampled region was stratified vertically by distinct temperature layers and horizontally into a stratiform region on the west side, and a region of elevated convection on the east side. In the stratiform region, precipitation formed near cloud top as side-plane, polycrystalline, and platelike particles. These habits occurred through cloud depth, implying that the cloud-top region was the primary source of particles. Almost no supercooled water was present. The ice water content within the stratiform region showed an overall increase with depth between the aircraft flight levels, while the total number concentration slightly decreased, consistent with growth by vapor deposition and aggregation. In the convective region, new particle habits were observed within each temperature-defined layer along with detectable amounts of supercooled water, implying that ice particle formation occurred in several layers. Total number concentration decreased from cloud top to the −8°C level, consistent with particle aggregation. At temperatures > −8°C, ice particle concentrations in some regions increased to >100 L
−1
, suggesting secondary ice production occurred at lower altitudes. WSR-88D reflectivity composites during the sampling period showed a weak, loosely organized banded feature. The band, evident on earlier flight legs, was consistent with enhanced vertical motion associated with frontogenesis, and at least partial melting of ice particles near the surface. A conceptual model of precipitation growth processes within the comma head is presented.
Significance Statement
Snowstorms over the northeast United States have major impacts on travel, power availability, and commerce. The processes by which snow forms in winter storms over this region are complex and their snowfall totals are hard to forecast accurately because of a poor understanding of the microphysical processes within the clouds composing the storms. This paper presents a case study from the NASA IMPACTS field campaign that involved two aircraft sampling the storm simultaneously with radars, and probes that measure the microphysical properties within the storm. The paper examines how variations in stability and frontal structure influence the microphysical evolution of ice particles as they fall from cloud top to the surface within the storm.
Objective: Self-compassion is a positive psychological construct characterized by extending compassion toward oneself, often during periods of suffering. Whereas self-compassion has been associated ...with psychological outcomes, research linking self-compassion to physical health is limited. We tested the hypothesis that greater self-compassion would be associated with less subclinical cardiovascular disease (CVD) as assessed by carotid intima-media thickness (IMT). We adjusted for demographics, CVD risk factors and additionally depressive symptoms in these associations. Method: Women (N = 195; M age = 59 years) without CVD were recruited. Women completed questionnaires (Neff Self-Compassion Scale, Center for Epidemiology Studies of Depression Scale); physical measures (body mass index BMI, blood pressure BP); phlebotomy (lipids, insulin resistance); and ultrasound assessments of the carotid artery (mean, maximal IMT). Cross-sectional associations between self-compassion and IMT were assessed in linear regression models covarying for age, race/ethnicity, education, and CVD risk factors (BMI, BP, insulin resistance, lipids, medications), and additionally depressive symptoms. Results: Higher self-compassion was associated with lower mean IMT B(SE)=−.03 (.01), p = .02, adjusting for demographic factors and CVD risk factors. Associations persisted adjusting for depressive symptoms. When considering self-compassion subscale bifactors, the positive self-compassion bifactor (self-compassion), but not negative self-compassion bifactor (self-coldness), was related to lower IMT. Conclusions: Self-compassion is associated with lower subclinical CVD. Associations were not explained by standard CVD risk factors nor by depressive symptoms. Future research should consider whether enhancing self-compassion improves women's vascular health.
Online interventions that elicit kindness may enhance well-being. We tested the efficacy of three kindness interventions among breast cancer survivors. Participants (N = 137, M
age
= 62.65 years) ...were randomized to perform acts of kindness for others, acts of kindness for self, self-kindness meditation, or a daily-activities-writing control and completed three activities each week for 4 weeks. Primary (well-being, depressive symptoms) and secondary outcomes (social support, self-kindness) were assessed pre- and post-intervention. No differences emerged in the primary outcomes. However, relative to controls, participants in the acts of kindness to others condition reported greater increases in social support, and participants in the self-kindness meditation condition reported greater decreases in self-kindness. Among breast cancer survivors, performing prosocial acts may enhance feelings of social support. The two self-kindness conditions yielded either null or detrimental effects, suggesting that further research is needed on best practices for conducting self-focused kindness interventions.
Although gratitude is typically conceptualized as a positive emotion, it may also induce socially oriented negative feelings, such as indebtedness and guilt. Given its mixed emotional experience, we ...argue that gratitude motivates people to improve themselves in important life domains. Two single-timepoint studies tested the immediate emotional and motivational effects of expressing gratitude. We recruited employees (n = 224) from French companies in Study 1 and students (n = 1026) from U.S. high schools in Study 2. Participants in both studies were randomly assigned to either write gratitude letters to benefactors or outline their weekly activities (control condition). Expressing gratitude led to mixed emotional experiences (e.g., greater elevation and indebtedness) for employees and students as compared with the control group. Students also felt more motivated and capable of improving themselves, as well as conveyed stronger intentions to muster effort towards self-improvement endeavors.
Prosocial behavior can improve psychological well-being and physical health. However, the underlying biological mechanisms that mediate the relationship between prosociality and health remain ...unclear. In this pre-registered experiment, we tested whether a 4-week kindness intervention could slow leukocyte telomere shortening and increase well-being.
Community adults (N = 230) were randomly assigned to complete 1 of 3 activities, each week for 4 weeks: to perform 3 kind acts for other people, to perform 3 kind acts for themselves, or to list daily activities. At baseline and post-intervention, participants came to the lab to provide a small dried blood spot (DBS) sample via finger prick for analysis of telomere length. Participants completed psychological measures (e.g., loneliness, life satisfaction) at baseline, post-intervention, and at the 2-week follow up.
Participants who performed kind acts for others did not demonstrate hypothesized changes in well-being, nor in telomere length, relative to controls. Exploratory analyses revealed that, relative to controls, participants who did kind acts for others showed reductions in loneliness through the 2-week follow up.
The salubrious effects of prosocial behavior in the short term are not likely due to the inhibition of cellular aging (at least as indexed by telomere length). However, extending kindness to others holds promise as a future research direction for interventions to alleviate loneliness.
•Prosocial behavior is associated with better health, but mechanisms remain unclear.•We report a pre-registered investigation of prosocial behavior and telomere length.•A 4-week prosocial behavior intervention did not slow rates of telomere shortening.•Performing prosocial behavior for others was linked with reductions in loneliness.•Prosocial behavior may reduce loneliness but does not appear to impact telomeres.
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