Background and purpose
Specific respiratory tract infections, including COVID‐19, may cause smell and/or taste disorders (STDs) with increased frequency. The aim was to determine whether new‐onset ...STDs are more frequent amongst COVID‐19 patients than influenza patients.
Method
This was a case–control study including hospitalized patients of two tertiary care centres. Consecutive patients positive for COVID‐19 polymerase chain reaction (cases) and patients positive for influenza polymerase chain reaction (historical control sample) were assessed during specific periods, employing a self‐reported STD questionnaire.
Results
Seventy‐nine cases and 40 controls were included. No significant differences were found in basal features between the two groups. New‐onset STDs were significantly more frequent amongst cases (31, 39.2%) than in the control group (5, 12.5 %) adjusted odds ratio 21.4 (2.77–165.4, P = 0.003). COVID‐19 patients with new‐onset STDs were significantly younger than COVID‐19 patients without STDs (52.6 ± 17.2 vs. 67.4 ± 15.1, P < 0.001). Amongst COVID‐19 patients who presented STDs, 22 (70.9%) recalled an acute onset and it was an initial manifestation in 11 (35.5%). Twenty‐five (80.6%) presented smell disorders (mostly anosmia, 14, 45.2%) and 28 (90.3%) taste disorders (mostly ageusia, 14, 45.2%). Only four (12.9 %) reported concomitant nasal obstruction. The mean duration of STD was 7.5 ± 3.2 days and 12 patients (40%) manifested complete recovery after 7.4 ± 2.3 days of onset.
Conclusion
New‐onset STDs were significantly more frequent amongst COVID‐19 patients than influenza patients; they usually had an acute onset and were commonly an initial manifestation. The use of STD assessment in anamnesis as a hint for COVID‐19 and to support individuals’ self‐isolation in the current epidemic context is suggested.
We present results from the most comprehensive radio monitoring campaign towards the closest star to our Sun, Proxima Centauri. We report 1.1–3.1 GHz observations with the Australia Telescope Compact ...Array over 18 consecutive days in April 2017. We detected radio emission from Proxima Centauri for most of the observing sessions, which spanned ~1.6 orbital periods of the planet Proxima b. The radio emission is stronger at the low-frequency band, centered around 1.6 GHz, and is consistent with the expected electron-cyclotron frequency for the known star’s magnetic field intensity of ~600 gauss. The 1.6 GHz light curve shows an emission pattern that is consistent with the orbital period of the planet Proxima b around the star Proxima, with its maxima of emission happening near the quadratures. We also observed two short-duration flares (a few minutes) and a long-duration burst (about three days) whose peaks happened close to the quadratures. We find that the frequency, large degree of circular polarization, change in the sign of circular polarization, and intensity of the observed radio emission are all consistent with expectations from electron cyclotron-maser emission arising from sub-Alfvénic star–planet interaction. We interpret our radio observations as signatures of interaction between the planet Proxima b and its host star Proxima. We advocate for monitoring other dwarf stars with planets to eventually reveal periodic radio emission due to star–planet interaction, thus opening a new avenue for exoplanet hunting and the study of a new field of exoplanet–star plasma interaction.
Abstract The aim of this experimental study is to predict the long-term mechanical behavior of a porous scaffold implanted in a cartilage defect for tissue engineering purpose. Fatigue studies were ...performed by up to 100,000 unconfined compression cycles in a polycaprolactone (PCL) scaffold with highly interconnected pores architecture. The scaffold compliance, stress–strain response and hysteresis energy have been measured after different number of fatigue cycles, while the morphology has been observed by scanning electron microscopy at the same fatigue times. To simulate the growing tissue in the scaffold/tissue construct, the scaffold was filled with an aqueous solution of polyvinyl alcohol (PVA) and subjected to repeating cycles of freezing and thawing that increase the hydrogel stiffness. Fatigue studies show that the mechanical loading provokes failure of the dry scaffold at a smaller number of deformation cycles than when it is immersed in water, and also that 100,000 compressive dynamic cycles do not affect the scaffold/gel construct. This shows the stability of the scaffold implanted in a chondral defect and gives a realistic simulation of the mechanical performance from implantation of the empty scaffold to regeneration of the new tissue inside the scaffold׳s pores.
Summary
Aim: Urinary tract infection (UTI) caused by resistant bacteria is becoming more prevalent. We investigate characteristics and associated risk factors for UTIs resulting from ...extended‐spectrum beta‐lactamase (ESBL)‐producing enterobacteria.
Methods: Retrospective study of urinary tract isolates of ESBL‐producing enterobacteria in adults (2009 and 2010). We included 400 patients and 103 controls (UTI caused by non‐ESBL Escherichia coli). Clinical and demographic information was obtained from medical records. Comorbidity was evaluated using Charlson Index (CI). Strains were identified using VITEK 2 system.
Results: A total of 400 isolates were obtained (93%E. coli and 7%Klebsiella spp). In 2009, 6% of cultures were ESBL‐producing E. coli and 7% in 2010. 37% of patients were men and 81% were aged ≥ 60 years. CI was 2.3 ± 1.8 (high comorbidity: 42.8%). 41.5% of strains were susceptible to amoxicillin‐clavulanate, 85.8% to fosfomycin and 15.5% to ciprofloxacin. The total number of ESBL E. coli positive urine cultures during hospital admission was 97 and, compared with 103 controls, risk factors for UTI caused by ESBL‐ E. coli strains in hospitalised patients were nursing home residence (p < 0.001), diabetes (p = 0.032), recurrent UTI (p = 0.032) and high comorbidity (p = 0.002). In addition, these infections were associated with more symptoms (p < 0.001) and longer admission (p = 0.004).
Conclusions: Urinary tract infection caused by ESBL are a serious problem and identifying risk factors facilitates early detection and improved prognosis. Male sex, hospitalisation, institutionalisation, diabetes, recurrent UTI and comorbidity were risk factors and were associated with more symptoms and longer hospital stay.
Abstract
Observations of the Galactic Center supermassive black hole Sagittarius A* (Sgr A*) with very long-baseline interferometry (VLBI) are affected by interstellar scattering along our line of ...sight. At long radio observing wavelengths (≲1 cm), the scattering heavily dominates image morphology. At 3.5 mm (86 GHz), the intrinsic source structure is no longer sub-dominant to scattering, and thus the intrinsic emission from Sgr A* is resolvable with the Global Millimeter VLBI Array (GMVA). Long-baseline detections to the phased Atacama Large Millimeter/submillimeter Array (ALMA) in 2017 provided new constraints on the intrinsic and scattering properties of Sgr A*, but the stochastic nature of the scattering Requires multiple observing epochs to reliably estimate its statistical properties. We present new observations with the GMVA+ALMA, taken in 2018, which confirm non-Gaussian structure in the scattered image seen in 2017. In particular, the ALMA–GBT baseline shows more flux density than expected for an anistropic Gaussian model, providing a tight constraint on the source size and an upper limit on the dissipation scale of interstellar turbulence. We find an intrinsic source extent along the minor axis of ∼100
μ
as both via extrapolation of longer wavelength scattering constraints and direct modeling of the 3.5 mm observations. Simultaneously fitting for the scattering parameters, we find an at-most modestly asymmetrical (major-to-minor axis ratio of 1.5 ± 0.2) intrinsic source morphology for Sgr A*.
Lithium-sulfur batteries (Li-S) are identified as one of the most promising rechargeable energy systems due to their high theoretical capacity, high gravimetric energy density, low cost and low ...environmental impact. However, the insulating nature of sulfur and the migration of soluble polysulfides during discharge limit their practical application. In an attempt to mitigate these drawbacks here we report the preparation of a novel composite formed by hydrothermally reduced graphene oxide (HrGO) and submicrometer-sized sulfur particles. The role of HrGO is not restricted to enhance the electronic conductivity of the composite, but also sulfur wrapping in order to prevent polysulfides migration. Besides, the addition of polyvinylpyrrolidone (PVP) during the synthesis of the sulfur particles allows a greater control of their size and improves its homogeneous distribution within the composite. The material is tested as cathode for Li-S batteries showing reversible capacities over 900 mAh g−1 at a rate of 0.2 C and more than 650 mAh g−1 after 100 charge-discharge cycles. Moreover, this simplistic and environmentally friendly approach allow obtaining composites with sulfur loadings as high as 92 wt%, and large areal capacities up to 1.5 mAh cm−2.
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Microgastrine wasps are among the most species‐rich and numerous parasitoids of caterpillars (Lepidoptera). They are often host‐specific and thus are extensively used in biological control efforts ...and figure prominently in trophic webs. However, their extraordinary diversity coupled with the occurrence of many cryptic species produces a significant taxonomic impediment. We present and release the results of 8 years (2004–2011) of DNA barcoding microgastrine wasps. Currently they are the best represented group of parasitoid Hymenoptera in the Barcode of Life Data System (BOLD), a massive barcode storage and analysis data management site for the International Barcoding of Life (iBOL) program. There are records from more than 20 000 specimens from 75 countries, including 50 genera (90% of the known total) and more than 1700 species (as indicated by Barcode Index Numbers and 2% MOTU). We briefly discuss the importance of this DNA data set and its collateral information for future research in: (1) discovery of cryptic species and description of new taxa; (2) estimating species numbers in biodiversity inventories; (3) clarification of generic boundaries; (4) biological control programmes; (5) molecular studies of host‐parasitoid biology and ecology; (6) evaluation of shifts in species distribution and phenology; and (7) fostering collaboration at national, regional and world levels. The integration of DNA barcoding with traditional morphology‐based taxonomy, host records, and other data has substantially improved the accuracy of microgastrine wasp identifications and will significantly accelerate further studies on this group of parasitoids.
Regio- and stereoselective Baeyer–Villiger oxidations are difficult to achieve by classical chemical means, particularly when large, functionalized molecules are to be converted. Biocatalysis using ...flavin-containing Baeyer–Villiger monooxygenases (BVMOs) is a well-established tool to address these challenges, but known BVMOs have shortcomings in either stability or substrate selectivity. We characterized a novel BVMO from the thermophilic fungus Thermothelomyces thermophila, determined its three-dimensional structure, and demonstrated its use as a promising biocatalyst. This fungal enzyme displays excellent enantioselectivity, acts on various ketones, and is particularly active on polycyclic molecules. Most notably we observed that the enzyme can perform oxidations on both the A and D ring when converting steroids. These functional properties can be linked to unique structural features, which identify enzymes acting on bulky substrates as a distinct subgroup of the BVMO class.
There is emerging literature demonstrating a relationship between the timing of feeding and weight regulation in animals. However, whether the timing of food intake influences the success of a ...weight-loss diet in humans is unknown.
To evaluate the role of food timing in weight-loss effectiveness in a sample of 420 individuals who followed a 20-week weight-loss treatment.
Participants (49.5% female subjects; age (mean ± s.d.): 42 ± 11 years; BMI: 31.4 ± 5.4 kg m(-2)) were grouped in early eaters and late eaters, according to the timing of the main meal (lunch in this Mediterranean population). 51% of the subjects were early eaters and 49% were late eaters (lunch time before and after 1500 hours, respectively), energy intake and expenditure, appetite hormones, CLOCK genotype, sleep duration and chronotype were studied.
Late lunch eaters lost less weight and displayed a slower weight-loss rate during the 20 weeks of treatment than early eaters (P=0.002). Surprisingly, energy intake, dietary composition, estimated energy expenditure, appetite hormones and sleep duration was similar between both groups. Nevertheless, late eaters were more evening types, had less energetic breakfasts and skipped breakfast more frequently that early eaters (all; P<0.05). CLOCK rs4580704 single nucleotide polymorphism (SNP) associated with the timing of the main meal (P=0.015) with a higher frequency of minor allele (C) carriers among the late eaters (P=0.041). Neither sleep duration, nor CLOCK SNPs or morning/evening chronotype was independently associated with weight loss (all; P>0.05).
Eating late may influence the success of weight-loss therapy. Novel therapeutic strategies should incorporate not only the caloric intake and macronutrient distribution - as is classically done - but also the timing of food.
The Galactic center supermassive black hole Sagittarius A* (Sgr A*) is one of the most promising targets to study the dynamics of black hole accretion and outflow via direct imaging with very long ...baseline interferometry (VLBI). At 3.5 mm (86 GHz), the emission from Sgr A* is resolvable with the Global Millimeter VLBI Array (GMVA). We present the first observations of Sgr A* with the phased Atacama Large Millimeter/submillimeter Array (ALMA) joining the GMVA. Our observations achieve an angular resolution of ∼87 as, improving upon previous experiments by a factor of two. We reconstruct a first image of the unscattered source structure of Sgr A* at 3.5 mm, mitigating the effects of interstellar scattering. The unscattered source has a major-axis size of 120 34 as (12 3.4 Schwarzschild radii) and a symmetrical morphology (axial ratio of ), which is further supported by closure phases consistent with zero within 3 . We show that multiple disk-dominated models of Sgr A* match our observational constraints, while the two jet-dominated models considered are constrained to small viewing angles. Our long-baseline detections to ALMA also provide new constraints on the scattering of Sgr A*, and we show that refractive scattering effects are likely to be weak for images of Sgr A* at 1.3 mm with the Event Horizon Telescope. Our results provide the most stringent constraints to date for the intrinsic morphology and refractive scattering of Sgr A*, demonstrating the exceptional contribution of ALMA to millimeter VLBI.
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