The technological prototype of the CALICE highly granular silicon–tungsten electromagnetic calorimeter (SiW-ECAL) was tested in a beam at DESY in 2017. The setup comprised seven layers of silicon ...sensors. Each layer comprised four sensors, with each sensor containing an array of 256 5.5×5.5 mm2 silicon PIN diodes. The four sensors covered a total area of 18 × 18 cm and comprised a total of 1024 channels. The readout was split into a trigger line and a charge signal line. Key performance results for signal over noise for the two output lines are presented, together with a study of the uniformity of the detector response. Measurements of the response to electrons for the tungsten loaded version of the detector are also presented.
Objective
Symptomatic intracerebral hemorrhage (sICH) is a common complication of acute ischemic stroke (AIS) associated with limited treatments and poor outcomes. We aimed to identify predictive ...factors of sICH in patients with AIS following mechanical thrombectomy (MT) in a real-world setting.
Methods
Patients with large vessel occlusion of the anterior circulation treated with MT were consecutively included in a prospective monocentric cohort. Clinical, biological, and radiological parameters were collected to identify pre-procedural predictors for sICH.
Results
637 patients were included in our study. Magnetic resonance imaging was performed on most patients (86.7%). sICH occurred in 55 patients (8.6%). 428 patients (67.2%) were treated with intravenous thrombolysis. After multivariate analysis, prior use of antiplatelet therapies (odd ratio (OR) 1.84, 95% confidence interval (CI) 1.01–3.32), high C-reactive protein (OR per standard deviation (SD) increase 1.28, 95% 1.01–1.63), elevated mean arterial blood pressure (OR per 10 mmHg increase 1.22, 95% CI 1.03–1.44), hyperglycemia (OR per one SD-log increase 1.38, 95% CI 1.02–1.87), and low ASPECTS (OR per 1-point decrease 1.42, 95% CI 1.12–1.80) were found to be independent predictive factors of sICH. The pre-procedural predictors did not change when the absence of successful recanalization was considered as a covariate. Patients with strokes of unknown onset time were not especially vulnerable for sICH.
Conclusion
sICH after MT was associated with several pre-procedural risk factors: prior use of antiplatelet therapies, high C-reactive protein and hyperglycemia at baseline, elevated mean arterial blood pressure, and low ASPECTS.
The Ξ_{c}^{+}K^{-} mass spectrum is studied with a sample of pp collision data corresponding to an integrated luminosity of 3.3 fb^{-1}, collected by the LHCb experiment. The Ξ_{c}^{+} is ...reconstructed in the decay mode pK^{-}π^{+}. Five new, narrow excited Ω_{c}^{0} states are observed: the Ω_{c}(3000)^{0}, Ω_{c}(3050)^{0}, Ω_{c}(3066)^{0}, Ω_{c}(3090)^{0}, and Ω_{c}(3119)^{0}. Measurements of their masses and widths are reported.
The 1,3-diaminepropane-3-propyl-anchored silica gel (DAPPS) was successfully employed as a sorbent in a spectrophotometric flow system for the preconcentration of Cu
2+ in digests of biological ...materials (maize powder, soybean, citrus leaves, corn stalks) as well as water samples (river, stream, streamlet, springwater and well). The system presented a minicolumn packed with DAPPS, where the sample solution was passed through it for a period of time, and subsequently, an eluent solution, stripped-out the retained analyte which was further determined with DDTC at 460
nm.
The better preconcentration conditions utilized were: 120
s loading, 60
s elution, 30
s regeneration of the column, loading flow rate 6.5
ml
min
−1, buffer solution for the preconcentration and regeneration of the column-borate buffer pH 8.5, elution flow rate 2.3
ml
min
−1, time of elution 60
s, eluent composition, 0.4
mol
l
−1 HNO
3. Under these conditions, the preconcentration factor obtained was 36, and the detection limit achieved was 8.4
ng
ml
−1 in water samples and 0.84
μg
g
−1 in biological material. The maximum adsorption capacity of DAPPS to Cu
2+ was 0.49
mmol
g
−1 (31.1
mg
g
−1) obtained in a batch system.
The recovery of copper in the water samples ranged from 96.9 to 102.4% and in the biological materials ranged from 97.0 to 102.6%.
Measurements of the cross section for producing b quarks in the reaction pp→bbover ¯X are reported in 7 and 13 TeV collisions at the LHC as a function of the pseudorapidity η in the range 2<η<5 ...covered by the acceptance of the LHCb experiment. The measurements are done using semileptonic decays of b-flavored hadrons decaying into a ground-state charmed hadron in association with a muon. The cross sections in the covered η range are 72.0±0.3±6.8 and 154.3±1.5±14.3 μb for 7 and 13 TeV. The ratio is 2.14±0.02±0.13, where the quoted uncertainties are statistical and systematic, respectively. The agreement with theoretical expectation is good at 7 TeV, but differs somewhat at 13 TeV. The measured ratio of cross sections is larger at lower η than the model prediction.
A growing body of research supports stromal tumour‐infiltrating lymphocyte (TIL) density in breast cancer to be a robust prognostic and predicive biomarker. The gold standard for stromal TIL ...density quantitation in breast cancer is pathologist visual assessment using haematoxylin and eosin‐stained slides. Artificial intelligence/machine‐learning algorithms are in development to automate the stromal TIL scoring process, and must be validated against a reference standard such as pathologist visual assessment. Visual TIL assessment may suffer from significant interobserver variability. To improve interobserver agreement, regulatory science experts at the US Food and Drug Administration partnered with academic pathologists internationally to create a freely available online continuing medical education (CME) course to train pathologists in assessing breast cancer stromal TILs using an interactive format with expert commentary. Here we describe and provide a user guide to this CME course, whose content was designed to improve pathologist accuracy in scoring breast cancer TILs. We also suggest subsequent steps to translate knowledge into clinical practice with proficiency testing.
The doubly charmed baryon decay Ξ_{cc}^{++}→Ξ_{c}^{+}π^{+} is observed for the first time, with a statistical significance of 5.9σ, confirming a recent observation of the baryon in the ...Λ_{c}^{+}K^{-}π^{+}π^{+} final state. The data sample used corresponds to an integrated luminosity of 1.7 fb^{-1}, collected by the LHCb experiment in pp collisions at a center-of-mass energy of 13 TeV. The Ξ_{cc}^{++} mass is measured to be 3620.6±1.5(stat)±0.4(syst)±0.3(Ξ_{c}^{+}) MeV/c^{2} and is consistent with the previous result. The ratio of branching fractions between the decay modes is measured to be B(Ξ_{cc}^{++}→Ξ_{c}^{+}π^{+})×B(Ξ_{c}^{+}→pK^{-}π^{+})/B(Ξ_{cc}^{++}→Λ_{c}^{+}K^{-}π^{+}π^{+})×B(Λ_{c}^{+}→pK^{-}π^{+})=0.035±0.009(stat)±0.003(syst).
The first amplitude analysis of the B^{±}→π^{±}K^{+}K^{-} decay is reported based on a data sample corresponding to an integrated luminosity of 3.0 fb^{-1} of pp collisions recorded in 2011 and 2012 ...with the LHCb detector. The data are found to be best described by a coherent sum of five resonant structures plus a nonresonant component and a contribution from ππ↔KK S-wave rescattering. The dominant contributions in the π^{±} K^{∓} and K^{+} K^{-} systems are the nonresonant and the B^{±}→ρ(1450)^{0}π^{±} amplitudes, respectively, with fit fractions around 30%. For the rescattering contribution, a sizable fit fraction is observed. This component has the largest CP asymmetry reported to date for a single amplitude of (-66±4±2)%, where the first uncertainty is statistical and the second systematic. No significant CP violation is observed in the other contributions.
Third level trigger of the DIRAC experiment Gallas, M
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment,
04/2002, Letnik:
481, Številka:
1
Journal Article
Recenzirano
A fast and complete programmable high level trigger processor for the DIRAC experiment at CERN was designed and arranged based on state-of-art Field Programmable Gate Array (FPGA) technology. The ...implemented logic was created from Monte Carlo simulation results and further checked with real experimental data. Correspondence between desired and implemented logic was proved previously by use of a complete digital pattern generator built also with FPGA technology. The resulting trigger processor provides a selection of charged particle pairs with a small relative momentum.
PDF
