Intersection Lawson homology Gajer, Pawel
Transactions of the American Mathematical Society,
04/1997, Letnik:
349, Številka:
4
Journal Article
Recenzirano
Odprti dostop
The aim of this paper is to construct and describe basic properties of a theory that unifies Lawson homology and intersection homology. It is shown that this theory has a localization sequence, is ...functorial, satisfies a property analogous to the Lawson Suspension Theorem, and is equipped with an operation analogous to the Friedlander-Mazur \mathbf s-operation.
A method of handling uncertain statistical information and its (approximate) propagation through an IC is proposed, utilizing the concepts of fuzzy numbers and fuzzy arithmetic, combined with the ...propagation of moments method of statistical analysis, leading to a new method of propagation of fuzzy variance. A symbolic implementation of this method is proposed, allowing one to efficiently represent the relevant membership functions.
The vaginal microbiota helps protect the female genital tract from disease. We sought to describe the composition of the vaginal microbiota in premenopausal, perimenopausal, and postmenopausal women ...and to explore the association between the microbiota and vulvovaginal atrophy (VVA).
Eighty-seven women (aged 35-60 y) were classified as premenopausal (n = 30), perimenopausal (n = 29), or postmenopausal (n = 28) according to Stages of Reproductive Aging Workshop guidelines. Midvaginal bacterial community composition was characterized by 16S ribosomal RNA gene analysis.
Bacterial communities clustered into six community state types (CSTs), of which four were dominated by Lactobacillus crispatus, Lactobacillus gasseri, Lactobacillus iners, or Lactobacillus jensenii, and two (CST IV-A and CST IV-B) had low relative abundance of Lactobacillus. CST IV-A was characterized by Streptococcus and Prevotella, whereas CST IV-B was characterized by Atopobium. There were significant associations between menopause stage and CST (P = 0.004) and between VVA and CST (P = 0.002). Perimenopausal women were more likely to be classified as CST IV-A or L. gasseri CST, whereas postmenopausal women were often classified as CST IV-A. CSTs dominated by L. crispatus and L. iners were more prevalent in premenopausal women. Nineteen participants had signs of mild or moderate VVA. Compared with women with no VVA, the vaginal microbiota of women with mild or moderate atrophy had 25-fold greater odds of being classified as CST IV-A versus L. crispatus CST (adjusted odds ratio, 25.89; 95% credible interval, 2.98-406.79).
A distinct bacterial community state (CST IV-A) with a low relative abundance of Lactobacillus is associated with VVA. Future studies recruiting a larger number of women are needed to replicate the findings. This study provides an impetus for future longitudinal studies designed to manage, modulate, and restore vaginal microbiota homeostasis, which would provide stronger evidence for a causal relationship with VVA and ultimately improve the treatment and prevention of atrophic vaginitis in menopause.
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