A solution of 225Ac was standardized by NRC using the triple-to-double coincidence ratio (TDCR) method. The counting efficiencies were calculated assuming a counting efficiency of 100% for alpha ...decays and those calculated using the MICELLE2 Monte Carlo code for beta decays and was approximately 500% for the NRC TDCR system. The relative uncertainty for the activity concentration was determined to be 0.25%. This agreed with measurements performed using gamma spectroscopy and a predicted calibration factor for the Vinten 671 ionization chamber as calculated using an EGSnrc model, implementing radioactive decay. Finally, the half-life of 225Ac was determined from long-term measurements using ionization chambers and liquid scintillation counting. The NRC measured half-life for 225Ac was found to be 9.914(4) days and is consistent within an expanded uncertainty coverage of k = 2 with the most recent (Kossert et al., 2020; Pommé et al., 2012) measurements of this decay parameter.
The need for exit signs that attract attention when they need to be conspicuous, to redirect people to not just an exit route, but a viable and if possible an optimal exit route in an evolving ...emergency has driven the development of a new generation of advanced signage, the Intelligent Active Dynamic Signage System (IADSS). The IADSS, attempts to meet these needs through the development of a novel Active Dynamic Signage System (ADSS) which can be controlled by an intelligent decision support system. This paper presents results that refine the effectiveness of the ADSS. When an exit route is considered non-viable, the adapted ADSS provides not only negative information i.e. that an exit is no longer available, but also positive information, i.e. indicating a viable alternative exit. In addition, in situations where a voice alarm system is used in conjunction with the ADSS, it is also important to ensure that the messaging does not contradict the intent of the ADSS. The improved ADSS was tested in full-scale evacuation trials in a rail station. Results suggest that the improved ADSS with voice alarm messaging that does not contradict the signage system successfully redirected 66% of the participants to the intended exit.
The neoplastic tumour suppressors, Scribble, Dlg and Lgl, originally discovered in the vinegar fly Drosophila melanogaster, are currently being actively studied for their potential role in mammalian ...tumourigenesis. In Drosophila, these tumour suppressors function in a common genetic pathway to regulate apicobasal cell polarity and also play important roles in the control of cell proliferation, survival, differentiation and in cell migration/invasion. The precise mechanism by which Scribble, Dlg and Lgl function is not clear; however, they have been implicated in the regulation of signalling pathways, vesicle trafficking and in the Myosin II-actin cytoskeleton. We review the evidence for the involvement of Scribble, Dlg, and Lgl in cancer, and how the various functions ascribed to these tumour suppressors in Drosophila and mammalian systems may impact on the process of tumourigenesis.
•Autonomous cars were perceived as a “somewhat low risk” form of transport.•Attitudes towards these cars revealed little opposition but several concerns.•Road user perspective (passenger, pedestrian) ...altered perceived risk and attitudes.•Males, younger adults more accepting; premature to draw conclusions on risk-takers.•Acceptance will require further focus on road user and individual characteristics.
Fully automated self-driving cars, with expected benefits including improved road safety, are closer to becoming a reality. Thus, attention has turned to gauging public perceptions of these autonomous vehicles. To date, surveys have focused on the public as potential passengers of autonomous cars, overlooking other road users who would interact with them. Comparisons with perceptions of other existing vehicles are also lacking. This study surveyed almost 1000 participants on their perceptions, particularly with regards to safety and acceptance of autonomous vehicles. Overall, results revealed that autonomous cars were perceived as a “somewhat low risk“ form of transport and, while concerns existed, there was little opposition to the prospect of their use on public roads. However, compared to human-operated cars, autonomous cars were perceived differently depending on the road user perspective: more risky when a passenger yet less risky when a pedestrian. Autonomous cars were also perceived as more risky than existing autonomous trains. Gender, age and risk-taking had varied relationships with the perceived risk of different vehicle types and general attitudes towards autonomous cars. For instance, males and younger adults displayed greater acceptance. Whilst their adoption of this autonomous technology would seem societally beneficial – due to these groups’ greater propensity for taking road user risks, behaviours linked with poorer road safety – other results suggested it might be premature to draw conclusions on risk-taking and user acceptance. Future studies should therefore continue to investigate people’s perceptions from multiple perspectives, taking into account various road user viewpoints and individual characteristics.
The National Research Council (NRC) of Canada's primary method for emission rate for radionuclide neutron sources utilizes a manganese salt bath which was last calibrated in the 1960s. At that time, ...an NRC RaBe neutron source was used to irradiate a solution of calcium permanganate to take advantage of the Szilard-Chalmers effect in producing the bulk 56Mn material for standardization and calibration of the bath. When attempting to repeat this exercise, a small amount (~100 kBq) was produced. This amount was sufficient for the standardization process but did not yield enough material to calibrate the bath to a sufficient level of precision.
Improvements upon the previous separation scheme adopted at NRC for the separation of the 56Mn from the bulk irradiated material included the rinsing of the 56Mn dioxide precipitate using a mixture of sulfuric acid and hydrogen peroxide. While these improvements made in the separation chemistry improved the yield of 56Mn extraction from 60% to above 95% the maximum amount of activity was still quite low. Hence in March of 2018, the SLOWPOKE-2 Facility at the Royal Military College in Kingston, ON, was used to irradiate three vials of KMnO4 in solution. An estimated 2 GBq was produced and sent to NRC, from which the extraction procedure recovered essentially all of the available 56Mn.
The 56Mn was standardized using the 4πβ−γ anti-coincidence counting system and confirmed using the CIEMAT/NIST primary method. The resulting bulk material was certified with an uncertainty of 0.8% (k = 2). Minor quantities of 65Zn, 69mZn and 42K were unexpectedly observed but were in minute quantities so as not to affect the results of the standardization or calibration. The standardized 56Mn artifact was used to calibrate the Secondary Standard Ionizing Radiation Chamber System (SSIRCS) for a more rapid deployment of the calibrant in the future.
•The NRC primary standard for neutron emission rate, the Manganese salt bath was calibrated.•The Szilard-Chalmers effect, along with an improved purification scheme produced a pure 56Mn bulk source for standardization.•The resulting calibration recovered the neutron emission rates of traceable sealed neutron sources at NRC.
Since the early 2000 s the practice of free-range egg production has increased in developed countries, partly driven by consumer perception that free-range housing is better for hen welfare. While ...poultry in free-range systems have more behavioural opportunities compared with poultry in caged systems, free-range systems are associated with greater frequencies of infectious disease, predation and 'smothering', a condition where birds pile on top of one another with death occurring due to suffocation. Although the frequency of smothering deaths in Australian free-range layer poultry is anecdotally high, there is a lack of empirical evidence quantifying smothering cause-specific mortality rates and identifying factors that place birds at higher risk of death from smothering. This was a prospective cohort study of poultry flocks managed by three commercial free-range layer organisations in Eastern Australia. Flocks were enrolled into the study from 1 January 2019 to 29 March 2021 and were followed until the end of lay or until the end of the study on 31 March 2022, whichever occurred first. Throughout the follow-up period flock managers provided production details for each flock and details of smothering events using custom-designed logbooks.A total of 84 flocks were enrolled in the study: 32 from Organisation 1, 35 from Organisation 2 and 17 from Organisation 3. The number of birds per flock ranged from 16,000 to 45,000. The total mortality rate was 1131 deaths per 10,000 bird-years. Smothering mortality rate across the three organisations was 183 (minimum 133, maximum 223) deaths per 10,000 bird-years at risk. Smothering accounted for around 16% (minimum 9%, maximum 22%) of all deaths.We identified no distinctive temporal pattern in daily smothering risk as a function of either the number of days since placement or calendar date. The locations of smothering events in sheds and in the outdoor range were not consistent, with relatively large numbers of smothering events occurring in specific locations for some sheds but not others. To the best of our knowledge, this study is the largest prospective study of smothering mortality in commercial free-range layer flocks conducted to date. Estimates of smothering incidence rate and how that varies within and between flocks and organisations over time provides a critically important benchmark for further investigations into this substantial area of productivity loss.
The National Physical Laboratory Vinten 671 chamber was selected as a proving ground for a new radionuclide source model in the EGSnrc software. The computational Vinten model is validated against ...measurements of radionuclide artifacts whose activities were determined by absolute methods. The response of the Vinten chamber is first calculated as a function of gamma energy, but more strikingly, an explicit simulation of radionuclide decay was implemented and now permits the direct determination of a calibration factor, including additional effects due to all decay paths of the radionuclide. The Monte Carlo and experimental calibration factors are found to agree at the percent level, in absolute terms.
•An EGSnrc model of the Vinten chamber has been created.•A radionuclide decay generation scheme has been included in EGSnrc.•Preliminary comparison of calibration factors between Monte Carlo and experiment show percent level agreement.
•Longer-term fear responses can be shaped by early life experiences.•Early positive human contact produced the most sustained reductions in fear of people.•Rearing piglets in farrowing crates as ...opposed to pens reduced fear early in life.•The design of the farrowing environment can affect the human-animal relationship.•Early human and housing experiences affect fear and hold importance to pig welfare.
The development of fear and stress responses in animals can be influenced by early life experiences, including interactions with humans, maternal care, and the physical surroundings. This paper is the first of three reporting on a large experiment examining the effects of the early housing environment and early positive human contact on stress resilience in pigs. This first paper reports on the responses of pigs to humans, novelty, and social isolation. Using a 2 × 2 factorial design, 48 litters of pigs were reared in either a conventional farrowing crate (FC) where the sow was confined or a loose farrowing pen (LP; PigSAFE pen) which was larger, more physically complex and allowed the sow to move freely throughout the farrowing and lactation period. Piglets were provided with either routine contact from stockpeople (C), or routine contact plus regular opportunities for positive human contact (+HC) involving 5 min of scratching, patting and stroking imposed to the litter 5 days/week from 0–4 weeks of age. The positive handling treatment was highly effective in reducing piglets’ fear of humans, based on +HC piglets showing greater approach and less avoidance of an unfamiliar person at 3 weeks of age. There was evidence that this reduction in fear of humans lasted well beyond when the treatment was applied (lactation), with +HC pigs showing greater approach and less avoidance of humans in tests at 6, 9 and 14 weeks of age. The +HC treatment also reduced piglets’ fear of a novel object at 3 weeks of age, and for pigs in FC, the cortisol response after social isolation at 7 weeks of age. Rearing in FC compared to LP reduced piglets’ fear of novelty at 3 weeks of age, as well as their vocalisations and cortisol response to isolation at 7 weeks of age. The FC pigs showed greater approach and less avoidance of humans compared to LP pigs at 3, 4 and 6 weeks of age, but not at 9 and 14 weeks of age. These results show that positive handling early in life can reduce pigs’ fear of humans, fear of novelty and physiological stress response to social isolation. The LP pigs were reared in a more isolated environment with less overall contact with stockpeople and other pigs, which may have increased their fear responses to humans and novel situations, suggesting that different housing systems can modulate these pigs’ responses.
•Early life experiences can affect how pigs cope with routine farming practices.•Positive human contact improved coping during husbandry practices, including weaning.•Rearing in farrowing crates ...compared to pens also improved coping.•Rearing in farrowing crates compared to pens improved ease of handling later in life.•Responses to husbandry challenges align with the fear levels of pigs reported in Part 1.
The ability of pigs to cope with routine farming practices can affect their welfare. This paper is part of a series on early experiences and stress, and reports on the effects of early human contact and housing on the responses of pigs to routine husbandry practices. Using a 2 × 2 factorial design, 48 litters of pigs were raised in either a conventional farrowing crate (FC) or a loose farrowing pen (LP; PigSAFE pen) which was larger, more physically complex and allowed the sow to move freely. Piglets were provided with either routine contact from stockpeople (C), or routine contact plus regular opportunities for positive human contact (+HC) involving 5 min of scratching, patting and stroking imposed to the litter 5 days/week from 0 to 4 weeks of age. At 4 weeks of age, piglets were weaned and re-housed with controlled mixing of litters within treatment. At 4 days of age, after only 3 bouts of the handling treatment, +HC pigs showed less escape behaviour than C pigs after capture by a stockperson for vaccinations and tail docking, and shorter durations of vocalisations throughout the procedures. The +HC pigs also showed less escape behaviour when captured by a stockperson at 3 weeks of age. The FC pigs showed less escape behaviour than LP pigs after capture by a stockperson at 4 days of age but not at 3 weeks of age. Serum cortisol concentrations were lower in FC pigs than LP pigs 2 h after weaning but not at 49 h after weaning, whereas serum cortisol concentrations were lower in +HC pigs than C pigs at 49 h after weaning but not at 2 h after weaning. In the period from 0 to 1 h after weaning, C pigs from LP performed the most escape attempts, although escape attempts were rare overall. When being moved out of the home pen by a stockperson at 21 weeks of age, FC pigs showed less baulking than LP pigs, but there were no detected effects of human contact treatment. In conclusion, both housing system and human contact during lactation affected the stress responses of pigs to routine husbandry practices. The +HC and FC pigs appeared to cope better than C and LP pigs, based on lower responses indicative of stress including escape behaviour, vocalisations and cortisol concentrations. These findings are consistent with corresponding reductions in fear that were reported in Part 1 of this series of papers.
•Rearing in farrowing crates without positive human contact reduced brain-derived neurotrophic factor.•Piglet play behaviour and sow interaction were less frequent in farrowing crates than in ...pens.•Positive human contact reduced piglets’ injuries.•Early housing and human contact did not affect longer-term behaviour and physiology at rest.•Human contact has more effect on resilience to acute stressors than on basal physiology and behaviour.
Early experiences can have long-term impacts on stress adaptability. This paper is the last of three in a series on early experiences and stress in pigs, and reports on the effects of early human contact and housing on the ability of pigs to cope with their general environment. Using a 2 × 2 factorial design, 48 litters of pigs were reared in either a farrowing crate (FC) or a loose farrowing pen (LP; PigSAFE pen) which was larger, more physically complex and allowed the sow to move freely. Piglets were provided with either routine contact from stockpeople (C), or routine contact plus regular opportunities for positive human contact (+HC) involving 5 min of scratching, patting and stroking imposed to the litter 5 days/week from 0 to 4 weeks of age. At 4 weeks of age (preweaning), C piglets that were reared in FC had considerably lower concentrations of serum brain-derived neurotrophic factor (BDNF) than piglets from the other treatment combinations. Compared to C pigs, +HC pigs had fewer injuries at 4 weeks of age. There were no clear effects of human contact on BDNF concentrations or injuries after weaning, or on basal cortisol or immunoglobulin-A concentrations, behavioural time budgets, tear staining, growth, or piglet survival. Compared to FC piglets, LP piglets showed more play behaviour and interactions with the dam and less repetitive nosing towards pen mates during lactation. There was no evidence that early housing affected pigs’ behavioural time budgets or physiology after weaning. Tear staining severity was greater in LP piglets at 4 weeks of age, but this may have been associated with the higher growth rates of LP piglets preweaning. There was no effect of lactation housing on growth after weaning. Preweaning piglet mortality was higher in the loose system. The findings on BDNF concentrations, injuries and play behaviour suggest improved welfare during the treatment period in +HC and LP piglets compared to C and FC piglets, respectively. These results together with those from the other papers in this series indicate that positive human interaction early in life promotes stress adaptability in pigs. Furthermore, while the farrowing crate environment deprives piglets of opportunities for play behaviour and sow interaction, there was no evidence that rearing in crates negatively affected pig welfare or stress resilience after weaning. Whether these findings are specific to the two housing systems studied here, or can be generalised to other housing designs, warrants further research.
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