Aims.
Our aim is to investigate the role of acoustic and magneto-acoustic waves in heating the solar chromosphere. Observations in strong chromospheric lines are analyzed by comparing the deposited ...acoustic-energy flux with the total integrated radiative losses.
Methods.
Quiet-Sun and weak-plage regions were observed in the Ca
II
854.2 nm and H
α
lines with the Fast Imaging Solar Spectrograph (FISS) at the 1.6-m Goode Solar Telescope on 2019 October 3 and in the H
α
and H
β
lines with the echelle spectrograph attached to the Vacuum Tower Telescope on 2018 December 11 and 2019 June 6. The deposited acoustic energy flux at frequencies up to 20 mHz was derived from Doppler velocities observed in line centers and wings. Radiative losses were computed by means of a set of scaled non-local thermodynamic equilibrium 1D hydrostatic semi-empirical models obtained by fitting synthetic to observed line profiles.
Results.
In the middle chromosphere (
h
= 1000–1400 km), the radiative losses can be fully balanced by the deposited acoustic energy flux in a quiet-Sun region. In the upper chromosphere (
h
> 1400 km), the deposited acoustic flux is small compared to the radiative losses in quiet as well as in plage regions. The crucial parameter determining the amount of deposited acoustic flux is the gas density at a given height.
Conclusions.
The acoustic energy flux is efficiently deposited in the middle chromosphere, where the density of gas is sufficiently high. About 90% of the available acoustic energy flux in the quiet-Sun region is deposited in these layers, and thus it is a major contributor to the radiative losses of the middle chromosphere. In the upper chromosphere, the deposited acoustic flux is too low, so that other heating mechanisms have to act to balance the radiative cooling.
In 2018, the Mexican Caribbean coast received a massive influx of pelagic Sargassum spp. that accumulated and decayed on beaches producing organic decomposition products that made the water turbid ...and brown. Between May and September of the same year there were several reports of mass mortality of marine biota in this area. From these reports we estimate that organisms belonging to 78 faunal species died as result of this event, with demersal neritic fish and Crustacea being the most affected groups. The cause of mortality appears to be the combined effect of high ammonium and hydrogen sulfide concentrations, together with hypoxic conditions. If massive arrival of pelagic Sargassum spp. continues and algae is left to decay on the beach in large volumes then deterioration in water quality could affect coral reefs close to shore. Furthermore, barriers placed in lagoons to intercept the Sargassum spp. before it reaches the beach could impact reef fauna if the algae is left to die and sink on site.
•Organisms of 78 faunal species died due to Sargassum decay along Mexico's Caribbean coast in 2018.•The cause appears to be hypoxia combined with high ammonium and hydrogen sulfide concentrations.•Deterioration in water quality extended at least as far as 480 m from shore.•Continued massive influx of Sargassum may have a deleterious impact on the coral reefs of the region.
Context.
Analyses of the magnetic properties on umbrae boundaries have led to the Jurčák criterion, which states that umbra-penumbra boundaries in stable sunspots are equally defined by a constant ...value of the vertical magnetic field,
B
ver
crit
, and by a 50% continuum intensity of the quiet Sun,
I
QS
. Umbrae with vertical magnetic fields stronger than
B
ver
crit
are stable, whereas umbrae with vertical magnetic fields weaker than
B
ver
crit
are unstable and prone to vanishing.
Aims.
We aim to investigate the existence of a critical value of the vertical magnetic field on a pore boundary and its role in the evolution of the magnetic structure.
Methods.
We analysed SDO/HMI vector field maps corrected for scattered light and with a temporal cadence of 12 min during a 26.5-hour period. A continuum intensity threshold (
I
c
= 0.55
I
QS
) is used to define the pore boundary and we study the temporal evolution of the magnetic properties there.
Results.
We observe well-defined stages in the pore evolution: (1) during the initial formation phase, total magnetic field strength (
B
) and vertical magnetic field (
B
ver
) increase to their maximum values of ∼1920 G and ∼1730 G, respectively; (2) then the pore reaches a stable phase; (3) in a second formation phase, the pore undergoes a rapid growth in terms of size, along with a decrease in
B
and
B
ver
on its boundary. In the newly formed area of the pore,
B
ver
remains mostly below 1731 G and
B
remains everywhere below 1921 G; (4) ultimately, pore decay starts. We find overall that pore areas with
B
ver
< 1731 G, or equivalently
B
< 1921 G, disintegrate faster than regions that fulfil this criteria.
Conclusions.
We find that the most stable regions of the pore, similarly to the case of umbral boundaries, are defined by a critical value of the vertical component of the magnetic field that is comparable to that found in stable sunspots. In addition, in this case study, the same pore areas can be similarly well-defined by a critical value of the total magnetic field strength.
Genetic events mediating transformation from premalignant monoclonal gammopathies (MG) to multiple myeloma (MM) are unknown. To obtain a comprehensive genomic profile of MG from the early to late ...stages, we performed high-resolution analysis of purified plasma cells from 20 MGUS, 20 smoldering MM (SMM) and 34 MM by high-density 6.0 SNP array. A progressive increase in the incidence of copy number abnormalities (CNA) from MGUS to SMM and to MM (median 5, 7.5 and 12 per case, respectively) was observed (P=0.006). Gains on 1q, 3p, 6p, 9p, 11q, 19p, 19q and 21q along with 1p, 16q and 22q deletions were significantly less frequent in MGUS than in MM. Although 11q and 21q gains together with 16q and 22q deletions were apparently exclusive of MM status, we observed that these abnormalities were also present in minor subclones in MGUS. Overall, a total of 65 copy number-neutral LOH (CNN-LOH) were detected. Their frequency was higher in active MM than in the asymptomatic entities (P=0.047). A strong association between genetic lesions and fragile sites was also detected. In summary, our study shows an increasing genomic complexity from MGUS to MM and identifies new chromosomal regions involved in CNA and CNN-LOH.
Onset of penumbra formation García-Rivas, M.; Jurčák, J.; Bello González, N. ...
Astronomy and astrophysics (Berlin),
06/2024, Letnik:
686
Journal Article
Recenzirano
Odprti dostop
Context. Fully fledged penumbrae have been widely studied both observationally and theoretically. Yet the relatively fast process of penumbra formation has not been studied closely with high spatial ...resolution. Aims. We investigate the stages previous to and during the formation of penumbral filaments in a developing sunspot. Methods. We analysed Milne-Eddington inversions from spectro-polarimetric data of the leading sunspot of NOAA 11024 during the development of its penumbra. We focused on selected areas of this protospot in which segments of penumbra develop. Results. We find that few types of distinctive flow patterns develop at the protospot limb and centre sides previous to penumbra formation. The flow in the centre side is often characterised by a persistent (> 20 min) inflow-outflow pattern extending radially over 4 arcsec at the direct periphery of the protospot umbra. This inflow-outflow system often correlates with elongated granules, as seen in continuum intensity maps, and is also coupled with magnetic bipolar patches at its edges, as seen in magnetograms. The field is close to horizontal between the bipolar patches, which is indicative of its possible loop configuration. All of these aspects are analogous to observations of magnetic flux emergence. In the protospot limb side, however, we observed a mostly regular pattern associated with small granules located near the protospot intensity boundary. Locally, an inflow develops adjacent to an existing penumbral segment, and this inflow is correlated with a single bright penumbral filament that is brighter than filaments containing the Evershed flow. All investigated areas at the centre and limb side eventually develop penumbral filaments with an actual Evershed flow that starts at the umbral boundary and grows outwards radially as the penumbral filaments become longer in time.
Virgin olive oil (VOO) is the only food product requiring official sensory analysis to be classified in commercial categories, in which the evaluation of the aroma plays a very important role. The ...selection of parents, with the aim of obtaining new cultivars with improved oil aroma, is of paramount importance in olive breeding programs. We have assessed the volatile fraction by headspace-solid-phase microextraction/gas chromatography-mass spectrometry-flame ionization detection (HS-SPME/GC-MS-FID) and the deduced aroma properties of VOO from a core set of olive cultivars (Core-36) which possesses most of the genetic diversity found in the World Olive Germplasm Collection (IFAPA Alameda del Obispo) located in Cordoba, Spain. The VOO volatile fractions of Core-36 cultivars display a high level of variability. It is mostly made of compounds produced from polyunsaturated fatty acids through the lipoxygenase pathway, which confirms to be a general characteristic of the olive species (
L.). The main group of volatile compounds in the oils was six straight-chain carbon compounds derived from linolenic acid, some of them being the main contributors to the aroma of the olive oils according to their odor activity values (OAV). The high level of variability found for the volatile fraction of the oils from Core-36 and, therefore, for the aroma odor notes, suggest that this core set may be a very useful tool for the choice of optimal parents in olive breeding programs in order to raise new cultivars with improved VOO aroma.
Peach allergy is highly prevalent in the Mediterranean area; it is persistent and potentially severe, and therefore a prime target for immunotherapy. We aimed to study the efficacy and safety of ...sublingual immunotherapy (SLIT) with a peach extract quantified in mass units for Pru p 3, the peach lipid transfer protein. Randomized, double-blind, placebo-controlled (DBPC) clinical trial. The main efficacy outcome was the change in the response to a DBPC food challenge (DBPCFC) with peach. Secondary efficacy outcomes were the changes in skin prick test (SPT), and in specific immunoglobulin E (IgE) and IgG₄ to Pru p 3. Tolerance was assessed with a careful recording of adverse events. After 6 months of SLIT, the active group tolerated a significantly higher amount of peach (three- to ninefold), presented a significant decrease (5.3 times) in SPT, and a significant increase in IgE and IgG₄ to Pru p 3. No significant changes were observed within the placebo group. Statistically significant inter-group differences were only observed in the SPT and IgG₄ responses. No serious adverse events were reported. Systemic reactions were mild, and observed with a similar frequency in both groups. Local reactions were significantly more frequent in the active group (three times) and 95% of them restricted to the oral cavity. In this first exploratory clinical trial, SLIT for peach allergy seems to be a promising therapeutic option that could modify the clinical reactivity of the patients to peach intake and the underlying immunological response with a good tolerance.
Introduction
Molecular testing of Inherited bleeding coagulation disorders (IBCDs) not only offers confirmation of diagnosis but also aids in genetic counselling, prenatal diagnosis and in certain ...cases genotype–phenotype correlations are important for predicting the clinical course of the disease and to allow tailor‐made follow‐up of individuals. Until recently, genotyping has been mainly performed by Sanger sequencing, a technique known to be time consuming and expensive. Currently, next‐generation sequencing (NGS) offers a new potential approach that enables the simultaneous investigation of multiple genes at manageable cost.
Aim
The aim of this study was to design and to analyse the applicability of a 23‐gene NGS panel in the molecular diagnosis of patients with IBCDs.
Methods
A custom target enrichment library was designed to capture 31 genes known to be associated with IBCDs. Probes were generated for 296 targets to cover 86.3 kb regions (all exons and flanking regions) of these genes. Twenty patients with an IBCDs phenotype were studied using NGS technology.
Results
In all patients, our NGS approach detected causative mutations. Twenty‐one pathogenic variants were found; while most of them were missense (18), three deletions were also identified. Six novel mutations affecting F8, FGA, F11, F10 and VWF genes, and 15 previously reported variants were detected. NGS and Sanger sequencing were 100% concordant.
Conclusion
Our results demonstrate that this approach could be an accurate, reproducible and reliable tool in the rapid genetic diagnosis of IBCDs.
Boronated polymers are in the focus of dynamic functional materials due to the versatility of the B-O interactions and accessibility of precursors. Polysaccharides are highly biocompatible, and ...therefore, an attractive platform for anchoring boronic acid groups for further bioconjugation of cis-diol containing molecules. We report for the first time the introduction of benzoxaborole by amidation of the amino groups of chitosan improving solubility and introducing cis-diol recognition at physiological pH.
The chemical structures and physical properties of the novel chitosan-benzoxaborole (CS-Bx) as well as two phenylboronic derivatives synthesized for comparison, were characterized by nuclear magnetic resonance (NMR), infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), dynamic light scattering (DLS), rheology and optical spectroscopic methods. The novel benzoxaborole grafted chitosan was perfectly solubilized in an aqueous buffer at physiological pH, extending the possibilities of boronated materials derived from polysaccharides. The dynamic covalent interaction between boronated chitosan and model affinity ligands, was studied by means of spectroscopy methods. A glycopolymer derived from poly(isobutylene-alt-anhydride) was also synthesized to study the formation of dynamic assemblies with benzoxaborole-grafted chitosan. A first approximation to apply fluorescence microscale thermophoresis for the interactions of the modified polysaccharide is also discussed. Additionally, the activity of CSBx against bacterial adhesion was studied.
Myelofibrosis (MF) occurs as part of the natural history of polycythemia vera (PV) and essential thrombocythemia (ET), and remarkably shortens survival. Although JAK2V617F and CALR allele burden are ...the main transformation risk factors, inflammation plays a critical role by driving clonal expansion toward end-stage disease. NF-κB is a key mediator of inflammation-induced carcinogenesis. Here, we explored the involvement of miR-146a, a brake in NF-κB signaling, in MPN susceptibility and progression. rs2910164 and rs2431697, that affect miR-146a expression, were analyzed in 967 MPN (320 PV/333 ET/314 MF) patients and 600 controls. We found that rs2431697 TT genotype was associated with MF, particularly with post-PV/ET MF (HR = 1.5; p < 0.05). Among 232 PV/ET patients (follow-up time=8.5 years), 18 (7.8%) progressed to MF, being MF-free-survival shorter for rs2431697 TT than CC + CT patients (p = 0.01). Multivariate analysis identified TT genotype as independent predictor of MF progression. In addition, TT (vs. CC + CT) patients showed increased plasma inflammatory cytokines. Finally, miR-146a
mice showed significantly higher Stat3 activity with aging, parallel to the development of the MF-like phenotype. In conclusion, we demonstrated that rs2431697 TT genotype is an early predictor of MF progression independent of the JAK2V617F allele burden. Low levels of miR-146a contribute to the MF phenotype by increasing Stat3 signaling.
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