Pasteurella species are small Gram-negative coccobacilli which are frequent commensals of the upper respiratory and gastrointestinal tract of many wild and domestic animals (usually cats and dogs). ...While they are mainly veterinary pathogens, they have been also reported worldwide as causative agents of human infections 1,2. Pasteurella multocida is the most frequently isolated species from local infections following animal bites, chronic pulmonary disease, and systemic disease, including bacteremia and meningitis 1–4.
We report here a case of P. multocida septicemia and meningitis in a 29-day-old infant, following a cat scratch injury on the head.
We measured plasma atrial natriuretic peptide (ANP) levels in 30 children with idiopathic hypercalciuria (IH) and 19 normal controls (NC). A calcium (Ca) loading test was performed in all patients to ...determine the type of IH. Subsequently plasma ANP, cAMP and renin activity (PRA), serum total and ionized Ca, intact parathyroid hormone, aldosterone, and 1,25-dihydroxyvitamin D as well as urine Ca, cAMP, and electrolytes were determined in all subjects. The mean (SD) plasma ANP levels were significantly lower in patients with renal hypercalciuria (RH) 21.4 (4.8) pg/ml than in those with absorptive hypercalciuria (AH) 26.8 (7.6) pg/ml, P<0.05 and NC 27.6 (6.6) pg/ml, P<0.001. PRA was significantly lower in AH 2.9 (1.3) ng/ml per hour than in RH patients 7.8 (6.8) ng/ml per hour, P<0.01 and in NC 6.8 (4.6) ng/ml per hour, P<0.005. Serum aldosterone values were significantly lower in AH 14.5 (11.4) ng/dl than in RH patients 25.4 (14.1) ng/dl, P<0.05 and in NC 32.6 (20.5), P<0.001. The lower plasma ANP levels in RH than in AH patients and in NC may be due to Ca depletion. The lower PRA and serum aldosterone levels in AH than in RH patients and in NC may be attributed to Ca excess.
In three patients with chronic conjugated hyperbilirubinemia who carried the diagnosis of Rotor syndrome, 99mTc-HIDA cholescintigraphy was performed. In these patients, the liver was either not ...visualized or it was seen very faintly with slow liver uptake, persistent visualization of the cardiac blood pool and prominent kidney excretion. The present observation emphasizes the contribution of cholescintigraphy in the diagnosis of Rotor syndrome.
Dyskeratosis congenita (DC) is a rare disease characterised by bone marrow failure and skin manifestations. Patients with DC may exhibit short stature that is not usually related to growth hormone ...(GH) deficiency. Replacement treatment with GH should be done cautiously as it can predispose to haematological malignancy. We present a 10-year-old boy with DC and GH deficiency.
Ornithine transcarbamylase deficiency, an X-linked disorder, is the most common inherited urea cycle defect. Previous reports have documented the existence of several different mutations that can, ...partly at least, explain the phenotypic variability of the disorder. We describe the only male with T343K mutation, which also is present in his mother. We underline the disorientation of the beginning of clinical presentation; the patient became ill when fruits were added to his diet.
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