The relaxation spectrum of glassy solids has long been considered to probe their structural features and deformation mechanisms. Here, by systematically investigating the structural evolution, ...dynamical relaxations and mechanical properties of a Zr-based metallic glass subjected to different cryogenic treatment time, we build a bridge to connect the relaxation processes and mechanical properties. It is found that the β-relaxation triggered by local excitations has no memory effect of the thermal history or initial free volume content of the system. However, some local denser areas with a high potential energy created by CT might contribute to β′-relaxation that activated at a much lower energy, which may play a crucial important role in the fundamental deformation mechanisms of metallic glasses. The relaxation behaviors and the related improved mechanical properties can be rationalized in terms of the atomic-level stress theory. These findings will advance our understanding of the intrinsic correlation between local excitations and mechanical properties of metallic glasses, thereby may help guide to develop amorphous alloys with high mechanical performance.
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•Effect of cryogenic treatment on dynamical relaxations and mechanical properties were systematically investigated.•β-relaxation is independent of thermal history while β′-relaxation is enhanced with cryogenic treatment time.•A plausible atomic mechanism that correlates the relaxation processes and mechanical properties is proposed.
We examine the validity of the generalized factorization method and calculate the angular correlations in the charmful three-body baryonic decays of B super(0) arrow right LambdapD(*) super(+). With ...the timelike baryonic form factors newly extracted from the measured baryonic B decays, we obtain bernouli(B super(0) arrow right LambdapD super(+),LambdaipiD super(+)) =(1.85+ or -0.30,2.75+ or -0.24)x10 super(-5) to agree with the recent data from the Belle Collaboration, which demonstrates that the theoretical approach based on the factorization still works well. For the angular distribution asymmetries, we find scriptA sub(theta)(B super(0) arrow right LambdapD super(+),LambdapD super(+))=(-0.030+ or -0.002,+0.150+ or -0.000), which are consistent with the current measurements. Moreover, we predict that scriptA sub(theta)(B super(0) arrow right ppD super(0),ppD* super(0))=+0.04+ or -0.01. Future precise explorations of these angular correlations at Belle and LHCb as well as super-Belle are important to justify the present factorization approach in the charmful three-body baryonic decays.
•Supplementation with active dry yeast improved meat tenderness in beef cattle.•The mechanism of improved tenderness was explored.•Supplementation with active dry yeast increased secretion of matrix ...metalloproteinases.•Supplementation with active dry yeast reduced oxidative stress in beef cattle.•These results lay a foundation for elucidating the mechanism of improved beef quality.
Supplementing diets with active dry yeast (ADY, Saccharomyces cerevisiae) improves the carcass quality grade of beef cattle and the tenderness of beef. The relevant mechanisms have not been fully elucidated, but may be related to the effect of ADY on oxidative stress and the activity of matrix metalloproteinases (MMPs). To provide further insight into these mechanisms, this study evaluated the influence of ADY supplementation on growth performance, carcass traits, meat quality, concentrations of MMPs in serum (MMP-2, MMP-9 and MMP-13), oxidative stress indices and antioxidant capacity indices in beef cattle. Forty-six crossbred Simmental × Yanbian bulls (∼18 months of age, BW 436 ± 35 kg) participated in a 145-day finishing trial. ADY supplementation significantly improved marbling deposition, intramuscular fat content, and beef tenderness (P < 0.05); altered individual fatty acid proportions in the beef and increased saturated fatty acids while decreasing polyunsaturated fatty acids (P < 0.05); significantly decreased the abundance of reactive oxygen species in serum and meat; significantly increased the level of superoxide dismutase in meat (P < 0.05); tended to increase the level of catalase (P = 0.075) in serum and glutathione reductase (P = 0.066) in meat; and increased the secretion of MMPs. The improvement of beef tenderness following ADY supplementation of finishing bulls is related to the effects of ADY on the secretion of MMPs and the lowering of oxidative stress.
Primary analysis of the phase III trial BG01-1323L demonstrated that utidelone plus capecitabine significantly improved progression-free survival (PFS) and overall response rate (ORR) versus ...capecitabine alone in heavily-pretreated patients with metastatic breast cancer (MBC). Here, we report the final overall survival (OS) analysis and updates of other endpoints.
In total, 405 patients were randomised 2:1 to receive utidelone (30 mg/m2 IV daily, days 1-5, over 90 min) plus capecitabine (1000 mg/m2 orally b.i.d., days 1-14) or capecitabine alone (1250 mg/m2 orally b.i.d., days 1-14) every 21 days. The secondary endpoint, OS, was estimated using the Kaplan–Meier product-limit approach at a two-sided alpha level of 0.05 after the prespecified 310 death events had been reached. Exploratory analyses of the primary endpoint, PFS, and the secondary endpoint, ORR, were also done. Safety was analysed in patients who had at least one dose of study drug.
At the final OS analysis, the median duration of follow-up was 19.6 months in the utidelone plus capecitabine group and 15.4 months in the capecitabine alone group. In the intention-to-treat population, 313 deaths had occurred at data cut-off, 203 of 270 patients in the combination group and 110 of 135 in the monotherapy group. Median OS in the combination group was 19.8 months compared with 16.0 months in the monotherapy group hazard ratio (HR) = 0.75, 95% confidence intervals (CI) 0.59-0.94, P = 0.0142. The updated analysis of PFS and ORR showed that the combination therapy remained superior to monotherapy. Safety results were similar to those previously reported with respect to incidence, severity and specificity. No late-emerging toxicities or new safety concerns occurred.
For heavily-pretreated, anthracycline- and taxane-resistant MBC patients, utidelone plus capecitabine significantly improved OS versus capecitabine alone. These results support the use of utidelone plus capecitabine as a novel therapeutic regimen for patients with MBC.
•The phase III study evaluated utidelone plus CAP versus CAP alone in patients with anthracycline- and taxane-refractory MBC.•In this final analysis of OS, utidelone plus CAP significantly improved OS compared with CAP alone.•No significant differences were observed in the safety profiles of the treatment groups.•Of note, utidelone caused only mild myelosuppression and no significant hepatic toxicity.•Although peripheral neuropathy was common, it was generally manageable and reversible with dose modifications.
μ–τ symmetry in Zee–Babu model Araki, Takeshi; Geng, C.Q.
Physics letters. B,
11/2010, Letnik:
694, Številka:
2
Journal Article
Recenzirano
Odprti dostop
We study the Zee–Babu two-loop neutrino mass generation model and look for a possible flavor symmetry behind the tri-bimaximal neutrino mixing. We find that there probably exists the μ–τ symmetry in ...the case of the normal neutrino mass hierarchy, whereas there may not be in the inverted hierarchy case. We also propose a specific model based on a Froggatt–Nielsen-like Z5 symmetry to naturally accomplish the μ–τ symmetry on the neutrino mass matrix for the normal hierarchy case.
and hadronic [Formula omitted] decays Hsiao, Y. K; Geng, C. Q
The European physical journal. C, Particles and fields,
03/2015, Letnik:
75, Številka:
3
Journal Article
Recenzirano
We study the hadronic decays based on the existence of the resonant state . In particular, we are able to explain the unexpected large experimental result of measured recently by the LHCb ...collaboration due to the resonant contribution in with , while it is estimated to be at most of order in terms of the OZI rule without the resonance. In addition, we find that , , and , while and . Moreover, we predict that the decay branching ratios of are and . Some of the predicted decays are accessible to the experiments at the LHCb.
Using supercell method, the alloying effect of platinum group metals (PGMs) on the lattice parameters of gamma'-Ni3Al and the site preference of these elements are systematically studied based on ...first-principle full-potential linearized augmented-plane-wave method. Due to the addition of PGMs, the lattice parameters of gamma' is increased in the order: Mo < Rh < Ru < Ir < Pd < Os < Pt. The calculated site preference energies show that there are three site preference behaviors for PGMs additions in gamma'. The calculations of cohesive energies show that Mo and Ru can stabilize the gamma' phase, further in order to better explain the alloying effect of the two elements in the gamma'-Ni3Al, the impurity-induced charge density characteristics and the partial density of states are calculated for the systems containing Mo or Ru. The results show that the alloying effect of the two elements in the gamma'-Ni3Al is different.
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