The spin-orbit interaction couples the electrons' motion to their spin. As a result, a charge current running through a material with strong spin-orbit coupling generates a transverse spin current ...(spin Hall effect, SHE) and vice versa (inverse spin Hall effect, ISHE). The emergence of SHE and ISHE as charge-to-spin interconversion mechanisms offers a variety of novel spintronic functionalities and devices, some of which do not require any ferromagnetic material. However, the interconversion efficiency of SHE and ISHE (spin Hall angle) is a bulk property that rarely exceeds ten percent, and does not take advantage of interfacial and low-dimensional effects otherwise ubiquitous in spintronic hetero- and mesostructures. Here, we make use of an interface-driven spin-orbit coupling mechanism-the Rashba effect-in the oxide two-dimensional electron system (2DES) LaAlO
/SrTiO
to achieve spin-to-charge conversion with unprecedented efficiency. Through spin pumping, we inject a spin current from a NiFe film into the oxide 2DES and detect the resulting charge current, which can be strongly modulated by a gate voltage. We discuss the amplitude of the effect and its gate dependence on the basis of the electronic structure of the 2DES and highlight the importance of a long scattering time to achieve efficient spin-to-charge interconversion.
Through combined ferromagnetic resonance, spin pumping, and inverse spin Hall effect experiments in Co|Pt bilayers and Co|Cu|Pt trilayers, we demonstrate consistent values of ℓsfPt=3.4±0.4 nm and ...θSHEPt=0.056±0.010 for the respective spin diffusion length and spin Hall angle for Pt. Our data and model emphasize the partial depolarization of the spin current at each interface due to spin-memory loss. Our model reconciles the previously published spin Hall angle values and explains the different scaling lengths for the ferromagnetic damping and the spin Hall effect induced voltage.
The development of a ventricular septal defect (VSD) after myocardial infarction (MI) is an uncommon but highly lethal complication. We examined The Society of Thoracic Surgeons database to ...characterize patients undergoing surgical repair of post-MI VSD and to identify risk factors for poor outcomes.
This was a retrospective review of The Society of Thoracic Surgeons database to identify adults (aged≥18 years) who underwent post-MI VSD repair between 1999 and 2010. Patients with congenital heart disease were excluded. The primary outcome was operative death. The covariates in the current The Society of Thoracic Surgeons model for predicted coronary artery bypass grafting operative death were incorporated in a logistic regression model in this cohort.
The study included 2,876 patients (1,624 men 56.5%), who were a mean age of 68±11 years. Of these, 215 (7.5%) had prior coronary artery bypass grafting operations, 950 (33%) had prior percutaneous intervention, and 1,869 (65.0%) were supported preoperatively with an intraaortic balloon pump. Surgical status was urgent in 1,007 (35.0%) and emergencies in 1,430 (49.7%). Concomitant coronary artery bypass grafting was performed in 1,837 (63.9%). Operative mortality was 54.1% (1,077 of 1,990) if repair was within 7 days from MI and 18.4% (158 of 856) if more than 7 days from MI. Multivariable analysis identified several factors associated with increased odds of operative death.
In the largest study to date to examine post-MI VSD repair, ventricular septal rupture remains a devastating complication. As alternative therapies emerge to treat this condition, these results will serve as a benchmark for future comparisons.
Abstract
Context
Invited update on the management of systemic autoimmune Graves disease (GD) and associated Graves orbitopathy (GO).
Evidence acquisition
Guidelines, pertinent original articles, ...systemic reviews, and meta-analyses.
Evidence synthesis
Thyrotropin receptor antibodies (TSH-R-Abs), foremost the stimulatory TSH-R-Abs, are a specific biomarker for GD. Their measurement assists in the differential diagnosis of hyperthyroidism and offers accurate and rapid diagnosis of GD. Thyroid ultrasound is a sensitive imaging tool for GD. Worldwide, thionamides are the favored treatment (12-18 months) of newly diagnosed GD, with methimazole (MMI) as the preferred drug. Patients with persistently high TSH-R-Abs and/or persistent hyperthyroidism at 18 months, or with a relapse after completing a course of MMI, can opt for a definitive therapy with radioactive iodine (RAI) or total thyroidectomy (TX). Continued long-term, low-dose MMI administration is a valuable and safe alternative. Patient choice, both at initial presentation of GD and at recurrence, should be emphasized. Propylthiouracil is preferred to MMI during the first trimester of pregnancy. TX is best performed by a high-volume thyroid surgeon. RAI should be avoided in GD patients with active GO, especially in smokers. Recently, a promising therapy with an anti-insulin-like growth factor-1 monoclonal antibody for patients with active/severe GO was approved by the Food and Drug Administration. COVID-19 infection is a risk factor for poorly controlled hyperthyroidism, which contributes to the infection–related mortality risk. If GO is not severe, systemic steroid treatment should be postponed during COVID-19 while local treatment and preventive measures are offered.
Conclusions
A clear trend towards serological diagnosis and medical treatment of GD has emerged.
For 20 years, monoclonal antibodies (mAbs) have been a standard component of cancer therapy, but there is still much room for improvement. Efforts continue to build better cancer therapeutics based ...on mAbs. Anticancer mAbs function through various mechanisms, including directly targeting the malignant cells, modifying the host response, delivering cytotoxic moieties and retargeting cellular immunity towards the malignant cells. Characteristics of mAbs that affect their efficacy include antigen specificity, overall structure, affinity for the target antigen and how a mAb component is incorporated into a construct that can trigger target cell death. This Review discusses the various approaches to using mAb-based therapeutics to treat cancer and the strategies used to take advantage of the unique potential of each approach, and provides examples of current mAb-based treatments.
Facing the ever-growing demand for data storage will most probably require a new paradigm. Nanoscale magnetic skyrmions are anticipated to solve this issue as they are arguably the smallest spin ...textures in magnetic thin films in nature. We designed cobalt-based multilayered thin films in which the cobalt layer is sandwiched between two heavy metals and so provides additive interfacial Dzyaloshinskii-Moriya interactions (DMIs), which reach a value close to 2 mJ m(-2) in the case of the Ir|Co|Pt asymmetric multilayers. Using a magnetization-sensitive scanning X-ray transmission microscopy technique, we imaged small magnetic domains at very low fields in these multilayers. The study of their behaviour in a perpendicular magnetic field allows us to conclude that they are actually magnetic skyrmions stabilized by the large DMI. This discovery of stable sub-100 nm individual skyrmions at room temperature in a technologically relevant material opens the way for device applications in the near future.
BACKGROUND
The incidence of rectal cancer in patients younger than 50 years is increasing. To test the hypothesis that the biology in this younger cohort may differ, this study compared survival ...patterns, stratifying patients according to National Comprehensive Cancer Network (NCCN) guideline–driven care and age.
METHODS
The National Cancer Data Base was queried for patients treated with curative‐intent transabdominal resections with negative surgical margins for stage I to III rectal cancer between 2004 and 2014. Outcomes and overall survival for patients younger than 50 years and patients 50 years old or older were compared by subgroups based on NCCN guideline–driven care.
RESULTS
A total of 43,106 patients were analyzed. Younger patients were more likely to be female and minorities, to be diagnosed at a higher stage, and to have travelled further to be treated at academic/integrated centers. Short‐ and long‐term outcomes were significantly better for patients younger than 50 years, with age‐specific survival rates calculated. Younger patients were more likely to receive radiation treatment outside NCCN guidelines for stage I disease. In younger patients, the administration of neoadjuvant chemoradiation for stage II and III disease was not associated with an overall survival benefit.
CONCLUSIONS
Age‐specific survival data for patients with rectal cancer treated with curative intent do not support an overall survival benefit from NCCN guideline–driven therapy for stage II and III patients younger than 50 years. These data suggest that early‐onset disease may differ biologically and in its response to multimodality therapy.
Age‐specific survival data for patients with rectal cancer treated with curative intent do not support an overall survival benefit from National Comprehensive Cancer Network guideline–driven therapy for stage II and III patients younger than 50 years. These data suggest that early‐onset disease may differ biologically and in its response to multimodality therapy.
See editorial on pages 3474‐5, this issue.
Ambient afterglow luminescence from metal‐free organic chromophores would provide a promising alternative to the well‐explored inorganic phosphors. However, the realization of air‐stable and ...solution‐processable organic afterglow systems with long‐lived triplet or singlet states remains a formidable challenge. In the present study, a delayed sensitization of the singlet state of organic dyes via phosphorescence energy transfer from organic phosphors is proposed as an alternative strategy to realize “afterglow fluorescence”. This concept is demonstrated with a long‐lived phosphor as the energy donor and commercially available fluorescent dyes as the energy acceptor. Triplet‐to‐singlet Förster‐resonance energy‐transfer (TS‐FRET) between donor and acceptor chromophores, which are co‐organized in an amorphous polymer matrix, results in tuneable yellow and red afterglow from the fluorescent acceptors. Moreover, these afterglow fluorescent hybrids are highly solution‐processable and show excellent air‐stability with good quantum yields.
Phosphorescence energy transfer from long‐lived organic phosphors (donors) is introduced as a novel design strategy for realizing afterglow fluorescence from commercially available organic dyes (acceptors) under ambient conditions. This triplet‐to‐singlet Förster‐resonance energy transfer leads to ambient red afterglow in water‐processable and flexible films via a delayed sensitization process of the acceptor singlet state.
Pathways to Complexity synthesizes a wealth of new archaeological data to illuminate the origins of Maya civilization and the rise of Classic Maya culture. In this volume, prominent Maya scholars ...argue that the development of social, religious, and economic complexity began during the Middle Preclassic period (1000-300 B.C.), hundreds of years earlier than previously thought. Contributors reveal that villages were present in parts of the lowlands by 1000 B.C., challenging the prevailing models estimating when civilization took root in the area. Combining recent discoveries from the northern lowlands-an area often neglected in other volumes-and the southern lowlands, the collection then traces the emergence of sociopolitical inequality and complexity in all parts of the Yucatan peninsula over the course of the Middle Preclassic period. They show that communities evolved in different ways due to influences such as geographical location, ceramic exchange, shell ornament production, agricultural strategy, religious ritual, ideology, and social rankings. These varied pathways to complexity developed over half a millennium and culminated in the institution of kingship by the Late Preclassic period. Presenting exciting work on a dynamic and poorly understood time period,Pathways to Complexity demonstrates the importance of a broad, comparative approach to understanding Preclassic Maya civilization and will serve as a foundation for future research and interpretation.Contributors: M. Kathryn Brown | George Bey III | Tara Bond-Freeman | Fernando Robles Castellanos | Tomas Gallareta Negron | E. Wyllys Andrews V | Anthony Andrews | David S. Anderson | Lauren Sullivan | Jaime J. Awe | James F. Garber | Mary Jane Acuña | William Saturno | Bobbi Hohmann | Terry Powis | Paul Healy | Richard Hansen | Donald W. Forsyth | David Freidel | Barbara Arroyo | Richard E. W. Adams A volume in the series Maya Studies, edited by Diane Z. Chase and Arlen F. Chase
Cancer immunotherapy has proven to be challenging as it depends on overcoming multiple mechanisms that mediate immune tolerance to self-antigens. A growing understanding of immune tolerance has been ...the foundation for new approaches to cancer immunotherapy. Adoptive transfer of immune effectors such as antitumor mAb and chimeric antigen receptor T cells bypasses many of the mechanisms involved in immune tolerance by allowing for expansion of tumor-specific effectors ex vivo. Vaccination with whole tumor cells, protein, peptide, or dendritic cells has proven challenging, yet may be more useful when combined with other cancer immunotherapeutic strategies. Immunomodulatory approaches to cancer immunotherapy include treatment with agents that enhance and maintain T-cell activation. Recent advances in the use of checkpoint blockade to block negative signals and to maintain the antitumor response are particularly exciting. With our growing knowledge of immune tolerance and ways to overcome it, combination treatments are being developed, tested, and have particular promise. One example is in situ immunization that is designed to break tolerance within the tumor microenvironment. Progress in all these areas is continuing based on clear evidence that cancer immunotherapy designed to overcome immune tolerance can be useful for a growing number of patients with cancer.
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