Earthquakes in the Sea of Azov are quite commonplace. Until now, the idea of their nature has focused on tectonic processes in the Earth’s crust. In our work, using morphotectonic analysis, we ...examined on a lithospheric scale the geodynamic situation in the collision zone of the East Black Sea Plate and the margin of the East European Platform, in order to show that not only in the crust, but also in the lower lithosphere, the necessary tectonic prerequisites exist for the accumulation of seismic energy with subsequent release in the form of earthquakes. Based on a case study of an earthquake that occurred on October 15, 2018, in the Sea of Azov, we showed the possible causes of its occurrence for two options of solving the seismological problem, obtained by the Geophysical Service of the Russian Academy of Sciences and including in the solution according to V.Yu. Burmin’s method. The following focal parameters are published on the Geophysical Survey website: latitude, 46.36; longitude, 37.18; depth, 5 km;
m
b
= 4.3. The focal parameters were obtained for the solution using the Burmin method: latitude, 46.42564; longitude, 37.24274;
H
= 133.4 km. The mechanisms of two solutions were constructed; for a source with a depth of 5 km, the focal mechanism was obtained: a reverse fault, with the source confined to the intersection of Kalmius-Dzhiginsky and the Main Azov faults; for 133.4 km, a strike-slip fault, with the source confined to the intersection of the Gubkinsky-Central Azov, Kalmius-Dzhiginsky, and the Main Azov faults. The constructed model of collision of the continental lithosphere of the East European Platform and the subducting East Black Sea Plate shows that under conditions of weak compressive forces from the side of the Arabian indenter, a pseudosubduction situation is formed, as a result of which shear stresses occur in the deformable frontal part of the continental lithosphere of the East European Platform, transitioning to a reverse fault along the line of shear. During this process, seismic energy is accumulated, accompanied by weak and moderate earthquakes, of a reverse-fault type for the earth’s crust in the region of the Azov Rise, and a normal-fault type in the lower part of the wedge of the continental lithosphere as a result of its destruction. Regional morphotectonic analysis did not allow us to choose the most probable focal mechanism for the earthquake. However, it is noteworthy that the results of our research have shown that the occurrence of deep earthquakes has all the necessary tectonic prerequisites, despite the well-established opinion of seismologists about the exclusively crustal location of earthquakes in this region.
The aim of the study is to study the state of the immunological and hormonal background in patients with non-hospital pneumonia (NP) - liquidators of the accident at the Chernobyl nuclear power plant ...(ChNPP) after treatment.
Patients with NP were divided into 2 groups of liquidators of the Chernobyl accident (main group), patients with NP who did not participate in liquidation of the Chernobyl accident (control group), which determined immunological parameters CD3+, CD4+, CD8+, CD16+, CD20+ expressing cells, immunoglobulin concentrations (Ig) A, M, G and hormonal indicators (antibodies to thyroglobulin, thyroglobulin, triiodothyronine, thyroxin, cortisol, insulin, testosterone, estradiol, estriol). The main group - liquidators of the Chernobyl accident in an immunological study of 32 NP patients, hormonal - 20; control group - respectively 37 and 38.
Combined therapy contributed to an increase in T-lymphocytes in the main and control groups, as well as T-suppressors (Tc) and T-helper cells (Tx), respectively (p<0.05). Also increased the content of B-lymphocytes, IgA, IgM, complement and phagocytic activity in the main and control groups. The ratio Tx/Tc decreased, also decreased IgG, load index, zero cells in the main and control groups.The study of hormonal background in patients with NP showed that the content of thyroglobulin after complex therapy in the main group increased, in the control group their content did not change. The content of triiodothyronine and thyroxine increased after treatment in the main group. In patients with NP of the control group, on the contrary, there was a decrease in thyroid function in terms of thyroglobulin. The study of sex hormones showed that the content of testosterone, estradiol, estriol in patients with NP of the main group increased after treatment, whereas in the control group there was a decrease in estradiol confidence, and testosterone level remained unchanged. The content of estriol increased (p<0.001) in the control group. The increased amount of insulin decreased (p<0.01) in the main group, whereas in the control group these indicators almost did not change.
After complex therapy, immunological parameters in NP patients in both the main and control groups are normalized, however, recovery in the main group is slower, which requires continued immunological correction in the outpatient setting. Hormonal background approaching the norm more in patients with NP of the control group than the main one.
A thorough analysis of liability for administrative offence is not possible without clear understanding of its preconditions. The problem of preconditions for administrative responsibility is ...directly related to administrative delictization of offenses, effectiveness of the fight against delict, prominent state policy in the field of law enforcement and law order. In this aspect, the role of the preconditions for administrative responsibility is a lot more important because they formulate proper foundations for achieving its general objectives. Thus, they determine the effectiveness of administrative responsibility at sectoral and general social levels. The importance of the definition is due to the urgent needs of rule-making and law enforcement practice, the effectiveness of which directly depends on how reasonable and appropriate each administrative delict norm is. Unfortunately, despite all its scientific and practical significance, the issue of preconditions for administrative liability has not been resolved yet. Therefore, there is a need to form unified, consistent scientific approach to understanding the grounds for administrative liability. To this end, the article provides a critical analysis of the basic doctrinal concepts of the preconditions of administrative responsibility. A wide range of social, economic, technical and other factors that determine the effectiveness of administrative responsibility, its current state, its dynamics and prospects for its development have been studied. Discovered the role of these factors in creating a favorable socio-economic and information-technical environment for the implementation of the main tasks of administrative responsibility, in particular: offences prevention, reliable protection of public relations and education of citizens in the spirit of law. The author concluded the scientific and practical expediency of the systematic study of the preconditions for establishing administrative responsibility (preconditions for administrative delictization) and the preconditions for the effectiveness of administrative responsibility.
Juvenile idiopathic arthritis with systemic onset is a special, rare and the most severe variant of juvenile idiopathic arthritis. The article analyzes the clinical features of the onset and course ...of juvenile idiopathic arthritis with systemic onset in children living in the ecologically disadvantaged Donetsk region and the efficacy of therapy. Clinical cases are described. According to its clinical manifestations, the systemic variant of juvenile idiopathic arthritis is characterized by the severity of the general inflammatory response, a bright clinical picture, severe damage to internal organs, the development of polyserositis, can lead to the development of life-threatening conditions, such as macrophage activation syndrome, and also leads to the formation of deforming arthritis with early disability of the sick child. The relevance of studying the problem of juvenile idiopathic arthritis with a systemic onset is related to the late diagnosis of the disease, because at the onset of the disease there may be no joint syndrome, and therefore it is impossible to use the criteria of the International League of Rheumatology Associations to verify the diagnosis, which leads to diagnostic errors. Nonsteroidal anti-inflammatory drugs, glucocorticosteroids, and immunosuppressants are used for treatment. The prescription of genetic engineering biological therapy, the choice of the drug, is carried out according to the recommendations of the American College of Rheumatology, depending on the preference for systemic or joint manifestations of the disease. But the question of the optimal approach to regimens of dose reduction, duration of biological therapy, and rules for its withdrawal remains open. Until now, the optimal approach to the treatment of juvenile idiopathic arthritis with a systemic onset is unknown. To date, the issue of treatment in patients with pharmacoresistant variants and persistent course of the disease has not been solved. Therefore, further in-depth study of this problem, optimization of the diagnostic algorithm and an individual approach to therapy are needed.
PDF
