The Problem
The COVID-19 pandemic has shone a stark light on workplace inequities and injustices. Aside from disrupting daily routines and ways of working, the pandemic has unmasked significant and ...troubling differences in the treatment and status of productive and reproductive labor. As we recover from the pandemic, how can workplaces properly recognize and value the contribution of reproductive labor?
The Recommendation
We focus on ethics of care as a foundational aspect of learning and human development. Care is proximal and contextual and expressions of care require managers and HRD professionals to engage with and address employees’ needs in a way that recognizes the complexity of individual situations. This may lead to the transformation of work and workplaces and bring employees into a more participatory, inclusive and democratic relationship with employers. We offer four suggestions for how HRD practitioners can practically embed an ethics of care approach within organizations.
The Stakeholders
This article is relevant to human resource development (HRD) scholars and practitioners who are interested in building sustainable, caring and healthy workplaces in a post-pandemic world.
The identification of cancer-associated mutations in the tricarboxylic acid (TCA) cycle enzymes isocitrate dehydrogenases 1 and 2 (IDH1/2) highlights the prevailing notion that aberrant metabolic ...function can contribute to carcinogenesis. IDH1/2 normally catalyse the oxidative decarboxylation of isocitrate into α-ketoglutarate (αKG). In gliomas and acute myeloid leukaemias, IDH1/2 mutations confer gain-of-function leading to production of the oncometabolite R-2-hydroxyglutarate (2HG) from αKG. Here we show that generation of 2HG by mutated IDH1/2 leads to the activation of mTOR by inhibiting KDM4A, an αKG-dependent enzyme of the Jumonji family of lysine demethylases. Furthermore, KDM4A associates with the DEP domain-containing mTOR-interacting protein (DEPTOR), a negative regulator of mTORC1/2. Depletion of KDM4A decreases DEPTOR protein stability. Our results provide an additional molecular mechanism for the oncogenic activity of mutant IDH1/2 by revealing an unprecedented link between TCA cycle defects and positive modulation of mTOR function downstream of the canonical PI3K/AKT/TSC1-2 pathway.
As distance learning continues to grow, universities are seeking ways to integrate traditional student community service into online courses. Supported by seven years of successful implementation, ...this book presents an award-winning service-learning model through which online students serve as consultants to organizations nationwide.
Pathological angiogenesis is the hallmark of diseases such as cancer and retinopathies. Although tissue hypoxia and inflammation are recognized as central drivers of vessel growth, relatively little ...is known about the process that bridges the two. In a mouse model of ischemic retinopathy, we found that hypoxic regions of the retina showed only modest rates of apoptosis despite severely compromised metabolic supply. Using transcriptomic analysis and inducible loss-of-function genetics, we demonstrated that ischemic retinal cells instead engage the endoplasmic reticulum stress inositol-requiring enzyme 1α (IRE1α) pathway that, through its endoribonuclease activity, induces a state of senescence in which cells adopt a senescence-associated secretory phenotype (SASP). We also detected SASP-associated cytokines (plasminogen activator inhibitor 1, interleukin-6, interleukin-8, and vascular endothelial growth factor) in the vitreous humor of patients suffering from proliferative diabetic retinopathy. Therapeutic inhibition of the SASP through intravitreal delivery of metformin or interference with effectors of senescence (semaphorin 3A or IRE1α) in mice reduced destructive retinal neovascularization in vivo. We conclude that the SASP contributes to pathological vessel growth, with ischemic retinal cells becoming prematurely senescent and secreting inflammatory cytokines that drive paracrine senescence, exacerbate destructive angiogenesis, and hinder reparative vascular regeneration. Reversal of this process may be therapeutically beneficial.
•The Bafoussam-Dshang region in West Cameroon Highlands records numbers of landslides.•The Analytical Hierarchical Process (AHP) delineate the landslide susceptibility.•Geology, orography, ...hydrography and vegetation cover are landslide causative factors.•Landslides susceptibility defines the Low, Moderate, High, and Very High classes.•Landslides fall into the high to very high susceptibility zone at ∼ 87% in the BDR.
The main goal of this study is to produce a landslide susceptibility map of the Bafoussam-Dschang region (BDR) which is often subjected to landsliding by using Analytical Hierarchical Process (AHP). To achieve this objective, landslide triggering factors such as the lithology, slope, soil, land use, flow density, curvature, elevation and aspect have been combined with field observations. These Parameters were plotted on thematic layers using Geographical Information System (GIS) according to the AHP principles. Factors of weights were attributed based on the frequency of mass movements. The impact of one to another was assessed, allowing weights to be assigned to the different parameters. Subsequently, field observations revealed 100 mass movements including 97 landslides, 01 mudflow, 01 rock fall and 01 collapse within - the BDR. The field data including remote sensing techniques have subdivided the landslides susceptibility map into “Low (3%)”, “Moderate (10%)”, “High (21%)”, and “Very High (66%)” susceptibility zones respectively. The majority of these mass movements fall into the high to very high susceptibility zones equivalent to ∼ 87% of landslides. These results permit to identify the landslide susceptibility zones linked to the steep landscaping West Cameroon Highland (Cameroon Volcanic Line).
The Problem
The combination of flatter organizational structures, globalization, cost-saving initiatives, and the increased emphasis on knowledge sharing has been a contributor to the use of virtual ...teams in U.S. organizations.
The Solution
To perform efficiently in a virtual environment, team members must develop swift trust, which does not come inherently with team membership. Understanding the individual, team, organizational, and technological barriers affecting the development of swift trust is critical to an appreciation of how such barriers can be overcome.
The Stakeholders
In this article, we indicate how virtual human resource development (VHRD) can assist virtual teams, managers, and HR professionals overcome swift trust development barriers. The intended audience for this article includes HRD scholars, scholar-practitioners, practitioners, and students interested in understanding how trust is fostered in virtual teams and how HRD practitioners can make a valuable contribution to the effectiveness of virtual teams.
Long-term erosion rate in the SW Cameroon margin Ngapna, Moussa Nsangou; Owona, Sébastien; Mboudou, Germain Marie Monespérance ...
Environmental earth sciences,
04/2023, Letnik:
82, Številka:
7
Journal Article
Recenzirano
The SW Cameroon margin within the Gulf of Guinea (2°–5° N and 8°–13° E) displays a complex landscape and crosscut by three active pre- and syn-rift structures: the Sanaga Fault, Benue Triple Junction ...and Cameroon Volcanic Line (CVL). We evaluated the erosion activity on this margin using for the first time the erosion rate quantification (ERQ). From the Digital elevation model (DEM, 30 m), we extracted compound topographic attributes (CTA), areal morphometric parameters (Ar) and differential tectonic drainage system (DTD) which were combined with field data and the following results were obtained: CTA indicates the relationship between erosion rate variation and the different forms of landscape, runoff diversity and sediments transportation under lithostructural (Precambrian basement and Cretaceous to Recent volcano-sedimentary cover) control. Ar reveals a variable erosion activity triggering sedimentation, denudation and landsliding referring to specific lithostructural units and landscape types. DTD underlines the control of the erosion activity in South Cameroon Low Plateau-, West Cameroon Highlands-, Coastal Plain morphological units and associated lithostructural domains. The stream power index (SPI) and the topographic wetness index (TWI) outline the erosion heterogeneity/variability and represent the key indicators of the state of erosion within the lithostructural units and landscape types. The ERQ, therefore, demonstrates the complexity of the SW Cameroon margin landscape as a result of long-term heterogeneous erosion applicable to South American, Asian and Australian Precambrian to Recent terranes.
The Problem
Social movements can impact organizations and employees through changes in policies and procedures in the workplace. Measuring the degree to which collective protests, rallies, and ...marches have influenced organizational actions can be complex due to the variance in activist practices and the resistance or amiableness of organizations to change.
The Solution
Protests, rallies, and marches can create a disruptive stage for challenging and confronting organizational policies and practices that maintain power structures. Through the examination of the literature and the review of recent worldwide events, this article illustrates how social movements have affected organizations and led to organizational changes, illuminating change processes in established fields such as business. Specifically, we aim to answer how protests, rallies, and marches influence organizational policies and practices attributed to human resource development (HRD). We conclude by discussing how a recent social movement is applicable to the field of HRD and suggest areas for future research.
The Stakeholders
This article may be of interest to employees at all levels of the organization, researchers, and practitioners in the field of HRD.
Purpose
The purpose of this paper is to explore compassion fatigue and psychosocial risks among healthcare professionals, which lead to increased work-related costs, including occupational suicide. ...Through this review and synthesis of the literature, the authors shed light on the causes that lead medical professionals to take their own lives. In addition, the authors explore the role of compassion fatigue as a leading cause of self-inflicted death.
Design/methodology/approach
A systematic approach was used to guide the review and synthesis of the literature. Key bibliographic and review databases were searched from the fields of social work, nursing, medical education, educational leadership, psychology, sociology and human resources.
Findings
In the USA alone, suicide has increased by 25 per cent since 1999, making it a leading cause of death. Data indicate that medical professionals are prone to compassion fatigue, work-related stresses and suicide at a greater rate than the general population, with surgeons reporting up to three times more thoughts of suicide than the general population. The synthesis and analysis of the literature yielded the following themes: compassion fatigue and suicides, burnout and compassion fatigue, career longevity and moral distress.
Research limitations/implications
Job stress and its negative impact on the workforce is rather well documented. Yet, job stress has shown to be a leading cause of workplace suicide, which represents a commensurable human and economic loss and has a direct impact on multiple human resources variables. Ongoing research is needed to see how the initial literature has evolved as new data emerges.
Practical implications
This paper presents best practices for training and development professionals to better respond to psychosocial risks and reduce work-related costs in the medical profession and beyond.
Originality/value
Studies on employee stress and suicide in the healthcare industry are scarce. Yet, they have human and economic impacts on organisations.
More than 170 million people worldwide are infected with the hepatitis C virus (HCV), for which future therapies are expected to rely upon a combination of oral antivirals. For a rapidly evolving ...virus like HCV, host-targeting antivirals are an attractive option. To decipher the role of novel HCV–host interactions, we used a proteomics approach combining immunoprecipitation of viral–host protein complexes coupled to mass spectrometry identification and functional genomics RNA interference screening of HCV partners. Here, we report the proteomics analyses of protein complexes associated with Core, NS2, NS3/4A, NS4B, NS5A, and NS5B proteins. We identified a stringent set of 98 human proteins interacting specifically with one of the viral proteins. The overlap with previous virus–host interaction studies demonstrates 24.5% shared HCV interactors overall (24/98), illustrating the reliability of the approach. The identified human proteins show enriched Gene Ontology terms associated with the endoplasmic reticulum, transport proteins with a major contribution of NS3/4A interactors, and transmembrane proteins for Core interactors. The interaction network emphasizes a high degree distribution, a high betweenness distribution, and high interconnectivity of targeted human proteins, in agreement with previous virus–host interactome studies. The set of HCV interactors also shows extensive enrichment for known targets of other viruses. The combined proteomic and gene silencing study revealed strong enrichment in modulators of HCV RNA replication, with the identification of 11 novel cofactors among our set of specific HCV partners. Finally, we report a novel immune evasion mechanism of NS3/4A protein based on its ability to affect nucleocytoplasmic transport of type I interferon-mediated signal transducer and activator of transcription 1 nuclear translocation. The study revealed highly stringent association between HCV interactors and their functional contribution to the viral replication cycle and pathogenesis.
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