The hippocampus (CA3 field) was studied in rats with different behavioral characteristics. Protein contents in the neuronal cytoplasm and nuclei, as well as the size of neurons in animals predisposed ...to stress, poorly trained in a shuttle box, and exhibiting low locomotor activity in the open field were lower than in rats resistant to stress and characterized by high learning capacity and locomotor activity. Our results suggest that neuronal differences in the hippocampal CA3 field are associated with variations in learning capacity of animals.
Differences in the response of August rats' hippocampal field СА1 and СА3 neurons to the chronic haloperidol administration (a model of parkinsonism) were revealed by interferometric methods. Based ...on the morphochemical parameters (nuclear and cytoplasmic area, protein content and concentration), the changes of field СА1 neurons can be regarded as functionally active (all parameters are significantly higher than in controls), and those of field СА3 neurons - as initial stages of degeneration (the significant decrease of neuron sizes). The differences in the response found in this study can be associated with the functional characteristics of СА1 and СА3 fields.
Quantitative interferometry showed that chronic amphetamine administration to August rats (2.5 mg/kg/day for 3 weeks) increased the area of neuronal cytoplasm and nuclei and content and ...concentrations of proteins in hippocampal CA3 neurons. These changes persisted after single injection of delta sleep-inducing peptide (60 microg/kg). The reaction of the entire neuronal population of hippocampal CA3 neurons to amphetamine is similar.
The influence of a single injection of "delta-sleep-inducing peptide" (DSIP; 30 microg/kg body weight) on neurochemical parameters of rats' brain was studied under the conditions of chronic ...administration of dopamine analogs inducing DA-system hyperactivity - 50 mg/kg body weight of L-DOPA for 30 days or 2,5 mg/kg body weight of amphetamine for 21 days. The parameters of serotonergic system (MAO A activity, 5-HT, and 5-HIAA contents) and of dopaminergic system (MAO B activity, DA, NA, and HVA contents) were investigated in the cortex and caudate nucleus of control, DA or amphetamine, and DSIP receiving rats. Changes caused by the two DA-system activating drugs had both similarities and differences, and the corrective action of DSIP also had certain peculiarities depending on the pharmacological preparation used for the induction of DA-system hyperactivity and on the investigated brain structure. It is supposed that DSIP action might be based on the activation of serotonergic system that ensures the adaptive behavior of the animals.
Using the ARGUS detector at the
e
+
e
− storage ring DORIS II, we have searched for the real and imaginary part of the electric dipole formfactor
d
τ
of the
τ lepton in the production of
τ pairs at
q
...2=100
GeV
2
. This is the first direct measurement of this
CP
violating formfactor. We applied the method of optimised observables which takes into account all available information on the observed
τ decay products. No evidence for
CP
violation was found, and we derive the following results:
Re(d
τ)=(1.6±1.9)·10
−16
e
cm
and
Im(d
τ)=(−0.2±0.8)·10
−16
e
cm
, where statistical and systematic errors have been combined.
Brain structures were examined in two mouse strains differing in active avoidance learning in a shuttle box. Protein content and concentration, area of the cytoplasm and nuclei of neuron in layers ...III and V of the sensorimotor cortex were higher in rats with high learning ability. The detected morphochemical differences between the same brain structures of rats with high and low learning capacity can be attributed to this capacity.
The effect of single delta;sleep inducing peptide (DSIP- 60g/kg body weight) administration on the parameters of rat brainmetabolism under the conditions of chronic amphetamine (2.5mg/kg body weight, ...21 days) or Madopar-125 in a dose corresponding to 50 mg L;DOPA/kg body weight (30 days) was investigated. The neurotransmitter systems were evaluated based onthe content of biogenic amines, their metabolites, and activity ofneurotransmitter-catabolising enzymes: serotoninergic systemwas characterized by MAO A activity, serotonin (5-OT) and 5-hydroxyindolil acetic acid (5-HIAA) content, and dopaminergic system by MAO B activity, dopamine (DA), noradrenalin(NA), and homovanilliс acid (HVA) content in the cortex andcaudate nucleus of control and experimental rats. The changesin neurotransmitter metabolism parameters induced by DA-activating substances had certain specificity. Characteristics ofthe corrective effect of DSIP under the conditions of amphetamine or L;DOPA action were demonstrated depending on thetype of a pharmacologic agent or brain structures. It is proposedthat DSIP effect in vivo is based on the activation of serotonergic system and normalizes brain metabolism, which leads toadaptive behavior of animals. A possibility of using DSIP, byanalogy with a drug Deltaran, for the treatment of depressions ofvarious origin, cerebral ischemia, etc. is discussed.
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