A non-oxido V(v) complex with glutaroimide-dioxime (H
L), a ligand for recovering uranium from seawater, was synthesized from aqueous solution as NaV(L)
·2H
O, and the structure determined by X-ray ...diffraction. It is the first non-oxido V(v) complex that has been directly synthesized in and crystallized from aqueous solution. The distorted octahedral structure contains two fully deprotonated ligands (L
) coordinating to V
, each in a tridentate mode
the imide N (
= 1.96 Å) and oxime O atoms (
= 1.87-1.90 Å). Using
O-labelled vanadate as the starting material, concurrent
O/
V/
H/
C NMR, in conjunction with ESI-MS, unprecedentedly demonstrated the stepwise displacement of the oxido Vdouble bond, length as m-dashO bonds by glutaroimide-dioxime and verified the existence of the "bare" V
/glutaroimide-dioxime complex, V(L)
, in aqueous solution. In addition, the crystal structure of an intermediate 1 : 1 V(v)/glutaroimide-dioxime complex, VO
(HL)
, in which the oxido bonds of vanadate are only partially displaced, corroborates the observations by NMR and ESI-MS. Results from this work provide important insights into the strong sorption of vanadium on poly(amidoxime) sorbents in the recovery of uranium from seawater. Also, because vanadium plays important roles in biological systems, the syntheses of the oxido and non-oxido V
complexes and the unprecedented demonstration of the displacement of the oxido Vdouble bond, length as m-dashO bonds help with the on-going efforts to develop new vanadium compounds that could be of importance in biological applications.
RECIST have limitations when applied to potentially curable locally advanced squamous cell carcinoma of the head and neck (SCCHN). 18Ffluorodeoxyglucose–positron emission tomography (PET) scan may be ...useful in assessing treatment response and predicting patient outcome.
We studied patients with previously untreated stages III–IVb SCCHN treated with primary concurrent chemoradiotherapy on five prospective clinical trials. Response was assessed by clinical exam, computed tomography (CT), and PET portions of combined PET–CT scan ∼8 weeks after completion of chemoradiotherapy.
Fifty-three patients were analyzed. Complete response (CR) was demonstrated in 42 patients (79%) by clinical exam, 15 (28%) by CT, and 27 (51%) by PET. CR as assessed by PET, but not as assessed by clinical exam or CT using RECIST, correlated significantly with progression-free status (PFS) (P < 0.0001). The 2-year PFS for patients with CR and without CR by PET was 93% and 48%, respectively (P = 0.0002).
A negative PET scan on combined PET–CT after chemoradiotherapy is a powerful predictor of outcome in patients receiving curative chemoradiotherapy for SCCHN. PET–CT is indicated for response evaluation in this setting to improve the accuracy of post-treatment assessment by CT.
These remarks represent the author’s personal perspective regarding ideas presented at this fifth Asia Pacific Conference on Few-Body Problems in Physics. They are not intended as a comprehensive ...summary of what we witnessed during this week of stimulating presentations and intense discussions. However, these remarks do characterize some of the physics we heard and some of the key questions raised. The ideas presented will hopefully outlive the rapporteurs who brought their work and that of others to our attention here in the International Hall of the Sungkyunkwan University in Seoul, Republic of Korea. Finally, we bid adieu to our friend, colleague, and mentor, John A. Tjon.
Conjecture: A Possible nn Λ Resonance Gibson, B. F.; Afnan, I. R.
EPJ Web of Conferences,
01/2016, Letnik:
113
Journal Article, Conference Proceeding
Recenzirano
Odprti dostop
We address the question of whether there might exist a resonance in the nnΛ system, using a rank one separable potential formulation of the Hamiltonian. We explore the eigenvalues of the kernel of ...the Faddeev equation in the complex energy plane using contour rotation to allow us to analytically continue the kernel onto the second energy sheet. We follow the largest eigenvalue as the nΛ potentials are scaled and the nnΛ continuum is turned into a resonance and then into a bound state of the system.
Summary
Background
Eosinophilic airway inflammation is a key pathophysiological feature of asthma that can predict treatment response. However, the prognostic value of sputum eosinophilia is not ...established.
Objective
The aim of this study was to determine the influence of induced sputum eosinophilia on the prognosis of childhood asthma.
Methods
A cohort of children with asthma was evaluated by induced sputum analysis at inception and classified as having either eosinophilic asthma (EA) (sputum eosinophils >2.5%) or non‐eosinophilic asthma (NEA). After a mean follow‐up period of 5 years, eligible subjects (n=83) were contacted and 69 subjects (33 EA, 36 NEA) evaluated. The children had a mean age of 15.9 years, and 61% were male.
Results
Children with EA reported more wheeze during the follow‐up period (27% vs. 6% wheezed most years; P<0.0001), increased night waking during the past 12 months (28% vs. 3% reported weekly waking; P=0.01), and greater impairment of quality of life due to asthma (P=0.04). Subsequent β2‐agonist use was increased in children with EA (P=0.02), although there was no difference in corticosteroid use. In EA, subsequent forced expiratory volume in 1 s/forced vital capacity was lower (79% vs. 86%; P=0.01) and grass pollen allergy was more prevalent (77% vs. 27%; P=0.006).
Conclusion
In children, eosinophilic airway inflammation is associated with deteriorating asthma over time. This is consistent with the hypothesis that airway inflammation has an adverse impact on the prognosis of childhood asthma, and suggests a role for monitoring inflammation in asthma management.
We studied the combination of pemetrexed, a multi-targeted antifolate, and cetuximab, an mAb against the epidermal growth factor receptor, with radiotherapy in poor prognosis head and neck cancer.
...Patients received pemetrexed on days 1, 22, and 43 on a dose-escalation scheme with starting level (0) 350 mg/m2 (level -1, 200 mg/m2; level +1, 500 mg/m2) with concurrent radiotherapy (2 Gy/day) and cetuximab in two separate cohorts, not previously irradiated (A) and previously irradiated (B), who received 70 and 60–66 Gy, respectively. Genetic polymorphisms of thymidylate synthase and methylenetetrahydrofolate reductase were evaluated.
Thirty-two patients were enrolled. The maximum tolerated dose of pemetrexed was 500 mg/m2 in cohort A and 350 mg/m2 in cohort B. Prophylactic antibiotics were required. In cohort A, two dose-limiting toxicities (DLTs) occurred (febrile neutropenia), one each at levels 0 and +1. In cohort B, two DLTs occurred at level +1 (febrile neutropenia; death from perforated duodenal ulcer and sepsis). Grade 3 mucositis was common. No association of gene polymorphisms with toxicity or efficacy was evident.
The addition of pemetrexed 500 mg/m2 to cetuximab and radiotherapy is recommended for further study in not previously irradiated patients.
Summary
With the new opportunities from DNA technology, multitier breeding schemes have the potential to become more effective and more integrated. Integrated breeding schemes can also be better ...adapted to account for potential genotype by environment interactions (G × E) between tiers. In this case, phenotypic and genotype information from lower tiers becomes more valuable as it involves measurement of traits that directly represent the breeding objective. The objective of this study was to compare scenarios that represented different selection strategies and their economic effectiveness in fine‐wool commercial sheep operations that exploit multitier breeding structures. Genomic selection (GS) applied in the multiplier and the commercial tier presented the largest additional revenue among all scenarios, as it resulted in the largest amount of genetic progress. The largest benefits from GS were outweighed by the genotyping costs, which made DNA parentage the most feasible strategy for the multiplier tier, resulting in the highest cumulative net present value (CNPV). The benefits of phenotypes and genotype information from the commercial environment were larger in the presence of G × E between the nucleus and the commercial tier. The CNPV was larger with a 50% reduction in genotyping costs, which increased the returns of GS scenarios by 2.7‐fold on average. Higher selection intensity when selecting multiplier rams also resulted in larger benefits. In this case, returns for the breeding scheme were 3.5‐fold higher when 33% of multiplier males were selected based on commercial information, compared to scenarios selecting 50% of the available multiplier rams. The benefits of collecting commercial phenotypes and genotypes were long term, which means that return on investment often took more than 10 years to be achieved, and were largely dependent on two‐stage selection to reduce cost while maintaining selection efficiency and on the cost of a genotype test.
The Reid93 potential provides a representation of the nucleon–nucleon (
NN
) scattering data that rivals that of a partial wave analysis. We present here a unitary pole approximation (UPA) for this ...contemporary
NN
potential that provides a rank one separable potential for which the wave function of the deuteron (
3
S
1
-
3
D
1
) and singlet anti-bound (
1
S
0
) state are exactly those of the original potential. Our motivation is to use this UPA potential to investigate the sensitivity of the electric dipole moment for the deuteron and
3
H and
3
He to the ground state nuclear wave function. We compare the Reid93 results with those for the original Reid (Reid68) potential to illustrate the accuracy of the bound state properties.
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