•This ESMO Clinical Practice Guideline provides key recommendations on the management of testicular seminoma and non-seminoma.•Authorship includes a multidisciplinary group of experts from different ...institutions and countries in Europe.•Key treatment recommendations are provided.•Recommendations are based on available scientific data and the authors’ collective expert opinion.
We investigate the origin, structure, and evolution of the small gas cloud G2, which is on an orbit almost straight into the Galactic central supermassive black hole (SMBH). G2 is a sensitive probe ...of the hot accretion zone of Sgr A*, requiring gas temperatures and densities that agree well with models of captured shock-heated stellar winds. Its mass is equal to the critical mass below which cold clumps would be destroyed quickly by evaporation. Its mass is also constrained by the fact that at apocenter its sound crossing timescale was equal to its infall timescale. Our numerical simulations show that the observed structure and evolution of G2 can be well reproduced if it forms in pressure equilibrium with its surroundings in 1995 at a distance from the SMBH of 7.6 x 10 super(16) cm. If the cloud had formed at apocenter in the "clockwise" stellar disk as expected from its orbit, it would be torn into a very elongated spaghetti-like filament by 2011, which is not observed. This problem can be solved if G2 is the head of a larger, shell-like structure that formed at apocenter. Our numerical simulations show that this scenario explains not only G2's observed kinematical and geometrical properties but also the Br gamma observations of a low surface brightness gas tail that trails the cloud. In 2013, while passing the SMBH, G2 will break up into a string of droplets that within the next 30 years will mix with the surrounding hot gas and trigger cycles of active galactic nucleus activity.
For men with advanced castration-resistant prostate cancer (CRPC), several treatment options are available, including androgen receptor (AR) pathway inhibitors (abiraterone acetate, enzalutamide), ...taxanes (docetaxel, cabazitaxel) and the radionuclide (radium-223). However, cross-resistance is a clinically relevant problem. Platinum compounds have been tested in a number of clinical trials in molecularly unselected prostate cancer patients. Advances in CRPC molecular profiling have shown that a significant proportion of patients harbour DNA repair defects, which may serve as predictive markers for sensitivity to platinum agents.
To systematically identify and analyse clinical trials that have evaluated platinum agents in advanced prostate cancer patients.
PubMed was searched to identify published clinical trials of platinum agents in advanced prostate cancer. The PRIMSA statement was followed for the systematic review process. Identified trials are analysed for study design, statistical plan, assessments of anti-tumour activity and the potential value of predictive biomarkers.
A total of 163 references were identified by the literature search and 72 publications that met the selection criteria were included in this review; of these 33 used carboplatin, 27 cisplatin, 6 satraplatin, 4 oxaliplatin and 2 other platinum compounds. Overall, anti-tumour activity varies in the range of 10%–40% for objective response and 20%–70% for PSA decline ≥50%. Response seemed highest for the combinations of carboplatin with taxanes or oxaliplatin with gemcitabine. The interpretation of the clinical data is limited by differences in response criteria used and patient populations studied.
Platinum compounds have moderate anti-tumour activity in molecularly unselected patients with advanced prostate cancer. Translational evidence of DNA repair deficiency should be leveraged in future studies to select prostate cancer patients most likely to benefit from platinum-based therapy.
We study the young S-stars within a distance of 0.04 pc from the supermassive black hole in the center of our Galaxy. Given how inhospitable the region is for star formation, their presence is more ...puzzling the younger we estimate their ages. In this study, we analyze the result of 12 years of high-resolution spectroscopy within the central arcsecond of the Galactic Center (GC). By co-adding between 55 and 105 hr of spectra we have obtained high signal-to-noise H- and K-band spectra of eight stars orbiting the central supermassive black hole. Using deep H-band spectra, we show that these stars must be high surface gravity (dwarf) stars. We compare these deep spectra to detailed model atmospheres and stellar evolution models to infer the stellar parameters. Our analysis reveals an effective temperature of 21,000-28,500 K, a rotational velocity of 60-170 km s−1, and a surface gravity of 4.1-4.2. These parameters imply a spectral type of B0-B3V for these stars. The inferred masses lie within 8-14 . We derive an age of Myr for the star S2, which is compatible with the age of the clockwise-rotating young stellar disk in the GC. We estimate the ages of all other studied S-stars to be less than 15 Myr, which is compatible with the age of S2 within the uncertainties. The relatively low ages for these S-stars favor a scenario in which the stars formed in a local disk rather than a field binary-disruption scenario that occurred over a longer period of time.
We present new observations of the recently discovered gas cloud G2 currently falling toward the massive black hole in the Galactic Center. The new data confirm that G2 is on a highly elliptical ...orbit with a predicted pericenter passage mid-2013. The updated orbit has an even larger eccentricity of 0.966, an epoch of pericenter two months later than estimated before, and a nominal minimum distance of 2200 Schwarzschild radii only. The velocity gradient of G2 has developed further to 600 km s super(-1) FWHM in summer 2012. We also detect the tail of similar total flux and on the same orbit as G2 along the trajectory at high significance. No hydrodynamic effects are detected yet, since the simple model of a tidally shearing gas cloud still describes the data very well. The flux of G2 has not changed by more than 10% between 2008 and 2012, disfavoring models where additional gas from a reservoir is released to the disrupting diffuse gas component.
Near-infrared observations of stellar orbits at the Galactic Center provide conclusive evidence for a massive black hole associated with the compact radio source Sgr A*. The astrometric reference ...frame for these observations is tied to a set of red giant stars, which are also detectable at radio wavelengths through SiO maser emission in their envelopes. We have improved the precision and long-term stability of this reference frame, in which Sgr A* is localized to within a factor 5 better than previously: ∼0.17 mas in position (in 2009) and ∼0.07 mas yr−1 in velocity. This improvement is the result of modelling and correcting optical distortion in the VLT/NACO imager to a submas level and including new infrared and radio measurements, which now both span more than a decade in time. A further improvement will follow future observations and facilitate the detection of relativistic orbital effects.
The broadening of atomic emission lines by high-velocity motion of gas near accreting supermassive black holes is an observational hallmark of quasars
. Observations of broad emission lines could ...potentially constrain the mechanism for transporting gas inwards through accretion disks or outwards through winds
. The size of regions for which broad emission lines are observed (broad-line regions) has been estimated by measuring the delay in light travel time between the variable brightness of the accretion disk continuum and the emission lines
-a method known as reverberation mapping. In some models the emission lines arise from a continuous outflow
, whereas in others they arise from orbiting gas clouds
. Directly imaging such regions has not hitherto been possible because of their small angular size (less than 10
arcseconds
). Here we report a spatial offset (with a spatial resolution of 10
arcseconds, or about 0.03 parsecs for a distance of 550 million parsecs) between the red and blue photo-centres of the broad Paschen-α line of the quasar 3C 273 perpendicular to the direction of its radio jet. This spatial offset corresponds to a gradient in the velocity of the gas and thus implies that the gas is orbiting the central supermassive black hole. The data are well fitted by a broad-line-region model of a thick disk of gravitationally bound material orbiting a black hole of 3 × 10
solar masses. We infer a disk radius of 150 light days; a radius of 100-400 light days was found previously using reverberation mapping
. The rotation axis of the disk aligns in inclination and position angle with the radio jet. Our results support the methods that are often used to estimate the masses of accreting supermassive black holes and to study their evolution over cosmic time.
ABSTRACT
Using general relativistic magnetohydrodynamic simulations of accreting black holes, we show that a suitable subtraction of the linear polarization per pixel from total intensity images can ...enhance the photon ring feature. We find that the photon ring is typically a factor of ≃2 less polarized than the rest of the image. This is due to a combination of plasma and general relativistic effects, as well as magnetic turbulence. When there are no other persistently depolarized image features, adding the subtracted residuals over time results in a sharp image of the photon ring. We show that the method works well for sample, viable GRMHD models of Sgr A* and M87*, where measurements of the photon ring properties would provide new measurements of black hole mass and spin, and potentially allow for tests of the ‘no-hair’ theorem of general relativity.
ABSTRACT
The Galactic centre black hole candidate Sgr A* is the best target for studies of low-luminosity accretion physics, including with near-infrared (NIR) and submillimetre wavelength long ...baseline interferometry experiments. Here, we compare images and spectra generated from a parameter survey of general relativistic MHD simulations to a set of radio to NIR observations of Sgr A*. Our models span the limits of weak and strong magnetization and use a range of sub-grid prescriptions for electron heating. We find two classes of scenarios can explain the broad shape of the submillimetre spectral peak and the highly variable NIR flaring emission. Weakly magnetized ‘disc-jet’ models where most of the emission is produced near the jet wall, consistent with past work, as well as strongly magnetized (magnetically arrested disc) models where hot electrons are present everywhere. Disc-jet models are strongly depolarized at submillimetre wavelengths as a result of strong Faraday rotation, inconsistent with observations of Sgr A*. We instead favour the strongly magnetized models, which provide a good description of the median and highly variable linear polarization signal. The same models can also explain the observed mean Faraday rotation measure and potentially the polarization signals seen recently in Sgr A* NIR flares.
Measurements of stellar orbits provide compelling evidence that the compact radio source Sagittarius A* at the Galactic Centre is a black hole four million times the mass of the Sun. With the ...exception of modest X-ray and infrared flares, Sgr A* is surprisingly faint, suggesting that the accretion rate and radiation efficiency near the event horizon are currently very low. Here we report the presence of a dense gas cloud approximately three times the mass of Earth that is falling into the accretion zone of Sgr A*. Our observations tightly constrain the cloud's orbit to be highly eccentric, with an innermost radius of approach of only ∼3,100 times the event horizon that will be reached in 2013. Over the past three years the cloud has begun to disrupt, probably mainly through tidal shearing arising from the black hole's gravitational force. The cloud's dynamic evolution and radiation in the next few years will probe the properties of the accretion flow and the feeding processes of the supermassive black hole. The kilo-electronvolt X-ray emission of Sgr A* may brighten significantly when the cloud reaches pericentre. There may also be a giant radiation flare several years from now if the cloud breaks up and its fragments feed gas into the central accretion zone.
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