The main scope of the InterPACIFIC (Intercomparison of methods for site parameter and velocity profile characterization) project is to assess the reliability of in-hole and surface-wave methods, used ...for estimating shear wave velocity. Three test-sites with different subsurface conditions were chosen: a soft soil, a stiff soil and a rock outcrop. This paper reports the surface-wave methods results. Specifically 14 teams of expert users analysed the same experimental surface-wave datasets, consisting of both passive and active data. Each team adopted their own strategy to retrieve the dispersion curve and the shear-wave velocity profile at each site. Despite different approaches, the dispersion curves are quite in agreement with each other. Conversely, the shear-wave velocity profiles show a certain variability that increases in correspondence of major stratigraphic interfaces. This larger variability is mainly due to non-uniqueness of the solution and lateral variability. As expected, the observed variability in VS,30 estimates is small, as solution non-uniqueness plays a limited role.
•Variability of surface wave analysis results are studied with a blind test.•Three subsoil conditions are considered: soft soil, stiff soil, rock outcrop.•Different methods are used to analyze active and passive data.•A low variability is observed on the estimates of the experimental dispersion curve.•Variability in VS profiles is due to parameterization and solution non-uniqueness.
We consider the problem of calculation of correlation functions in the six-vertex model with domain wall boundary conditions. To this aim, we formulate the model as a scalar product of off-shell ...Bethe states, and, by applying the quantum inverse scattering method, we derive three different integral representations for these states. By suitably combining such representations, and using certain antisymmetrization relation in two sets of variables, it is possible to derive integral representations for various correlation functions. In particular, focusing on the emptiness formation probability, besides reproducing the known result, obtained by other means elsewhere, we provide a new one. By construction, the two representations differ in the number of integrations and their equivalence is related to a hierarchy of highly nontrivial identities.
The knowledge of the local soil structure is important for the assessment of seismic hazards. A widespread, but time-consuming technique to retrieve the parameters of the local underground is the ...drilling of boreholes. Another way to obtain the shear wave velocity profile at a given location is the inversion of surface wave dispersion curves. To ensure a good resolution for both superficial and deeper layers, the used dispersion curves need to cover a wide frequency range. This wide frequency range can be obtained using several arrays of seismic sensors or a single array comprising a large number of sensors. Consequently, these measurements are time-consuming. A simpler alternative is provided by the use of the ellipticity of Rayleigh waves. The frequency dependence of the ellipticity is tightly linked to the shear wave velocity profile. Furthermore, it can be measured using a single seismic sensor. As soil structures obtained by scaling of a given model exhibit the same ellipticity curve, any inversion of the ellipticity curve alone will be ambiguous. Therefore, additional measurements which fix the absolute value of the shear wave velocity profile at some points have to be included in the inversion process. Small-scale spatial autocorrelation measurements or MASW measurements can provide the needed data. Using a theoretical soil structure, we show which parts of the ellipticity curve have to be included in the inversion process to get a reliable result and which parts can be omitted. Furthermore, the use of autocorrelation or high-frequency dispersion curves will be highlighted. The resulting guidelines for inversions including ellipticity data are then applied to real data measurements collected at 14 different sites during the European NERIES project. It is found that the results are in good agreement with dispersion curve measurements. Furthermore, the method can help in identifying the mode of Rayleigh waves in dispersion curve measurements.
Saliva testing is a non-invasive and inexpensive test that can serve as a source of information useful for diagnosis of disease. As we enter the era of genomic technologies and -omic research, ...collection of saliva has increased. Recent proteomic platforms have analysed the human salivary proteome and characterised about 3000 differentially expressed proteins and peptides: in saliva, more than 90% of proteins in weight are derived from the secretion of three couples of "major" glands; all the other components are derived from minor glands, gingival crevicular fluid, mucosal exudates and oral microflora. The most common aim of proteomic analysis is to discriminate between physiological and pathological conditions. A proteomic protocol to analyze the whole saliva proteome is not currently available. It is possible distinguish two type of proteomic platforms: top-down proteomics investigates intact naturally-occurring structure of a protein under examination; bottom-up proteomics analyses peptide fragments after pre-digestion (typically with trypsin). Because of this heterogeneity, many different biomarkers may be proposed for the same pathology. The salivary proteome has been characterised in several diseases: oral squamous cell carcinoma and oral leukoplakia, chronic graft-versus-host disease Sjögren's syndrome and other autoimmune disorders such as SAPHO, schizophrenia and bipolar disorder, and genetic diseases like Down's Syndrome and Wilson disease. The results of research reported herein suggest that in the near future human saliva will be a relevant diagnostic fluid for clinical diagnosis and prognosis.
(1) Background: Extravasation injuries in pediatric patients can lead to significant harm if they are not promptly diagnosed and treated. However, evidence-based standardization on extravasation ...management remains limited, particularly for extensive wound necrosis. This case report presents the management of an 8-week-old premature patient with an extensive extravasation injury involving the right forearm and dorsum of the hand. (2) Methods: The patient was evaluated by a multidisciplinary team in our Neonatal Intensive Care Unit. Surgical intervention involved the debridement of necrotic tissues, followed by temporary coverage with an acellular dermal matrix. Definitive coverage was achieved through Meek micrografting after three weeks. Physical therapy was provided with pre- and post-rehabilitation range of motion assessed using goniometric measurements. Scar quality was evaluated using the Vancouver Scar Scale. (3) Results: The engraftment rate of the Meek micrografts was 93%, with 16 out of 226 micrografts lost. The patient achieved a Vancouver Scar Scale score of 6, indicating a moderate degree of scarring. Significant improvements in elbow, wrist, and finger joint range of motion were observed at a 1-year follow-up. (4) Conclusions: Close observation and heightened awareness of extravasation risks by trained personnel are crucial. Meek micrografting combined with dermal substitute coverage represents an innovative approach to managing extravasation wounds in pediatric patients.
Long term survival and its determinants after Percutaneous Coronary Intervention (PCI) on Unprotected Left Main Coronary Artery (ULMCA) remain to be appraised. In 9 European Centers 470 consecutive ...patients performing PCI on ULMCA between 2002 and 2005 were retrospectively enrolled. Survival from all cause and cardiovascular (CV) death were the primary end points, while their predictors at multivariate analysis the secondary ones. Among the overall cohort 81.5% of patients were male and mean age was 66 ± 12 years. After 15 years (IQR 13 to 16), 223 patients (47%) died, 81 (17.2%) due to CV etiology. At multivariable analysis, older age (HR 1.06, 95%CI 1.02 to 1.11), LVEF < 35% (HR 2.97, 95%CI 1.24 to 7.15) and number of vessels treated during the index PCI (HR 1.75, 95%CI 1.12 to 2.72) were related to all-cause mortality, while only LVEF <35% (HR 4.71, 95%CI 1.90 to 11.66) to CV death. Repeated PCI on ULMCA occurred in 91 (28%) patients during the course of follow up and did not significantly impact on freedom from all-cause or CV mortality. In conclusion, in a large, unselected population treated with PCI on ULMCA, 47% died after 15 years, 17% due to CV causes. Age, number of vessels treated during index PCI and depressed LVEF increased risk of all cause death, while re-PCI on ULMCA did not impact survival.
Background
The novel cryoballoon Advance (CB-A) has proven to achieve significantly lower temperatures and faster pulmonary vein isolation (PVI) times in comparison with the first-generation device. ...Although acutely very effective, to the best of our knowledge, data on mid-term clinical follow-up is lacking.
Aims
The aim of the study was to analyse the freedom from recurrence of atrial fibrillation (AF) on a 1-year follow-up period, in a series of consecutive patients having undergone PVI with the CB-A for paroxysmal AF (PAF).
Methods and results
Forty-two patients 30 male (71%); mean age: 57.9 ± 21.1 years were included. All patients underwent a procedure with the large 28 mm CB-A. A total 168 PVs were depicted on the pre-procedural computed tomography scan. All PVs (100%) could be isolated with the CB only. The freedom from AF off-antiarrhythmic drug treatment after a single procedure was 78% of patients at a mean 11.6 ± 2.0 months follow-up. If considering a blanking period (BP) of 3 months, success rate was 83%. Phrenic nerve palsy (PNP) was the most frequent complication occurring in 19% of individuals.
Conclusion
The CB-A is very effective in producing PVI and affords freedom from AF at 12 months follow-up in 83% of patients affected by drug-resistant PAF following a 3-month BP. The most frequent complication observed was PNP which occurred in 19% of patients. All PNP reverted during follow-up.
To assess the 1 year efficacy of pulmonary vein isolation (PVI) as index procedure for persistent atrial fibrillation (PersAF) comparing conventional radiofrequency irrigated-tip catheter ablation ...(RFCA) using contact-force technology and ablation using the second-generation cryoballoon (CB-AdvA).
One hundred consecutive patients (74 male, 74%; mean age 62.4 ± 9.6 years) with drug-refractory PersAF undergoing PVI using RFCA and CB-AdvA were enrolled. Follow-up was based on outpatient clinic visits including Holter-electrocardiograms. Recurrence of atrial tachyarrhythmias (ATas) was defined as a symptomatic or documented episode >30 s. Among 100 patients, 50 underwent RFCA whereas 50 CB-AdvA. Mean procedure and fluoroscopy times were 90.5 ± 41.7 vs. 140.2 ± 46.9 min and 14.5 ± 6.6 vs. 19.8 ± 6.8 min in the CB-Adv and in the RFCA group, respectively (P < 0.01). At 1 year follow-up, after a 3 months blanking period (BP), freedom from ATas off-drugs after a single procedure was 60% (28/50 patients) in the CB-Adv and 56% (27/50 patients) in the RFCA group (P = 0.71). Multivariate analysis demonstrated that PersAF duration (P = 0.01) and relapses during BP (P = 0.02) were independent predictors of ATa recurrences following the index procedure.
Freedom from ATas following PersAF ablation with RFCA and CB-Adv is comparable at 1 year follow-up after a single procedure. Ablation with the CB-Adv is associated with shorter procedure time and radiation exposure as compared with RFCA. Atrial tachyarrhythmias occurrence during BP and longer time of PersAF seem to be significant predictors of arrhythmia recurrences after the index procedure.
The elastic strain energy release rate and seismic waves emitted during earthquakes are controlled by the on-fault temporal evolution of the shear stress during rupture propagation. High velocity ...friction experiments highlighted that shear stress on the fault surface evolves rapidly during seismic slip pulses. This temporal evolution of shear stress is controlled by both fault weakening at seismic slip initiation and re-strengthening rate towards the end of slip. While numerous studies focused on fault weakening, less attention was given to co-seismic re-strengthening processes. Here we performed 53 friction experiments (normal stress ≤30 MPa, slip-rate ≤6.5 ms−1) imposing constant slip acceleration and deceleration (7.8 ms−2), on cohesive Carrara marble (99% calcite) and micro-gabbro (silicate-built rock) under dry, vacuum and water pressurized conditions. Microstructural observations showed that micro-gabbro accommodated seismic slip by bulk melting of the sliding surfaces, whereas Carrara marble by coupled decarbonation and grain-size dependent crystal plastic processes. Under room humidity conditions and low imposed power density (i.e., product of normal stress per slip rate), re-strengthening rate during the deceleration stage was up to ∼ 17 times faster in marble than in micrograbbro. In the latter, the re-strengthening rate increased slightly with the power density. The presence of water enhanced further this trend. On the contrary, in marbles the re-strengthening rate decreased drastically with power density and in the presence of water. Our experimental observations highlighted the first order importance of the mineralogy and rheology of the slip zone materials and, to a second order, of the presence of water in controlling co-seismic re-strengthening of faults during seismic slip deceleration.
•Effect of rock composition and water content on fault re-strengthening during earthquakes.•Re-strengthening rate is faster in carbonate-than silicate-bearing rocks at low power density.•In silicate rocks, re-strengthening rate increases with power density and in presence of water.•In carbonate rocks, re-strengthening rate decreases with power density and in presence of water.•Silicate rocks promote intense high frequency radiation during deceleration of the seismic slip.
We present the results of seismological and geophysical investigations performed by the “
Istituto Nazionale di Geofisica e Vulcanologia
” team operating in Amatrice village (Central Italy), in the ...emergency phases following the Mw 6.0 event of August 24th 2016, that caused severe damage in downtown and surrounding areas. Data from seven seismic stations equipped with both weak and strong motion sensors are analyzed in terms of standard spectral ratio to empirically define amplification function using a bedrock reference site. Ambient vibration spectral ratios between horizontal and vertical component of motion are also evaluated in a large number of sites, spread out in the investigated area, to recover the resonance frequency of the soft soil outcropping layers and to generalize the results obtained by earthquake data. Ambient noise vibration are also used for applying a 2D array approach based on surface waves techniques in order to define the near-surface velocity model and to verify its lateral variation. The results allows to better understand the amplification factors in the investigated area, showing spatial variation of site effects despite of the homogeneous shallow geological condition indicated by the microzonation studies available at moment of the described field campaign. The analysis reveals a diffuse amplification effect which reaches its maximum values in downtown area with a resonant frequency of about 2 Hz. The obtained results were used to integrate the microzonation studies and they can be used for urban planning and reconstruction activities.
PDF
