Climate change and exposure to environmental pollutants play a key role in the onset and aggravation of allergic diseases. As different climate-dependent patterns of molecular immunoglobulin E (IgE) ...reactivity have been regionally described, we sought to investigate the evolving allergen exposome in distinctive allergic phenotypes and subtropical weather conditions through a Precision Allergy Molecular Diagnosis (PAMD@) model. Concurrent sensitization to several house dust mites (HDM) and storage mite molecules were broadly dominant in the investigated cohort, followed by the major cat allergen Fel d 1, and regardless of the basal allergic disease. Although a complex repertoire of allergens was recognized, a steadily increasing number of IgE binding molecules was associated with the complexity of the underlying atopic disease. Besides the highly prevalent IgE responses to major HDM allergens, Der p 21, Der p 5, and Der p 7 also showed up as serodominant molecules, especially in subjects bothered by asthma and atopic dermatitis. The accurate characterization of the external exposome at the molecular level and their putative role as clinically relevant allergens is essential to elucidate the phenotypic diversity of atopic disease in terms of personalized diagnosis and therapy.
The identification of anthropogenically-modified carnivoran bones in archaeological sites is rare in Pleistocene contexts, especially in the most ancient periods. Neanderthal groups have clearly ...shown a great variety of subsistence activities and the use of carnivoran resources, until rare, is also present in some archaeological sites.
However, the identification of the bone surface modifications (BSM) that allow us to infer the presence of anthropogenic marks in faunal remains are usually difficult to be differentiate among other BSM. Recently, several statistical and computing techniques have been developed to differentiate among different types of BSM in an objective way.
To date, the most powerful approach is the use of Convolutional Neural Networks, which are the essential part of what is referred to as Deep Learning. In this work, ResNet50 and Inception V3 models are used through transfer learning. The algorithm architecture reaches an accuracy of >96.3% when differentiating among experimental trampling, cut and tooth marks. Once the transfer models were re-trained with the experimental BSM, they were used to classify several archaeological BSM previously identified as cut marks by human analysts. These BSM have been found on a bear ulna and on a hyena phalanx, both recovered at the Navalmaíllo Rock Shelter (Madrid, Spain).
The BSM located on the hyaena phalanx have been identified as cut marks with a high probability while marks on the bear ulna are non-anthropogenic. This bone adds to the existing sample of anthropogenically-modified carnivoran elements by Neanderthal populations and hint to use of carnivore pelts by Neanderthals.
•Computer vision allows correct analysis of Neanderthal cut marks on a hyena phalanx.•Computer vision also allows to interpret correctly trampling marks on a bear ulna.•These cut marks are clearly related to skinning activities of the hyena pelt.•This evidence is the first related to skinning of a hyena in the Pleistocene record.
The interior of the Iberian Peninsula has few Middle Palaeolithic sites, especially when compared to other areas of the Mediterranean Basin and the northern Spanish region. Few in number too are the ...zooarchaeological and taphonomic studies that throw light on the relationships between Neanderthal groups, their environment, and the use they made of it. The present work examines, both zooarchaeologically and taphonomically, the faunal remains of levels F and D of the Navalmaíllo Rock Shelter (Pinilla del Valle, Madrid, Spain) - the largest collection of such remains ever studied from the Iberian interior. The results allow this site to be interpreted as a Neanderthal hunting camp where occupations were short-term. Neanderthal people were the main agents that accumulated the site's faunal remains - largely those of large bovids and to a lesser extent medium-sized cervids. The activity of carnivores was also identified, but these animals mostly left behind the remains of small prey or fed upon carcasses abandoned at the camp by human hunters.
•Navalmaíllo Rock Shelter has been interpreted as a Neanderthal hunting camp.•All phases of butchery were identified, along with the extraction of bone marrow.•Bovines and cervids are the more common taxa in the assemblage.•There is a low degree of competition between hominins and large carnivores.•The faunal assemblage was little affected by post-depositional processes.
To understand the identity of the early Acheulean, it is necessary to discriminate between the variables that influenced the selection of technological strategies. Functionality of the archaeological ...sites is crucial in assessing the manufacturing strategies of lithic tools. To achieve this goal, analysis of the post-depositional processes must be evaluated. When bone remains have been preserved, anthropic animal processing can be identified through zooarchaeological and taphonomic analyses, and the spatial relationships among all the components can also be assessed, especially when bone surface is not sufficiently preserved.
There are two levels present at Thiongo Korongo, ~1.3 Ma, TKLF and TKSF. These are in autochthonous position with no significant temporal diachrony but with substantial technological differences in the manufacturing of the lithic tools, which enables the analysis of the influence of human activities on technological behaviour. In order to evaluate this issue at TKSF, we present lithic, faunal, taphonomic, fabric, and spatial analyses.
An assemblage of megaherbivores, among which Sivatherium is outstanding, dominate the TKSF faunal remains. Cortical preservation is poor; there is no intervention of carnivores, the rate of green fractures is low, and a few cut marks on size 5 and 3b animals were identified. Hence, apparently human intervention on the fauna was not intensive. Spatial and geostatistical analyses hints of a specific area where megaherbivores were processed by humans. Through wear use and biomarker analyses on stone tools, we are currently trying to understand the activities that were carried out in the remaining paleosurface.
At paleosurface TKLF, the main anthropogenic input could be related to activities other than animal resource exploitation, in which large handaxes were necessary. Without the assessment of site functionality and chronological context, this data could have lead to the differences observed at TKLF and TKSF being attributed to different Acheulean stages.
The Iberian Pyrite Belt (IPB), in the southwestern Iberian Peninsula, is a large metallogenic province exploited since ancient times. As a result of historical and current mining activity, a vast ...volume of metallic mineral waste, mainly derived from the processing of pyrite, is still in situ and polluting the environment. A specific mine waste residuum locally known in the area as “morrongos”, which was produced during pyrite roasting mainly in the 19th century, is evaluated here in order to unravel untapped resources of high-tech metals commonly used in high-tech devices. Applying a combination of whole-rock geochemical (ICP-AES, ICPMS, FA-AAS) and single-grain mineralogical techniques (EPMA, LA-ICP-MS, FESEM, and FIB-HRTEM) on the “morrongos”, we unhide the still-present remarkable concentrations of Au, Ag, Pb, Zn, and Cu in them. The mineralogical expressions for these economic metals include oxides (hematite, magnetite, and hercynite), arsenates, sulfates of the jarosite group, native metals, and, to a lesser extent, relictic sulfides. This first-ever estimation of these economic metals in this type of residue allows their revalorization, highlighting them as suitable sources for the exploitation and recovery of metals necessary for the clean energy transition.
Neanderthals have been claimed to have had a selective adaptation to rugged, wooded landscapes that would have partially compensate their high basal metabolic rate and locomotor energetic costs ...through reducing search time and increasing diet breadth. The archaeological site of the Navalmaíllo rockshelter (Pinilla del Valle, Madrid), located in a mountain environment in central Iberian Peninsula, has been interpreted as a repeated short-term occupation hunting camp by Neanderthal groups, mainly focused on primary access to large bovids and cervids. Navalmaíllo rockshelter has also furnished fish, toads, frogs, tortoises, lizards and snakes remains. This association of amphibians and reptiles suggests a much warmer climate (+2.8 °C) for layer F than at present, with similar temperatures during the summer but higher temperatures throughout the remaining months. Rainfall was slightly more abundant (+180.6 mm) than today, with a more contrasted regime during the year, with rainier winters and drier summers. A two-month period of aridity is observed during summer, representing a similar duration to present-day climatic conditions. Reconstructed landscapes are mainly constituted by open areas with dry grassland and rocky or stony areas, evolving laterally to humid meadows, probably close to the aquatic and peri-aquatic areas, such as rivers or ponds with riverside vegetation. Woodland environments are also well represented around the site, with medium scrublands to forest formations. Fish complete this reconstruction by documenting the presence of a pre-mountain well-developed river system characterized by relatively cold, permanent, oxygen-rich, and running waters. Such reconstruction is in disagreement with previous pollen interpretation for Layer F that suggested a very open and cold environment. Our new interpretation suggests that the Neanderthal occupation of the Navalmaíllo rockshelter occurred during a somewhat temperate and humid period, probably within the later part of the Marine Isotope Stage 5, effectively favouring the presence of a high biodiversity around the site.
•Neanderthal paleoecology from the Navalmaíllo rockshelter is revisited.•Amphibians and reptiles suggest warm and humid climate conditions.•Woodland environments are well represented around the site.•Such reconstruction is in disagreement with previous pollen-based interpretation.•Neanderthal occupation was favored by the presence of a high biodiversity.
Spatial analysis has been much used to examine the distribution of archaeological remains at Pleistocene sites. However, little is known about the distribution patterns at sites identified as hunting ...camps, i.e., places occupied over multiple short periods for the capture of animals later transported to a base camp. The present work examines a Neanderthal hunting camp (the Navalmaíllo Rock Shelter in Pinilla del Valle, Madrid, Spain) to determine whether different activities were undertaken in different areas of the site. A spatial pattern was detected with a main cluster of materials (lithic tools, faunal remains, and coprolites) clearly related to the presence of nearby hearths—the backbone of the utilised space. This main cluster appears to have been related to collaborative and repetitive activities undertaken by the hunting parties that used the site. Spatial analysis also detected a small, isolated area perhaps related to carcasses processing at some point in time and another slightly altered by water.
Buena Pinta Cave (Pinilla del Valle, Madrid) has been interpreted as a hyena den with sporadic occupations of
Homo neanderthalensis
in the western part of the site (level 23). In order to identify ...the different formation processes in this area of the site, spatial analyses have been carried out with GIS and spatial statistics based on the taphonomic analysis of the faunal remains. Based on the vertical and sectional analyses of the assemblage, it has been possible to determine that level 23 actually corresponds to three archaeological levels with well-differentiated characteristics: a lower level with few faunal remains and fossil-diagenetic alterations related to humid environments associated with clays; an intermediate level with a high percentage of remains with water-related modifications and evidences of transport; and an upper level delimited mainly thanks to by a paraconformity evidenced by the concentration of weathered remains in this area and a significant reduction in remains with water-related alterations above. The results obtained show the necessity to redefine field layers and the usefulness of integrating taphonomic data and spatial studies.
Kill/butchering sites are some of the most important places for understanding the subsistence strategies of hunter-gatherer groups. However, these sites are not common in the archaeological record, ...and they have not been sufficiently analysed in order to know all their possible variability for ancient periods of the human evolution. In the present study, we have carried out the spatial analysis of the Early Middle Palaeolithic (MIS 9–8) site of Cuesta de la Bajada site (Teruel, Spain), which has been previously identified as a kill/butchering site through the taphonomic analysis of the faunal remains. Our results show that the spatial properties of the faunal and lithic tools distribution in levels CB2 and CB3 are well-preserved although the site is an open-air location. Both levels show a similar segregated (i.e. regular) spatial point pattern (SPP) which is different from the SPP identified at other sites with similar nature from the ethnographic and the archaeological records. However, although the archaeological materials have a regular distribution pattern, the lithic and faunal remains are positively associated, which is indicating that most parts of both types of materials were accumulated during the same occupation episodes, which were probably sporadic and focused on getting only few animal carcasses at a time.
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