Colistin use has reemerged for the treatment of infections caused by multidrug-resistant Gram-negative bacteria. However, the information on its pharmacokinetics is limited, especially in patients ...with end-stage renal disease, in which dosage adjustments are contradictory, and evidences the need to investigate the removal of colistin through renal replacement therapies like haemodialysis. This case study showed efficient removal of colistin methanesulphonate and formed colistin during intermittent haemodialysis in a patient infected by polymyxin-only-susceptible Pseudomonas aeruginosa. These results suggest the importance to monitor colistin plasma concentrations in these patients to minimize treatment failure due to suboptimal exposure to antibacterial colistin.
Las especies de Puya (Bromeliaceae) en la Argentina Gómez Romero, Silvia E.(UNT Facultad de Ciencias Naturales e Instituto Miguel Lillo); Grau, Alfredo(UNT Facultad de Ciencias Naturales e Instituto Miguel Lillo)
Boletín de la Sociedad Argentina de Botánica,
2009, Letnik:
44, Številka:
1-2
Journal Article
Eighteen species are described and illustrated, two of them for the first time: P. novarae Varadarajan ex Gómez Romero & A. Grau and P. vervoorstii Gómez Romero & Grau. Two keys for identifying the ...species are presented, one of them based entirely on vegetative characters.
Se describen e ilustran 18 especies, dos de las cuales son nuevas para la ciencia: P. novarae Varadarajan ex Gómez Romero & A. Grau, P. vervoorstii Gómez Romero & A. Grau. Se incluyen dos claves para identificar las especies, una de ellas con caracteres exclusivamente vegetativos
Local and regional drivers of headwater streams metabolism: Insights from the first AIL collaborative project 68 Pastor et al. Streams play a key role in the global biogeochemical cycles, processing ...material from adjacent terrestrial systems and transporting it downstream. However, the drivers of stream metabolism, especially those acting at broad spatial scales, are still not well understood. Moreover, stream metabolism can be affected by hydrological changes associated with seasonality, and thus, assessing the temporality of metabolic rates is a key question to understand stream function. This study aims to analyse the geographical and temporal patterns in stream metabolism and to identify the main drivers regulating the wholeecosystem metabolic rates at local and regional scales. Using a coordinated distributed experiment, we studied ten headwaters streams located across five European ecoregions during summer and fall 2014.We characterized the magnitude and variability of gross primary production (GPP) and ecosystem respiration (ER) with the open-channel method. Moreover, we examined several climatic, geographical, hydrological, morphological, and physicochemical variables that can potentially control stream metabolic rates. Daily rates of stream metabolism varied considerately across streams, with GPP and ER ranging from 0.06 to 4.33 g O 2 m -2 d -1 and from 0.72 to 14.20 gO 2 m -2 d -1 , respectively. All streams were highly heterotrophic (P/R < 1), except the southernmost one. We found that the drier climates tended to have the highest GPP, while humid regions presented the highest ER. Between the sampling periods no statistical differences were found. Partial-least squares models (PLS) explained i"80% of the variance in GPP and ER rates across headwater streams and included both local and regional variables. Rates of GPP varied primarily in response to the local variables, such as streambed substrate and stream water temperature. In contrast, regional variables, such as the mean annual temperature or the land use of the catchment, had more relevance to explain ER. Overall, our results highlight that stream metabolism depends on both local and regional drivers and show the positive experience of a young network of researchers to assess scientific challenges across large-scale geographic areas
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