Pancreas-related complications are some of the most serious ones in abdominal surgery. The goal of this study was to develop and validate novel near-infrared (NIR) fluorophores that would enable ...real-time pancreas imaging to avoid the intraoperative pancreatic injury.
After initial screening of a large NIR fluorophore library, the performance of 3 selected pancreas-targeted 700 nm NIR fluorophores, T700-H, T700-F, and MB, were quantified in mice, rats, and pigs. Dose ranging using 25 and 100 nmol, and 2.5 µmol of T700-F, and its imaging kinetics over a 4 h period were tested in each species. Three different 800 nm NIR fluorophores were employed for dual-channel FLARE™ imaging in pigs: 2 μmol of ZW800-1 for vessels and kidney, 1 μmol of ZW800-3C for lymph nodes, and 2 μmol of ESNF31 for adrenal glands.
T700-F demonstrated the highest signal to background ratio (SBR), with peak SBR at 4 h postinjection in mice. In pigs, T700-F produced an SBR≥2 against muscle, spleen, and lymph nodes for up to 8 h after a single intravenous injection. The combination of T700-F with each 800 nm NIR fluorophore provided simultaneous dual-channel intraoperative imaging of pancreas with surrounding organs in real time.
Pancreas-targeted NIR fluorophores combined with the FLARE dual-channel imaging system enable the real-time intraoperative pancreas imaging which helps surgeons perform safer and more curative abdominal surgeries.
Cloud computing architectures involve different actors that can be divided into four categories: infrastructure- and platform-as-a-service providers, PaaS clients, and end users. These actors ...establish contracts with each other, with the intention of optimizing their costs and offering quality service. Paying attention to end users' context and providing context awareness as a service at the PaaS provider level offers several benefits, including that it lets PaaS clients develop multimodal services and thus optimize infrastructure use. In this article, the authors describe how to include context awareness in cloud infrastructure and the impact it could have at each actor's level.
We consider the problem of computing identifying codes of graphs and its fractional relaxation. The ratio between the size of optimal integer and fractional solutions is between 1 and $2\ln(|V|)+1$ ...where $V$ is the set of vertices of the graph. We focus on vertex-transitive graphs for which we can compute the exact fractional solution. There are known examples of vertex-transitive graphs that reach both bounds. We exhibit infinite families of vertex-transitive graphs with integer and fractional identifying codes of order $|V|^{\alpha}$ with $\alpha \in \{\frac{1}{4},\frac{1}{3},\frac{2}{5}\}$. These families are generalized quadrangles (strongly regular graphs based on finite geometries). They also provide examples for metric dimension of graphs.
Solitaire Clobber is a one-player combinatorial game on graphs. Each vertex of a graph G starts with a black or a white stone. A stone on one vertex can clobber an adjacent stone of the opposite ...color, removing it and taking its place. The goal is to minimize the number of stones remaining when no further move is possible. An initial configuration is k-reducible if it can be reduced to k stones. A graph is strongly 1-reducible if, for any vertex v, any initial configuration that is not monochromatic outside v can be reduced to one stone, on v, of either color. Every such graph has a Hamiltonian path ending at v. For the path Pn, we prove that the rth distance power Pnr is strongly 1-reducible when r≥3 but not when r=2 (Pn2 is 2-reducible). As a consequence, circulant graphs containing edges of lengths 1, 2, and 3 are strongly 1-reducible; we show also that those containing Cn2 are 1-reducible.
A set
S
of vertices in a graph
G
is a paired-dominating set of
G
if every vertex of
G
is adjacent to some vertex in
S
and if the subgraph induced by
S
contains a perfect matching. The ...paired-domination number of
G
, denoted by
γ
pr
(
G
), is the minimum cardinality of a paired-dominating set of
G
. In Dorbec P, Gravier S, Henning MA, J Comb Optim 14(1):1–7, 2007, the authors gave tight bounds for paired-dominating sets of generalized claw-free graphs. Yet, the critical cases are not claws but subdivided stars. We here give a bound for graphs containing no induced subdivided stars, depending on the size of the star.
The increasing number of methodologies and tools currently available to analyse gene expression microarray data can be confusing for non specialist users.
Based on the experience of biostatisticians ...of Institut Curie, we propose both a clear analysis strategy and a selection of tools to investigate microarray gene expression data. The most usual and relevant existing R functions were discussed, validated and gathered in an easy-to-use R package (EMA) devoted to gene expression microarray analysis. These functions were improved for ease of use, enhanced visualisation and better interpretation of results.
Strategy and tools proposed in the EMA R package could provide a useful starting point for many microarrays users. EMA is part of Comprehensive R Archive Network and is freely available at http://bioinfo.curie.fr/projects/ema/.
The structure of Zr sub(x)Ni sub(100-x) thin film metallic glasses (TFMGs) has been studied for a variety of compositions obtained by DC magnetron sputtering using a composite ZrNi target. The ...crystallization has been characterized by X-ray diffraction and transmission electron microscopy revealing also short and medium range order for amorphous compositions. The TFMGs thermodynamic stability has been evaluated by exploiting the Nagel and Tauc criterion, justifying the occurrence of crystallization in the Zr-rich specimens.
Après avoir tenté les concours de la fonction publique territoriale, Coline Gravier a décidé de monter son entreprise en étude et valorisation du patrimoine bâti : Gravier & Patrimoines. Face au ...manque de visibilité et de reconnaissance de la valeur du patrimoine des petites communes, Coline a souhaité mettre ses compétences au service de la mise en valeur des trésors architecturaux qui jalonnent les régions de France. Elle travaille ainsi à la promotion et à la sensibilisation du patrimoine...
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