Mu2e Solenoid Field Mapping System Design Feher, Sandor; DeLurgio, Patrick; Elementi, Luciano ...
IEEE transactions on applied superconductivity,
04/2018, Letnik:
28, Številka:
3
Journal Article
Recenzirano
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The Mu2e experiment at Fermilab plans to search for charged-lepton flavor violations by looking for neutrino-less muon to electron conversions in the field of the nucleus. A complex solenoid system ...and precise knowledge of its magnetic field play a major role in the experimental approach Mu2e has chosen. It is essential to map the solenoid field up to 10 -4 accuracy. This article describes the design of the Field Mapping System Mu2e will use to measure the magnetic field. Two different mechanical mapper systems, a survey-based position determination of the in-house calibrated three-dimensional Hall probes, a motion control system, and a data acquisition and readout system are presented.
The goal of the Mu2e experiment at Fermilab is to search for charged-lepton flavor violation by looking for neutrino-less muon to electron conversion in the field of the nucleus. The Mu2e ...experimental apparatus utilizes a complex magnetic field in the muon generation and momentum and charge selection process. Precise knowledge of the magnetic field is crucial. It is planned to map the solenoid field with calibrated three-dimensional (3-D) Hall probes up to 10 -5 accuracy. This article describes a new design of a Hall probe calibration system that will be used to calibrate 3-D Hall probes to better than 10 -5 accuracy for the Mu2e solenoid field mapping system.
To compare depression-related treatment costs and total healthcare costs for patients diagnosed with depression and treated with either sertraline, paroxetine, or fluoxetine.
Claims records from a ...national database of patients diagnosed with depression who began treatment with an SSRI in 1995, following an antidepressant medication-free period of at least 6 months, were included. Treatment course and associated depression-related treatment and total healthcare costs during the subsequent 12-month treatment period were examined using univariate and multivariate methods.
Nine-hundred five (905) patients taking sertraline, 492 on paroxetine, and 945 on fluoxetine met inclusion criteria. The groups were similar and representative with respect to gender and age. Mean dose over the 12-month treatment period increased 24%, indicating significant titration in all cohorts. Patients treated with paroxetine had shorter treatment duration (157.0 days) than did patients treated with fluoxetine (192.6 days) or sertraline (166.9 days, P < 0.001). Patients receiving index treatment with paroxetine were most likely to switch to another SSRI (21.3%); those taking sertraline were second most likely to switch (16.1%); and those on fluoxetine were least likely (12.4%, P = 0.001). Mean costs for depression-related outpatient visits and hospitalizations were similar. Mean antidepressant prescription costs differed, being $586, $419, and $446 for fluoxetine, paroxetine and sertraline cohorts, respectively (P < 0.001). In this sample, the fluoxetine cohort did not have lower nonpharmaceutical healthcare costs to offset higher pharmaceutical acquisition costs. Conclusions from median and multivariate analyses were robust to these findings.
During this study period when fluoxetine, paroxetine, and sertraline were all well-established agents, similar depression-related treatment courses and cost characteristics among all 3 drugs were observed.
Since conventional randomized clinical trials often do not reflect the real world circumstances of prescribing behavior and patient outcomes, the use of retrospective administrative claims databases ...(RACD) has become more common in treatment cost comparisons among alternative pharmaceutical compounds. Several recent RACD studies have compared treatment costs for depressed patients prescribed SSRIs such as fluoxetine, sertraline and paroxetine. These cost comparisons have reached mixed conclusions. To begin to explain and reconcile the mixed SSRI cost comparison evidence, we undertake a variety of alternative multivariate analyses using a publicly available RACD.
The 1995 to 1996 data encompasses a time period when all three SSRIs had become well-established agents. We report and compare results from multivariate linear regressions, logistic regressions, ordered probits and sample selectivity models, and examine robustness when adjustments are made for outlier observations and skewed distributions.
While choice of initial SSRI is nonrandom, the effect of sample selectivity on total depression-related and total health care expenditure is neutral across SSRIs. Although most cost measures are numerically greatest for fluoxetine, depression-related outpatient and hospitalization costs do not significantly differ by choice of initial SSRI. These findings are robust to alternative assumptions, specifications, and procedures. Antidepressant medication costs, however, are significantly higher when fluoxetine is the initial SSRI rather than sertraline or paroxetine, reflecting the larger proportion of fluoxetine patients prescribed a daily dosage of two or more capsules. Both total depression-related and total health care log–transformed costs are significantly lower for sertraline than fluoxetine.
The complete 5.4 kton MINOS far detector has been taking data since the beginning of August 2003 at a depth of 2070 meters water-equivalent in the Soudan mine, Minnesota. This paper presents the ...first MINOS observations of muon neutrino and muon anti-neutrino charged-current atmospheric neutrino interactions based on an exposure of 418 days. The ratio of upward to downward-going events in the data is compared to the Monte Carlo expectation in the absence of neutrino oscillations giving: R_data(up/down)/R_MC(up/down) = 0.62^{+0.19}_{-0.14} (stat.) +- 0.02 (sys.). An extended maximum likelihood analysis of the observed L/E distributions excludes the null hypothesis of no neutrino oscillations at the 98 % confidence level. Using the curvature of the observed muons in the 1.3 T MINOS magnetic field muon neutrino and muon anti-neutrino interactions are separated. The ratio of muon neutrino to muon anti-neutrino events in the data is compared to the Monte Carlo expectation assuming neutrinos and anti-neutrinos oscillate in same manner giving: R_data(numubar/numu)/R_MC(numubar/numu) = 0.96^{+0.38}_{-0.27} (stat.) +- 0.15 (sys.), where the errors are the statistical and systematic uncertainties. Although the statistics are limited, this is the first direct observation of atmospheric neutrino interactions separately for muon neutrinos and muon anti-neutrinos.
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