Identification of grain shape determining genes can facilitate breeding of rice cultivars with optimal grain shape and appearance quality. Here, we identify GS9 (Grain Shape Gene on Chromosome 9) ...gene by map-based cloning. The gs9 null mutant has slender grains, while overexpression GS9 results in round grains. GS9 encodes a protein without known conserved functional domain. It regulates grain shape by altering cell division. The interaction of GS9 and ovate family proteins OsOFP14 and OsOFP8 is modulated by OsGSK2 kinase, a key regulator of the brassinosteroids signaling pathway. Genetic interaction analysis reveals that GS9 functions independently from other previously identified grain size genes. Introducing the gs9 allele into elite rice cultivars significantly improves grain shape and appearance quality. It suggests potential application of gs9, alone or in combination with other grain size determining genes, in breeding of rice varieties with optimized grain shape.
Necroptosis plays an essential role in acute kidney injury and is mediated by receptor-interacting protein kinase 1 (RIPK1), receptor-interacting protein kinase 3 (RIPK3), and mixed lineage kinase ...domain-like pseudokinase (MLKL). A novel RIPK3 inhibitor, compound 42 (Cpd-42) alleviates the systemic inflammatory response. The current study was designed to investigate whether Cpd-42 exhibits protective effects on acute kidney injury and reveal the underlying mechanisms.
The effects of Cpd-42 were determined in vivo through cisplatin- and ischaemia/reperfusion (I/R)-induced acute kidney injury and in vitro through cisplatin- and hypoxia/re-oxygenation (H/R)-induced cell damage. Transmission electron microscopy and periodic acid-Schiff staining were used to identify renal pathology. Cellular thermal shift assay and RIPK3-knockout mouse renal tubule epithelial cells were used to explore the relationship between Cpd-42 and RIPK3. Molecular docking and site-directed mutagenesis were used to determine the binding site of RIPK3 with Cpd-42.
Cpd-42 reduced human proximal tubule epithelial cell line (HK-2) cell damage, necroptosis and inflammatory responses in vitro. Furthermore, in vivo, cisplatin- and I/R-induced acute kidney injury was alleviated by Cpd-42 treatment. Cpd-42 inhibited necroptosis by interacting with two key hydrogen bonds of RIPK3 at Thr94 and Ser146, which further blocked the phosphorylation of RIPK3 and mitigated acute kidney injury.
Acting as a novel RIPK3 inhibitor, Cpd-42 reduced kidney damage, inflammatory response and necroptosis in acute kidney injury by binding to sites Thr94 and Ser146 on RIPK3. Cpd-42 could be a promising treatment for acute kidney injury.
I document a U-shaped pattern of distress risk across accrual portfolios. The lack of close substitutes in the extreme accrual stocks is likely to create barriers to arbitrage away the accrual ...mispricing. I find that the profits of the accrual trading strategies are mostly concentrated in firms with high default probability. The effect of distress risk on accrual anomaly is not subsumed by previously documented cross-sectional characteristics, and also holds in various market states and subsamples. Furthermore, I show that firms with high distress risk not only exhibit lower institutional ownership but also have higher institutional concentration. These findings provide a possible justification for why the accrual strategy is more profitable for firms with higher distress risk, and suggest that the distress-based accrual strategy can be explained by the limits-to-arbitrage story.
Abstract
Although the CoSb
3
-based skutterudite thermoelectric devices have been highly expected for wide uses such as waste heat recovery and space power supply, the limited long-term service ...stability majorly determined by the degradation of electrode interface obstructs its applications. Here, we built up an effective criterion for screening barrier layer based on the combination of negative interfacial reaction energy and high activation energy barrier of Sb migration through the formed interfacial reaction layer. Accordingly, we predicted niobium as a promising barrier layer. The experimental results show the skutterudite/Nb joint has the slowest interfacial reaction layer growth rate and smallest interfacial electrical resistivity. The fabricated 8-pair skutterudite module using Nb as barrier layer achieves a recorded conversion efficiency of 10.2% at hot-side temperature of 872 K and shows excellent stability during long-time aging. This simple criterion provides an effective guidance on screening barrier layer with bonding-blocking-conducting synergetic functions for thermoelectric device integration.
The radiation of electromagnetic and mechanical waves depends not only on the intrinsic properties of the emitter but also on the surrounding environment. This principle has laid the foundation for ...the development of lasers, quantum optics, sonar, musical instruments and other fields related to wave–matter interaction. In the conventional wisdom, the environment is defined exclusively by its eigenstates, and an emitter radiates into and interacts with these eigenstates. Here we show experimentally that this scenario breaks down at a non-Hermitian degeneracy known as an exceptional point. We find a chirality-reversal phenomenon in a ring cavity where the radiation field reveals the missing dimension of the Hilbert space, known as the Jordan vector. This phenomenon demonstrates that the radiation field of an emitter can become fully decoupled from the eigenstates of its environment. The generality of this striking phenomenon in wave–matter interaction is experimentally confirmed in both electromagnetic and acoustic systems. Our finding transforms the fundamental understanding of light–matter interaction and wave–matter interaction in general, and enriches the intriguing physics of exceptional points.The modes of the radiation field generated from an emitter are usually determined by the eigenstates of the surrounding environment. However, this scenario breaks down in a non-Hermitian system, at the spectral degeneracy known as an exceptional point.
It is challenging for flexible solid‐state hybrid capacitors to achieve high‐energy‐high‐power densities in both Li‐ion and Na‐ion systems, and the kinetics discrepancy between the sluggish faradaic ...anode and the rapid capacitive cathode is the most critical issue needs to be addressed. To improve Li‐ion/Na‐ion diffusion kinetics, flexible oxygen‐deficient TiO2−x/CNT composite film with ultrafast electron/ion transport network is constructed as self‐supported and light‐weight anode for a quasi‐solid‐state hybrid capacitor. It is found that the designed porous yolk–shell structure endows large surface area and provides short diffusion length, the oxygen‐deficient composite film can improve electrical conductivity, and enhance ion diffusion kinetic by introducing intercalation pseudocapacitance, therefore resulting in advance electrochemical properties. It exhibits high capacity, excellent rate performance, and long cycle life when utilized as self‐supported anodes for Li‐ion and Na‐ion batteries. When assembled with activated carbon/carbon nanotube (AC/CNT) flexible cathode, using ion conducting gel polymer as the electrolyte, high energy densities of 104 and 109 Wh kg−1 are achieved at 250 W kg−1 in quasi‐solid‐state Li‐ion and Na‐ion capacitors (LICs and SICs), respectively. Still, energy densities of 32 and 36 Wh kg−1 can be maintained at high power densities of 5000 W kg−1 in LICs and SICs.
The designed TiO2−x/CNT//AC/CNT hybrid capacitors integrate the advantages of (1) large surface area and short diffusion length, (2) enhanced Na‐ion diffusion kinetics and ultrafast ion/e− transport network, (3) flexible and light‐weight features, and (4) better safety from quasi‐solid‐state electrolyte, therefore maximum energy densities of 104 and 109 Wh kg−1 are achieved in Li‐ion and Na‐ion capacitors, respectively.
The introduction of metasurfaces has renewed the Snell's law and opened up new degrees of freedom to tailor the optical wavefront at will. Here, we theoretically demonstrate that the generalized ...Snell's law can be achieved for reflected acoustic waves based on ultrathin planar acoustic metasurfaces. The metasurfaces are constructed with eight units of a solid structure to provide discrete phase shifts covering the full 2π span with steps of π/4 by coiling up the space. By careful selection of the phase profiles in the transverse direction of the metasurfaces, some fascinating wavefront engineering phenomena are demonstrated, such as anomalous reflections, conversion of propagating waves into surface waves, planar aberration-free lens and nondiffracting Bessel beam generated by planar acoustic axicon. Our results could open up a new avenue for acoustic wavefront engineering and manipulations.
Sepsis-associated cerebral dysfunction is complex pathophysiology, generated from primary infections that are developed elsewhere in the body. The neonates, elderly population and chronically ill and ...long-term hospitalized patients are predominantly vulnerable to sepsis and related cerebral damage. Generally, electrophysiological recordings, severity and sedation scales, computerized imaging and spectroscopy techniques are used for its detection and diagnosis. About the underlying mechanisms, enhanced blood-brain barrier permeability and metalloprotease activity, tight junction protein loss and endothelial cell degeneration promote the influx of inflammatory and toxic mediators into the brain, triggering cerebrovascular damage. An altered neutrophil count and phenotype further dysregulate the normal neuroimmune responses and neuroendocrine stability via modulated activation of protein kinase C-delta, nuclear factor kappa-B and sphingolipid signaling. Glial activation, together with pro-inflammatory cytokines and chemokines and the Toll-like receptor, destabilize the immune system. Moreover, superoxides and hydroperoxides generate oxidative stress and perturb mitochondrial dynamics and ATP synthesis, propagating neuronal injury cycle. Activated mitochondrial apoptotic pathway, characterized by increased caspase-3 and caspase-9 cleavage and Bax/Bcl2 ratio in the hippocampal and cortical neurons, stimulate neurocognitive impairments. Additionally, altered LC3-II/I and P62/SQSTM1, p-mTOR, p-AMPK1 and p-ULK1 levels and dysregulated autophagosome-lysosome fusion decrease neuronal and glial energy homeostasis. The therapies and procedures for attenuating sepsis-induced brain damage include early resuscitation, cerebral blood flow autoregulation, implantable electric vagus nerve stimulation, antioxidants, statins, glucocorticoids, neuroimmune axis modulators and PKCδ inhibitors. The current review enumerates the pathophysiology of sepsis-induced brain damage, its diagnosis, the role of critical inducers and mediators and, ultimately, therapeutic measures attenuating cerebrovascular degeneration.
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