Higher‐order residual ionospheric errors in Global Navigation Satellite System (GNSS) radio occultation (RO) data can induce a systematic residual ionospheric bias (RIB) in RO bending angles, which ...can impact stratospheric climate monitoring. The main RIB causes are the ray path splitting of dual‐frequency GNSS signals, the electron density distribution along the ray path and at the RO receiver location, and the geomagnetic field. In this study, we investigate the ionospheric and geomagnetic effects on RO‐retrieved stratospheric bending angle and temperature profiles by inspecting the kappa and bi‐local RIB correction methods, the current state‐of‐the‐art methods, using multiple RO satellite mission data in different ionospheric and geomagnetic conditions. We find that, globally, the layer mean/median RIBs of the kappa and bi‐local correction methods exhibit similar behaviors for different RO missions: the estimated bending angle RIBs reach about −0.025/−0.01 and −0.024/−0.008 μrad in the upper (40–45 km) and lower (30–35 km) stratosphere, respectively, while the temperature RIBs reach about −1.0/−0.3 and −0.2/−0.1 K in these layers. However, in the equatorial day time region, the RIB statistics of the mission results diverge. Both the kappa and bi‐local RIBs increase in magnitude with increasing ionization and geomagnetic field strength but show no increase with an increasing degree of ionospheric asymmetry. Overall, the more refined bi‐local method has higher capacity than the comparatively simple kappa method to represent the variability of the ionospheric and geomagnetic conditions that affect RO events. This is important for regional‐scale studies, where the geomagnetic term can be of key relevance.
Key Points
Ionospheric, geomagnetic and orbit‐height effects play a role for ionospheric errors in radio occultation bending angle and temperature
Residual ionospheric biases (RIBs) in bending angle and temperature were modeled for these effects using the kappa and bi‐local methods
The kappa and bi‐local methods show larger RIBs for higher ionization and geomagnetic activity and clear deviations in equatorial daytime
Plant reproduction is influenced by the net outcome of plant-herbivore and plant-pollinator interactions. While both herbivore impacts and pollinator impacts on plant reproduction have been widely ...studied, few studies examine them in concert.
Here, we review the contemporary literature that examines the net outcomes of herbivory and pollination on plant reproduction and the impacts of herbivores on pollination through damage to shared host plants using systematic review tools. The direct or indirect effects of herbivores on floral tissue and reported mechanisms were compiled including the taxonomic breadth of herbivores, plants and pollinators.
A total of 4,304 studies were examined producing 59 relevant studies for synthesis that reported both pollinator and herbivore measures. A total of 49% of studies examined the impact of direct damage to floral tissue through partial florivory while 36% of studies also examined the impact of vegetative damage on pollination through folivory, root herbivory, and stem damage. Only three studies examined the effects of both direct and indirect damage to pollination outcomes within the same study.
It is not unreasonable to assume that plants often sustain simultaneous forms of damage to different tissues and that the net effects can be assessed through differences in reproductive output. Further research that controls for other relative drivers of reproductive output but examines more than one pathway of damage simultaneously will inform our understanding of the mechanistic relevance of herbivore impacts on pollination and also highlight interactions between herbivores and pollinators through plants. It is clear that herbivory can impact plant fitness through pollination; however, the relative importance of direct and indirect damage to floral tissue on plant reproduction is still largely unknown.
By misdirecting the activity of Activation-Induced Deaminase (AID) to a conditional
MYC transgene, we have achieved sporadic, AID-dependent
MYC activation in germinal center B cells of Vk
∗MYC mice. ...Whereas control C57BL/6 mice develop benign monoclonal gammopathy with age, all Vk
∗MYC mice progress to an indolent multiple myeloma associated with the biological and clinical features highly characteristic of the human disease. Furthermore, antigen-dependent myeloma could be induced by immunization with a T-dependent antigen. Consistent with these findings in mice, more frequent
MYC rearrangements, elevated levels of MYC mRNA, and
MYC target genes distinguish human patients with multiple myeloma from individuals with monoclonal gammopathy, implicating a causal role for
MYC in the progression of monoclonal gammopathy to multiple myeloma.
Electronic health record (EHR) data are underutilized for abstracting classification criteria for heart disease. We compared extraction of EHR data on troponin I and T levels with human abstraction.
...Using EHR for hospitalizations identified through the Atherosclerosis Risk in Communities (ARIC) Study in four US hospitals, we compared blood levels of troponins I and T extracted from EHR structured data elements with levels obtained through data abstraction by human abstractors to 3 decimal places. Observations were divided randomly 50/50 into training and validation sets. Bayesian multilevel logistic regression models were used to estimate agreement by hospital in first and maximum troponin levels, troponin assessment date, troponin upper limit of normal (ULN), and classification of troponin levels as normal (< ULN), equivocal (1-2× ULN), abnormal (>2× ULN), or missing.
Estimated overall agreement in first measured troponin level in the validation data was 88.2% (95% credible interval: 65.0%-97.5%) and 95.5% (91.2-98.2%) for the maximum troponin level observed during hospitalization. The largest variation in probability of agreement was for first troponin measured, which ranged from 66.4% to 95.8% among hospitals.
Extraction of maximum troponin values during a hospitalization from EHR structured data is feasible and accurate.
•Algorithmic extraction of troponin values from EHR is accurate.•Algorithmic protocols can accommodate serial troponin assessments.•Such information can be easily applied in diagnostic classification.
1. Parasites can affect the communities of their hosts; and hosts, in turn, shape communities of parasites and other symbionts. This makes host–symbiont relationships a key but often overlooked ...aspect of community ecology.
2. Mites associated with bees have a range of lifestyles; however, little is known about mites associated with wild bees or about factors influencing the make‐up of bee‐associated mite communities. This study investigated how mite communities associated with bumble bees (
Bombus
spp.) are shaped by the
Bombus
community and geographic proximity.
3. Bees were collected from 15 sites in Ontario, Canada, and examined for mites. Mite abundance and species richness increased with local bee abundance. Several bee species also differed in mite abundance, species richness, prevalence, and diversity. Locally uncommon species tended to have more mites than other bees. Queen bees had the most mites, and males had more mites than workers.
4. Spatial proximity was not a predictor of mite community composition, despite a strong effect of proximity on bee community similarity.
5. On the 11
Bombus
spp. examined, 33 mite species were found. Whereas nearly half of these mite species are obligate associates of bumble bees, none was restricted to particular
Bombus
species.
6. The best predictor of mite community composition was bee identity. Although many parasite communities show strong geographic patterns, the communities of primarily commensalistic bee‐mites in this study did not. These findings have implications for bumble bee conservation, given that pollen‐feeding commensals might become harmful at high densities or act as disease vectors.
•Insect-pollinated shrub Larrea tridentata increases the pollinator visitation to annuals.•The effect of Larrea tridentata on pollinator visitation is inconsistent between years.•Wind-pollinated ...shrub Ambrosia dumosa reduces the visitation duration of flies to annuals.•Surrounding annuals reduce the visitation duration of pollinators to the shrub Larrea tridentata.
The magnet species hypothesis proposes that flowering plants that are attractive to pollinators can increase the relative pollination rates of neighbouring plants by acting as ‘magnets.’ Here, we test the hypothesis that insect-pollinated shrub species Larrea tridentata and wind-pollinated shrub species Ambrosia dumosa act as magnets for the pollinator visitation of understory annual plant species in an arid ecosystem. As an extension to the magnet species hypothesis, we propose the double magnet species hypothesis in which we further test for reciprocity by the floral island created in the understory of the benefactor shrubs as an additional pollinator magnet for the shrub itself. We used an annual plant placed near each shrub and the open to measure the effect of shrubs on annuals. The double magnet species hypothesis was tested using L. tridentata with and without surrounding annuals. We measured pollinator visitation and visit duration using video and in-situ observation techniques to test whether shrubs increase pollinator visitation to understory annual plants, if insect-pollinated shrubs act as better pollinator magnets than wind-pollinated shrubs (to determine the effects of the floral resource itself), and whether shrubs with annuals in their understory have higher pollinator visitation rates relative to shrubs without annuals. We found that insect-pollinated shrubs increased the visitation rate and duration of visits by pollinators to their understory plants and that wind-pollinated shrubs decreased the duration of visits of some insect visitors, but these relationships varied between years. While the presence of annuals did not change the visitation rate of all possible pollinators to L. tridentata flowers, they did decrease the visitation duration of specifically bees, indicating a negative reciprocal effect of the understory on pollination. Thus, the concentrated floral resources of flowers on insect-pollinated shrubs can act as a magnet that attract pollinators but that in turn provide a cost to pollination of the shrub. However, while wind-pollinated shrubs may provide other benefits, they may provide a cost to the pollination of their understory. These findings support the magnet species hypothesis as an additional mechanism of facilitation by insect-pollinated shrubs to other plant species within arid ecosystems.
Dominant vegetation in many ecosystems is an integral component of structure and habitat. In many drylands, native shrubs function as foundation species that benefit other plants and animals. ...However, invasive exotic plant species can comprise a significant proportion of the vegetation. In Central California drylands, the facilitative shrub Ephedra californica and the invasive Bromus rubens are widely dispersed and common. Using comprehensive survey data structured by shrub and open gaps for the region, we compared network structure with and without this native shrub canopy and with and without the invasive brome. The presence of the invasive brome profoundly shifted the network measure of centrality in the microsites structured by a shrub canopy (centrality scores increased from 4.3 under shrubs without brome to 6.3, i.e. a relative increase of 42%). This strongly suggests that plant species such as brome can undermine the positive and stabilizing effects of native foundation plant species provided by shrubs in drylands by changing the frequency that the remaining species connect to one another. The net proportion of positive and negative associations was consistent across all microsites (approximately 50% with a total of 14% non-random co-occurrences on average) suggesting that these plant-plant networks are rewired but not more negative. Maintaining resilience in biodiversity thus needs to capitalize on protecting native shrubs whilst also controlling invasive grass species particularly when associated with shrubs.
ObjectivesUsing free-text clinical notes and reports from hospitalised patients, determine the performance of natural language processing (NLP) ascertainment of Framingham heart failure (HF) criteria ...and phenotype.Study designA retrospective observational study design of patients hospitalised in 2015 from four hospitals participating in the Atherosclerosis Risk in Communities (ARIC) study was used to determine NLP performance in the ascertainment of Framingham HF criteria and phenotype.SettingFour ARIC study hospitals, each representing an ARIC study region in the USA.ParticipantsA stratified random sample of hospitalisations identified using a broad range of International Classification of Disease, ninth revision, diagnostic codes indicative of an HF event and occurring during 2015 was drawn for this study. A randomly selected set of 394 hospitalisations was used as the derivation dataset and 406 hospitalisations was used as the validation dataset.InterventionUse of NLP on free-text clinical notes and reports to ascertain Framingham HF criteria and phenotype.Primary and secondary outcome measuresNLP performance as measured by sensitivity, specificity, positive-predictive value (PPV) and agreement in ascertainment of Framingham HF criteria and phenotype. Manual medical record review by trained ARIC abstractors was used as the reference standard.ResultsOverall, performance of NLP ascertainment of Framingham HF phenotype in the validation dataset was good, with 78.8%, 81.7%, 84.4% and 80.0% for sensitivity, specificity, PPV and agreement, respectively.ConclusionsBy decreasing the need for manual chart review, our results on the use of NLP to ascertain Framingham HF phenotype from free-text electronic health record data suggest that validated NLP technology holds the potential for significantly improving the feasibility and efficiency of conducting large-scale epidemiologic surveillance of HF prevalence and incidence.
Positive interactions enhance biodiversity and ecosystem function, but can also exacerbate biological invasions. Facilitation of exotic invaders by exotic foundation species (invasional meltdown) has ...been studied extensively, but facilitation of exotic invaders by native foundation species has attracted less attention. Specifically, very few studies have examined the extent that native foundation species facilitate native and exotic competitors. Understanding the processes that mediate interactions between native and exotic species can help explain, predict, and improve management of biological invasions. Here, we examined the effects of native foundation shrubs on the relative abundance of the annual plant community – including native and exotic taxa – from 2015–2018 in a desert ecosystem at Carrizo Plain National Monument, California, USA (elevation: 723 m). Shrub effects varied by year and by the identity of annual species, but shrubs consistently enhanced the abundance of the annual plant community and facilitated both native (n=17 species) and exotic (n=4 species) taxa. However, at the provenance level, exotic annuals were facilitated 2.75 times stronger in abundance than native annuals, and exotic annuals were always more abundant than natives both near and away from shrubs. Our study reaffirms facilitation as an important process in the organisation of plant communities and confirms that both native and exotic species can form positive associations with native foundation species. However, facilitation by native foundation species can exacerbate biological invasions by increasing the local abundance of exotic invaders. Thus, the force of facilitation can have a dark side relevant to ecosystem function and management.