•Successful experimental demonstration of VMAT combined with MRI-guided MLC tracking.•MLC tracking on the MR-linac has clear dosimetric advantages for lung SBRT.•Novel time-resolved and motion ...included pseudo-3D MR-linac dosimetry setup.
VMAT is not currently available on MR-linacs but could maximize plan conformality. To mitigate respiration without compromising delivery efficiency, MRI-guided MLC tumour tracking was recently developed for the 1.5 T Unity MR-linac (Elekta AB, Stockholm, Sweden) in combination with IMRT. Here, we provide a first experimental demonstration of VMAT + MLC tracking for several lung SBRT indications.
We created central patient and phantom VMAT plans (8×7.5 Gy, 2 arcs) and we created peripheral phantom plans (3×18 & 1×34 Gy, 4 arcs). A motion phantom mimicked subject-recorded respiratory motion (A‾=11 mm, f‾=0.33 Hz, drift‾=0.3 mm/min). This was monitored using 2D-cine MRI at 4 Hz to continuously realign the beam with the target. VMAT + MLC tracking performance was evaluated using 2D film dosimetry and a novel motion-encoded and time-resolved pseudo-3D dosimetry approach.
We found an MLC leaf and jaw end-to-end latency of 328.05(±3.78) ms and 317.33(±4.64) ms, which was mitigated by a predictor. The VMAT plans required maximum MLC speeds of 12.1 cm/s and MLC tracking superimposed an additional 1.48 cm/s. A local 2%/1 mm gamma analysis with a static measurement as reference, revealed pass-rates of 28–46% without MLC tracking and 88–100% with MLC tracking for the 2D film analysis. Similarly, the pseudo-3D gamma passing-rates increased from 22–77% to 92–100%. The dose area histograms showed that MLC tracking increased the GTV D98% by 5–20% and the PTV D95% by 7–24%, giving similar target coverage as their respective static reference.
MRI-guided VMAT + MLC tracking is technically feasible on the MR-linac and results in highly conformal dose distribution.
Purpose
The treatment margins for lung stereotactic body radiotherapy (SBRT) are often large to cover the tumor excursions resulting from respiration, such that underdosage of the tumor can be ...avoided. Magnetic resonance imaging (MRI)‐guided multi‐leaf collimator (MLC) tracking can potentially reduce the influence of respiration to allow for smaller treatment margins. However, tracking is accompanied by system latency that may induce residual tracking errors. Alternatively, a simpler mid‐position delivery combined with trailing can be used. Trailing reduces influences of respiration by compensating for baseline motion, to potentially improve target coverage. In this study, we aim to show the feasibility of MRI‐guided tracking and trailing to reduce influences of respiration during lung SBRT.
Methods
We implemented MRI‐guided tracking on the MR‐linac using an Elekta research tracking interface to track tumor motion during intensity modulated radiotherapy (IMRT). A Quasar MRI4D phantom was used to generate Lujan motion (cos4, 4 s period, 20 mm peak‐to‐peak amplitude) with and without 1.0 mm/min cranial drift. Phantom tumor positions were estimated from sagittal 2D cine‐MRI (4 or 8 Hz) using cross‐correlation‐based template matching. To compensate the anticipated system latency, a linear ridge regression predictor was optimized for online MRI by comparing two predictor training approaches: training on multiple traces and training on a single trace. We created 15‐beam clinical‐grade lung SBRT plans for central targets (8 × 7.5 Gy) and peripheral targets (3 × 18 Gy) with different PTV margins for mid‐position based motion management (3–5 mm) and for MLC tracking (3 mm). We used a film insert with a 3 cm spherical target to measure the spatial distribution and quantity of the delivered dose. A 1%/1 mm local gamma‐analysis quantified dose differences between motion management strategies and reference cases. Additionally, a dose area histogram (DAH) revealed the target coverage relative to the reference scenario.
Results
The prediction filter gain was on average 25% when trained on multiple traces and 44% when trained on a single trace. The filter reduced system latency from 313 ± 2 ms to 0 ± 5 ms for 4 Hz imaging and from 215 ± 3 ms to 3 ± 3 ms for 8 Hz. The local gamma analysis for the central delivery showed that tracking improved the gamma pass‐rate from 23% to 96% for periodic motion and from 14% to 93% when baseline drift was applied. For the peripheral delivery during periodic motion, delivery pass‐rates improved from 22% to 93%. Comparing mid‐position delivery to trailing for periodic+drift motion increased the local gamma pass rate from 15% to 98% for a central delivery and from 8% to 98% for a peripheral delivery. Furthermore, the DAHs revealed a relative D98% GTV coverage of 101% and 97% compared to the reference scenario for, respectively, central and peripheral tracking of periodic+drift motion. For trailing, a relative D98% of 99% for central and 98% for peripheral trailing was found.
Conclusions
We provided a first experimental demonstration of the technical feasibility of MRI‐guided MLC tracking and trailing for central and peripheral lung SBRT. Tracking maximizes the sparing of healthy tissue, while trailing is highly effective in mitigating baseline motion.
•5 patients with pelvic lymph node metastases received SBRT using a 1.5 T MR-linac.•Session time was <60 min for all 25 treatment fractions.•All quality assurance tests were passed (dose calculations ...& film measurements).
Online adaptive radiotherapy using the 1.5 Tesla MR-linac is feasible for SBRT (5 × 7 Gy) of pelvic lymph node oligometastases. The workflow allows full online planning based on daily anatomy. Session duration is less than 60 min. Quality assurance tests, including independent 3D dose calculations and film measurements were passed.
Curative-intent radiotherapy plays an integral role in the treatment of lung cancer and therefore improving its therapeutic index is vital. MR guided radiotherapy (MRgRT) systems are the latest ...technological advance which may help with achieving this aim. The majority of MRgRT treatments delivered to date have been stereotactic body radiation therapy (SBRT) based and include the treatment of (ultra-) central tumors. However, there is a move to also implement MRgRT as curative-intent treatment for patients with inoperable locally advanced NSCLC. This paper presents the initial clinical experience of using the two commercially available systems to date: the ViewRay MRIdian and Elekta Unity. The challenges and potential solutions associated with MRgRT in lung cancer will also be highlighted.
The out-of-field surface dose contribution due to backscattered or ejected electrons, focused by the magnetic field, is evaluated in this work. This electron streaming effect (ESE) can contribute to ...out-of-field skin doses in orthogonal magnetic resonance guided radiation therapy machines. Using the EGSnrc Monte Carlo package, a phantom is set-up along the central axis of an incident 10 10 cm2 7 MV FFF photon beam. The phantom exit or entry surface is inclined with respect to the magnetic field, and an out-of-field water panel is positioned 10 cm away from, and centered on, the isocenter. The doses from streaming backscattered or ejected electrons, for either a 0.35 T or 1.5 T magnetic field, are evaluated in the out-of-field water panel for surface inclines of 10, 30, and 45°. The magnetic field focuses electrons emitted from the inclined phantom. Dose distributions at the surface of the out-of-field water panel are sharper in the 1.5 T magnetic field as compared to 0.35 T. The maximum doses for the 0.35 T simulations are 23.2%, 37.8%, and 39.0% for the respective 10, 30, and 45° simulations. For 1.5 T, for the same angles, the maximum values are 17.1%, 29.8%, and 35.8%. Dose values drop to below 2% within the first 1 cm of the out-of-field water phantom. The phantom thickness is an important variable in the magnitude of the ESE dose. The ESE can produce large out-of-field skin doses and must be a consideration in treatment planning in the MRgRT work-flow. Treatments often include multiple beams which will serve to spread out the effect, and many beams, such as anterior-posterior, will reduce the skin dose due to the ESE. A 1 cm thick shielding of either a bolus placed on the patient or mounted on the present RF coils would greatly reduce the ESE dose contributions. Further exploration of the capabilities of treatment planning systems to screen for this effect is required.
•First treatments with active motion management on a 1.5 T MR-Linac.•Image-based target tracking for gating and tumor drift correction.•Motion management improved congruence to planned dose.
This ...work reports on the first seven patients treated with gating and baseline drift correction on the high-field MR-Linac system. Dosimetric analysis showed that the active motion management system improved congruence to the planned dose, efficiently mitigating detrimental effects of intrafraction motion in the upper abdomen.
Purpose
The purpose of this study was to evaluate the potential skin dose toxicity contribution of spiralling contaminant electrons (SCE) generated in the air in an MR‐linac with a 0.35 or 1.5 T ...magnetic field using the EGSnrc Monte Carlo (MC) code. Comparisons to experimental results at 1.5 T are also performed.
Methods
An Elekta generated phase space file for the Unity MR‐linac is used in conjunction with the EGSnrc enhanced electric and magnetic field transport macros to simulate surface dose profiles and depth‐dose curves in panels located 5 cm away from the beam edge and positioned either parallel or perpendicular to the magnetic field. Electrons generated in the air will spiral along the magnetic field lines, and though surface doses within the field will be reduced, the electrons can contribute to out‐of‐field surface doses.
Results
Surface dose profiles showed good agreement with experimental findings and the maximum simulated doses at surfaces perpendicular to the magnetic field were 3.77 ± 0.01% and 3.55 ± 0.01% for 1.5 and 0.35 T. These results are expressed as a percentage of the maximum dose to water delivered by the photon beam. The surface dose variations in the out‐of‐field region converge to the 0 T doses within the first 0.5 cm of material. An asymmetry in the dose distribution in surfaces positioned on either side of the photon beam and aligned parallel to the magnetic field is determined to be due to the magnetic field directing electrons deeper into, or localizing them to the surface of, the measurement panel.
Conclusions
These results confirm the SCE dose contribution in surfaces perpendicular to the magnetic field and show these doses to be of the order of a few percentage of the maximum dose to water of the beam. Good agreement in the dose profiles is seen in comparisons between the MC simulations and experimental work. The effect is apparent in 0.35 and 1.5 T magnetic fields and dissipates within the first few millimeters of material. It should be noted that only SCEs from beam anteriorly incident on the patient will influence the patient surface dose, and the use of beams incident over different angles will reduce the dose to any particular patient surface.
The lack of radiation-attenuating tuning capacitors in high impedance coils (HICs) make HICs an interesting building block of receive arrays for MRI-guided radiotherapy (MRIgRT). Additionally, their ...flexibility and limited channel coupling allow for low-density support materials, which are likely to be more radiation transparent (radiolucent). In this work, we introduce the use of HICs in receive arrays for MRIgRT treatments. We discuss the design and show the dosimetric feasibility of a HIC receive array that has a high channel count and aims to improve the imaging performance of the 1.5 T MR-linac. Our on-body design comprises an anterior and posterior element, which each feature a channel layout (32 channels total). The anterior element is flexible, while the posterior element is rigid to support the patient. Mockups consisting of support materials and conductors were built, irradiated, and optimized to minimize impact on the surface dose (7% of the dose maximum) and dose at depth (0.8% under a single conductor and 1.4% under a conductor crossing). Anatomical motion and the use of multiple beam angles will ensure that these slight dose changes at depth are clinically insignificant. Subsequently, several functional, single-channel HIC imaging prototypes and a 5-channel array were built to assess the performance in terms of signal-to-noise ratio (SNR). The performance was compared to the clinical MR-linac array and showed that the 5-channel imaging prototype outperformed the clinical array in terms of SNR and channel coupling. Imaging performance was not affected by the radiation beam. In conclusion, the use of HICs allowed for the design of our flexible, on-body receive array for MRIgRT. The design was shown to be dosimetrically feasible and improved the SNR. Future research with a full array will need to show the gain in parallel imaging performance and thus acceleration.
•Magnetic resonance guided intrafraction drift correction was researched.•Target coverage benefits of intrafraction adaptation methods were shown.•Two adaptation methods both showed a median target ...coverage of 100.0% for 55 fractions.•The experimental results verified the new method with a gamma passing rate of 99.1%.
MRI-guided online adaptive treatments can account for interfractional variations, however intrafraction motion reduces treatment accuracy. Intrafraction plan adaptation methods, such as the Intrafraction Drift Correction (IDC) or sub-fractionation, are needed. IDC uses real-time automatic monitoring of the tumor position to initiate plan adaptations by repositioning segments. IDC is a fast adaptation method that occurs only when necessary and this method could enable margin reduction. This research provides a treatment planning evaluation and experimental validation of the IDC.
An in silico treatment planning evaluation was performed for 13 prostate patients mid-treatment without and with intrafraction plan adaptation (IDC and sub-fractionation). The adaptation methods were evaluated using dose volume histogram (DVH) metrics. To experimentally verify IDC a treatment was mimicked whereby a motion phantom containing an EBT3 film moved mid-treatment, followed by repositioning of segments. In addition, the delivered treatment was irradiated on a diode array phantom for plan quality assurance purposes.
The planning study showed benefits for using intrafraction adaptation methods relative to no adaptation, where the IDC and sub-fractionation showed consistently improved target coverage with median target coverages of 100.0%. The experimental results verified the IDC with high minimum gamma passing rates of 99.1% and small mean dose deviations of maximum 0.3%.
The straightforward and fast IDC technique showed DVH metrics consistent with the sub-fractionation method using segment weight re-optimization for prostate patients. The dosimetric and geometric accuracy was shown for a full IDC workflow using film and diode array dosimetry.
Background
Lung stereotactic body radiotherapy (SBRT) has proven an effective treatment for medically inoperable lung tumors, even for (ultra‐)central tumors. Recently, there has been growing ...interest in radiation‐induced cardiac toxicity in lung radiotherapy. More specifically, dose to cardiac (sub‐)structures (CS) was found to correlate with survival after radiotherapy.
Purpose
Our goal is first, to investigate the percentage of patients who require CS sparing in an magnetic resonance imaging guided lung SBRT workflow, and second, to quantify how successful implementation of cardiac sparing would be.
Methods
The patient cohort consists of 34 patients with stage II–IV lung cancer who were treated with SBRT between 2017 and 2020. A mid‐position computed tomography (CT) image was used to create treatment plans for the 1.5 T Unity MR‐linac (Elekta AB, Stockholm, Sweden) following clinical templates. Under guidance of a cardio‐thoracic radiologist, 11 CS were contoured manually for each patient. Dose constraints for five CS were extracted from the literature. Patients were stratified according to their need for cardiac sparing depending on the CS dose in their non‐CS constrained MR‐linac treatment plans. Cardiac sparing treatment plans (CSPs) were then created and dosimetrically compared with their non‐CS constrained treatment plan counterparts. CSPs complied with the departmental constraints and were considered successful when fulfilling all CS constraints, and partially successful if some CS constraints could be fulfilled. Predictors for the need for and feasibility of cardiac sparing were explored, specifically planning target volume (PTV) size, cranio‐caudal (CC) distance, 3D distance, and in‐field overlap volume histograms (iOVH).
Results
47% of the patients (16 out of 34) were in need of cardiac sparing. A successful CSP could be created for 62.5% (10 out of 16) of these patients. Partially successful CSPs still complied with two to four CS constraints. No significant difference in dose to organs at risk (OARs) or targets was identified between CSPs and the corresponding non‐CS constrained MR‐linac plans. The need for cardiac sparing was found to correlate with distance in the CC direction between target and all of the individual CS (Mann–Whitney U‐test p‐values <10−6). iOVHs revealed that complying with dose constraints for CS is primarily determined by in‐plane distance and secondarily by PTV size.
Conclusion
We demonstrated that CS can be successfully spared in lung SBRT on the MR‐linac for most of this patient cohort, without compromising doses to the tumor or to other OARs. CC distance between the target and CS can be used to predict the need for cardiac sparing. iOVHs, in combination with PTV size, can be used to predict if cardiac sparing will be successful for all constrained CS except the left ventricle.
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