C-Reactive Protein Gene Polymorphisms, C-Reactive Protein Blood Levels, and Cardiovascular Disease Risk Fadi G. Hage, Alexander J. Szalai C-reactive protein (CRP) is a powerful predictor of ...cardiovascular event risk in the general population. We review what is known about CRP gene polymorphisms, discuss how these might affect the epidemiology of CRP and our understanding of CRP’s contribution to cardiovascular disease, and examine their potential clinical usefulness. Certain variations in the CRP gene sequence, mostly single nucleotide polymorphisms, predictably and strongly influence the blood level of CRP. Some of these are associated with clinical correlates of cardiovascular disease. If future studies can establish with certainty that CRP influences cardiovascular biology, then CRP gene profiling could have clinical utility.
Author Affiliation: (1) Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Lyons Harrison Research Building 306, 701 19th Street South, 35294, ...Birmingham, AL, USA (2) Section of Cardiology, Birmingham Veterans Affairs Medical Center, Birmingham, AL, USA (a) fadihage@uab.edu Article History: Registration Date: 07/06/2019 Received Date: 07/02/2019 Accepted Date: 07/03/2019 Online Date: 07/26/2019 Byline:
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