Nuclear physics research at CENS Ahn, S.; Ahn, D. S.; Kim, S. ...
Journal of the Korean Physical Society,
03/2023, Letnik:
82, Številka:
6
Journal Article
Recenzirano
Understanding fundamental interactions of elementary particles is a long sought goal of nuclear physics study. Nuclear theorists recently estimated about 4000 nuclei are still unknown and their ...structures and reaction mechanisms need to be studied by both experiment and theory. The nuclear properties are also important to find the origin of elements in the Universe. The Center for Exotic Nuclear Studies (CENS) at the Institute for Basic Science was founded to address such fundamental problems in astrophysics and nuclear physics. In this paper, the latest research activities at CENS is highlighted and the status of experimental device developments performed by the center is reported.
Hard-scattered parton probes produced in collisions of large nuclei indicate large partonic energy loss, possibly with collective produced-medium response to the lost energy. We present measurements ...of π^{0} trigger particles at transverse momenta p{T}{t}=4-12 GeV/c and associated charged hadrons (p{T}{a}=0.5-7 GeV/c) vs relative azimuthal angle Δϕ in Au+Au and p+p collisions at sqrts{NN}=200 GeV. The Au+Au distribution at low p{T}{a}, whose shape has been interpreted as a medium effect, is modified for p{T}{t}<7 GeV/c. At higher p{T}{t}, the data are consistent with unmodified or very weakly modified shapes, even for the lowest measured p{T}{a}, which quantitatively challenges some medium response models. The associated yield of hadrons opposing the trigger particle in Au+Au relative to p+p (I{AA}) is suppressed at high p{T} (I{AA}≈0.35-0.5), but less than for inclusive suppression (R{AA}≈0.2).
Experimental studies of the collisions of heavy nuclei at relativistic energies have established the properties of the quark–gluon plasma (QGP), a state of hot, dense nuclear matter in which quarks ...and gluons are not bound into hadrons1–4. In this state, matter behaves as a nearly inviscid fluid5 that efficiently translates initial spatial anisotropies into correlated momentum anisotropies among the particles produced, creating a common velocity field pattern known as collective flow. In recent years, comparable momentum anisotropies have been measured in small-system proton–proton (p+p) and proton–nucleus (p+A) collisions, despite expectations that the volume and lifetime of the medium produced would be too small to form a QGP. Here we report on the observation of elliptic and triangular flow patterns of charged particles produced in proton–gold (p+Au), deuteron–gold (d+Au) and helium–gold (3He+Au) collisions at a nucleon–nucleon centre-of-mass energy \\sqrt {s_{{\mathrm{NN}}}\ = 200 GeV. The unique combination of three distinct initial geometries and two flow patterns provides unprecedented model discrimination. Hydrodynamical models, which include the formation of a short-lived QGP droplet, provide the best simultaneous description of these measurements.
Glucagon-like peptide-1 (GLP-1) and its analog exendin-4 (EX) have been considered as a growth factor implicated in pancreatic islet mass increase and beta-cell proliferation. This study aimed to ...investigate the effect of EX on cyclin D1 expression, a key regulator of the cell cycle, in the pancreatic beta-cell line INS-1. We demonstrated that EX significantly increased cyclin D1 mRNA and subsequently its protein levels. Although EX induced phosphorylation of Raf-1 and extracellular-signal-regulated kinase (ERK), both PD98059 and exogenous ERK1 had no effect on the cyclin D1 induction by EX. Instead, the cAMP-elevating agent forskolin induced cyclin D1 expression remarkably and this response was inhibited by pretreatment with H-89, a protein kinase A (PKA) inhibitor. Promoter analyses revealed that the cAMP-responsive element (CRE) site (at position -48; 5'-TAACGTCA-3') of cyclin D1 gene was required for both basal and EX-induced activation of the cyclin D1 promoter, which was confirmed by site-directed mutagenesis study. For EX to activate the cyclin D1 promoter effectively, CRE-binding protein (CREB) should be phosphorylated and bound to the putative CRE site, according to the results of electrophoretic mobility shift and chromatin immunoprecipitation assays. Lastly, a transfection assay employing constitutively active or dominant-negative CREB expression plasmids clearly demonstrated that CREB was largely involved in both basal and EX-induced cyclin D1 promoter activities. Taken together, EX-induced cyclin D1 expression is largely dependent on the cAMP/PKA signaling pathway, and EX increases the level of phosphorylated CREB and more potently trans-activates cyclin D1 gene through binding of the CREB to the putative CRE site, implicating a potential mechanism underlying beta-cell proliferation by EX.
Within the SEASTAR III campaign at the Radioactive Isotope Beam Factory, at the RIKEN Nishina Center, neutron-rich isotopes in the vicinity of 53K were produced from the fragmentation of the primary ...70Zn beam on a 9Be target. After nucleon knockout reactions on the secondary liquid hydrogen MINOS target the known γ rays of the neutron-rich 55Sc isotope were observed (shown in this proceedings) and γ rays from 57,59Sc isotopes have been identified for the first time. The evolution of the occupied nucleon orbitals of these nuclei in the ground and excited state is investigated under the prism of the tensor force.
The aim of this study was to investigate the effect of exendin-4 on the expression of cyclin D1 gene (Ccnd1), which is critical in regulating the progression of the cell cycle in INS-1 cells.
INS-1 ...cells were stimulated with exendin-4 (10 nmol/l). Transient transfection and luciferase reporter assays were performed to measure promoter activities of rat Ccnd1. Electrophoretic mobility shift and chromatin immunoprecipitation assays were used to examine the binding of transcription factors to sites responsive to exendin-4 in vitro and in vivo, respectively.
Exendin-4 increased both Ccnd1 mRNA and its protein levels in a time-dependent manner. The region from -174 to +130 of the promoter was found to contain cis-regulatory elements responsible for exendin-4-mediated gene induction. Early growth response-1 (EGR1) protein was bound to the region from -153 to -134, which includes the putative EGR1 binding site (5'-CACCCCCGC-3'). Moreover, exendin-4 recruited EGR1 protein to the promoter in vivo.
These findings suggest that exendin-4 activates Ccnd1 transcription through induction of EGR1 binding to a cis-regulatory element between -153 and -134 on the rat Ccnd1 promoter. These results provide an important indication that exendin-4 is a growth factor regulating beta cell proliferation.
Nuclear astrophysics is an interdisciplinary research field of nuclear physics and astrophysics, seeking for the answer to a question, how to understand the evolution of the universe with the nuclear ...processes which we learn. We review the research activities of nuclear astrophysics in east and southeast Asia which includes astronomy, experimental and theoretical nuclear physics, and astrophysics. Several hot topics such as the Li problems, critical nuclear reactions and properties in stars, properties of dense matter, r-process nucleosynthesis, and
ν
-process nucleosynthesis are chosen and discussed in further details. Some future Asian facilities, together with physics perspectives, are introduced.
The
α
resonant scattering on
18
Ne was measured in inverse kinematics to understand the
α
-clustering of proton-rich
22
Mg nucleus, performed at the CNS Radio-Isotope Beam Separator (CRIB) of Center ...for Nuclear Study, University of Tokyo, located at the RIBF of RIKEN Nishina Center. The excitation function of
22
Mg was obtained for the excitation energies of 10–16 MeV by adopting the thick-target method. Several resonances were evident in the present work, which implies the existence of energy levels with large
α
widths. Since energy levels were not clearly observed at the astrophysically important energy range, upper limits on the
18
Ne (
α
,
α
)
18
Ne cross section were set. The astrophysical impact was also investigated by estimating the
18
Ne (
α
,
p
)
21
Na cross section.
Lifetime measurement of the 26 0 g.s. at SAMURAI Storck, S; Caesar, C; Kahlbow, J ...
27th International Nuclear Physics Conference, INPC 2019, Glasgow, United Kingdom,
12/2020, Letnik:
1643, Številka:
1
Journal Article, Conference Proceeding
Recenzirano
Odprti dostop
Abstract
The ground state of the neutron unbound nucleus
26
O is speculated to have a lifetime in the pico-second regime. In order to determine the decay lifetime of the
26
O ground state with high ...sensitivity and precision, a new method has been applied. The experiment was performed in December 2016 at the Superconducting Analyzer for MUlti-particle from Radio Isotope Beams (SAMURAI) at the Radioactive Isotope Beam Factory (RIBF) at RIKEN. A
27
F beam was produced in the fragment separator BigRIPS and impinged on a W/Pt target
26
O
26
O
outside the target. Thus, the velocity difference between the decay neutrons and the fragment 1 O delivers a characteristic spectrum from which the lifetime can be extracted.
The Wien filter is one of the key components in ion optics to improve the mass separation performance. The KoBRA Wien filter will be installed at the low-energy beamline KoBRA of RAON in Korea. The ...specifications of the KoBRA Wien filter were determined based on the ion beams expected in the KoBRA beamline, especially, beam energies less than about 5 MeV/nucleon suitable for nuclear astrophysics experiments. The Wien filter is designed to have the maximum field intensities of 0.2 T for the magnetic field and 2.0 kV/mm for the electric field in the ±75(H)×±50(V)×2500(L)mm3 good-field region. Performance of the Wien filter was estimated by the ion optics calculations of the KoBRA beamline for 40Ar beams at 18.5 MeV/nucleon and 14O beams at 2.5 MeV/nucleon. The mass resolving powers are 42.65 and 517, respectively. Currently, the KoBRA Wien filter is being manufactured, and will perform a factory acceptance test.
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