Methods for the preparation of new condensed derivatives of pyrido3',2':4,5thieno3,2-
d
pyrimidines based on 5,6-dimethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile were developed. Substitution ...reactions in the 3rd and 4th positions of 7,8-dimethylpyrido3',2':4,5thieno3,2-
d
pyrimidin-4(3
H
)-one were conducted. The neurotropic activity of 12 obtained compounds was studied in vivo in rats and mice. Eight compounds were found to have an anticonvulsant effect of antagonism with corazole. Four selected compounds had anxiolytic and behavior activating effects. Molecular docking of the synthesized compounds was performed to predict their interaction with the GABA
A
receptor. Five compounds were identified, the complexation of which with the GABA
A
receptor occurs in two places: the benzamidine site of subsite 1 and subsite 3 of the ECD interface, which indicates the inhibitory effect of the compounds on the target.
The invariant spectra of
π
− mesons produced in (
π
+/K
+)p interactions at 250 GeV/
c are analysed in the framework of the hydrodynamical model of three-dimensionally expanding cylindrically ...symmetric finite systems. A satisfactory description of experimental data is achieved. The data favour the pattern according to which the hadron matter undergoes predominantly longitudinal expansion and non-relativistic transverse expansion with mean transverse velocity 〈
u
t〉=0.20±0.07, and is characterized by a large temperature inhomogeneity in the transverse direction: the extracted freeze-out temperature at the center of the tube and at the transverse rms radius are 140±3 MeV and 82±7 MeV, respectively. The width of the (longitudinal) space-time rapidity distribution of the pion source is found to be
Δη=1.36±0.02. Combining this estimate with results of the Bose-Einstein correlation analysis in the same experiment, one extracts a mean freeze-out time of the source of 〈
τ
f〉=1.4±0.1 fm/
c and its transverse geometrical rms radius,
R
G(rms)=1.2±0.2 fm.
A method based on condensed 4-cyanopyridinethiones using
O
-tosylhydroxylamine as the aminating agent was developed for preparing tosylates of
N
-amino-derivatives of pyrano3,4-
c
pyridines; ...5,6,7,8-tetrahydroisoquinolines; and cyclopenta
c
pyridines. The antibacterial activity of the synthesized compounds was assessed.
With the simultaneous presence of positive and negative components both in the permittivity tensor ɛ
ij
and in the tensor of magnetic permeability μ
ij
, the propagation of an electromagnetic wave in ...optically homogeneous anisotropic media, and in periodically inhomogeneous media with a spiral structure is considered. It is shown that depending on polarization, such media exhibit the properties of both dextrorotatory and levorotatory substances. It is shown also that the medium with a spiral periodic structure may have the property of total diffraction reflection of the wave of any polarization. In the case of the presence of different signs of components of ɛ
ij
and μ
ij
in the spiral medium, it is revealed that two regions of diffraction reflection are formed, corresponding to the two waves with circular polarization with mutually opposite rotation of the polarization.
The AREAL laser-driven RF gun provides 2–5MeV energy ultrashort electron pulses for experimental study in life and materials sciences. We report the first experimental results of the AREAL beam ...application in the study of molecular-genetic effects, silicon-dielectric structures, ferroelectric nanofilms, and single crystals for scintillators.
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