This first of a kind book places spatial data within the broader domain of information technology (IT) while providing a comprehensive and coherent explanation of the guiding principles, methods, ...implementation and operational management of spatial databases within the workplace. The text explains the key concepts, issues and processes of spatial data implementation and provides a holistic management perspective that complements the technical aspects of spatial data stressed in other textbooks. In this respect, this book is unique in its coverage of spatial database principles and architecture, database modelling including UML, database and spatial data standards, spatial data infrastructure, database implementation, and workplace-oriented project management including user needs study and end user education. The text first overviews the current state of spatial information technology and it concludes with a speculative account of likely future developments. Cutting edge research and practical workplace needs are defined and explained. Topics covered, among others, include strategies for end user education, current spatial data standards and their importance, legal issues and liabilities in the ownership and use of spatial data, spatial metadata use within distributed databases, the Internet and Web-based solutions to database deployment, quality assurance and quality control in database implementation and use, spatial decision support, and spatial data mining. The book applies equally to senior undergraduate and graduate courses and students, as well as spatial data managers and practitioners already in the workplace. It will enhance their technical and human-resource based understanding of spatial data management. Certification courses that seek to prepare students for careers in the spatial information industry and courses targeted at enhancing needed geospatial workplace knowledge and skills will benefit greatly from its content.
The prevalence of diabetes mellitus (DM) is increasing rapidly in the 21st century as a result of obesity, an ageing population, lack of exercise, and increased migration of susceptible patients. ...This costly and chronic disease has been likened recently to the ‘Black Death’ of the 14th century. Type 2 DM is the more common form and the primary aim of management is to delay the micro- and macrovascular complications by achieving good glycaemic control. This involves changes in lifestyle, such as weight loss and exercise, and drug therapy. Increased knowledge of the pathophysiology of diabetes has contributed to the development of novel treatments: glucagon-like peptide-1 (GLP-1) mimetics, dipeptidyl peptidase-4 (DPP-4) inhibitors, thiazolidinediones (TZDs), and insulin analogues. GLP-1 agonists mimic the effect of this incretin, whereas DPP-4 inhibitors prevent the inactivation of the endogenously released hormone. Both agents offer an effective alternative to the currently available hypoglycaemic drugs but further evaluation is needed to confirm their safety and clinical role. The past decade has seen the rise and fall in the use of the TZDs (glitazones), such that the only glitazone recommended is pioglitazone as a third-line treatment. The association between the use of rosiglitazone and adverse cardiac outcomes is still disputed by some authorities. The advent of new insulin analogues, fast-acting, and basal release formulations, has enabled the adoption of a basal-bolus regimen for the management of blood glucose. This regimen aims to provide a continuous, low basal insulin release between meals with bolus fast-acting insulin to limit hyperglycaemia after meals. Insulin therapy is increasingly used in type 2 DM to enhance glycaemic control. Recently, it has been suggested that the use of the basal-release insulins, particularly insulin glargine may be associated with an increased risk of cancer. Although attention is focused increasingly on newer agents in the treatment of diabetes, metformin and the sulphonylureas are still used in many patients. Metformin, in particular, remains of great value and may have novel anti-cancer properties.
Chemical warfare agents containing phosphonate ester bonds are among the most toxic chemicals known to mankind. Recent global military events, such as the conflict and disarmament in Syria, have ...brought into focus the need to find effective strategies for the rapid destruction of these banned chemicals. Solutions are needed for immediate personal protection (for example, the filtration and catalytic destruction of airborne versions of agents), bulk destruction of chemical weapon stockpiles, protection (via coating) of clothing, equipment and buildings, and containment of agent spills. Solid heterogeneous materials such as modified activated carbon or metal oxides exhibit many desirable characteristics for the destruction of chemical warfare agents. However, low sorptive capacities, low effective active site loadings, deactivation of the active site, slow degradation kinetics, and/or a lack of tailorability offer significant room for improvement in these materials. Here, we report a carefully chosen metal-organic framework (MOF) material featuring high porosity and exceptional chemical stability that is extraordinarily effective for the degradation of nerve agents and their simulants. Experimental and computational evidence points to Lewis-acidic Zr(IV) ions as the active sites and to their superb accessibility as a defining element of their efficacy.
The Asian citrus psyllid (ACP), Diaphorina citri Kuwayama (Hemiptera: Psyllidae), is an important pest of citrus because it transmits phloem-limited bacteria Candidatus Liberibacter spp., notably Ca. ...L. asiaticus (LAS) associated with huanglongbing (HLB; citrus greening disease), currently considered the world's most serious disease of citrus. Asian citrus psyllid transmits LAS in a persistent manner and, although the rate of LAS transmission by ACP individuals usually is low, HLB can spread rapidly in a citrus grove and the geographic range of the disease is expanding, threatening citrus industries in new areas. Intensive chemical control of ACP is the primary management strategy currently advocated for HLB, but this strategy is costly, unsustainable, and generally ineffective. The scientific community is searching aggressively for solutions to HLB on many fronts, but it could still be years before solutions are found and implemented. Plant resistance to LAS is one area of research being pursued, whereby traits that confer resistance are identified and incorporated into citrus germplasm through conventional or transgenic methods. It remains to be seen if a solution to HLB can be found that specifically targets ACP, but research on ACP has been stepped up in a number of areas, notably on ACP-LAS-plant interactions, on host plant resistance to ACP, and on molecular methods of silencing ACP genes to induce mortality or to block its ability to transmit HLB-causing bacteria. Advancements in these and other research areas may depend greatly on a better understanding of basic ACP biology and vector-pathogen-host plant interactions at the molecular, cellular, and community levels. Here we present an updated review of ACP and HLB with an emphasis on the problem in Florida.
Classification of arthrogryposis Hall, Judith G; Kimber, Eva; Dieterich, Klaus
American journal of medical genetics. Part C, Seminars in medical genetics,
September 2019, Letnik:
181, Številka:
3
Journal Article
Odprti dostop
There is a need for a system to classify various forms of arthrogryposis. None is satisfactory or complete. Nevertheless, several have been developed to meet the needs of clinicians, prenatal ...diagnosticians, researchers, and basic scientists. They all await more insight into basic mechanisms.
The pattern of structural brain alterations associated with major depressive disorder (MDD) remains unresolved. This is in part due to small sample sizes of neuroimaging studies resulting in limited ...statistical power, disease heterogeneity and the complex interactions between clinical characteristics and brain morphology. To address this, we meta-analyzed three-dimensional brain magnetic resonance imaging data from 1728 MDD patients and 7199 controls from 15 research samples worldwide, to identify subcortical brain volumes that robustly discriminate MDD patients from healthy controls. Relative to controls, patients had significantly lower hippocampal volumes (Cohen's d=-0.14, % difference=-1.24). This effect was driven by patients with recurrent MDD (Cohen's d=-0.17, % difference=-1.44), and we detected no differences between first episode patients and controls. Age of onset ⩽21 was associated with a smaller hippocampus (Cohen's d=-0.20, % difference=-1.85) and a trend toward smaller amygdala (Cohen's d=-0.11, % difference=-1.23) and larger lateral ventricles (Cohen's d=0.12, % difference=5.11). Symptom severity at study inclusion was not associated with any regional brain volumes. Sample characteristics such as mean age, proportion of antidepressant users and proportion of remitted patients, and methodological characteristics did not significantly moderate alterations in brain volumes in MDD. Samples with a higher proportion of antipsychotic medication users showed larger caudate volumes in MDD patients compared with controls. This currently largest worldwide effort to identify subcortical brain alterations showed robust smaller hippocampal volumes in MDD patients, moderated by age of onset and first episode versus recurrent episode status.
Zinc, through its structural and cofactor roles, affects a broad range of critical physiological functions, including growth, metabolism, immune and neurological functions. Zinc deficiency is ...widespread among populations around the world, and it may, therefore, underlie much of the global burden of malnutrition. Current zinc fortification strategies include biofortification and fortification with zinc salts with a primary focus on staple foods, such as wheat or rice and their products. However, zinc fortification presents unique challenges. Due to the influences of phytate and protein on zinc absorption, successful zinc fortification strategies should consider the impact on zinc bioavailability in the whole diet. When zinc is absorbed with food, shifts in plasma zinc concentrations are minor. However, co-absorbing zinc with food may preferentially direct zinc to cellular compartments where zinc-dependent metabolic processes primarily occur. Although the current lack of sensitive biomarkers of zinc nutritional status reduces the capacity to assess the impact of fortifying foods with zinc, new approaches for assessing zinc utilization are increasing. In this article, we review the tools available for assessing bioavailable zinc, approaches for evaluating the zinc nutritional status of populations consuming zinc fortified foods, and recent trends in fortification strategies to increase zinc absorption.
Although anthropogenic climate change is causing increased wildfire activity in the United States (US), humans are also an important ignition source. Humans cause a surge in wildfire ignitions every ...4
th
of July (Independence Day in the US) through the use of fireworks. We examine the 4
th
of July peak in fireworks-caused wildfire ignitions and show that their spatial distribution varies but has been heavily concentrated in the west and north central US and predominantly on tribal lands. Further, we show that the weekly timing of the 4
th
of July influences both the number and weekly distribution structure of fireworks-caused ignitions. We interpret these weekly and daily-scale distribution patterns of fireworks-caused ignitions to reflect the influences of human behavioral variations, culture, and fireworks regulations. For example, our analysis suggests that weekends and religious days of rest (e.g., Saturday, Sunday) have a dampening effect on the number on wildfire ignitions due to fireworks, and that weekends and the timing of work holidays likely impact the weekly distribution of fireworks-caused ignitions. Additionally, comparisons of fireworks-caused ignitions before and after the 4
th
of July at the daily and weekly scale likely reflect the efficacy of firework sales regulations and human behavioral tendencies towards pre-holiday impulsiveness. Given the predictability of the fireworks-caused ignitions and rising costs of wildfire mitigation, these results have several important management and policy implications.
Aseptic loosening is the dominant failure mechanism in contemporary knee replacement surgery, but diagnostic techniques are poorly sensitive to the early stages of loosening and poorly specific in ...delineating aseptic cases from infections. Smart implants have been proposed as a solution, but incorporating components for sensing, powering, processing, and communication increases device cost, size, and risk; hence, minimising onboard instrumentation is desirable. In this study, two wireless, battery-free smart implants were developed that used passive biotelemetry to measure fixation at the implant-cement interface of the tibial components. The sensing system comprised of a piezoelectric transducer and coil, with the transducer affixed to the superior surface of the tibial trays of both partial (PKR) and total knee replacement (TKR) systems. Fixation was measured via pulse-echo responses elicited via a three-coil inductive link. The instrumented systems could detect loss of fixation when the implants were partially debonded (+7.1% PKA, +32.6% TKA, both
< 0.001) and fully debonded in situ (+6.3% PKA, +32.5% TKA, both
< 0.001). Measurements were robust to variations in positioning of the external reader, soft tissue, and the femoral component. With low cost and small form factor, the smart implant concept could be adopted for clinical use, particularly for generating an understanding of uncertain aseptic loosening mechanisms.
Abstract
Background
Our randomized trial found that pictorial cigarette pack warnings elicited more quit attempts than text-only warnings.
Purpose
In the current study, we sought to identify ...psychological mechanisms that explain why pictorial cigarette pack warnings change behavior.
Methods
In 2014 and 2015, we recruited 2,149 adult smokers in NC and CA, USA. We randomly assigned smokers to receive on their cigarette packs for 4 weeks either a text-only warning (one of the USA’s current warnings on the side of cigarette packs) or a pictorial warning (one of the USA’s proposed text warnings with pictures on the top half of the front and back of cigarette packs).
Results
Pictorial warnings increased attention to, reactions to, and social interactions about cigarette pack warnings (all p < .05). However, pictorial warnings changed almost no belief or attitude measures. Mediators of the impact of pictorial warnings included increased attention, negative affect, social interactions, thinking about the warning and harms of smoking, and intentions to quit (all p < .05). Analyses also found that pictorial warnings led to greater avoidance of the warnings, which was associated with more quit attempts (p < .05).
Conclusions
Pictorial warnings increased quit attempts by eliciting aversive reactions and by keeping the message vividly in smokers’ minds. Contrary to predictions from several theories of health behavior, the warnings exerted little of their influence through changes in beliefs and attitudes and none of their influence through changes in risk perception. We propose the Tobacco Warnings Model based on these findings.
Clinical Trial information
ClinicalTrials.gov identifier: NCT02247908; https://clinicaltrials.gov/ct2/show/NCT02247908.
Pictorial cigarette pack warnings increased quit attempts by eliciting aversive reactions and by keeping the message vividly in smokers’ minds.
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