This fifth edition of Principles of Lasers includes corrections to the previous edition as well as being the first available as an ebook. Its mission remains to provide a broad, unified description ...of laser behavior, physics, technology, and applications.
X-structures are often observed in galaxies hosting the so-called B/PS (boxy/peanuts) bulges and are visible from the edge-on view. They are the most notable features of B/PS bulges and appear as ...four rays protruding from the disk of the host galaxy and distinguishable against the B/PS bulge background. In some works, their origin is thought to be connected with the so-called banana-shaped orbits with a vertical resonance 2:1. A star in such an orbit performs two oscillations in the vertical direction per one revolution in the bar frame. Several recent studies that analyzed ensembles of orbits arising in different N-body models do not confirm the dominance of the resonant 2:1 orbits in X-structures. In our work, we analyze two N-body models and show how the X-structure in our models is gradually assembled from the center to the periphery from orbits with less than 2:1 frequency ratio. The most number of such orbits is enclosed in a "farfalle"-shape (Italian pasta) form and turns out to be non-periodic. We conclude that the X-structure is akin to the envelope curve of regions of high density caused by the crossing or folding of different types of orbits at their highest points, and does not have a "backbone" similar to that of the in-plane bar. Comparing the orbital structure of two different numerical models, we show that the dominance of one or another family of orbits with a certain ratio of the vertical oscillations frequency to the in-plane frequency depends on the parameters of the underlying galaxy and ultimately determines the morphology of the X-structure and the opening angle of its rays.
This study focused on variation in fish mercury (Hg) concentrations in 185 Nile perch (Lates niloticus) samples collected across four different habitat types in Lake Nabugabo, Uganda, a tropical lake ...located proximate to Lake Victoria. We quantified the stomach contents of Nile perch using the % index of relative importance, as well as, nitrogen and carbon isotopic concentrations to assess the role of diet and trophic level on Hg concentrations. In each habitat, we also evaluated a suite of chemical and physical characteristics that are commonly associated with variation in Hg bioavailability in temperate systems. Using linear mixed models and ANOVA, we demonstrate that habitat of capture is an important predictor of Hg concentrations in Nile perch from Lake Nabugabo and that the relationship between habitat and Hg is size and diet dependent. Nile perch diet as well as dissolved oxygen concentration and pH were also correlated with observed differences in fish Hg. Overall, Hg concentrations in Nile perch were all well below the WHO/FAO recommended guideline of 500 ng/g (mean 13.6 ± 0.4 ng/g wet weight; range 4.9 and 29.3 ng/g wet weight). This work contributes to a growing awareness of intra-lake divergence in Nile perch, as well as, divergence in Hg concentrations between varying aquatic habitat types, particularly wetlands.
Rock breakdown due to diurnal thermal cycling has been hypothesized to drive boulder degradation and regolith production on airless bodies. Numerous studies have invoked its importance in driving ...landscape evolution, yet morphological features produced by thermal fracture processes have never been definitively observed on an airless body, or any surface where other weathering mechanisms may be ruled out. The Origins, Spectral Interpretation, Resource Identification, and Security-Regolith Explorer (OSIRIS-REx) mission provides an opportunity to search for evidence of thermal breakdown and assess its significance on asteroid surfaces. Here we show boulder morphologies observed on Bennu that are consistent with terrestrial observations and models of fatigue-driven exfoliation and demonstrate how crack propagation via thermal stress can lead to their development. The rate and expression of this process will vary with asteroid composition and location, influencing how different bodies evolve and their apparent relative surface ages from space weathering and cratering records.
Context.
Asteroid (101955) Bennu is the target of NASA’s Origins, Spectral Interpretation, Resource Identification, and Security–Regolith Explorer (OSIRIS-REx) mission. The spacecraft’s instruments ...have characterized Bennu at global and local scales to select a sampling site and provide context for the sample that will be returned to Earth. These observations include thermal infrared spectral characterization by the OSIRIS-REx Thermal Emission Spectrometer (OTES).
Aims.
To understand the degree of compositional and particle size variation on Bennu, and thereby predict the nature of the returned sample, we studied OTES spectra, which are diagnostic of these properties.
Methods.
We created and mapped spectral indices and compared them with the distribution of geomorphic features. Comparison to laboratory spectra of aqueously altered carbonaceous chondrites constrains the amount of compositional variability that is observable.
Results.
The OTES spectra exhibit two end-member shapes (or types), and compositional variability appears limited at the spatial resolution of the observations. The global distribution of these spectral types corresponds with the locations of regions composed of (i) large, dark, relatively rough boulders and (ii) relatively smooth regions lacking large boulders.
Conclusions.
The two spectral types appear to be diagnostic primarily of particle size variations, with contributions from other properties. The spectra resemble experimental data of solid substrates with very thin accumulations (a few to tens of microns) of fine particles (<~65–100 μm). The dustier surfaces commonly correspond with rougher rocks that may produce and/or act as traps for the particles. Anhydrous silicates are limited in abundance, and the bulk mineralogy is consistent with the most aqueously altered carbonaceous chondrites. We expect the returned samples to include these physical and mineralogical characteristics.
The use of anthracycline chemotherapeutic drugs is restricted owing to potentially fatal cardiotoxic side effects. It has been hypothesized that anthracycline metabolites have a primary role in this ...cardiac dysfunction; however, information on the molecular interactions of these compounds in the heart is scarce. Here we provide novel evidence that doxorubicin and its metabolite, doxorubicinol, bind to the cardiac ryanodine receptor (RyR2) and to the sarco/endoplasmic reticulum Ca(2+) ATPase (SERCA2A) and deleteriously alter their activity. Both drugs (0.01 μM-2.5 μM) activated single RyR2 channels, and this was reversed by drug washout. Both drugs caused a secondary inhibition of RyR2 activity that was not reversed by drug washout. Preincubation with the reducing agent dithiothreitol (DTT, 1 mM) prevented drug-induced inhibition of channel activity. Doxorubicin and doxorubicinol reduced the abundance of thiol groups on RyR2, further indicating that oxidation reactions may be involved in the actions of the compounds. Ca(2+) uptake into sarcoplasmic reticulum vesicles by SERCA2A was inhibited by doxorubicinol, but not doxorubicin. Unexpectedly, in the presence of DTT, doxorubicinol enhanced the rate of Ca(2+) uptake by SERCA2A. Together the evidence provided here shows that doxorubicin and doxorubicinol interact with RyR2 and SERCA2A in similar ways, but that the metabolite acts with greater efficacy than the parent compound. Both compounds modify RyR2 and SERCA2A activity by binding to the proteins and also act via thiol oxidation to disrupt SR Ca(2+) handling. These actions would have severe consequences on cardiomyocyte function and contribute to clinical symptoms of acute anthracycline cardiotoxicity.
Using approved methods, circulating tumor cells (CTCs) are only isolated from blood in 30%-50% of metastatic colorectal cancer (mCRC) patients. We previously validated a technique to isolate ...circulating tumor cells (CTCs) in a cohort of mCRC patients by combining immunomagnetic enrichment of EpCAM
/CD45
cells with qRT-PCR amplification of CK20 and survivin expression. Here, we examined the prognostic utility of CTC epithelial-mesenchymal transition (EMT) and stem cell gene expression. An 8 ml blood sample was collected from 78 consecutive mCRC patients before treatment with investigational and standard chemotherapeutics. The mRNA expression of EMT (PI3Kα, Akt-2, Twist1) and stem cell (ALDH1) markers was measured. Associations between CTC gene expression and progression-free survival (PFS) and overall survival (OS) were determined using Cox regression models. Among patients without CK20 or survivin-expressing CTCs (n=17), 55% had expression of ALDH1, PI3Kα and/or Akt-2. Patients with positive CTC Akt-2 expression had a significantly shorter median PFS (3.0 versus 4.0 months) compared with those without CTC Akt-2 expression in univariable (hazard ratio (HR)=1.61; log-rank P=0.034) and multivariable analyses (HR=1.70; adjusted P=0.041). In univariable analysis, CTC ALDH1 expression was associated with shorter OS (10.0 versus 38.6 months; HR=2.04, P=0.021). Patients with CTCs expressing ALDH1, PI3Kα and/or Akt-2 had a significantly inferior PFS (3.0 versus 7.7 months; HR=1.88, P=0.015) and OS (10.0 versus 26.8+ months; HR=2.25, P=0.050) in univariable, but not multivariable, analysis.
CTC Akt-2 expression may serve as a clinically useful prognostic marker in mCRC patients and warrants further evaluation in prospective trials.
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