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zadetkov: 4.127
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  • The discovery of Alzheimer‐... The discovery of Alzheimer‐causing mutations in the APP gene and the formulation of the “amyloid cascade hypothesis”
    Hardy, John The FEBS journal, April 2017, 2017-04-00, 20170401, Letnik: 284, Številka: 7
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    The cloning of APP and genetic analysis of families with Alzheimer's disease were both reported in 1987 and much present work on the disease is based upon the foundations laid at that time. Progress ...
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  • amyloid hypothesis for Alzh... amyloid hypothesis for Alzheimer's disease: a critical reappraisal
    Hardy, John Journal of neurochemistry, August 2009, Letnik: 110, Številka: 4
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    The amyloid hypothesis has been the basis for most work on the pathogenesis of Alzheimer's disease. Recent clinical trials based on this hypothesis have been inconclusive. In this article I review ...
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3.
  • A Hundred Years of Alzheime... A Hundred Years of Alzheimer's Disease Research
    Hardy, John Neuron, 10/2006, Letnik: 52, Številka: 1
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    On the 100 th anniversary of Alzheimer's lecture describing the clinicopathological entity which bears his eponym, this article reviews the major areas of progress in our understanding of the disease ...
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4.
  • The amyloid hypothesis of A... The amyloid hypothesis of Alzheimer's disease at 25 years
    Selkoe, Dennis J; Hardy, John EMBO molecular medicine, June 2016, Letnik: 8, Številka: 6
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    Despite continuing debate about the amyloid β‐protein (or Aβ hypothesis, new lines of evidence from laboratories and clinics worldwide support the concept that an imbalance between production and ...
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5.
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6.
  • Metallosupramolecular grid ... Metallosupramolecular grid complexes: towards nanostructured materials with high-tech applications
    Hardy, John G Chemical Society reviews, 2013-Oct-07, Letnik: 42, Številka: 19
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    Metallosupramolecular grid complexes (hereafter referred to as metallogrids) are well-defined oligonuclear metal ion complexes involving essentially planar arrays of the metal ions sited at the ...
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7.
  • The Neuropathology and Neur... The Neuropathology and Neurobiology of Traumatic Brain Injury
    Blennow, Kaj; Hardy, John; Zetterberg, Henrik Neuron, 12/2012, Letnik: 76, Številka: 5
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    The acute and long-term consequences of traumatic brain injury (TBI) have received increased attention in recent years. In this Review, we discuss the neuropathology and neural mechanisms associated ...
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9.
  • Failures in Protein Clearan... Failures in Protein Clearance Partly Underlie Late Onset Neurodegenerative Diseases and Link Pathology to Genetic Risk
    Hardy, John Frontiers in neuroscience, 12/2019, Letnik: 13
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    As we identify the loci involved in late onset neurodegenerative disease, we are finding that the majority of them are involved in damage response processes. In this short review, I propose that it ...
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10.
  • The Evolution of Genetics: ... The Evolution of Genetics: Alzheimer’s and Parkinson’s Diseases
    Singleton, Andrew; Hardy, John Neuron, 06/2016, Letnik: 90, Številka: 6
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    Genetic discoveries underlie the majority of the current thinking in neurodegenerative disease. This work has been driven by the significant gains made in identifying causal mutations; however, the ...
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