Many unintended and undesired consequences of Healthcare Information Technologies (HIT) flow from interactions between the HIT and the healthcare organization’s sociotechnical system—its workflows, ...culture, social interactions, and technologies. This paper develops and illustrates a conceptual model of these processes that we call Interactive Sociotechnical Analysis (ISTA). ISTA captures common types of interaction with special emphasis on recursive processes, i.e., feedback loops that alter the newly introduced HIT and promote second-level changes in the social system. ISTA draws on prior studies of unintended consequences, along with research in sociotechnical systems, ergonomics, social informatics, technology-in-practice, and social construction of technology. We present five types of sociotechnical interaction and illustrate each with cases from published research. The ISTA model should further research on emergent and recursive processes in HIT implementation and their unintended consequences. Familiarity with the model can also foster practitioners’ awareness of unanticipated consequences that only become evident during HIT implementation.
This paper essentially reviews the types of graphene-based nanofillers and the fabrication of graphene/polymer nanocomposites. Routes to produce graphene materials, along with the methods and ...modifications used to efficiently disperse graphene nanofillers within the polymer matrices are discussed. In addition, the mechanical properties, morphological, structural, electrical conductivities, electrochemical activities, thermal stabilities, and gas barrier properties are evaluated, along with the direct relationships of these properties with the graphene-polymer interactions and their dispersion in the polymer matrix. Finally, a brief summary of the practical applications of polymeric-graphene materials along with the current trends in the field is presented to progressively show future prospects for the development of these materials.
Graphene-based nanofillers and their applications. Fabrication methods of graphene-based nanocomposites. Interaction and dispersion of graphene-based fillers in polymer matrices. Current trends and prospects of graphene-based nanocomposites.
The recent rapid growth in graphene-based supercapacitors has reached the point where there is a need for solid-state devices with physical flexibility, which will be a crucial advantage in modern ...electronic devices. Herein, we summarize recent developments toward an all solid-state graphene-based flexible supercapacitor. The routes to produce graphene-based electrode materials, along with the typical fabrication techniques for flexible devices, are thoroughly discussed. Furthermore, the structural morphology of the electrode materials is closely related to the electrochemical performance, and the influence of the electrode components on the mechanical flexibility of the fabricated devices is examined. Lastly, a summary of the overall electrochemical properties and current development of the reported devices is presented progressively to predict the future trends toward the realization of an ultimate-performance graphene-based flexible supercapacitor.
Basin-scale planning is needed to minimize impacts in mega-diverse rivers
The world's most biodiverse river basins—the Amazon, Congo, and Mekong—are experiencing an unprecedented boom in construction ...of hydropower dams. These projects address important energy needs, but advocates often overestimate economic benefits and underestimate far-reaching effects on biodiversity and critically important fisheries. Powerful new analytical tools and high-resolution environmental data can clarify trade-offs between engineering and environmental goals and can enable governments and funding institutions to compare alternative sites for dam building. Current site-specific assessment protocols largely ignore cumulative impacts on hydrology and ecosystem services as ever more dams are constructed within a watershed (
1
). To achieve true sustainability, assessments of new projects must go beyond local impacts by accounting for synergies with existing dams, as well as land cover changes and likely climatic shifts (
2
,
3
). We call for more sophisticated and holistic hydropower planning, including validation of technologies intended to mitigate environmental impacts. Should anything less be required when tampering with the world's great river ecosystems?
Subfossil pollen and plant macrofossil data derived from
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C-dated sediment profiles can provide quantitative information on glacial and interglacial climates. The data allow climate variables ...related to growing-season warmth, winter cold, and plant-available moisture to be reconstructed. Continental-scale reconstructions have been made for the mid-Holocene (MH, around 6 ka) and Last Glacial Maximum (LGM, around 21 ka), allowing comparison with palaeoclimate simulations currently being carried out as part of the fifth Assessment Report (AR5) of the Intergovernmental Panel on Climate Change. The synthesis of the available MH and LGM climate reconstructions and their uncertainties, obtained using modern-analogue, regression and model-inversion techniques, is presented for four temperature variables and two moisture variables. Reconstructions of the same variables based on surface-pollen assemblages are shown to be accurate and unbiased. Reconstructed LGM and MH climate anomaly patterns are coherent, consistent between variables, and robust with respect to the choice of technique. They support a conceptual model of the controls of Late Quaternary climate change whereby the first-order effects of orbital variations and greenhouse forcing on the seasonal cycle of temperature are predictably modified by responses of the atmospheric circulation and surface energy balance.
The blood-cerebrospinal fluid barrier (BCSFB) is a highly dynamic transport interface that serves brain homeostasis. To date, however, understanding of its role in brain development and pathology has ...been hindered by the absence of a non-invasive technique for functional assessment. Here we describe a method for non-invasive measurement of BSCFB function by using tracer-free MRI to quantify rates of water delivery from arterial blood to ventricular cerebrospinal fluid. Using this method, we record a 36% decrease in BCSFB function in aged mice, compared to a 13% decrease in parenchymal blood flow, itself a leading candidate biomarker of early neurodegenerative processes. We then apply the method to explore the relationship between BCSFB function and ventricular morphology. Finally, we provide proof of application to the human brain. Our findings position the BCSFB as a promising new diagnostic and therapeutic target, the function of which can now be safely quantified using non-invasive MRI.
Increased hyperphosphorylated tau and the formation of intracellular neurofibrillary tangles are associated with the loss of neurons and cognitive decline in Alzheimer's disease, and related ...neurodegenerative conditions. We applied two diffusion models, diffusion tensor imaging (DTI) and neurite orientation dispersion and density imaging (NODDI), to in vivo diffusion magnetic resonance images (dMRI) of a mouse model of human tauopathy (rTg4510) at 8.5months of age. In grey matter regions with the highest degree of tau burden, microstructural indices provided by both NODDI and DTI discriminated the rTg4510 (TG) animals from wild type (WT) controls; however only the neurite density index (NDI) (the volume fraction that comprises axons or dendrites) from the NODDI model correlated with the histological measurements of the levels of hyperphosphorylated tau protein. Reductions in diffusion directionality were observed when implementing both models in the white matter region of the corpus callosum, with lower fractional anisotropy (DTI) and higher orientation dispersion (NODDI) observed in the TG animals. In comparison to DTI, histological measures of tau pathology were more closely correlated with NODDI parameters in this region. This in vivo dMRI study demonstrates that NODDI identifies potential tissue sources contributing to DTI indices and NODDI may provide greater specificity to pathology in Alzheimer's disease.
•We analyzed the microstructural changes in rTg4510 and wild type mice at 8.5months.•We correlated microstructural findings with histological measures of tau burden•We compare two diffusion MR models: DTI and NODDI.•Both models revealed changes in tissue microstructure due to tau pathology.•The NODDI metrics demonstrated a good correlation with histological measures of tau burden.
Leather and textile industrial effluents are the main disseminating routes for chromium contamination of water bodies, causing adverse impacts on public and environmental health. The attempt to ...remediate chromium through conventional wastewater treatment methods is inefficient. Therefore, this study aims to synthesize zinc-doped nickel ferrite pinecone biochar (Zn-NiF@PBC) nanocomposite for the removal of chromium from wastewater systems. The Zn-NiF@PBC nanocomposite was synthesized via the co-precipitation method. The properties of zinc-doped nickel ferrite (Zn-NiF) were effectively modified by blending with biochar at 1, 5, 10, and 15 % (w/w) which was successfully embedded with Zn-Ni ferrite nanoparticles. This was characterized and confirmed by typical adsorbent properties such as a high surface area of 104 m2/g, conducive pore volume of 0.117 cm3/g and pore size of 3.41 nm (BET), interactive multi-functional groups (FTIR), surface charge determination (pHpzc,), crystalline structure (XRD) and very rough surface morphology (SEM). The maximum chromium adsorption was found to be 95 % at the specific experimental condition of pH 3, adsorbent dose 1 g/50 mL, contact time 120 min, and initial chromium concentration 100 mg/L. The adsorption experimental data was best fitted with the Langmuir isotherm at R2 0.98 indicating the adsorption process was homogeneous and monolayer whereas the kinetics adsorption was resembling the second-order kinetic at R2 0.99. Moreover, the adsorption thermodynamics was spontaneous, endothermic, and increased the change in entropy. Finally, the regeneration of Zn-NiF@PBC was found to be effective up to five 5 cycles but gradually degrading in terms of removal efficiency after 3 cycles. In general, Zn-NiF@PBC can remediate chromium from wastewater with huge potential for scale-up and extend to other pollutants clear-up.
High concentration of chromium in aquatic environments is the trigger for researchers to remediate it from wastewater environments. However, conventional water treatment methods have not been ...satisfactory in removing chromium from water and wastewater over the last decade. Similarly, many adsorption studies have been focused on one aspect of the treatment, but this study dealt with all aspects of adsorption packages to come up with a concrete conclusion. Therefore, this study aimed to prepare pinecone biochar (PBC) via pyrolysis and apply it for Cr(VI) removal from wastewater. The PBC was characterized using FTIR, SEM-EDX, BET surface area, pHpzc, Raman analyses, TGA, and XRD techniques. Chromium adsorption was studied under the influence of PBC dose, solution pH, initial Cr(VI) concentration, and contact time. The characteristics of PBC are illustrated by FTIR spectroscopic functional groups, XRD non-crystallite structure, SEM rough surface morphology, and high BET surface area125 m2/g, pore volume, 0.07 cm3/g, and pore size 1.4 nm. On the other hand, the maximum Cr (VI) adsorption of 69% was found at the experimental condition of pH 2, adsorbent dosage 0.25 mg/50 mL, initial Cr concentration 100 mg/L, and contact time of 120 min. Similarly, the experimental data were well-fitted with the Langmuir adsorption isotherm at R2 0.96 and the pseudo-second-order kinetics model at R2 0.99. This implies the adsorption process is mainly attributed to monolayer orientation between the adsorbent and adsorbate. In the thermodynamics study of adsorption, ΔG was found to be negative implying the adsorption process was feasible and spontaneous whereas the positive values of ΔH and ΔS indicated the adsorption process was endothermic and increasing the degree of randomness, respectively. Finally, adsorbent regeneration and reusability were successful up to three cycles. In conclusion, biochar surface modification and reusability improvements are urgently required before being applied at the pilot scale.
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•Effective biochar adsorbent was successfully synthesized via pyrolysis for Cr (VI) removal.•Adsorption isotherm was described by the Langmuir model and kinetics was by pseudo-second-order.•Maximum Cr (VI) adsorption of 69% was recorded at the optimum experimental condition.•The stability and reusability of pinecone biochar were effective for up to five cycles.•This pinecone biochar has to be improved in terms of surface area and performance.
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