ABSTRACT
Previous studies have shown that physically small, low-luminosity radio galaxies, which we refer to as galaxy scale jets (GSJ), could potentially have a significant effect upon the host ...galaxy’s evolution. Using 6-arcsec resolution images taken from the first release of the LOFAR Two Metre Sky Survey (LoTSS DR1), we identified a representative sample of nine potential GSJ for which we obtained high-resolution, 2–4 GHz data using the Karl G. Jansky Very Large Array (VLA). Using these data, we aim to verify the GSJ nature of these sources as well as investigating the potential role of feedback. Our VLA images reveal a diversity of structures, confirm the hosts for four of the sources and find that a fifth is the first known example of a galaxy-scale remnant showing that some radio galaxies never grow beyond the GSJ stage. We also derive spectral ages and the first estimates of the lobe expansion speeds of GSJ. We find our GSJ have maximum spectral ages of 60 Myr with most between about 5 and 20 Myr, consistent with being located along an evolutionary path joining compact sources and larger radio galaxies. We find lobe advance speeds a few times the local sound speed, with most GSJ predicted to be driving strong shocks into their environment and having a significant impact upon the host’s evolution. Our discovery of a remnant GSJ, which will eventually transfer all of its energy directly into the local environment, represents an important and previously hidden aspect of AGN life cycles.
Context.
Restarted radio galaxies represent a unique tool for investigating the duty cycle of the jet activity in active galactic nuclei (AGN). The radio galaxy 3C388 has long been claimed to be a ...peculiar example of an AGN with multi-epoch activity because it shows a very sharp discontinuity in the GHz spectral index distribution of its lobes.
Aims.
We present here for the first time a spatially resolved study of the radio spectrum of 3C388 down to MHz frequencies aimed at investigating the radiative age of the source and constraining its duty cycle.
Methods.
We used new low-frequency observations at 144 MHz performed with the Low Frequency Array and at 350 MHz performed with the Very Large Array that we combined with archival data at higher frequencies (614, 1400, and 4850 MHz).
Results.
We find that the spectral indices in the lower frequency range, 144−614 MHz, have flatter values (
α
low
∼ 0.55−1.14) than those observed in the higher frequency range, 1400−4850 MHz, (
α
high
∼ 0.75−1.57), but they follow the same distribution across the lobes, with a systematic steepening towards the edges. However, the spectral shape throughout the source is not uniform and often deviates from standard models. This suggests that mixing of different particle populations occurs, although it remains difficult to understand whether this is caused by observational limitations (insufficient spatial resolution and/or projection effects) or by the intrinsic presence of multiple particle populations, which might be related to the two different outbursts.
Conclusions.
Using single-injection radiative models, we compute that the total source age is ≲80 Myr and that the duty cycle is about
t
on
/
t
tot
∼ 60%, which is enough to prevent the intracluster medium from cooling, according to X-ray estimates. While to date the radio spectral distribution of 3C388 remains a rare case among radio galaxies, multi-frequency surveys performed with new-generation instruments will soon allow us to investigate whether more sources with the same characteristics exist.
The combination of in vitro multi-electrode arrays (MEAs) and the neuronal differentiation of stem cells offers the capability to study human neuronal networks from patient or engineered human cell ...lines. Here, we use MEA-based assays to probe synaptic function and network interactions of hiPSC-derived neurons. Neuronal network behaviour first emerges at approximately 30 days of culture and is driven by glutamate neurotransmission. Over a further 30 days, inhibitory GABAergic signalling shapes network behaviour into a synchronous regular pattern of burst firing activity and low activity periods. Gene mutations in L-type voltage gated calcium channel subunit genes are strongly implicated as genetic risk factors for the development of schizophrenia and bipolar disorder. We find that, although basal neuronal firing rate is unaffected, there is a dose-dependent effect of L-type voltage gated calcium channel inhibitors on synchronous firing patterns of our hiPSC-derived neural networks. This demonstrates that MEA assays have sufficient sensitivity to detect changes in patterns of neuronal interaction that may arise from hypo-function of psychiatric risk genes. Our study highlights the utility of in vitro MEA based platforms for the study of hiPSC neural network activity and their potential use in novel compound screening.
Coordinated programs of gene expression drive brain development. It is unclear which transcriptional programs, in which cell-types, are affected in neuropsychiatric disorders such as schizophrenia. ...Here we integrate human genetics with transcriptomic data from differentiation of human embryonic stem cells into cortical excitatory neurons. We identify transcriptional programs expressed during early neurogenesis in vitro and in human foetal cortex that are down-regulated in DLG2
lines. Down-regulation impacted neuronal differentiation and maturation, impairing migration, morphology and action potential generation. Genetic variation in these programs is associated with neuropsychiatric disorders and cognitive function, with associated variants predominantly concentrated in loss-of-function intolerant genes. Neurogenic programs also overlap schizophrenia GWAS enrichment previously identified in mature excitatory neurons, suggesting that pathways active during prenatal cortical development may also be associated with mature neuronal dysfunction. Our data from human embryonic stem cells, when combined with analysis of available foetal cortical gene expression data, de novo rare variants and GWAS statistics for neuropsychiatric disorders and cognition, reveal a convergence on transcriptional programs regulating excitatory cortical neurogenesis.
Cosmological simulations predict that an intergalactic magnetic field (IGMF) pervades the large scale structure (LSS) of the Universe. Measuring the IGMF is important to determine its origin (i.e. ...primordial or otherwise). Using data from the LOFAR Two Metre Sky Survey (LoTSS), we present the Faraday rotation measure (RM) and depolarisation properties of the giant radio galaxy J1235+5317, at a redshift of z = 0.34 and 3.38 Mpc in size. We find a mean RM difference between the lobes of 2.5 ± 0.1 rad m−2, in addition to small scale RM variations of ∼0.1 rad m−2 . From a catalogue of LSS filaments based on optical spectroscopic observations in the local universe, we find an excess of filaments intersecting the line of sight to only one of the lobes. Associating the entire RM difference to these LSS filaments leads to a gas density-weighted IGMF strength of ∼0.3 μG. However, direct comparison with cosmological simulations of the RM contribution from LSS filaments gives a low probability (∼5%) for an RM contribution as large as 2.5 rad m−2, for the case of IGMF strengths of 10–50 nG. It is likely that variations in the RM from the Milky Way (on 11′ scales) contribute significantly to the mean RM difference, and a denser RM grid is required to better constrain this contribution. In general, this work demonstrates the potential of the LOFAR telescope to probe the weak signature of the IGMF. Future studies, with thousands of sources with high accuracy RMs from LoTSS, will enable more stringent constraints on the nature of the IGMF.
ABSTRACT
Hybrid morphology radio sources (HyMoRS) are a rare group of radio galaxies in which differing Fanaroff & Riley morphologies (FR I/II) are observed for each of the two lobes. While they ...potentially provide insights into the formation of lobe structure, particle acceleration, and the FR dichotomy, previous work on HyMoRS has mainly been limited to low-resolution studies, searches for new candidates, and milliarcsecond-scale VLBI observations of the core region. In this paper, we use new multi-array configuration Very Large Array (VLA) observations between 1 and 8 GHz to determine the morphology of HyMoRS on arcsecond scales and perform the first well-resolved spectral study of these unusual sources. We find that while the apparent FR I lobe is centre brightened, this is the result of a compact acceleration region resembling a hotspot with a spectrum more consistent with an FR II (‘strong-flavour’) jet. We find that the spectra of the apparent FR I lobes are not similar to their classical counterparts and are likely the result of line-of-sight mixing of plasma across a range of spectral ages. We consider possible mechanisms that could lead to the formation of HyMoRS under such conditions, including environment asymmetry and restarted sources, concluding through the use of simple modelling that HyMoRS are the result of orientation effects on intrinsically FR II sources with lobes non-parallel to the inner jet.
Tuberous sclerosis complex (TSC) is a rare neurodevelopmental disorder resulting from autosomal dominant mutations in the TSC1 or TSC2 genes, leading to a hyperactivated mammalian target of rapamycin ...(mTOR) pathway, and gray and white matter defects in the brain. To study the involvement of neuron-glia interactions in TSC phenotypes, we generated TSC patient induced pluripotent stem cell (iPSC)-derived cortical neuronal and oligodendrocyte (OL) cultures. TSC neuron mono-cultures showed increased network activity, as measured by calcium transients and action potential firing, and increased dendritic branching. However, in co-cultures with OLs, neuronal defects became more apparent, showing cellular hypertrophy and increased axonal density. In addition, TSC neuron-OL co-cultures showed increased OL cell proliferation and decreased OL maturation. Pharmacological intervention with the mTOR regulator rapamycin suppressed these defects. Our patient iPSC-based model, therefore, shows a complex cellular TSC phenotype arising from the interaction of neuronal and glial cells and provides a platform for TSC disease modeling and drug development.
•TSC neuron mono-cultures show an increase in network activity and dendritic branching•TSC co-cultures show hypertrophy and an increase in axonal length and OL proliferation•mTOR regulators normalize TSC neuronal and glial phenotypes
Nadadhur et al. generated TSC disease models using patient iPSCs. While neuron mono-cultures showed an increase in network activity and dendritic branching, only when co-cultured with oligodendrocytes (OLs), hypertrophy and axonal abnormalities were observed. Neuron-OL interactions, modulated by mTOR regulators, support use of mixed cultures for TSC disease modeling and drug development.
Abstract
Continuous injection models of spectral ageing have long been used to determine the age of radio galaxies from their integrated spectrum; however, many questions about their reliability ...remain unanswered. With various large area surveys imminent (e.g. LOw Frequency ARray, MeerKAT, Murchison Widefield Array) and planning for the next generation of radio interferometers are well underway (e.g. next generation VLA, Square Kilometre Array), investigations of radio galaxy physics are set to shift away from studies of individual sources to the population as a whole. Determining if and how integrated models of spectral ageing can be applied in the era of big data is therefore crucial. In this paper, I compare classical integrated models of spectral ageing to recent well-resolved studies that use modern analysis techniques on small spatial scales to determine their robustness and validity as a source selection method. I find that integrated models are unable to recover key parameters and, even when known a priori, provide a poor, frequency-dependent description of a source's spectrum. I show a disparity of up to a factor of 6 in age between the integrated and resolved methods but suggest, even with these inconsistencies, such models still provide a potential method of candidate selection in the search for remnant radio galaxies and in providing a cleaner selection of high redshift radio galaxies in z − α selected samples.
ABSTRACT
Radio galaxies are linearly polarized – an important property that allows us to infer the properties of the magnetic field of the source and its environment. However, at low frequencies, ...Faraday rotation substantially depolarizes the emission, meaning that comparatively few polarized radio galaxies are known at low frequencies. Using the LOFAR Two-metre Sky Survey at 150 MHz and at a resolution of 20 arcsec, we select 342 radio galaxies brighter than 50 mJy and larger than 100 arcsec in angular size, of which 67 are polarized (18 per cent detection fraction). These are predominantly Fanaroff–Riley type II sources. The detection fraction increases with total flux density, and exceeds 50 per cent for sources brighter than 1 Jy. We compare the sources in our sample detected by the LOw Frequency ARray (LOFAR) to those also detected in NRAO VLA Sky Survey at 1400 MHz, and find that our selection bias towards bright radio galaxies drives a tendency for sources depolarized between 1400 and 150 MHz to have flatter spectra over that frequency range than those that remain polarized at 150 MHz. By comparing observed rotation measures with an analytic model, we find that we are preferentially sensitive to sources in low-mass environments. We also infer that sources with one polarized hotspot are inclined by a small angle to the line of sight, while sources with hotspots in both lobes lie in the plane of the sky. We conclude that low-frequency polarization in radio galaxies is related to a combination of environment, flux density, and jet orientation.
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