Assessing the impact offin-de-siecleJewish culture on subsequent developments in literature and culture, this book is the first to consider the historical trajectory of Austrian-Jewish writing across ...the20thcentury. It examines how Vienna, the city that stood at the center of Jewish life in the Austrian Empire and later the Austrian nation, assumed a special significance in the imaginations of Jewish writers as a space and an idea. The author focuses on the special relationship between Austrian-Jewish writers and the city to reveal a century-long pattern of living in tension with the city, experiencing simultaneously acceptance and exclusion, feeling "unheimlichheimisch"(eerily at home) in Vienna.
Objective
Accumulation of misfolded superoxide dismutase‐1 (SOD1) is a pathological hallmark of SOD1‐related amyotrophic lateral sclerosis (ALS) and is observed in sporadic ALS where its role in ...pathogenesis is controversial. Understanding in vivo protein kinetics may clarify how SOD1 influences neurodegeneration and inform optimal dosing for therapies that lower SOD1 transcripts.
Methods
We employed stable isotope labeling paired with mass spectrometry to evaluate in vivo protein kinetics and concentration of soluble SOD1 in cerebrospinal fluid (CSF) of SOD1 mutation carriers, sporadic ALS participants and controls. A deaminated SOD1 peptide, SDGPVKV, that correlates with protein stability was also measured.
Results
In participants with heterozygous SOD1A5V mutations, known to cause rapidly progressive ALS, mutant SOD1 protein exhibited ~twofold faster turnover and ~ 16‐fold lower concentration compared to wild‐type SOD1 protein. SDGPVKV levels were increased in SOD1A5V carriers relative to controls. Thus, SOD1 mutations impact protein kinetics and stability. We applied this approach to sporadic ALS participants and found that SOD1 turnover, concentration, and SDGPVKV levels are not significantly different compared to controls.
Interpretation
These results highlight the ability of stable isotope labeling approaches and peptide deamidation to discern the influence of disease mutations on protein kinetics and stability and support implementation of this method to optimize clinical trial design of gene and molecular therapies for neurological disorders.
Trial Registration
Clinicaltrials.gov: NCT03449212.
Rebirth of a culture Herzog, Hillary Hope; Herzog, Todd; Lapp, Benjamin
2008., 20080815, 2008, 2008-08-01
eBook
After 1945, Jewish writing in German was almost unimaginable—and then only in reference to the Shoah. Only in the 1980s, after a period of mourning, silence, and processing of the trauma, did a new ...Jewish literature evolve in Germany and Austria. This volume focuses on the re-emergence of a lively Jewish cultural scene in the German-speaking countries and the various cultural forms of expression that have developed around it. Topics include current debates such as the emergence of a post-Waldheim Jewish discourse in Austria and Jewish responses to German unification and the Gulf wars. Other significant themes addressed are the memorialization of the Holocaust in Berlin and Vienna, the uses of Kafka in contemporary German literature, and the German and American-Jewish dialogue as representative of both the history of exile and the globalization of postmodern civilization. The volume is enhanced by contributions from some of the most significant representatives of German-Jewish writing today such as Esther Dischereit, Barbara Honigmann, Jeanette Lander, and Doron Rabinovici. The result is a lively dialogue between European and North American scholars and writers that captures the complexity and dynamism of Jewish culture in Germany and Austria at the turn of the twenty-first century.
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