In the world of civil engineering, wire ropes are used in the structure of many structures. The main function of wire ropes in a structure is to transmit tensile forces or to put in compression the ...pre-stressed concrete. As they are important structural elements, they are subjected to mechanical, thermal and environmental stresses. A nonlinear transient model based on a sequentially coupled thermo-mechanical field analysis code has been developed in the ANSYS parametric design language, This model allows among other things to account for the effects of wire cross-section variations on contact-friction interactions, The ultimate goal is to determine the effects of mutual mechanical behavior using an analysis of variance (ANOVA) of the Taguchi method, a total of three parameters are considered with mixed levels and mixed factors and an orthogonal L27 network are generated. The objective of our work is to optimize the base material (E), friction (f) and temperature (T) to obtain the target structure.
ITO thin layers were deposited with good results on a glass substrate by Spray pyrolysis method under optimal conditions using the TAGUCHI experimental design. Structural, optical and electrical ...characteristics have been studied and evaluated via X-ray diffraction, UV–visible spectrophotometry and the 4-point probe method. On the optical analysis by taking measurements of average transmittance T (λ) and absorption A (λ) over the wavelength interval from 300 to 1000 nm, the indirect band gap energy can be determined. The analysis of our ITO thin films shows that the confirmatory test has the best performance. The ideal preparation conditions of ITO thin films were the following: surface temperature is 450 °C, the ratio of indium and tin was 10%, as well as the deposition time was 10 min. The mean optical transmittance in visual range and sheet resistance of ITO film were 85% and 22.38 Ω/□, respectively.
Metal oxide semiconductor gas sensors are used in a various applications in environmental, industrial and medical field, for instance. They are relatively inexpensive compared to other sensing ...technologies, robust, lightweight, long lasting and benefit from high material sensitivity and quick response times. Copper oxide (CuO) thin film has been promisingly proposed for chemical sensing applications. Particularly, it has been recommended as a sensitive layer for monitoring harmful and combustible gases. It is an attractive material because of nontoxic, inexpensive, abundance advantages, and its fabrication is easy. In this work, we have synthesized CuO thin films by Spray pyrolysis method. The effect of the temperature deposition is investigated:to say 350 °C, 400 °C, and 450 °C while the deposition duration was kipped to 15 min. The samples were analyzed by X-ray diffraction, Raman spectroscopy, XPS analysis, UV-visible transmission and four points probe method.
Chronic lymphocytic leukemia and chronic myeloid leukemia are the most common types of adult leukemia. However, it is rare for the same patient to suffer from both. Richter's transformation to ...diffuse large B-cell lymphoma is frequently observed in chronic lymphocytic leukemia. Purine analog therapy and the presence of trisomy 12, and CCND1 gene rearrangement have been linked to increased risk of Richter's transformation. The coexistence of chronic myeloid leukemia and diffuse large B-cell lymphoma in the same patient is extremely rare, with only nine reported cases. Here, we describe the first reported case of concurrent chronic myeloid leukemia and diffuse large B-cell lymphoma in a background of chronic lymphocytic leukemia.
A 60-year-old Saudi man known to have diabetes, hypertension, and chronic active hepatitis B was diagnosed as having Rai stage II chronic lymphocytic leukemia, with trisomy 12 and rearrangement of the CCND1 gene in December 2012. He required no therapy until January 2016 when he developed significant anemia, thrombocytopenia, and constitutional symptoms. He received six cycles of fludarabine, cyclophosphamide, and rituximab, after which he achieved complete remission. One month later, he presented with progressive leukocytosis (mostly neutrophilia) and splenomegaly. Fluorescence in situ hybridization from bone marrow aspirate was positive for translocation (9;22) and reverse transcription polymerase chain reaction detected BCR-ABL fusion gene consistent with chronic myeloid leukemia. He had no morphologic or immunophenotypic evidence of chronic lymphocytic leukemia at the time. Imatinib, a first-line tyrosine kinase inhibitor, was started. Eight months later, a screening imaging revealed new liver lesions, which were confirmed to be diffuse large B-cell lymphoma.
In chronic lymphocytic leukemia, progressive leukocytosis and splenomegaly caused by emerging chronic myeloid leukemia can be easily overlooked. It is unlikely that chronic myeloid leukemia arose as a result of clonal evolution secondary to fludarabine treatment given the very short interval after receiving fludarabine. It is also unlikely that imatinib contributed to the development of diffuse large B-cell lymphoma; rather, diffuse large B-cell lymphoma arose as a result of Richter's transformation. Fludarabine, trisomy 12, and CCND1 gene rearrangement might have increased the risk of Richter's transformation in this patient.
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