Spin Hall Effects in Metals Hoffmann, Axel
IEEE transactions on magnetics,
10/2013, Letnik:
49, Številka:
10
Journal Article
Odprti dostop
Spin Hall effects convert charge currents into spin currents and vice versa even in nonmagnetic conductors due to spin orbit coupling. This enables spin Hall effects to be utilized both for the ...generation and detection of spin currents and magnetization dynamics. This paper reviews the experimental characterization of these effects in metallic systems, which have so far shown the highest efficiency in using spin Hall effects for charge-to-spin interconversion. The advantages and disadvantages of complimentary measurement techniques are discussed and in addition an outlook of the possible impact on applications is presented.
Introduced transinfections of the inherited bacteria Wolbachia can inhibit transmission of viruses by Aedes mosquitoes, and in Ae. aegypti are now being deployed for dengue control in a number of ...countries. Only three Wolbachia strains from the large number that exist in nature have to date been introduced and characterized in this species. Here novel Ae. aegypti transinfections were generated using the wAlbA and wAu strains. In its native Ae. albopictus, wAlbA is maintained at lower density than the co-infecting wAlbB, but following transfer to Ae. aegypti the relative strain density was reversed, illustrating the strain-specific nature of Wolbachia-host co-adaptation in determining density. The wAu strain also reached high densities in Ae. aegypti, and provided highly efficient transmission blocking of dengue and Zika viruses. Both wAu and wAlbA were less susceptible than wMel to density reduction/incomplete maternal transmission resulting from elevated larval rearing temperatures. Although wAu does not induce cytoplasmic incompatibility (CI), it was stably combined with a CI-inducing strain as a superinfection, and this would facilitate its spread into wild populations. Wolbachia wAu provides a very promising new option for arbovirus control, particularly for deployment in hot tropical climates.
People often overestimate the prevalence of unfavorable behavior. To explain these misperceptions, social sampling models propose that individuals infer the social norm from the behavior of their own ...social circle. We investigated this idea by asking a friendship network of college freshmen to report their own behavior and norm perceptions across eight domains at two timepoints (N = 104). Assessing this complete social network allows to directly test if sampling from the social circle shapes norm perception. Replicating previous findings, freshmen systematically misperceived the average social norm within their cohort. Yet, these misperceptions persisted even when individuals judged their own social circle, indicating that sampling from social circles does not fully explain normative biases. Moreover, cognitive modelling of norm perceptions suggested that individuals unlikely limited their search to their own social circle.
Metabolomics using nontargeted tandem mass spectrometry can detect thousands of molecules in a biological sample. However, structural molecule annotation is limited to structures present in libraries ...or databases, restricting analysis and interpretation of experimental data. Here we describe CANOPUS (class assignment and ontology prediction using mass spectrometry), a computational tool for systematic compound class annotation. CANOPUS uses a deep neural network to predict 2,497 compound classes from fragmentation spectra, including all biologically relevant classes. CANOPUS explicitly targets compounds for which neither spectral nor structural reference data are available and predicts classes lacking tandem mass spectrometry training data. In evaluation using reference data, CANOPUS reached very high prediction performance (average accuracy of 99.7% in cross-validation) and outperformed four baseline methods. We demonstrate the broad utility of CANOPUS by investigating the effect of microbial colonization in the mouse digestive system, through analysis of the chemodiversity of different Euphorbia plants and regarding the discovery of a marine natural product, revealing biological insights at the compound class level.
Wolbachia bacteria are now being introduced into Aedes aegypti mosquito populations for dengue control. When Wolbachia infections are at a high frequency, they influence the local transmission of ...dengue by direct virus blocking as well as deleterious effects on vector mosquito populations. However, the effectiveness of this strategy could be influenced by environmental temperatures that decrease Wolbachia density, thereby reducing the ability of Wolbachia to invade and persist in the population and block viruses. We reared wMel-infected Ae. aegypti larvae in the field during the wet season in Cairns, North Queensland. Containers placed in the shade produced mosquitoes with a high Wolbachia density and little impact on cytoplasmic incompatibility. However, in 50% shade where temperatures reached 39°C during the day, wMel-infected males partially lost their ability to induce cytoplasmic incompatibility and females had greatly reduced egg hatch when crossed to infected males. In a second experiment under somewhat hotter conditions (>40°C in 50% shade), field-reared wMel-infected females had their egg hatch reduced to 25% when crossed to field-reared wMel-infected males. Wolbachia density was reduced in 50% shade for both sexes in both experiments, with some mosquitoes cleared of their Wolbachia infections entirely. To investigate the critical temperature range for the loss of Wolbachia infections, we held Ae. aegypti eggs in thermocyclers for one week at a range of cyclical temperatures. Adult wMel density declined when eggs were held at 26-36°C or above with complete loss at 30-40°C, while the density of wAlbB remained high until temperatures were lethal. These findings suggest that high temperature effects on Wolbachia are potentially substantial when breeding containers are exposed to partial sunlight but not shade. Heat stress could reduce the ability of Wolbachia infections to invade mosquito populations in some locations and may compromise the ability of Wolbachia to block virus transmission in the field. Temperature effects may also have an ecological impact on mosquito populations given that a proportion of the population becomes self-incompatible.
Type I interferon (IFN) is produced when host sensors detect foreign nucleic acids, but how sensors differentiate self from nonself nucleic acids, such as double-stranded RNA (dsRNA), is incompletely ...understood. Mutations in ADAR1, an adenosine-to-inosine editing enzyme of dsRNA, cause Aicardi-Goutières syndrome, an autoinflammatory disorder associated with spontaneous interferon production and neurologic sequelae. We generated ADAR1 knockout human cells to explore ADAR1 substrates and function. ADAR1 primarily edited Alu elements in RNA polymerase II (pol II)-transcribed mRNAs, but not putative pol III-transcribed Alus. During the IFN response, ADAR1 blocked translational shutdown by inhibiting hyperactivation of PKR, a dsRNA sensor. ADAR1 dsRNA binding and catalytic activities were required to fully prevent endogenous RNA from activating PKR. Remarkably, ADAR1 knockout neuronal progenitor cells exhibited MDA5 (dsRNA sensor)-dependent spontaneous interferon production, PKR activation, and cell death. Thus, human ADAR1 regulates sensing of self versus nonself RNA, allowing pathogen detection while avoiding autoinflammation.
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•ADAR1 edits are found in putative RNA polymerase II (but not III)-derived Alu repeats•ADAR1 prevents translational shutdown during the type I IFN response•ADAR1 dsRNA binding and catalytic activities are required to block PKR activation•ADAR1 KO NPCs exhibit MDA5-dependent IFN production, PKR activation, and cell death
The human RNA-editing enzyme ADAR1 prevents endogenous RNA from activating innate immune sensors (PKR, MDA5), which allows efficient translation during IFN response.
Physiological limits determine susceptibility to environmental changes, and can be assessed at the individual, population or species/lineage levels. Here I discuss these levels in Drosophila, and ...consider implications for determining species susceptibility to climate change. Limits at the individual level in Drosophila depend on experimental technique and on the context in which traits are evaluated. At the population level, evidence from selection experiments particularly involving Drosophila melanogaster indicate high levels of heritable variation and evolvability for coping with thermal stresses and aridity. An exception is resistance to high temperatures, which reaches a plateau in selection experiments and has a low heritability/evolvability when temperatures are ramped up to a stressful level. In tropical Drosophila species, populations are limited in their ability to evolve increased desiccation and cold resistance. Population limits can arise from trait and gene interactions but results from different laboratory studies are inconsistent and likely to underestimate the strength of interactions under field conditions. Species and lineage comparisons suggest phylogenetic conservatism for resistance to thermal extremes and other stresses. Plastic responses set individual limits but appear to evolve slowly in Drosophila. There is more species-level variation in lower thermal limits and desiccation resistance compared with upper limits, which might reflect different selection pressures and/or low evolvability. When extremes are considered, tropical Drosophila species do not appear more threatened than temperate species by higher temperatures associated with global warming, contrary to recent conjectures. However, species from the humid tropics may be threatened if they cannot adapt genetically to drier conditions.
Nucleic acid sensors, primarily TLR and RLR family members, as well as cGAS-STING signalling, play a critical role in the preservation of cellular and organismal homeostasis. Accordingly, deregulated ...nucleic acid sensing contributes to the origin of a diverse range of disorders, including infectious diseases, as well as cardiovascular, autoimmune and neoplastic conditions. Accumulating evidence indicates that normalizing aberrant nucleic acid sensing can mediate robust therapeutic effects. However, targeting nucleic acid sensors with pharmacological agents, such as STING agonists, presents multiple obstacles, including drug-, target-, disease- and host-related issues. Here, we discuss preclinical and clinical data supporting the potential of this therapeutic paradigm and highlight key limitations and possible strategies to overcome them.
Summary
Patients with atopic dermatitis (AD) have an increased risk of bacterial skin infections, which cause significant morbidity and, if untreated, may become systemic. Staphylococcus aureus ...colonizes the skin of most patients with AD and is the most common organism to cause infections. Overt bacterial infection is easily recognized by the appearance of weeping lesions, honey‐coloured crusts and pustules. However, the wide variability in clinical presentation of bacterial infection in AD and the inherent features of AD – cutaneous erythema and warmth, oozing associated with oedema, and regional lymphadenopathy – overlap with those of infection, making clinical diagnosis challenging. Furthermore, some features may be masked because of anatomical site‐ and skin‐type‐specific features, and the high frequency of S. aureus colonization in AD makes positive skin swab culture of suspected infection unreliable as a diagnostic tool. The host mechanisms and microbial virulence factors that underlie S. aureus colonization and infection in AD are incompletely understood. The aim of this article is to present the latest evidence from animal and human studies, including recent microbiome research, to define the clinical features of bacterial infections in AD, and to summarize our current understanding of the host and bacterial factors that influence microbial colonization and virulence.
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