Motivation: The lack of microarray data management systems and databases is still one of the major problems faced by many life sciences laboratories. While developing the public repository for ...microarray data ArrayExpress we had to find novel solutions to many non-trivial software engineering problems. Our experience will be both relevant and useful for most bioinformaticians involved in developing information systems for a wide range of high-throughput technologies. Results: ArrayExpress has been online since February 2002, growing exponentially to well over 10 000 hybridizations (as of September 2004). It has been demonstrated that our chosen design and implementation works for databases aimed at storage, access and sharing of high-throughput data. Availability: The ArrayExpress database is available at http://www.ebi.ac.uk/arrayexpress/. The software is open source. Contact: ugis@ebi.ac.uk
ArrayExpress is a public repository for microarray-based gene expression data, resulting from the implementation of the MAGE object model to ensure accurate data structuring and the MIAME standard, ...which defines the annotation requirements. ArrayExpress accepts data as MAGE-ML files for direct submissions or data from MIAMExpress, the MIAME compliant web-based annotation and submission tool of EBI. A team of curators supports the submission process, providing assistance in data annotation. Data retrieval is performed through a dedicated web interface. Relevant results may be exported to ExpressionProfiler, the EBI based expression analysis tool available online (http://www.ebi.ac.uk/arrayexpress).
Interaction Models Biggs, Norman L.
11/1977, Letnik:
v.Series Number 30
eBook
This book is based on a set of lectures given to a mixed audience of physicists and mathematicians. The desire to be intelligible to both groups is the underlying preoccupation of the author. ...Physicists nowadays are particularly interested in phase transitions. The typical situation is that a system of interacting particles exhibits an abrupt change of behaviour at a certain temperature, although the local forces between the particles are thought to be smooth functions of temperature. This account discusses the theory behind a simple model of such phenomena. An important tool is the mathematical discipline known as the Theory of Graphs. There are five chapters, each subdivided into sections. The first chapter is intended as a broad introduction to the subject, and it is written in a more informal manner than the rest. Notes and references for each chapter are given at the end of the chapter.
O artigo tem o objetivo de contextualizar o estado na teoria das formas sociais, mais especificamente em seu tratamento como formas-processos. Com isso, há uma sofisticação na teoria da derivação do ...estado que permite dar início a um debate sobre como aqueles que são críticos do estado podem comportar-se perante ele em sua vida cotidiana. Palavras-chave: Estado; Teoria da derivação do estado; Forma sociais; Formas-processos. The article aims to contextualize the state in the theory of social forms, more specifically in its treatment as forms-processes. With this, there is a sophistication in the theory of derivation of the state that allows us to begin a debate about how those who are critical of the state can behave before it in their daily lives. Keywords: State; Theory of derivation of the state; Social forms; Forms-processes.
Objetivo: analisar diagnósticos e tratamentos em pacientes no Hospital do Juquery no período Vargas. Método: estudo quanti-qualitativo, exploratório-descritivo, análise dos dados pelo referencial da ...análise documental e documentos históricos. Resultados: analisados 2.166 prontuários; épocas de conflitos sociais e guerras com incremento de prisões e internações; múltiplos diagnósticos para paciente; diagnósticos inconclusivos; principais diagnósticos: esquizofrenia (23,59%), psicose maníaca depressiva (4,20%), psicoses diversas (4,02%), delírio (3,83%), parafrenia (3,60%), depressão (3,19%), confusão mental (2,91%) configuravam 45,34% (982) do total; quadros sem serem estritamente psiquiátricos, mas poderiam ter sintomatologia derivada: sífilis (10,80%), deficiência intelectual (8,08%), epilepsia (4,06%), alcoolismo (3,81%); 2.023 (93,40%) prontuários sem observação médica; 08 (0,37%) pacientes diagnosticados “sem perturbação mental”; 37 (1,71%) “sem diagnóstico conclusivo”; 920 (42,47%) prontuários sem dados de tratamentos; 213 (9,83%) sem definição de tratamentos. Conclusão: múltiplos diagnósticos para mesmo indivíduo; alguns pacientes não tinham quadros psiquiátricos; tratamentos repetidos, majoritariamente orgânicos, não produziram resultados efetivos.
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