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zadetkov: 83
1.
  • The difference in the cellu... The difference in the cellular uptake of tocopherol and tocotrienol is influenced by their affinities to albumin
    Nakatomi, Takashi; Itaya-Takahashi, Mayuko; Horikoshi, Yosuke ... Scientific reports, 05/2023, Letnik: 13, Številka: 1
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    Vitamin E is classified into tocopherol (Toc) and tocotrienol (T3) based on its side chains. T3 generally has higher cellular uptake than Toc, though the responsible mechanism remains unclear. To ...
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2.
  • Molecular mechanisms underl... Molecular mechanisms underlying the promotion of wound repair by coenzyme Q10: PI3K/Akt signal activation via alterations to cell membrane domains
    Kurashiki, Tatsuyuki; Horikoshi, Yosuke; Kamizaki, Koki ... Journal of Clinical Biochemistry and Nutrition, 2022, Letnik: 70, Številka: 3
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    Coenzyme Q10 (CoQ10) promotes wound healing in vitro and in vivo. However, the molecular mechanisms underlying the promoting effects of CoQ10 on wound repair remain unknown. In the present study, we ...
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3.
  • Interaction between PAR-3 a... Interaction between PAR-3 and the aPKC-PAR-6 complex is indispensable for apical domain development of epithelial cells
    Horikoshi, Yosuke; Suzuki, Atsushi; Yamanaka, Tomoyuki ... Journal of cell science, 05/2009, Letnik: 122, Številka: 10
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    The evolutionarily conserved polarity proteins PAR-3, atypical protein kinase C (aPKC) and PAR-6 critically regulate the apical membrane development required for epithelial organ development. ...
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4.
  • System xc− in microglia is ... System xc− in microglia is a novel therapeutic target for post-septic neurological and psychiatric illness
    Kitagawa, Yoshinori; Nakaso, Kazuhiro; Horikoshi, Yosuke ... Scientific reports, 05/2019, Letnik: 9, Številka: 1
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    Abstract Post-septic neurological and psychiatric illness (PSNPI) including dementia and depression may be observed after sepsis. However, the etiology of PSNPI and therapeutic treatment of PSNPI are ...
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5.
  • Oncogenic role of TYRO3 rec... Oncogenic role of TYRO3 receptor tyrosine kinase in the progression of pancreatic cancer
    Morimoto, Masaki; Horikoshi, Yosuke; Nakaso, Kazuhiro ... Cancer letters, 02/2020, Letnik: 470
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    The expression and functions of TYRO3, a member of the TAM receptor tyrosine kinase family, in pancreatic cancer (PC) have not been specifically elucidated. In this study, we confirmed TYRO3 ...
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6.
  • Nicotine enhances the malig... Nicotine enhances the malignant potential of human pancreatic cancer cells via activation of atypical protein kinase C
    Hanaki, Takehiko; Horikoshi, Yosuke; Nakaso, Kazuhiro ... Biochimica et biophysica acta, November 2016, 2016-11-00, Letnik: 1860, Številka: 11
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    Pancreatic cancer (PC) is the most lethal malignancy among solid tumors, and the most common risk factor for its development is cigarette smoking. Atypical protein kinase C (aPKC) isozymes function ...
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7.
  • KIBRA Suppresses Apical Exo... KIBRA Suppresses Apical Exocytosis through Inhibition of aPKC Kinase Activity in Epithelial Cells
    Yoshihama, Yohei; Sasaki, Kazunori; Horikoshi, Yosuke ... CB/Current biology, 04/2011, Letnik: 21, Številka: 8
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    Epithelial cells possess apical-basolateral polarity and form tight junctions (TJs) at the apical-lateral border, separating apical and basolateral membrane domains. The PAR3-aPKC-PAR6 complex plays ...
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8.
  • Compound 48/80, a mast cell... Compound 48/80, a mast cell degranulator, causes oxidative damage by enhancing vitamin C synthesis via reduced glutathione depletion and lipid peroxidation through neutrophil infiltration in rat livers
    Ohta, Yosihiji; Yashiro, Koji; Ohashi, Koji ... Journal of Clinical Biochemistry and Nutrition, 01/2017, Letnik: 60, Številka: 3
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    In this study, we examined whether compound 48/80 (C48/80), a mast cell degranulator, causes hepatic oxidative damage in rats. Serum and liver biochemical parameters were determined 0.5, 3 or 6 h ...
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9.
  • TYRO3 promotes chemoresista... TYRO3 promotes chemoresistance via increased LC3 expression in pancreatic cancer
    Hara, Kazushi; Horikoshi, Yosuke; Morimoto, Masaki ... Translational oncology, 02/2023, Letnik: 28
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    Pancreatic cancer (PC) is an aggressive malignancy with few treatment options, and improved treatment strategies are urgently required. TYRO3, a member of the TAM receptor tyrosine kinase family, is ...
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10.
  • Dopamine-mediated oxidation... Dopamine-mediated oxidation of methionine 127 in α-synuclein causes cytotoxicity and oligomerization of α-synuclein
    Nakaso, Kazuhiro; Tajima, Naoko; Ito, Satoru ... PloS one, 02/2013, Letnik: 8, Številka: 2
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    Parkinson's disease (PD) is a neurodegenerative disorder characterized by the selective loss of dopaminergic neurons and the presence of Lewy bodies. Many recent studies focused on the interaction ...
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zadetkov: 83

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