Precise nutrient management of crops and soil fertility will be a major challenge worldwide in the coming decades because current agricultural practices rely predominantly on chemical fertilizers. ...The use of conventional fertilizers suffers from low crop nutrient efficiency, negative impacts on the environment, and high loss of water bodies. Nano-biotechnology is emerging as a promising alternative technique and has the potential to revolutionize agricultural systems by delivering nutrients to crops in a controlled release manner. Engineering nanoparticles-based nanofertilizers offer benefits in crop nutrition management by enhancing abiotic stress tolerance and improving agricultural productivity. This review focuses on the design, contribution, and interaction of nano-enabled fertilizers with edible plants based on very recent studies. Also, the review conveys the role of macronutrient, micronutrient-based nanofertilizer as well as nano-biofertilizer towards the development of smart and sustainable future agriculture.
•This review focuses on the design, contribution, and interaction of nano fertilizers.•The review conveys the role of nanofertilizer towards smart future agriculture.•This review summarizes an overview on usees of nano fertilizers in various crops.•The work discusses several models of nanoparticle acquisition and translocation.
The environmental effects of urbanization and globalization are still subject to debate among scholars. South Africa is the most globalized, most urbanized and the most carbon-intensive economy in ...Sub Saharan Africa (SSA) region. Taking this into cognizance, this study examines the effects of urbanization and globalization on CO2 emissions for South Africa using time series annual data for the period 1980–2017. Zivot and Andrews single and Bai and Perron multiple structural break unit root tests are employed to assess if all the series are stationary. This procedure follows ARDL cointegration test to check the presence of a long-run association among variables. Having been confirmed about such a cointegrating relation, ARDL short-run and long run coefficients indicate that urbanization induces CO2 emissions while only long-run significant emissions effect of globalization was noted. Toda-Yamamoto non-causality test reports a bi-directional causal link between urbanization and CO2 emissions. No causal link is observed between globalization and CO2 emissions. Variance decomposition results do not rule out these effects in future. Policy implications are discussed.
This paper considers the problem of dynamic power allocation in the downlink of multi-cell networks, where each cell utilizes non-orthogonal multiple access (NOMA)-based resource allocation. Also, ...coordinated multi-point (CoMP) transmission is utilized among multiple cells to serve users experiencing severe inter-cell interference (ICI). Under this CoMP- NOMA framework, CoMP transmission is applied to a user experiencing less distinctive channel gain with multiple base stations (BSs)/cells (i.e., severe ICI-prone user) and non-CoMP transmission (i.e., transmission without any coordination among multiple BSs) is applied to a user experiencing dominating channel gain with only one BS/cell, while NOMA is utilized at each BS to schedule CoMP and non-CoMP users over the same transmission resources, i.e., time, spectrum and space. After discussing various CoMP- NOMA models for downlink power allocation in multi-cell networks, we focus on a joint transmission CoMP- NOMA (JT-CoMP-NOMA) model. For the JT-CoMP-NOMA model, an optimal joint power allocation problem is formulated and the solution is derived for each CoMP- set consisting of multiple cooperating BSs (i.e., CoMP BSs). To avoid the huge computational complexity of the joint power optimization approach, we propose a distributed power optimization approach at each cooperating BS whose optimal solution is independent of the solution of other coordinating BSs. The distributed solution for the joint power optimization problem is validated and numerical performance evaluation is carried out for the proposed CoMP- NOMA models including JT-CoMP-NOMA and coordinated scheduling CoMP- NOMA (CS-CoMP-NOMA). The obtained results reveal significant gains in spectral and energy efficiency in comparison with conventional CoMP- orthogonal multiple access (CoMP-OMA) systems.
Ascaridia galli is the most common nematode in chickens. Ascaridia galli is highly prevalent in chickens reared in scavenging or semiscavenging systems. Here, we studied the epidemiology, pathology, ...genetic diversity, ex vivo culture protocol and anthelmintic sensitivity of A. galli prevalent in indigenous chickens in Bangladesh. Through morphological study and molecular analyses, the isolated worms were confirmed as A. galli. Of the chickens examined, 45.6% (178 out of 390) were found infected. The male and young chickens were significantly (P < 0.05) more prone to A. galli infection. Prevalence of the infection was significantly (P < 0.05) lower in the summer season. In heavy infections, A. galli blocked the small intestine. Marked inflammation, increased mucus production and petechial hemorrhages were evident in the small intestine, particularly in the duodenum. Also, there were desquamation and adhesion of the mucosal villi; degeneration, necrosis of the epithelial cells and goblet cell hyperplasia. The mucosal layer was infiltrated mainly with eosinophils and heterophils. We developed a hen egg white-based long-term ex vivo culture protocol which supported the survival and reproduction of A. galli for more than a week. Levamisole (LEV) and ivermectin (IVM) efficiently killed A. galli. However, albendazole (ABZ), mebendazole (MBZ), and piperazine (PPZ) did not kill the worms even at 120 μg/mL and 1mg/mL concentrations, respectively. Taken together, our results suggest that A. galli is highly prevalent in semiscavenging chickens in Bangladesh. Ascaridia galli can be easily maintained ex vivo in egg white supplemented M199 medium. LEV and IVM, but not ABZ, MBZ and PPZ, can be used for treating and controlling A. galli infections in chickens.
Meat and meat products are widely consumed worldwide as a source of high-quality proteins, essential amino acids, vitamins, and necessary minerals. The acceptability of Halal and Kosher meat products ...relies not only on the species origin but also on the manner of slaughtering of animals. Both Islam and Judaism have their own dietary laws in their holy books regarding acceptance and forbiddance of dietary items particularly meat and meat products. They also include many strictures to follow for ritual cleanliness of foods. Since the authenticity of Halal and Kosher food created increased concerns among consumers, the integrity of Halal and Kosher meat and meat products must be assured so that consumers can be accomplished with the originality of products. There is an increasing demand for reliable and sensitive techniques for the authentication of various Halal and Kosher meat products. This up-to-date review intends to provide an updated and extensive overview critically on the present situation, progress, and challenges of analytical techniques to authenticate animal species in meat items. It also addresses slaughtering procedure with brief discussion on Halal and Kosher laws with a view to creating consumer awareness against fraudulent practices. The available methods are schematically presented, and their salient features are comparatively elucidated in tables. Potential future technologies are predicted, and probable challenges are summarized. Overall, the present review article possesses substantial merits to be served as a reference guide in the field of academia and industry for the preparation/processing and identification of Halal and Kosher meat and meat products as well as may act as a platform to help improve existing authentication methods.
A hyperspectral image (HSI), which contains a number of contiguous and narrow spectral wavelength bands, is a valuable source of data for ground cover examinations. Classification using the entire ...original HSI suffers from the "curse of dimensionality" problem because (i) the image bands are highly correlated both spectrally and spatially, (ii) not every band can carry equal information, (iii) there is a lack of enough training samples for some classes, and (iv) the overall computational cost is high. Therefore, effective feature (band) reduction is necessary through feature extraction (FE) and/or feature selection (FS) for improving the classification in a cost-effective manner. Principal component analysis (PCA) is a frequently adopted unsupervised FE method in HSI classification. Nevertheless, its performance worsens when the dataset is noisy, and the computational cost becomes high. Consequently, this study first proposed an efficient FE approach using a normalized mutual information (NMI)-based band grouping strategy, where the classical PCA was applied to each band subgroup for intrinsic FE. Finally, the subspace of the most effective features was generated by the NMI-based minimum redundancy and maximum relevance (mRMR) FS criteria. The subspace of features was then classified using the kernel support vector machine. Two real HSIs collected by the AVIRIS and HYDICE sensors were used in an experiment. The experimental results demonstrated that the proposed feature reduction approach significantly improved the classification performance. It achieved the highest overall classification accuracy of 94.93% for the AVIRIS dataset and 99.026% for the HYDICE dataset. Moreover, the proposed approach reduced the computational cost compared with the studied methods.
β-tricalcium phosphate (β-TCP) was synthesized in an organic medium (acetone) to obtain a single-phase product while calcium carbonate (CaCO
3
) and
ortho
-phosphoric acid (H
3
PO
4
) were the ...sources of Ca, and P, respectively. The synthesized β-TCP was characterized by employing a number of sophisticated techniques vis. XRD, FTIR, FESEM, VSM and UV-Vis-NIR spectrometry. On the other hand, cytotoxicity, hemolysis, and antimicrobial activity for Gram-negative as well as Gram-positive (
E. coli
and
S. aureus
) bacteria were explored using this synthesized sample in powder format. However, to assess the drug loading and releasing profile, these powdered samples were first compressed into disks followed by sintering at 900 °C. Prior to loading the drug, porosity, density, and water absorbance characteristics of the scaffolds were examined in deionized water. Both loading and releasing profiles of the antibiotic (ciprofloxacin) were looked over at various selected time intervals which were continued up to 28 days. The observed results revealed that 2.87% of ciprofloxacin was loaded while 37% of this loaded drug was released within the selected time frame as set in this study. The scaffold was also immersed in SBF solution maintaining identical interim periods for the bioactivity evaluation. Furthermore, all three types of samples (
e.g.
drug-loaded, drug-released, and SBF-soaked) were characterized by FESEM and EDX while antimicrobial activity (against
E. coli
,
S. typhi
, and
S. aureus
) and efficacy to prevent hemolysis were also investigated. The drug-loaded scaffold presented a larger inhibition zone than the standard for all three types of microbes. Although powdered β-TCP was inactive in killing the Gram-negative bacteria, surprisingly the drug-released scaffold showed an inhibition zone.
β-tricalcium phosphate (β-TCP) was synthesized in an organic medium (acetone) to obtain a single-phase product while calcium carbonate (CaCO
3
) and
ortho
-phosphoric acid (H
3
PO
4
) were the sources of Ca, and P, respectively.
Cancer has become a significant concern in the medical sector with increasing disease complexity. Although some available conventional treatments are still a blessing for cancer patients, short-and ...long-term adverse effects and poor efficiency make it more difficult to treat cancer patients, demonstrating the need for new potent and selective anticancer drugs. In search of potent anticancer agents, naturally occurring compounds have always been admired due to their structural diversity, where Hesperetin (HSP) may be one of the potent candidates.
We aimed to summarize all sources, pharmacological properties, anticancer activities of HSP against numerous cancers types through targeting multiple pathological processes, mechanism of HSP on sensitizing the current anti-cancer agents and other phytochemicals, overcoming resistance pattern and determining absorption, distribution, metabolism, excretion, and toxicity (ADME/Tox).
Information was retrieved from PubMed, Science Direct, and Google Scholar based on some key points like Hesperetin, cancer name, anticancer resistance, nanoformulation, and ADME/Tox was determined by in silico approaches.
HSP is a phytoestrogen present in citrus fruits in a high concentration (several hundred mg/kg) and exhibited anti-cancer activities through interfering at several pathways. HSP can suppress tumor formation by targeting several cellular proteins such as cell cycle regulatory, apoptosis, metastatic, tyrosine kinase, growth factor receptor, estrogen metabolism, and antioxidant-related protein.HSP has shown remarkable synergistic properties in combination therapy and has been reported to overcome multidrug cancer resistance drugs, leading to an improved defensive mechanism. These anticancer activities of HSP may be due to proper structural chemistry.
Overall, HSP showed potential anticancer activities against all cancer and possess better pharmacokinetic properties. So this phytochemical alone or combination with other agents can be an effective alternative drug for cancer treatment.
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•Hesperetin is potential natural compound for its attributes in various anticancer activities.•Hesperetin can modulate diverse signaling pathways in cancer cells related to growth, metastasis, and apoptosis.•Hesperetin also increases chemosensitivity in chemotherapy in a synergistic approach.•Hesperetin processes less toxicity in human body but more bioavailability, conferring its application in clinical settings.
Cancer; Hesperetin; Anticancer agents; ADME/Tox.
Background: Neurological disorders represent one of the most prominent causes of morbidity and mortality that adversely affect the lifestyle of patients and a major percentage of these diseases ...exists in developing countries. Purpose: The objective of this study was to examine the prevalence and prescription pattern for outpatients with neurological disorders in Bangladesh. Methods: The study was conducted on 1,684 patients in 6 hospitals (National Institute of Neurosciences and Hospital, Dhaka Medical College and Hospital, Bangabandhu Sheikh Mujib Medical University, Shaheed Suhrawardy Medical College, Sir Salimullah Medical College, and Apollo Hospitals Dhaka) of the Dhaka City from March 2014 to June 2015. Data were collected through a predesigned questionnaire from the patients that contain information about gender, age, marital status, occupation, residential status, affected disease, self-medicated medicines, and prescribed medicines. Results: Out of 1,684 patients, 28.38% patients were aged 51–60 years and male, 57.19% predominance. The study exposed headache and migraine for 29.75% patients, followed by stroke for 23.93% patients and seizure for 7.07% patients. Genetic reason for the neurological disorders was seen only among 12.35% patients. In this study, 16.98% patients had been affected by neurological disorders for more than 2 years and 19% of patients for less than 6 months. Most extensively prescribed medicines were multivitamins and multiminerals used by 17.89% of patients followed by nonsteroidal anti-inflammatory drugs and other analgesic by 14.84%; afterwards antiulcerants were used by 12.62%, subsequently anticoagulants were used by 11.61% followed by antihyperlipidemic medicines by 10.26% and antiepileptic drugs by 8.08% of patients. The crucial reasons for the selection of prescribed medicines were the confidence that patients had with the physician’s prescribed medicines, which was shown for 40.97% patients and knowledge of the medicines was reported for 35.04% patients. The period of prescribed medicine usage was 1–3 months for 39.73% patients and 3–6 months for 29.16% patients. The patient’s compliance for prescribed medicines was satisfactory for 34.56% patients, good for 28.15% patients, and side effects were reported for 23.22% patients. Conclusion: In Bangladesh, it is not surprising to note that neurological diseases are more prevalent than other different diseases among different age groups and genders. Headache and migraine, stroke and seizure are most frequently encountered neurological disorders here. Treatment procedure of these disorders is not quite suitable due to the anomalies of health care management systems. Appropriate management of the health care system, especially the placement of hospital and community pharmacy can overcome the existing inconsistencies as well as increase the knowledge, awareness, and perception of the patients about health and neurological disorders.
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