Whether and how landscape context and habitat traits combine to shape animal assemblages and the rate and distribution of ecological functions remains unresolved in many aquatic settings. Saltmarshes ...are one such ecosystem in which these considerations are frequently acknowledged as important, but quantitative studies of these effects are rare, especially for ecological functions. In this study, the influence of landscape configuration and habitat traits on the composition of fish assemblages and rates of predation were quantified around 30 saltmarshes in three estuaries (i.e., 10 per estuary) in eastern Australia. Fish assemblages were surveyed using unbaited underwater video cameras, and predation was quantified using videoed “Squidpop” predation assays at 10 sites at each saltmarsh. The structure of fish assemblages was best explained by the estuary in which saltmarsh was located, the proximity of sites to estuary mouth, and the area of nearby saltmarsh and mangroves. Predation was dominated (90% of total predation events) by yellowfin bream
Acanthopagrus australis
(Sparidae), and so rates of predation correlated positively with yellowfin bream abundance. Predation peaked in the lower reaches of estuaries at saltmarshes with lower vegetation cover. These findings suggest that the mouths of estuaries might function as key transition zones that concentrate prey, the products of trophic relay, and the ecological effects of predators near the estuarine-sea interface.
Connectivity between land and sea through the movement of species, energy and nutrients means that land-based impacts can affect the structure and functioning of nearby coastal ecosystems. As the ...interface between land and sea, estuaries are often faced with increasing pressures from catchment modifications (e.g. the removal of terrestrial vegetation) which can alter the overall health of estuaries (e.g. the degradation of coastal water quality due to an increase in terrestrial runoff) and change the value of habitat for many marine species. These landscape-scale impacts can, however, be mediated through variations in the context and connectivity of seascapes (e.g. greater extent of vegetated ecosystems help to filter nutrients). We surveyed fish across five estuaries over four years using underwater videography and sought correlations between fish biodiversity and abundance with variables indexing catchment land use, seascape connectivity, and coastal water quality. Fish assemblages were more abundant and diverse at sites which had lower chlorophyll-a concentrations and were nearer to the estuary mouth, in conjunction with catchments containing higher percent of natural land and heterogenous seascapes. Sites with lower concentrations of chlorophyll-a supported indicator species from more diverse functional groups that had greater fisheries values, in comparison to indicator species from sites with high concentrations of chlorophyll-a. This research can help direct coastal management to better prioritise management in coastal ecosystems, thereby enhancing fish richness and abundance, functional group richness and fisheries value.
•Estuaries connect land to sea and are facing impacts from multiple spatial scales.•Coastal management requires quantitative data to disentangle multi-scaled impacts.•Sites with lower chlorophyll-a concentrations had more abundant and diverse fish.•Catchments with higher nature and conservation land had more diverse fish species.•Disentangling combined multi-scaled impacts can help prioritise coastal management.
Both theoretical and empirical evidence shows that intracrystalline U-Th heterogeneity in zircon can lead to biases in (U-Th)/He ages if not accurately accounted for in α-ejection corrections. We ...present a model for age correction for U-Th zoned crystals. We apply this to spherical and prismatic grains with bipyramidal terminations. The spherical calculation is simplistic but allows rapid calculation of the approximate effects of a wide variety of U-Th zoning patterns. The bipyramidal calculation is computationally intensive but permits an more complete estimate of the combined effects of crystal morphology and source zoning as relevant to zircon. Our principle findings are: (1) the assumption of U-Th homogeneity can result in errors of up to ∼30% (in rare cases, higher) for ejection-corrected ages for typical grain sizes and realistic zonation. (2) Tetragonal prisms with bipyramidal terminations, which are typical of most zircons, exhibit bulk retentivities that can differ by several percent from models considering crystals with pinacoidal terminations. When extreme cases, such as dipyramids, are considered, the bias can exceed 10% or more. (3) Morphologic effects can be accounted for to better than 1% precision by using new second-order polynomial parameters that describe retentivity as a function of surface-area-to-volume ratio calculated through more complete analysis of crystal dimensions including the height of pyramidal crystal sections. We illustrate application of our model using U-Th concentration profiles determined from single zircons by laser ablation ICP-MS from zoned Tardree Rhyolite zircons.
Treatment options are limited for patients with high-risk myelodysplastic syndrome (MDS). The azanucleosides, azacitidine and decitabine, are first-line therapy for MDS that induce promoter ...demethylation and gene expression of the highly immunogenic tumor antigen NY-ESO-1. We demonstrated that patients with acute myeloid leukemia (AML) receiving decitabine exhibit induction of NY-ESO-1 expression in circulating blasts. We hypothesized that vaccinating against NY-ESO-1 in patients with MDS receiving decitabine would capitalize upon induced NY-ESO-1 expression in malignant myeloid cells to provoke an NY-ESO-1-specific MDS-directed cytotoxic T-cell immune response.
In a phase I study, 9 patients with MDS received an HLA-unrestricted NY-ESO-1 vaccine (CDX-1401 + poly-ICLC) in a nonoverlapping schedule every four weeks with standard-dose decitabine.
Analysis of samples serially obtained from the 7 patients who reached the end of the study demonstrated induction of
expression in 7 of 7 patients and NY-ESO-1-specific CD4
and CD8
T-lymphocyte responses in 6 of 7 and 4 of 7 of the vaccinated patients, respectively. Myeloid cells expressing NY-ESO-1, isolated from a patient at different time points during decitabine therapy, were capable of activating a cytotoxic response from autologous NY-ESO-1-specific T lymphocytes. Vaccine responses were associated with a detectable population of CD141
conventional dendritic cells, which are critical for the uptake of NY-ESO-1 vaccine and have a recognized role in antitumor immune responses.
These data indicate that vaccination against induced NY-ESO-1 expression can produce an antigen-specific immune response in a relatively nonimmunogenic myeloid cancer and highlight the potential for induced antigen-directed immunotherapy in a group of patients with limited options.
.
We report a mountain-scale record of erosion rates in the central Patagonian Andes from >10 million years (Ma) ago to present, which covers the transition from a fluvial to alpine glaciated ...landscape. Apatite (U-Th)/He ages of 72 granitic cobbles from alpine glacial deposits show slow erosion before ~6 Ma ago, followed by a two- to threefold increase in the spatially averaged erosion rate of the source region after the onset of alpine glaciations and a 15-fold increase in the top 25% of the distribution. This transition is followed by a pronounced decrease in erosion rates over the past ~3 Ma. We ascribe the pulse of fast erosion to local deepening and widening of valleys, which are characteristic features of alpine glaciated landscapes. The subsequent decline in local erosion rates may represent a return toward a balance between rock uplift and erosion.