Summary
The aim of the current study was to use a Bayesian network meta-analysis to evaluate the relative benefits and risks of balloon kyphoplasty (BK), percutaneous vertebroplasty (PVP), and ...non-surgical treatment (NST) for patients with osteoporotic vertebral compression fractures (OVCFs). The results demonstrate that for pain and functional status, PVP was significantly better than NST, while the three treatments did not significantly differ in other outcomes.
Introduction
BK, PVP, and NST are widely used to treat OVCFs, but preferable treatment is unknown. The aim of the current study was to use a Bayesian network meta-analysis to evaluate the relative benefits and risks of BK, PVP, and NST for patients with OVCFs.
Methods
PubMed, EMBASE, and the Cochrane Library were screened. Based on the preplanned eligibility criteria, we screened and included randomized controlled trials that compared BK, PVP, and NST in treating patients with OVCFs. The risk of bias for individual studies was appraised. The data were pooled using a Bayesian network meta-analysis and a traditional direct comparison meta-analysis.
Results
Of the 1057 relevant studies, 15 were eligible and included. Compared with NST, PVP significantly reduced pain, Oswestry Disability Index (ODI), and Roland–Morris Disability Questionnaire (RMDQ). The comparative efficacy of BK and PVP was similar for pain (mean difference (MD) 0.51, 95% credible interval (CrI) − 0.35 to 1.4), ODI (MD 0.11, 95% CrI − 13 to 13), and RMDQ (MD 1.2, 95% CrI − 2.7 to 5.4). The European Quality of Life–5 Dimensions (EQ–5D) and Physical Component Summary subscales of the Medical Outcomes Study 36-Item Short-Form General Health Survey (SF-36 PCS) did not differ significantly. There were also no substantial differences in the risks of subsequent vertebral fractures, adjacent vertebral fractures, and re-fractures at the treated level across all comparators. The results of pairwise meta-analyses were almost consistent with those of network meta-analyses. The treatment ranking indicated that PVP had the highest probability of being the most effective for pain, ODI, RMDQ, and EQ-5D. BK had the highest probability of improving SF-36 PCS and of reducing the risk of subsequent vertebral fractures and re-fractures at the treated level. NST was ranked first in preventing adjacent vertebral fractures.
Conclusion
PVP was the most effective method for improving pain, functional status, and quality of life (based on EQ-5D). BK emerged as the best intervention for decreasing the risk of subsequent vertebral fractures and re-fractures at the treated level. NST could be ranked first in reducing adjacent vertebral fractures. The future directions of OVCFs treatment will depend on the outcomes of additional and larger randomized trials in comparing BK with PVP.
Abstract
Gamma-ray bursts (GRBs) are the most luminous explosions in and can be detectable out to the edge of the universe. They have long been thought to be able to extend the Hubble diagram to very ...high redshifts. Several correlations between temporal or spectral properties and GRB luminosities have been proposed to make GRBs cosmological tools. However, those correlations cannot be properly standardized. In this paper, we select a long-GRB sample with X-ray plateau phases produced by electromagnetic dipole emissions from central newborn magnetars. A tight correlation is found between the plateau luminosity and the end time of the plateau in the X-ray afterglows out to the redshift
z
= 5.91. We standardize these long-GRB X-ray light curves to a universal behavior through this correlation, with a luminosity dispersion of 0.5 dex. The derived distance–redshift relation of GRBs is in agreement with the standard ΛCDM model both at low and high redshifts. The evidence for an accelerating universe from this GRB sample is 3
σ
, which is the highest statistical significance from GRBs to date.
Electroencephalographic gamma band oscillations (GBOs) induced over the human primary somatosensory cortex (SI) by nociceptive stimuli have been hypothesized to reflect cortical processing involved ...directly in pain perception, because their magnitude correlates with pain intensity. However, as stimuli perceived as more painful are also more salient, an alternative interpretation of this correlation is that GBOs reflect unspecific stimulus-triggered attentional processing. In fact, this is suggested by recent observations that other features of the electroencephalographic (EEG) response correlate with pain perception when stimuli are presented in isolation, but not when their saliency is reduced by repetition. Here, by delivering trains of three nociceptive stimuli at a constant 1 s interval, and using different energies to elicit graded pain intensities, we demonstrate that GBOs recorded over SI always predict the subjective pain intensity, even when saliency is reduced by repetition. These results provide evidence for a close relationship between GBOs and the cortical activity subserving pain perception.
A critical challenge facing the basic long-pulse high-confinement operation scenario (H mode) for ITER is to control a magnetohydrodynamic (MHD) instability, known as the edge localized mode (ELM), ...which leads to cyclical high peak heat and particle fluxes at the plasma facing components. A breakthrough is made in the Experimental Advanced Superconducting Tokamak in achieving a new steady-state H mode without the presence of ELMs for a duration exceeding hundreds of energy confinement times, by using a novel technique of continuous real-time injection of a lithium (Li) aerosol into the edge plasma. The steady-state ELM-free H mode is accompanied by a strong edge coherent MHD mode (ECM) at a frequency of 35-40 kHz with a poloidal wavelength of 10.2 cm in the ion diamagnetic drift direction, providing continuous heat and particle exhaust, thus preventing the transient heat deposition on plasma facing components and impurity accumulation in the confined plasma. It is truly remarkable that Li injection appears to promote the growth of the ECM, owing to the increase in Li concentration and hence collisionality at the edge, as predicted by GYRO simulations. This new steady-state ELM-free H-mode regime, enabled by real-time Li injection, may open a new avenue for next-step fusion development.
ABSTRACT
Gamma-ray bursts (GRBs), as a possible probe to extend the Hubble diagram to high redshifts, have attracted much attention recently. In this paper, we select two samples of GRBs that have a ...plateau phase in X-ray afterglow. One is short GRBs (SGRBs) with plateau phases dominated by magnetic dipole (MD) radiations. The other is long GRBs (LGRBs) with gravitational wave (GW) dominated plateau phases. These GRBs can be well standardized using the correlation between the plateau luminosity L0 and the end time of plateau tb. The so-called circularity problem is mitigated by using the observational Hubble parameter data and Gaussian process method. The calibrated L0 – tb correlations are also used to constrain Lambda cold dark matter (ΛCDM) and w(z) = w0 models. Combining the MD–LGRBs sample from Wang et al. (2021) and the MD–SGRBs sample, we find $\Omega _{\mathrm{ m}} = 0.33_{-0.09}^{+0.06}$ and ΩΛ = $1.06_{-0.34}^{+0.15}$ excluding systematic uncertainties in the non-flat ΛCDM model. Adding Type Ia supernovae from Pantheon sample, the best-fitting results are w0 = $-1.11_{-0.15}^{+0.11}$ and Ωm = $0.34_{-0.04}^{+0.05}$ in the w = w0 model. These results are in agreement with the ΛCDM model. Our result supports that selection of GRBs from the same physical mechanism is crucial for cosmological purposes.
China overtook the U.S. in 2011 to become the country filing the largest number of patent applications. Has China's patenting ascendancy been propelled by Chinese firms’ increasing technological ...sophistication or their much greater propensity to seek patents? Using a unique and never before used data set, where the State Intellectual Property Office (SIPO) patent records have been matched to their applicant firms by SIPO, we differentiate the two potential explanations by estimating a patent production function and by relating a firm's patents in force to its labor productivity. Our main findings are: 1) while the patenting surge has been an across-the-board phenomenon, most of the growth has come from the extensive margin of growth – firms that were not actively applying for patents in the past; 2) the correlation between patents and R&D and that between patents and labor productivity have become weaker, particularly for utility models and for the extensive margin of growth. These results suggest that non-innovation related motives for acquiring patents may have played an important role in the patenting surge.
•The first study to use grant level data to assess the impact of public funding on the performance of Chinese science.•Exploited a major upgrade in 2011 of the Open Application Fund, the most ...important funding program of the National Natural Science Foundation of China.•Found a significant impact of the funding upgrade on research performance.•The impact substantially varies by researcher characteristics, including experience, field of science, and type of affiliated institutions.•Explored mechanisms through which the impact may have taken place.
We investigate the role of public funding in the rapid ascent of Chinese science by examining the impact of a major upgrade of a funding program of the National Natural Science Foundation of China in 2011. Using research grant level data and a difference-in-differences estimator, we found that the more generous funding resulted in higher research output, measured by the number of publications, the number of citation-weighted publications, the number of journal impact factor-adjusted publications, and the maximum journal impact factor. This belies significant variation in the impact of the change in funding by researcher characteristics: 1) less-established researchers benefit more from the funding upgrade; 2) scientific fields that are more likely to be financially constrained benefited more; and 3) researchers from less-prestigious research institutions made more productive use of the additional funds. Finally, we found that the funding upgrade has led to increasing collaboration with researchers from top science-producing foreign countries for the less-prestigious institutions.
Summary
Dysfunction of the immune regulatory system plays an important role in the pathogenesis of rheumatoid arthritis (RA). Vasoactive intestinal peptide (VIP) has multiple bioactivities. This ...study aims to investigate the role of VIP in the maintenance of the immune regulatory capacity of monocytes (Mos). Human peripheral blood samples were collected from RA patients and healthy control (HC) subjects. Mos and CD14+ CD71–CD73+CD25+ regulatory Mos (RegMos) were isolated from the blood samples and characterized by flow cytometry. A rat RA model was developed to test the role of VIP in the maintenance of the immune regulatory function of Mos. The results showed that RegMos of HC subjects had immune suppressive functions. RegMos of RA patients expressed less interleukin (IL)‐10 and showed an incompetent immune regulatory capacity. Serum levels of VIP were lower in RA patients, which were positively correlated with the expression of IL‐10 in RegMos. In‐vitro experiments showed that the IL‐10 mRNA decayed spontaneously in RegMos, which could be prevented by the presence of VIP in the culture. VIP suppressed the effects of tristetraprolin (TTP) on inducing IL‐10 mRNA decay in RegMos. Administration of VIP inhibited experimental RA in rats through restoring the IL‐10 expression in RegMos. RegMos have immune suppressive functions. VIP is required in maintaining IL‐10 expression in RegMos. The data suggest that VIP has translational potential in the treatment of immune disorders such as RA.
A fraction of peripheral monocyte has immune regulatory function, which is impaired in patients with rheumatoid arthritis.
PDF
