Objective: To analyze and compare therapy responses, outcomes, and incidence of severe hematologic adverse events of flumatinib and imatinib in patients newly diagnosed with chronic phase chronic ...myeloid leukemia (CML) . Methods: Data of patients with chronic phase CML diagnosed between January 2006 and November 2022 from 76 centers, aged ≥18 years, and received initial flumatinib or imatinib therapy within 6 months after diagnosis in China were retrospectively interrogated. Propensity score matching (PSM) analysis was performed to reduce the bias of the initial TKI selection, and the therapy responses and outcomes of patients receiving initial flumatinib or imatinib therapy were compared. Results: A total of 4 833 adult patients with CML receiving initial imatinib (n=4 380) or flumatinib (n=453) therapy were included in the study. In the imatinib cohort, the median follow-up time was 54 interquartile range (IQR), 31-85 months, and the 7-year cumulative incidences of CCyR, MMR, MR(4), and MR(4.5) were 95.2%
The focal plane camera is the core component of the Wide Field-of-view Cherenkov/fluorescence Telescope Array (WFCTA) of the Large High-Altitude Air Shower Observatory (LHAASO). Because of the ...capability of working under moonlight without aging, silicon photomultipliers (SiPM) have been proven to be not only an alternative but also an improvement to conventional photomultiplier tubes (PMT) in this application. Eighteen SiPM-based cameras with square light funnels have been built for WFCTA. The telescopes have collected more than 100 million cosmic ray events and preliminary results indicate that these cameras are capable of working under moonlight. The characteristics of the light funnels and SiPMs pose challenges (e.g. dynamic range, dark count rate, assembly techniques). In this paper, we present the design features, manufacturing techniques and performances of these cameras. Finally, the test facilities, the test methods and results of SiPMs in the cameras are reported here.
The target compound ethyl 3-(2,3-dihydrobenzofuran-5-yl)-2-propenoate was synthesized by a two-step reaction. A single crystal of this compound was grown in a suitable solvent system, the structure ...of this compound was confirmed by
1
H and
13
C NMR, MS, FT-IR, and X-ray single crystal diffraction methods. At the same time, conformational studies and crystallographic analysis of the structure were carried out. The Hirshfeld surface analysis method was used to analyze the intermolecular forces. The crystal structure of the target compound was optimized by density functional theory calculations. The crystal structure after X-ray crystal diffraction was compared with the crystal structure optimized by DFT calculation. The results showed that the single crystal structure determined by X-ray crystal diffraction was consistent with the molecular structure after DFT optimization. In addition, by further studying the molecular electrostatic potential and frontier molecular orbital of the target compound, the molecular physicochemical properties of the target compound are understood.
Background and purpose
Inflammation comprises important aspects of large‐artery atherosclerosis (LAA) stroke pathophysiology. YKL‐40 is a new and emerging biomarker that is associated with both acute ...and chronic inflammations. Elevated serum concentrations of YKL‐40 have been reported in patients with atherosclerosis and other cardiovascular diseases. This study investigates whether serum YKL‐40 concentrations on admission can predict 3‐month clinical outcomes after LAA stroke.
Methods
We recruited control patients (n=85) and those with LAA stroke (n=141) according to the TOAST classification system. The modified Rankin scale at 3 months after stroke was used to evaluate the prognosis. The prognostic accuracy was assessed by the receiver operating characteristic curve.
Results
Serum YKL‐40 level was significantly higher for LAA patients than for controls (P<.001). Patients with poor outcomes (n=36) had significantly increased serum YKL‐40 concentrations on admission (P=.01). High YKL‐40 levels predicted poor functional outcome (OR=6.47, P=.02). Moreover, the combination of YKL‐40 level and the NIHSS score could improve the prognostic accuracy of the NIHSS in predicting functional outcome (combined areas under the curve, 0.87; 95% CI, 0.80‐0.94; P<.001).
Conclusions
The level of serum YKL‐40 is a significant and independent biomarker to predict the clinical outcome of LAA stroke.
Relaxin (RLX) can prevent cardiac fibrosis. We aimed to investigate the possible mechanism and signal transduction pathway of RLX inhibiting cardiac fibrosis.
Isoproterenol (5 mg·kg(-1)·d(-1)) was ...used to establish the cardiac fibrosis model in rats, which were administered RLX. The cardiac function, related targets of cardiac fibrosis, and endothelial-mesenchymal transition (EndMT) were measured. Transforming growth factor β (TGF-β) was used to induce EndMT in human umbilical vein endothelial cells, which were pretreated with RLX, 200 ng·mL(-1), then with the inhibitor of Notch. Transwell cell migration was used to evaluate cell migration. CD31 and vimentin content was determined by immunofluorescence staining and Western blot analysis. Notch protein level was examined by Western blot analysis.
RLX improved cardiac function in rats with cardiac fibrosis; it reduced the content of collagen I and III, increased the microvascular density of the myocardium, and suppressed the EndMT in heart tissue. In vitro, RLX decreased the mobility of human umbilical vein endothelial cells induced by TGF-β, increased the expression of endothelial CD31, and decreased vimentin content. Compared to TGF-β and RLX co-culture alone, TGF-β + RLX + Notch inhibitor increased cell mobility and the EndMT, but decreased the levels of Notch-1, HES-1, and Jagged-1 proteins.
RLX may inhibit the cardiac fibrosis via EndMT by Notch-mediated signaling.
Mass excesses of short-lived A ¼ 2Z 1 nuclei 63Ge, 65As, 67Se, and 71Kr have been directly measured to be 46 921ð37Þ, 46 937ð85Þ, 46 580ð67Þ, and 46 320ð141Þ keV, respectively. The deduced proton ...separation energy of 90ð85Þ keV for 65As shows that this nucleus is only slightly proton unbound. X-ray burst model calculations with the new mass excess of 65As suggest that the majority of the reaction flow passes through 64Ge via proton capture, indicating that 64Ge is not a significant rp-process waiting point.
We present a measurement of the azimuthal asymmetries of two charged pions in the inclusive process e+ e- arrow right pipiX, based on a data set of 62 pb super(-1) at the center-of-mass energy of ...3.65 GeV collected with the BESIII detector. These asymmetries can be attributed to the Collins fragmentation function. We observe a nonzero asymmetry, which increases with increasing pion momentum. As our energy scale is close to that of the existing semi-inclusive deep inelastic scattering experimental data, the measured asymmetries are important inputs for the global analysis of extracting the quark transversity distribution inside the nucleon and are valuable to explore the energy evolution of the spin-dependent fragmentation function.
We report an empirical thermodynamic law for the synthesis of core/shell metal/heterogeneous oxide nanocapsules, such as Fe/SiO2, Ni/SiO2, Fe/B2O3, Ni/B2O3, Fe/Al2O3, Fe/MnO2, Fe/Y2O3, Fe/CeO2, and ...Fe/La2O3, by arc-discharge evaporating a compressed mixture of Fe (or Ni) powders and the oxide powders of shell components. By integrating such dielectric oxide shells and magnetic metal cores in each particle, the electromagnetic losses can be artificially manipulated at the whole S-band, C-band, X-band, and Ku frequency ranges. The microscopic origins of the controllability of electromagnetic losses are ascribed to the specific matching and interfacial coupling between the magnetic cores and dielectric shells.
The derivation of tissue-specific stem cells from human induced pluripotent stem cells (iPSCs) would have broad reaching implications for regenerative medicine. Here, we report the directed ...differentiation of human iPSCs into airway basal cells (“iBCs”), a population resembling the stem cell of the airway epithelium. Using a dual fluorescent reporter system (NKX2-1GFP;TP63tdTomato), we track and purify these cells as they first emerge as developmentally immature NKX2-1GFP+ lung progenitors and subsequently augment a TP63 program during proximal airway epithelial patterning. In response to primary basal cell medium, NKX2-1GFP+/TP63tdTomato+ cells display the molecular and functional phenotype of airway basal cells, including the capacity to self-renew or undergo multi-lineage differentiation in vitro and in tracheal xenografts in vivo. iBCs and their differentiated progeny model perturbations that characterize acquired and genetic airway diseases, including the mucus metaplasia of asthma, chloride channel dysfunction of cystic fibrosis, and ciliary defects of primary ciliary dyskinesia.
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•Directed differentiation of human iPSCs generates airway basal cells (“iBCs”)•iBCs self-renew and display multipotent differentiation in vitro and in vivo•By single-cell RNA-seq, iBCs are highly similar to adult primary airway basal cells•iBCs enable modeling of acquired and genetic airway diseases
Hawkins and colleagues report a directed differentiation protocol enabling the derivation of airway basal cells (“iBCs”) from human iPSCs. iBCs recapitulate hallmark stem cell properties of primary basal cells, including self-renewal and multi-lineage differentiation, thus enabling modeling of airway diseases in vitro and repopulation of tracheal xenografts in vivo.
NiO films were prepared by chemical bath deposition and electrodeposition method, respectively, using nickel foam as the substrate. The films were characterized by scanning electron microscopy (SEM) ...and the images showed that their morphologies were distinct. The NiO film prepared by chemical bath deposition was highly porous, while the film prepared by electrodeposition was dense, and both of their thickness was about 1
μm. As anode materials for lithium ion batteries, the porous NiO film prepared by chemical bath deposition exhibited higher coulombic efficiency and weaker polarization and its specific capacity after 50 cycles was 490
mAh
g
−1 at the discharge–charge current density of 0.5
A
g
−1, and 350
mAh
g
−1 at 1.5
A
g
−1, higher than the electrodeposited film (230
mAh
g
−1 at 0.5
A
g
−1, and 170
mAh
g
−1 at 1.5
A
g
−1). The better electrochemical performances of the film prepared by chemical bath deposition are attributed to its highly porous morphology, which shorted diffusion length of lithium ions, and relaxed the volume change caused by the reaction between NiO and Li
+.
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